GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	3536	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3536	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3536	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3536	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11693	1814	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1814	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1814	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1814	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1814	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1814	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	367	3795	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3795	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3795	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3795	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3795	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3795	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3795	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	3775	14443	26	None	-1	3	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	14443	26	None	-1	3	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	1613	2333	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2136	3073	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3073	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3073	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3073	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3073	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	5280343	188251	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL1520590	188251	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL50	188251	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	2247	504	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	4614	5359	103	None	-131	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	CHEMBL1071	5359	103	None	-131	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	47936	193398	88	None	-97	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193398	88	None	-97	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	180	400	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4940	14438	35	None	-18	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14438	35	None	-18	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	5573	67551	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1325297	67551	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL190044	67551	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	4919	206211	23	None	-5	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	206211	23	None	-5	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3316	31730	71	None	-22	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31730	71	None	-22	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	21109	74970	75	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL203266	74970	75	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	26248	161515	102	None	1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161515	102	None	1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	4413	98045	57	None	-3	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98045	57	None	-3	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	9429	202110	58	None	-588	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202110	58	None	-588	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3658	4076	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4076	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4076	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4076	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4076	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	2220	3112	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3112	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3112	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3112	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3112	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	68873	43534	64	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43534	64	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	443955	204347	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204347	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	21158560	112766	7	None	-3090	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL3305985	112766	7	None	-3090	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL5292015	194514	0	None	-29	5	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	41684	31191	105	None	-3	32	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31191	105	None	-3	32	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4477	36506	90	None	-12	4	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL1448	36506	90	None	-12	4	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	5284550	41691	15	None	-74	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41691	15	None	-74	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	3149	12582	15	None	-38	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12582	15	None	-38	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	2333	142310	97	None	1	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142310	97	None	1	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2713	205248	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205248	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205248	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205248	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205248	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205248	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205248	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	154257	178595	67	None	-42	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-42	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	68617	205504	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205504	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205504	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	216416	111554	48	None	-177	23	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111554	48	None	-177	23	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	5048	3111	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	8924	3111	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	9948102	3111	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL462605	3111	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB11642	3111	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	107771	120222	49	None	1	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	120222	49	None	1	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	5803	162203	84	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162203	84	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	6127	14467	8	None	1	6	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14467	8	None	1	6	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72093	35031	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	20628	96519	28	None	-40	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96519	28	None	-40	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	447715	196904	68	None	-26	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	196904	68	None	-26	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	1024	1558	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	556	1558	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294	1558	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL211456	1558	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	DB01364	1558	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	13314	84204	15	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL22097	84204	15	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	4450	178204	69	None	-26	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178204	69	None	-26	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	2335	11816	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	1816	2523	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2523	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2523	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2523	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2523	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4976	203556	29	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203556	29	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	46780481	107504	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107504	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107504	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107504	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	5210	33308	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	33308	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	33308	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	47936	193398	88	None	-97	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193398	88	None	-97	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	1530	2169	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2169	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2169	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2169	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2169	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	1971	2846	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3000322	3536	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3536	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3536	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3536	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3108	207264	116	None	1	7	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	207264	116	None	1	7	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	13789	38347	65	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL1463345	38347	65	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	26987	946	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	213046	2370	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	43815	186896	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186896	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186896	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	3081361	93905	123	None	-33	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93905	123	None	-33	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	100	3776	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3776	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3776	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3776	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3776	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	1056	3346	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3346	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3346	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3346	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3346	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	60753	194661	40	None	-6	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	194661	40	None	-6	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	187	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2131	57377	25	None	-3	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1652	57377	25	None	-3	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	3236	67579	43	None	-2	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	67579	43	None	-2	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	4832	55390	17	None	-1	4	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1619528	55390	17	None	-1	4	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	2705	3813	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3813	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3813	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3813	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3813	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	124	2960	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2960	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2960	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2960	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2960	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2402	3345	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3345	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3345	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3345	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3345	62	None	-851	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10184653	10965	107	None	-26	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	CHEMBL1173655	10965	107	None	-26	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	127151	35300	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	3022645	35300	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL14370	35300	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	19675	51640	43	None	-1862	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51640	43	None	-1862	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3949	100586	50	None	-25	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100586	50	None	-25	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	54697325	58949	35	None	2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58949	35	None	2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	25382	9125	37	None	-6	21	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9125	37	None	-6	21	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	3158	56237	27	None	-891	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-891	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	1210	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	90475904	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	915	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	5833	30453	74	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30453	74	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	2165	203760	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	203760	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	203760	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	2564	206161	51	None	-239	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL864	206161	51	None	-239	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	16363	593	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	593	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	593	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	593	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	593	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	10133	907	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	907	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	907	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	907	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	907	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	907	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	60606	61530	73	None	-13	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61530	73	None	-13	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2726	916	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2333	142310	97	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142310	97	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2895	203569	41	None	-38	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203569	41	None	-38	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	31101	726	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	131411	15360	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	15360	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	15360	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	5591	157507	90	None	-13	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157507	90	None	-13	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	2905	14466	50	None	-10	3	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201338	14466	50	None	-10	3	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	8612	11228	36	None	-7	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1179047	11228	36	None	-7	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	2381	660	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	374	660	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7128	660	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1101	660	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00810	660	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	123603	880	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	2684	880	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	584	880	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	9658	880	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	CHEMBL168815	880	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	23480	124064	23	None	-4	7	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL363295	124064	23	None	-4	7	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	2286	3161	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2551	791	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	791	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	791	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	791	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	791	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	4942	5686	50	None	-4	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5686	50	None	-4	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2166	3101	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	3101	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	3101	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	3101	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	3101	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2370	620	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	297	620	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	358	620	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	CHEMBL1482	620	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	DB01019	620	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	319	1312	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1312	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1312	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1312	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1312	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1312	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	6450551	19179	106	None	1	3	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	CHEMBL1289926	19179	106	None	1	3	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	1427	2000	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2000	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2000	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2000	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2000	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2200	3109	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3109	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3109	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3109	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3109	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	2540	4369	111	None	-660	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4369	111	None	-660	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	124087	1377	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2995	204382	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204382	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204382	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4746	204868	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204868	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204868	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	11504295	2902	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2902	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2902	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2902	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2902	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2583	3747	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3747	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3747	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3747	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3747	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	4122	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1224	1420	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1420	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1420	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1420	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1420	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1420	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	5453	203596	102	None	-13	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203596	102	None	-13	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	3652	4066	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4066	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4066	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4066	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4066	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	135	2515	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	5284632	67372	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	67372	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	67372	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	154417	23149	60	None	-2	7	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23149	60	None	-2	7	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	2470	3626	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	71496458	115538	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115538	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	657202	12498	6	None	-17	4	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1186610	12498	6	None	-17	4	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	54682461	84657	62	None	-1	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84657	62	None	-1	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	154257	178595	67	None	-42	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-42	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	1385580	29245	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29245	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29245	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16351	102703	47	None	-309	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102703	47	None	-309	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	4066	204603	78	None	-4	16	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204603	78	None	-4	16	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4642	41956	28	None	-2	3	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	41956	28	None	-2	3	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	2774	3839	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3839	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3839	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3839	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3839	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3839	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	135398737	955	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	24826799	10766	104	None	-24	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10766	104	None	-24	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	19861	207500	50	None	-3	10	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207500	50	None	-3	10	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	4150	785	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	785	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	785	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	785	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	785	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	3294	1993	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	1993	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	1993	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	1993	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	1993	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2337	3232	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	3042	1402	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1402	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1402	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1402	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1402	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	1201549	594	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	594	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	594	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	594	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	594	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	594	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24821094	67064	93	None	-4	8	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67064	93	None	-4	8	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	636403	188244	22	None	-3	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188244	22	None	-3	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	2267	557	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	557	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	557	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	557	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	557	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	129456	207149	14	None	8	2	Human	10.4	pEC50	=	10.4	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207149	14	None	8	2	Human	10.4	pEC50	=	10.4	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	10104167	2046	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	6937	2046	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL3121473	2046	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	42599070	16046	0	None	-251	5	Human	7.0	pEC50	=	7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223804	16046	0	None	-251	5	Human	7.0	pEC50	=	7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	137630848	161092	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061390	161092	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117131	161092	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	10386	161144	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092348	161144	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117554	161144	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	2230	464	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	296	464	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	CHEMBL7303	464	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	DB04365	464	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	2551	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	298	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	488	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	CHEMBL965	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	DB00411	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	49799920	10510	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL1169506	10510	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	11120503	4164	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100163	4164	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	137629935	160996	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44329977	111383	0	None	-10	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL327269	111383	0	None	-10	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	44589681	185264	0	None	-1	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	CHEMBL485913	185264	0	None	-1	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	22745278	187039	1	None	-5	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	CHEMBL491209	187039	1	None	-5	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	2551	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	298	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	488	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	CHEMBL965	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	DB00411	791	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	10104047	21605	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21605	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	137629935	160996	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191002	123586	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	CHEMBL3618445	123586	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	170332	160952	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3652	4066	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	57	4066	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	60809	4066	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	CHEMBL21536	4066	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	DB15357	4066	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	44303017	200810	0	None	-19	2	Human	5.9	pEC50	=	5.9	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60101	200810	0	None	-19	2	Human	5.9	pEC50	=	5.9	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	42598829	16048	0	None	-158	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223806	16048	0	None	-158	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	45786849	157781	34	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4083241	157781	34	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	44330073	208407	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL99884	208407	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44209166	59526	0	None	7	2	Human	7.9	pEC50	=	7.9	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL171721	59526	0	None	7	2	Human	7.9	pEC50	=	7.9	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	44303408	201923	0	None	-16	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60777	201923	0	None	-16	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10451242	203091	0	None	-218	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL64029	203091	0	None	-218	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	122189496	123310	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616500	123310	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	89777356	155858	0	None	-72	2	Human	5.8	pEC50	=	5.8	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4060475	155858	0	None	-72	2	Human	5.8	pEC50	=	5.8	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	53385782	74284	0	None	-56	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	CHEMBL2024331	74284	0	None	-56	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	424727	161150	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4095774	161150	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117601	161150	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	129456	207149	14	None	8	2	Human	7.7	pEC50	=	7.7	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207149	14	None	8	2	Human	7.7	pEC50	=	7.7	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	24967746	16023	0	None	-50	5	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223754	16023	0	None	-50	5	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9820835	116749	4	None	-	1	Human	5.7	pEC50	=	5.7	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL337676	116749	4	None	-	1	Human	5.7	pEC50	=	5.7	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	9927975	4158	0	None	-10	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100147	4158	0	None	-10	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	145973726	164606	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	CHEMBL4216213	164606	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	137629935	160996	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191003	123587	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618446	123587	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	137635723	156059	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4062934	156059	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	187	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	294	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	65	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	8593	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	CHEMBL667	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	DB03128	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	187	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	294	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	65	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	8593	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	CHEMBL667	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	DB03128	255	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	137630667	161068	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4100938	161068	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116890	161068	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	57230548	173209	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524085	173209	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	44330080	107693	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL319109	107693	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303018	202000	0	None	-218	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60833	202000	0	None	-218	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137631026	161126	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4093215	161126	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117321	161126	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	137628799	160969	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4064668	160969	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116150	160969	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189499	123311	0	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	CHEMBL3616504	123311	0	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	10686494	100510	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	CHEMBL291351	100510	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	10686494	100510	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	CHEMBL291351	100510	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	122191007	123590	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618449	123590	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	42598357	16073	0	None	-794	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223863	16073	0	None	-794	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42598359	16074	0	None	-199	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223864	16074	0	None	-199	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25207745	16094	0	None	-251	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223941	16094	0	None	-251	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	89777060	157097	0	None	-114	2	Human	5.6	pEC50	=	5.6	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4074908	157097	0	None	-114	2	Human	5.6	pEC50	=	5.6	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	5487543	205623	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	CHEMBL81878	205623	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	11725107	100585	0	None	-134	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL291872	100585	0	None	-134	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629887	160986	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4065555	160986	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116259	160986	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	10375002	24114	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL133905	24114	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	44158142	188646	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	CHEMBL503735	188646	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	5487543	205623	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	CHEMBL81878	205623	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	650899	54384	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1535797	54384	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1609153	54384	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	44158142	188646	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	CHEMBL503735	188646	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	57088082	173210	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524086	173210	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	53414666	159277	8	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099673	159277	8	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	178030	21339	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	CHEMBL131428	21339	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	129456	207149	14	None	8	2	Human	8.5	pEC50	=	8.5	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	207149	14	None	8	2	Human	8.5	pEC50	=	8.5	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	137629935	160996	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	137629935	160996	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191006	123589	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618448	123589	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	3652	4066	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	57	4066	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809	4066	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	CHEMBL21536	4066	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	DB15357	4066	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	42598360	16072	0	None	-158	5	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223862	16072	0	None	-158	5	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	87934	98053	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL273308	98053	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL542883	98053	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	122191004	123307	0	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616497	123307	0	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	122191001	123585	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618444	123585	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	187	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	647412	27288	9	None	-3	4	Human	4.3	pEC50	=	4.3	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	CHEMBL1367424	27288	9	None	-3	4	Human	4.3	pEC50	=	4.3	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	187	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	137639541	156679	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4070061	156679	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	42598358	16070	0	None	-501	5	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223860	16070	0	None	-501	5	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	187	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44303293	201403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60479	201403	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	53382542	86284	0	None	-7	6	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	CHEMBL2313377	86284	0	None	-7	6	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	187	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	122191005	123588	0	None	-3	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618447	123588	0	None	-3	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	2551	791	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	791	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	791	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	791	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	791	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	10426487	2821	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	291	2821	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	CHEMBL99521	2821	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	306	3430	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	3536	3430	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	53930639	3430	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	9577995	3430	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	CHEMBL134641	3430	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	42598591	16045	0	None	-125	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223803	16045	0	None	-125	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599068	16047	0	None	-199	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223805	16047	0	None	-199	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25230693	16093	0	None	-251	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223940	16093	0	None	-251	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	16071018	16022	20	None	-112	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL1223753	16022	20	None	-112	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16038385	80429	0	None	-10	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL2146598	80429	0	None	-10	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16123945	80430	12	None	-125	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	CHEMBL2146599	80430	12	None	-125	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	170332	160952	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2166	3101	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	305	3101	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	5910	3101	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	CHEMBL550	3101	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	DB01085	3101	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	170332	160952	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189495	123309	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616499	123309	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122191008	123591	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618450	123591	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303397	102261	0	None	-75	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL303360	102261	0	None	-75	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10104047	21605	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21605	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	10019339	102599	0	None	-138	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL304247	102599	0	None	-138	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	5441	2410	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	9893054	2410	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL3616501	2410	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	187	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	294	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	65	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	8593	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL667	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	DB03128	255	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	2551	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	298	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	488	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	CHEMBL965	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	DB00411	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	2551	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	298	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	488	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	CHEMBL965	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	DB00411	791	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	59654579	123581	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618440	123581	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122190994	123578	0	None	-14	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618436	123578	0	None	-14	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303294	201133	0	None	-16	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60331	201133	0	None	-16	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	170332	160952	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44303286	201295	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL60419	201295	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	44303286	201295	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	CHEMBL60419	201295	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	170332	160952	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44253016	80428	2	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	CHEMBL2146597	80428	2	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	44303019	100919	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL294082	100919	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	16071018	16022	20	None	-112	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223753	16022	20	None	-112	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	42598828	16071	0	None	-630	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223861	16071	0	None	-630	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599071	16092	0	None	-316	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223939	16092	0	None	-316	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9883040	100509	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL291339	100509	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL542622	100509	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44303396	201213	0	None	1	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60374	201213	0	None	1	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	118500	156975	63	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4073256	156975	63	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	44303323	163218	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL418491	163218	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10104047	21605	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21605	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	71792	78377	38	None	-2	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	CHEMBL2111051	78377	38	None	-2	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	44303327	162987	0	None	-31	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL417560	162987	0	None	-31	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	2551	791	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	298	791	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	488	791	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL965	791	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB00411	791	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44330081	208140	0	None	-17	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL98255	208140	0	None	-17	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303314	100906	0	None	-363	3	Human	6.0	pEC50	=	6.0	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL293982	100906	0	None	-363	3	Human	6.0	pEC50	=	6.0	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629744	161151	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4071109	161151	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117602	161151	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	644390	40382	6	None	-3	4	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	CHEMBL1482157	40382	6	None	-3	4	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	25010776	55925	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1559151	55925	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1624037	55925	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	137646732	157768	0	None	-12	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4083081	157768	0	None	-12	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	75356563	156933	23	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	CHEMBL4072787	156933	23	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	44372610	52513	0	None	181	2	Human	9.1	pED50	=	9.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL159208	52513	0	None	181	2	Human	9.1	pED50	=	9.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372301	49772	0	None	40	2	Human	8.7	pED50	=	8.7	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL156749	49772	0	None	40	2	Human	8.7	pED50	=	8.7	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372633	50278	0	None	-1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL157197	50278	0	None	-1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44372232	119794	0	None	-	0	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348412	119794	0	None	-	0	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	10058744	206359	0	None	1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL87622	206359	0	None	1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372253	49980	0	None	21	2	Human	7.9	pED50	=	7.9	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156925	49980	0	None	21	2	Human	7.9	pED50	=	7.9	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	9795428	96459	5	None	-30	5	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	CHEMBL262455	96459	5	None	-30	5	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	5487543	205623	4	None	-162	6	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81878	205623	4	None	-162	6	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	10266025	120140	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL351561	120140	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372580	119755	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348079	119755	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372492	155700	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL405426	155700	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	791	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	298	791	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	488	791	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	CHEMBL965	791	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	DB00411	791	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	10420458	206245	0	None	7	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL86903	206245	0	None	7	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372591	54315	0	None	-60	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160858	54315	0	None	-60	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372290	54421	0	None	-5	2	Human	6.6	pED50	=	6.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160939	54421	0	None	-5	2	Human	6.6	pED50	=	6.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	791	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	791	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	791	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	791	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	791	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	44372254	53936	0	None	-	1	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL160554	53936	0	None	-	1	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10086044	48948	0	None	6	2	Human	8.5	pED50	=	8.5	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL156050	48948	0	None	6	2	Human	8.5	pED50	=	8.5	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9903828	119467	0	None	28	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345415	119467	0	None	28	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372506	119443	0	None	19	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345205	119443	0	None	19	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372278	49380	0	None	11	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156445	49380	0	None	11	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	44372277	168339	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL434469	168339	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10242016	168275	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL434072	168275	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372289	119450	0	None	-2	2	Human	6.3	pED50	=	6.3	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345250	119450	0	None	-2	2	Human	6.3	pED50	=	6.3	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44213237	101894	0	None	-	0	Human	6.2	pED50	=	6.2	Functional	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL300998	101894	0	None	-	0	Human	6.2	pED50	=	6.2	Functional	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44372647	119994	0	None	-1	2	Human	8.1	pED50	=	8.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL350223	119994	0	None	-1	2	Human	8.1	pED50	=	8.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44371814	51369	0	None	3	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL158180	51369	0	None	3	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372452	119597	0	None	-	0	Human	6.0	pED50	=	6.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL346580	119597	0	None	-	0	Human	6.0	pED50	=	6.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9913341	82129	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL216927	82129	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL553058	82129	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44590172	170294	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444688	170294	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL527216	170294	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590171	178724	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL468609	178724	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554632	178724	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590176	189041	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509614	189041	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555707	189041	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	155566290	176556	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176556	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176556	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	11690968	106474	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085072	106474	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140185	106474	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44590179	172693	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450538	172693	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553446	172693	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590167	179000	0	None	-3	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL471214	179000	0	None	-3	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589495	185956	0	None	-10	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486982	185956	0	None	-10	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590122	192536	0	None	-15	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL521244	192536	0	None	-15	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16125400	84634	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222449	84634	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76313456	106482	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085066	106482	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140216	106482	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	162675053	183234	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4796491	183234	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	71455968	83897	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206599	83897	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	10397133	107035	1	None	1	3	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL315676	107035	1	None	1	3	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71716773	86537	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86537	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	162353372	181363	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4763422	181363	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	71463135	83905	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206607	83905	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71716773	86537	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86537	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	109018479	181794	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	CHEMBL4778178	181794	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	76327901	103468	0	None	1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085084	103468	0	None	1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	44233675	103351	0	None	-11	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084639	103351	0	None	-11	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11518068	106479	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085059	106479	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140213	106479	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	44590180	172622	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL449640	172622	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540398	172622	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590175	188608	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL503025	188608	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553433	188608	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	52176747	159007	1	None	-2	8	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159007	1	None	-2	8	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	162353379	180938	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4758449	180938	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	25034111	193394	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL526009	193394	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44590123	183836	0	None	-15	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480877	183836	0	None	-15	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034111	193394	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL526009	193394	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589497	175269	0	None	-5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL457302	175269	0	None	-5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44233417	86017	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2307674	86017	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10092649	193049	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193049	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	10092649	193049	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193049	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	290	2456	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	4022	2456	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	5926	2456	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL40554	2456	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL74300	2456	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	71450616	83904	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206606	83904	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	11503336	106487	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085071	106487	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140242	106487	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	76309756	103467	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085083	103467	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76313457	103464	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085080	103464	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	13940563	206007	5	None	5	2	Rat	5.9	pIC50	=	5.9	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL8510	206007	5	None	5	2	Rat	5.9	pIC50	=	5.9	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353393	179415	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	CHEMBL4740422	179415	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	16664965	84873	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223668	84873	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76320693	103466	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085082	103466	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	109035013	180451	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	CHEMBL4752973	180451	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	76309755	103462	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085079	103462	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76320692	106481	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085065	106481	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140215	106481	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71459691	83903	0	None	5	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206605	83903	0	None	5	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	44590170	188347	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501348	188347	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553431	188347	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	109032820	182851	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4791819	182851	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	162353369	180771	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756442	180771	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	44232953	103364	0	None	-1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084663	103364	0	None	-1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	15681301	120294	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL352832	120294	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	15945874	188741	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505452	188741	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	15945874	188741	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505452	188741	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589984	190534	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL518001	190534	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590035	191730	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL519760	191730	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034180	188388	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL502000	188388	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589571	172563	0	None	-10	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448904	172563	0	None	-10	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589570	172733	0	None	-15	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL451040	172733	0	None	-15	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10465524	58966	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL169011	58966	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161016	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137408729	190718	0	None	-870	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5182783	190718	0	None	-870	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	15681299	120453	0	None	-1	2	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	CHEMBL354259	120453	0	None	-1	2	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	156015978	178299	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10397356	120690	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL354738	120690	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161016	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	162353388	180955	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4758633	180955	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	71459689	83887	0	None	1	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206585	83887	0	None	1	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	168276820	190082	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190082	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190082	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	71454215	83896	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206595	83896	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	109013312	180110	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4748774	180110	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	162658112	181047	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4759774	181047	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	11602980	103475	0	None	-2	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085091	103475	0	None	-2	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	76324336	103470	0	None	-1	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085086	103470	0	None	-1	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	162353384	181066	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4760037	181066	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	71452455	83890	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206588	83890	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	44590125	183837	0	None	-12	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480878	183837	0	None	-12	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590036	188353	0	None	-6	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501419	188353	0	None	-6	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	152278786	182728	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182728	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162646559	179616	0	None	-154	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4742997	179616	0	None	-154	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	25034112	188369	0	None	-1	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL501727	188369	0	None	-1	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589585	188868	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507375	188868	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555474	188868	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590177	188898	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507874	188898	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554918	188898	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	163938	106891	13	None	316	2	Human	7.7	pIC50	=	7.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	CHEMBL314737	106891	13	None	316	2	Human	7.7	pIC50	=	7.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	152278786	182728	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182728	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162353375	179871	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4745885	179871	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	10262405	57566	0	None	-2	2	Human	4.7	pIC50	=	4.7	Functional	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166782	57566	0	None	-2	2	Human	4.7	pIC50	=	4.7	Functional	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44234194	103369	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084670	103369	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10262466	98316	0	None	-10	2	Rat	6.7	pIC50	=	6.7	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL275104	98316	0	None	-10	2	Rat	6.7	pIC50	=	6.7	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	76324335	103465	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085081	103465	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10399393	205763	0	None	1	2	Human	5.7	pIC50	=	5.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL83074	205763	0	None	1	2	Human	5.7	pIC50	=	5.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	162658421	181077	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4760150	181077	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	156015807	178275	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	76324334	106450	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085070	106450	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140112	106450	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	156015978	178299	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	138578683	184779	0	None	-1318	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	CHEMBL4851711	184779	0	None	-1318	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	44265375	206124	0	None	-3	2	Rat	6.6	pIC50	=	6.6	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL8610	206124	0	None	-3	2	Rat	6.6	pIC50	=	6.6	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	162353386	180956	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758635	180956	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	44233189	103374	0	None	1	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084678	103374	0	None	1	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	162667844	182509	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4787283	182509	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	44418764	82130	0	None	-1	4	Human	6.6	pIC50	=	6.6	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	CHEMBL216928	82130	0	None	-1	4	Human	6.6	pIC50	=	6.6	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	44590033	183654	0	None	-12	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480299	183654	0	None	-12	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590166	189392	0	None	-3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL513228	189392	0	None	-3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	76316970	103459	0	None	-3	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085076	103459	0	None	-3	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10220392	205982	0	None	-6	2	Human	4.6	pIC50	=	4.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL84893	205982	0	None	-6	2	Human	4.6	pIC50	=	4.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11508710	103473	0	None	-1	3	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085089	103473	0	None	-1	3	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	156493644	185038	0	None	-1737	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4855467	185038	0	None	-1737	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	156493614	185376	0	None	-338	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4860985	185376	0	None	-338	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	168272462	190140	0	None	-51	2	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5173887	190140	0	None	-51	2	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	137630050	161016	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	46830362	7862	0	None	-5	5	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1090097	7862	0	None	-5	5	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	76331543	103476	0	None	-2	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085092	103476	0	None	-2	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186204	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186204	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186204	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	9990434	106312	0	None	1	3	Human	5.6	pIC50	=	5.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL313918	106312	0	None	1	3	Human	5.6	pIC50	=	5.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44455159	97737	0	None	-25	5	Rat	4.5	pIC50	=	4.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL271704	97737	0	None	-25	5	Rat	4.5	pIC50	=	4.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	46682613	181132	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760823	181132	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	162353378	182887	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4792360	182887	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	44590174	170033	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444300	170033	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL466271	170033	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590178	172714	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450781	172714	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540400	172714	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	11583262	106470	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085060	106470	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140181	106470	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156493565	184962	0	None	-1318	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4854289	184962	0	None	-1318	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	168276820	190082	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190082	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190082	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	10058347	105904	0	None	-2	2	Human	4.5	pIC50	=	4.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL312823	105904	0	None	-2	2	Human	4.5	pIC50	=	4.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71450615	83902	0	None	-1	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206604	83902	0	None	-1	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	11819427	57522	0	None	-1	2	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166423	57522	0	None	-1	2	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	47358375	180738	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756164	180738	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	11584660	93239	8	None	-1	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	93239	8	None	-1	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	44590182	183127	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL479526	183127	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590034	189953	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL517087	189953	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094791	83228	0	None	-3	3	Human	5.5	pIC50	=	5.5	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL218755	83228	0	None	-3	3	Human	5.5	pIC50	=	5.5	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353374	180019	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4747590	180019	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	138578970	185643	0	None	-1862	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4864914	185643	0	None	-1862	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	71452456	83907	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206609	83907	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	122203596	155782	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	137637944	155791	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4059829	155791	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	71450617	83908	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206610	83908	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	162353382	181710	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	CHEMBL4777127	181710	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	11626847	106449	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085068	106449	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140111	106449	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	2551	791	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	298	791	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	488	791	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	CHEMBL965	791	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	DB00411	791	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	10092649	193049	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193049	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	44233419	103372	0	None	-1	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084674	103372	0	None	-1	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	10092649	193049	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193049	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	164606754	184678	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184678	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184678	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	138578253	186431	0	None	-1230	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4876599	186431	0	None	-1230	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	24882532	95088	0	None	-7	4	Rat	5.5	pIC50	=	5.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255523	95088	0	None	-7	4	Rat	5.5	pIC50	=	5.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	137638270	156853	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	CHEMBL4071900	156853	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	137647734	157822	0	None	-2	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4083681	157822	0	None	-2	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	156016041	178223	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155782	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	76327903	103477	0	None	-4	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085093	103477	0	None	-4	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	69444105	103460	0	None	-1	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085077	103460	0	None	-1	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015807	178275	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	137655063	158949	0	None	-3	5	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096143	158949	0	None	-3	5	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	11552174	103474	0	None	-3	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085090	103474	0	None	-3	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44589583	172457	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448294	172457	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555471	172457	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590168	172705	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450652	172705	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540399	172705	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589584	188755	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505651	188755	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540144	188755	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094788	141890	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL386983	141890	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353381	180005	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4747438	180005	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	44589498	172734	0	None	-3	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL451043	172734	0	None	-3	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	10419574	58065	0	None	2	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL167438	58065	0	None	2	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76327900	106456	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085061	106456	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140142	106456	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71457771	83900	0	None	-5	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206602	83900	0	None	-5	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	76320694	103469	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085085	103469	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	71454213	83893	0	None	11	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206591	83893	0	None	11	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	71450662	83977	0	None	1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207176	83977	0	None	1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	162649767	180078	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4748337	180078	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	71452454	83889	0	None	-41	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206587	83889	0	None	-41	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	54816802	181248	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4762056	181248	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	10081053	57540	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166593	57540	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44233187	85996	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2306159	85996	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	76327902	103472	0	None	-1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085088	103472	0	None	-1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	164606754	184678	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184678	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184678	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	109035056	181299	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	CHEMBL4762755	181299	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	11619198	106464	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085058	106464	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140170	106464	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015153	178283	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178283	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178283	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162353371	181626	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4775999	181626	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	16040727	169419	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL442672	169419	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL495102	169419	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590169	188219	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL499565	188219	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL539885	188219	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590181	173540	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL453248	173540	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL551113	173540	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034110	188742	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505453	188742	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	10376012	58703	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168561	58703	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76320690	106433	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085063	106433	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140092	106433	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	137654353	158992	0	None	-1	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096589	158992	0	None	-1	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	2986945	95026	7	None	-47	5	Rat	4.3	pIC50	=	4.3	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255169	95026	7	None	-47	5	Rat	4.3	pIC50	=	4.3	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	2904292	183556	13	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4800495	183556	13	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	15681300	57533	0	None	-1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166537	57533	0	None	-1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11510358	106457	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085069	106457	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140143	106457	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	58975257	103350	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084638	103350	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	36014865	182646	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	CHEMBL4789054	182646	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	44233928	86045	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2308786	86045	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	71455969	83901	0	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206603	83901	0	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11547053	106438	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085074	106438	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140097	106438	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	71454217	83899	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206601	83899	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	109014373	179778	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4744856	179778	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	156016041	178223	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	71455966	83892	0	None	2	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206590	83892	0	None	2	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	52176747	159007	1	None	-13	8	Rat	5.2	pIC50	=	5.2	Functional	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159007	1	None	-13	8	Rat	5.2	pIC50	=	5.2	Functional	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	15681303	58960	0	None	-1	2	Human	4.2	pIC50	=	4.2	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168991	58960	0	None	-1	2	Human	4.2	pIC50	=	4.2	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44590173	189067	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL510029	189067	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555019	189067	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	156015153	178283	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178283	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178283	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11712408	106495	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085067	106495	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140261	106495	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	108993425	181734	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4777543	181734	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	168289751	191786	0	None	-47	2	Human	5.2	pIC50	=	5.2	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	CHEMBL5198423	191786	0	None	-47	2	Human	5.2	pIC50	=	5.2	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	2551	791	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	298	791	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	488	791	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	CHEMBL965	791	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	DB00411	791	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	1201549	594	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	333	594	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	7601	594	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL1201203	594	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL438151	594	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	DB00245	594	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	44590124	169770	0	None	-39	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL443925	169770	0	None	-39	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	162657046	180819	0	None	-99	4	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4757103	180819	0	None	-99	4	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	76316969	106496	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085075	106496	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140262	106496	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	162353391	180797	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	CHEMBL4756873	180797	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	76313454	106480	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085064	106480	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140214	106480	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186204	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186204	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186204	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	76309754	106494	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085062	106494	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140260	106494	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	1421986	8233	4	None	-2	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1092461	8233	4	None	-2	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	11442478	106451	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085073	106451	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140113	106451	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	10109893	82136	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL216983	82136	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL544840	82136	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	162353376	180403	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4752380	180403	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	11820032	98196	0	None	1	2	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL274329	98196	0	None	1	2	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353377	181141	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760904	181141	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353390	180925	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4758316	180925	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	162670602	182913	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4792675	182913	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	133640439	181349	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4763304	181349	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	10240891	206075	0	None	1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL85678	206075	0	None	1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	16094783	136542	0	None	12	3	Human	7.1	pIC50	=	7.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL373888	136542	0	None	12	3	Human	7.1	pIC50	=	7.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44589496	185957	0	None	-15	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486983	185957	0	None	-15	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	174174	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	174174	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	260	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	320	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	CHEMBL517712	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	DB00572	521	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	76309757	103471	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085087	103471	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71463136	83906	0	None	-2	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206608	83906	0	None	-2	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71459724	83978	0	None	-63	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207177	83978	0	None	-63	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	302	2956	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	4630	2956	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL7634	2956	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	122203596	155782	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	71454214	83894	0	None	1	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206592	83894	0	None	1	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10375322	58700	0	None	-1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168545	58700	0	None	-1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71454212	83888	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206586	83888	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	16125704	84635	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222450	84635	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL4755618	214018	39	None	1	2	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at muscarinic M2 receptor (unknown origin)Agonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL		None	None	None		Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12	10.1021/acs.jmedchem.1c02148
	11617374	103461	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085078	103461	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	155522355	176385	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176385	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176385	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	49665121	170439	11	None	3	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	CHEMBL4448840	170439	11	None	3	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	162353387	181207	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4761549	181207	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	71457770	83898	0	None	-1	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206600	83898	0	None	-1	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10376182	58726	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168639	58726	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71455965	83891	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206589	83891	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	162353383	182553	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	CHEMBL4787944	182553	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	162657652	180961	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758742	180961	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	71463134	83895	0	None	-2	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206594	83895	0	None	-2	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11519069	3908	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070	3908	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	4816	3908	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	7354	3908	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	CHEMBL1187833	3908	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	DB09076	3908	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	25195533	78357	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2103803	78357	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2110584	78357	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589580	173124	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL452142	173124	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL553448	173124	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	132947	3835	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	361	3835	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	CHEMBL265256	3835	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	132947	3835	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	361	3835	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	CHEMBL265256	3835	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	25034186	201415	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL540396	201415	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL604842	201415	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589579	189030	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL509515	189030	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL540148	189030	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	11766733	155730	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202003	155730	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL405739	155730	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	132947	3835	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	361	3835	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	CHEMBL265256	3835	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	10770914	25029	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL134692	25029	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44232952	103356	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084650	103356	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10580398	21579	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL131748	21579	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	316	2816	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	317	2816	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	71183	2816	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL3140030	2816	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL376897	2816	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	DB00462	2816	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	316	2816	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	317	2816	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	71183	2816	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL3140030	2816	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL376897	2816	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	DB00462	2816	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	10109130	132990	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370232	132990	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10291366	140674	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381623	140674	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	69058946	106448	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084658	106448	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140110	106448	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10629559	23719	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL133561	23719	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	10628017	21684	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL131865	21684	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939891	169340	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL442014	169340	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939891	169340	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	CHEMBL442014	169340	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	9946298	72798	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200171	72798	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406481	72846	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200319	72846	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406573	72945	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200693	72945	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10532418	24573	0	None	-	0	Human	9.0	pKd	=	9.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL134294	24573	0	None	-	0	Human	9.0	pKd	=	9.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	25034182	172560	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL448870	172560	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL540359	172560	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	25034182	172560	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448870	172560	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540359	172560	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16116085	11814	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182201	11814	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219786	11814	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	12872437	12026	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL1183585	12026	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL306182	12026	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	11691950	12730	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL1187853	12730	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL524097	12730	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	174174	521	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	260	521	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	320	521	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	CHEMBL517712	521	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	DB00572	521	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	10771937	21661	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202004	21661	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL131846	21661	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	25034184	188373	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL501803	188373	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL539887	188373	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589581	188764	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL505751	188764	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL540145	188764	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	14939896	82058	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201996	82058	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216566	82058	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406686	140886	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL382213	140886	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	174174	521	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	260	521	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	320	521	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	CHEMBL517712	521	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	DB00572	521	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	44341782	9961	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL114885	9961	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44318928	205740	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	CHEMBL82859	205740	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	44319043	206036	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85391	206036	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11753447	187327	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493265	187327	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	2166	3101	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	305	3101	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	5910	3101	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL550	3101	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	DB01085	3101	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	128222	102061	6	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL302179	102061	6	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44341878	110313	0	None	-	0	Human	6.0	pKd	=	6.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL324026	110313	0	None	-	0	Human	6.0	pKd	=	6.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939893	9502	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL112244	9502	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	154734599	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	327	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	4108	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL27673	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	154734599	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	327	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	4108	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	CHEMBL27673	2486	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	44319071	205996	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL84993	205996	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11556983	187341	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493331	187341	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL538864	187341	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL555476	187341	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	44341782	9961	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL114885	9961	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	44341782	9961	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL114885	9961	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	10789183	104340	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310132	104340	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44318782	206110	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85996	206110	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44380974	57535	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	CHEMBL166544	57535	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	101720828	97091	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	16147087	97091	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202002	97091	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL267643	97091	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	44381057	58082	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL167587	58082	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44380592	59280	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	CHEMBL170554	59280	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	154734599	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	327	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	4108	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL27673	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	154734599	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	327	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	4108	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL27673	2486	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	101676031	97299	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16175987	97299	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201998	97299	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL269272	97299	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	319	1312	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	321	1312	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031	1312	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	784	1312	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	CHEMBL1346	1312	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	DB00496	1312	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	2705	3813	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	360	3813	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879	3813	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	CHEMBL1382	3813	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	DB01036	3813	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	44380973	120705	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	CHEMBL354855	120705	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	44319342	205695	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82512	205695	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319339	205884	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83982	205884	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44341864	109184	0	None	-	0	Human	5.8	pKd	=	5.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL321687	109184	0	None	-	0	Human	5.8	pKd	=	5.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44380309	58746	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168736	58746	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44298537	101015	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL294613	101015	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	44380837	58410	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	CHEMBL168304	58410	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	44381064	58231	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168235	58231	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	10316726	11996	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	11996	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	11996	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16144765	96850	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL265592	96850	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	44380612	59162	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	CHEMBL170113	59162	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	44341975	9496	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	CHEMBL112208	9496	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	44380613	58465	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	CHEMBL168322	58465	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	154734599	2486	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	327	2486	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	4108	2486	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL27673	2486	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	10049361	206098	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85892	206098	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	9913892	205814	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83459	205814	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	14537191	147964	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL39342	147964	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	10486393	141677	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202000	141677	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL385625	141677	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10794142	22904	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL132926	22904	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	1734	116	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	307	116	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	CHEMBL168067	116	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	16086059	80746	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215180	80746	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	10722780	22267	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL132377	22267	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355098	24671	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134382	24671	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355099	165227	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL422977	165227	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	11365314	187328	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493266	187328	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	44341764	9922	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL114681	9922	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10402105	110464	0	None	-	0	Human	5.6	pKd	=	5.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL324855	110464	0	None	-	0	Human	5.6	pKd	=	5.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	14211056	107136	0	None	-	1	Rat	5.6	pKd	=	5.6	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316309	107136	0	None	-	1	Rat	5.6	pKd	=	5.6	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380611	58794	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	CHEMBL168841	58794	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	44380972	120224	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL352334	120224	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	14939888	10130	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	CHEMBL115878	10130	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	44381066	58994	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	CHEMBL169290	58994	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	14939894	10264	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL116172	10264	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406598	72996	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200957	72996	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	129989	450	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	8584	450	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	CHEMBL43383	450	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	71128	96781	25	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	CHEMBL26505	96781	25	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	66875589	103363	0	None	-	1	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084662	103363	0	None	-	1	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589576	189032	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509520	189032	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555706	189032	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44406480	72815	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200210	72815	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44319009	106909	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL314831	106909	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11249888	187353	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493465	187353	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537192	100196	0	None	-	0	Human	5.5	pKd	=	5.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL288482	100196	0	None	-	0	Human	5.5	pKd	=	5.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	189509	105973	13	None	-	1	Rat	5.5	pKd	=	5.5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL313227	105973	13	None	-	1	Rat	5.5	pKd	=	5.5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44365882	58094	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL167690	58094	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	2028	2958	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	359	2958	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634	2958	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	CHEMBL1231	2958	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	DB01062	2958	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	44406520	135233	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL372566	135233	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	15114860	107129	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316282	107129	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	14211057	111398	0	None	-	1	Rat	5.4	pKd	=	5.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL327363	111398	0	None	-	1	Rat	5.4	pKd	=	5.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	10316726	11996	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	11996	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	11996	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16115945	12265	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1184886	12265	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376057	12265	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	10606253	157249	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL407678	157249	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939895	82090	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201997	82090	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216629	82090	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10055202	11501	1	None	-	0	Human	6.4	pKd	=	6.4	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	CHEMBL11805	11501	1	None	-	0	Human	6.4	pKd	=	6.4	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	14939897	96520	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201994	96520	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL262913	96520	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44233192	106455	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084643	106455	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140141	106455	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11504490	192578	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL521523	192578	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	11504490	192578	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	CHEMBL521523	192578	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	44589582	171617	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL446587	171617	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL550885	171617	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16042745	185277	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL485932	185277	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL538360	185277	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10557581	21742	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202001	21742	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL131913	21742	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10418181	9554	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112500	9554	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201995	9554	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	9843814	127223	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	CHEMBL36583	127223	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	14449843	24790	0	None	-	0	Human	6.3	pKd	=	6.3	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134488	24790	0	None	-	0	Human	6.3	pKd	=	6.3	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	14211049	106961	0	None	-	1	Rat	5.3	pKd	=	5.3	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL315191	106961	0	None	-	1	Rat	5.3	pKd	=	5.3	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	2200	3109	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	328	3109	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848	3109	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	CHEMBL9967	3109	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	DB00670	3109	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	44381142	59033	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	CHEMBL169523	59033	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	10653319	24211	0	None	-	0	Human	5.3	pKd	=	5.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL133993	24211	0	None	-	0	Human	5.3	pKd	=	5.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44380591	58721	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL168616	58721	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44406521	73877	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL201933	73877	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44233190	103375	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084679	103375	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589578	173146	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL452193	173146	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL540401	173146	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	44589577	188944	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL508343	188944	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL540146	188944	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	25132856	187192	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL492437	187192	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537188	136521	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL37372	136521	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	14211052	206513	0	None	-	1	Rat	6.2	pKd	=	6.2	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL88578	206513	0	None	-	1	Rat	6.2	pKd	=	6.2	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380614	57437	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	CHEMBL165700	57437	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	59993948	73113	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	CHEMBL2011501	73113	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	14537189	162619	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL416974	162619	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	14939893	9502	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112244	9502	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10369736	59334	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	CHEMBL170793	59334	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	44381205	57497	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	CHEMBL166232	57497	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	10508599	115203	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL334690	115203	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44381378	57496	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	CHEMBL166229	57496	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	129989	450	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	8584	450	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	CHEMBL43383	450	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	10651844	115463	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL335115	115463	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	14914761	9932	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	CHEMBL114738	9932	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	44380975	57577	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	CHEMBL166803	57577	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	44365718	58756	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168786	58756	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	9916852	204896	0	None	-	0	Human	11.0	pKi	=	11	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL76164	204896	0	None	-	0	Human	11.0	pKi	=	11	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	44314347	102836	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL305693	102836	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10230930	80605	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	CHEMBL2151158	80605	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	44314697	104153	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL309720	104153	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314564	204785	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL75108	204785	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188443	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188443	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188443	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314328	103684	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308787	103684	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10417432	104847	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311099	104847	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10009554	204688	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL74141	204688	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314698	205129	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL78131	205129	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188443	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188443	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188443	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314329	204533	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL72932	204533	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314699	103152	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308166	103152	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314713	104843	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311054	104843	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164615651	188487	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188487	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188487	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164614830	188476	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4858774	188476	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028275	188476	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314554	105656	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL312571	105656	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	3009356	105596	1	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL312344	105596	1	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	483747	105382	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL311795	105382	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	3009352	96610	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL263555	96610	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	3009353	168001	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL432170	168001	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	1935	3707	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3707	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3707	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3707	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3707	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	164615651	188487	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188487	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188487	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	313	2672	0	None	-	1	Human	6.3	pA2	<	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9862767
	2520	203985	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL1280	203985	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL6966	203985	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	1935	3707	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3707	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3707	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3707	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3707	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	1979	77297	70	None	-43	7	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77297	70	None	-43	7	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	123603	880	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2684	880	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	584	880	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	9658	880	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	CHEMBL168815	880	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2370	620	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	297	620	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	358	620	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	CHEMBL1482	620	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	DB01019	620	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	1273	1741	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1741	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1741	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1741	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1741	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1741	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1741	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	2166	3101	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3101	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3101	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3101	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3101	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5831	215938	0	None	-1	5	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	21158560	112766	7	None	3090	2	Pig	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	CHEMBL3305985	112766	7	None	3090	2	Pig	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	10101670	1497	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	7635	1497	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	CHEMBL32985	1497	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	10104167	2046	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	10104167	2046	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	6937	2046	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	6937	2046	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	CHEMBL3121473	2046	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	CHEMBL3121473	2046	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	288	251	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	288	251	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	6979053	251	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	6979053	251	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	286	252	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	286	252	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	6954180	252	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	6954180	252	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	18381	217679	0	None	-1	4	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	469	4	2	6	3.2	CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C(=NO1)C1=C(Cl)C=CC=C1Cl	None
	11434515	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11434515	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	11519741	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11519741	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	4484	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	4484	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	7449	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	7449	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	CHEMBL1194325	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	CHEMBL1194325	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	DB08897	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	DB08897	261	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	1935	3707	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	2551	3707	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	6687	3707	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	CHEMBL95	3707	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	DB00382	3707	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	154059	3610	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	2457	3610	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	7483	3610	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	CHEMBL1734	3610	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	DB01591	3610	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	11693	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	11693	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	3494	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	3494	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	4302	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	4302	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	7459	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	7459	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	CHEMBL1201335	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	CHEMBL1201335	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	DB00986	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	DB00986	1814	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	3536	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3536	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3536	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3536	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11434515	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	11519741	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	4484	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	7449	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL1194325	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	DB08897	261	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	367	3795	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3795	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3795	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3795	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3795	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3795	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3795	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	11693	1814	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1814	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1814	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1814	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1814	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1814	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	25897919	55622	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55622	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1464005	55622	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55622	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	25897919	55622	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55622	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1464005	55622	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55622	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	11693	1814	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1814	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1814	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1814	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1814	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1814	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	2705	3813	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3813	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3813	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3813	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3813	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	3157	1458	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1458	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1458	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1458	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1458	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	242	469	124	None	-295	52	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-295	52	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-295	52	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-295	52	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-295	52	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	133	2479	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	1723	2479	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	28693	2479	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL19215	2479	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	DB13520	2479	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL1630575	56313	0	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	441383	20301	57	None	-7	17	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1306	20301	57	None	-7	17	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	2335	11816	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	4919	206211	23	None	-3	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	206211	23	None	-3	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3652	4066	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4066	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4066	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4066	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4066	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	3152	188387	103	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188387	103	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	2200	3109	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3109	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3109	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3109	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3109	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	1613	2333	53	None	-42	45	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-42	45	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-42	45	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-42	45	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-42	45	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	43815	186896	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186896	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186896	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	1209	1645	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1645	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1645	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1645	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1645	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	5994	4609	88	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4609	88	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	2200	3109	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3109	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3109	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3109	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3109	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	5050	78171	58	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL2105300	78171	58	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
	31315	93379	63	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL245807	93379	63	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	5353853	17954	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9556529	17954	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1262	17954	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL3039583	210926	0	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
	3775	14443	26	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	14443	26	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	4097	14450	13	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1201264	14450	13	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	2774	3839	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3839	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3839	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3839	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3839	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3839	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	2402	3345	62	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3345	62	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3345	62	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3345	62	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3345	62	None	-	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	15387	45792	55	None	-16	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1531134	45792	55	None	-16	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	1273	1741	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	3450	1741	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	356	1741	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	6172	1741	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	67425	1741	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL360055	1741	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	DB00483	1741	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	4904	155497	48	None	-1	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL404215	155497	48	None	-1	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4209	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	176870	195462	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
	CHEMBL553	195462	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
	4209	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3141	75	None	-	34	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	3678	94763	57	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL253371	94763	57	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	460612	206021	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	6918992	206021	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL852	206021	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	5282592	14444	2	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1201235	14444	2	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	16222096	80454	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	CHEMBL2146883	80454	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	6918456	14483	110	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	CHEMBL1201772	14483	110	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	103	4122	61	None	-177	54	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-177	54	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-177	54	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-177	54	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-177	54	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2444	14446	26	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201245	14446	26	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	1201549	594	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	594	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	594	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	594	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	594	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	594	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24958200	8542	76	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
	CHEMBL1094636	8542	76	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
	5523	3822	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	8286	3822	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1237044	3822	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	DB00193	3822	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	5426	178661	117	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
	CHEMBL468	178661	117	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-38	66	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-38	66	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-38	66	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-38	66	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	3627	44099	18	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1515447	44099	18	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	3447	206353	28	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
	CHEMBL87563	206353	28	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
	2247	504	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	20299	14473	15	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201354	14473	15	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	1712	2475	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078	2475	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	7227	2475	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	CHEMBL1088	2475	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	DB00933	2475	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4594	42842	127	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
	CHEMBL1503	42842	127	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
	5584	203188	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL644	203188	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4735	195092	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL361506	195092	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL55	195092	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	2166	3101	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	3101	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	3101	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	3101	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	3101	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2745	3832	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	5572	3832	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	66007	3832	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7315	3832	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1490	3832	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00376	3832	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	154417	23149	60	None	-1	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23149	60	None	-1	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	5311064	1354	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	534	1354	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	806	1354	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL493682	1354	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	2286	3161	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2247	504	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2480	19408	49	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	CHEMBL129529	19408	49	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	49803313	112559	69	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL3301622	112559	69	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
	3344	198295	57	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	CHEMBL576127	198295	57	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	54758501	139042	58	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	CHEMBL3786343	139042	58	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	6127	14467	8	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14467	8	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72287	61031	38	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1764	61031	38	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL4743867	214010	14	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	71109	78177	10	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	CHEMBL2105453	78177	10	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	24821094	67064	93	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67064	93	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	62867	3107	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	7557	3107	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL398880	3107	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01621	3107	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	3103	41628	49	None	-	4	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1492	41628	49	None	-	4	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	9571107	167495	33	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	CHEMBL430	167495	33	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	2337	3232	77	None	-31	63	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-31	63	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-31	63	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-31	63	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-31	63	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5591	157507	90	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157507	90	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	1224	1420	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1420	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1420	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1420	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1420	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1420	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	40973	46005	70	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1533	46005	70	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	3606	203465	60	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL6615	203465	60	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	180	400	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1599	2326	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955	2326	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7215	2326	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL841	2326	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00836	2326	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135400189	44545	73	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	CHEMBL1520	44545	73	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	135398737	955	93	None	-22	92	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-22	92	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-22	92	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-22	92	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-22	92	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	4417	55532	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1439099	55532	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1620794	55532	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL5292015	194514	0	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6077	150674	31	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150674	31	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	40466968	207013	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	60947	207013	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL916	207013	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL5291995	194513	0	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	41049	106733	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	CHEMBL314437	106733	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	18609376	204336	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	6279	204336	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL717	204336	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	3294	1993	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	1993	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	1993	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	1993	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	1993	111	None	-194	45	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	1726	2480	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	1993	2480	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	7438	2480	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	CHEMBL978	2480	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	DB06709	2480	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	5440	28693	37	None	-	9	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28693	37	None	-	9	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	193962	103766	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	CHEMBL308954	103766	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	9853053	120493	74	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL354541	120493	74	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	24821094	67064	93	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67064	93	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	2895	203569	41	None	-1	8	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203569	41	None	-1	8	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	121515	199076	63	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL588934	199076	63	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	443869	78112	45	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2103761	78112	45	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	432824	78235	13	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	CHEMBL2106996	78235	13	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	10180	98841	47	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL279014	98841	47	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	208898	66169	78	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	CHEMBL184412	66169	78	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	4761	13409	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1193	13409	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1580221	13409	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	1547484	937	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	654	937	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	9072	937	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL43064	937	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00568	937	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	151537	162640	49	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	41867	162640	49	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL417	162640	49	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	9324	9206	60	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL110691	9206	60	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	5039	63153	17	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	CHEMBL1790041	63153	17	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	5284632	67372	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	67372	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	67372	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4642	41956	28	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	41956	28	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	4034	55792	55	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55792	55	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	7099	195499	59	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	CHEMBL55400	195499	59	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	9419	35892	35	None	-	6	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1442422	35892	35	None	-	6	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	4940	14438	35	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14438	35	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	4021	100452	122	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	CHEMBL290916	100452	122	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	9429	202110	58	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202110	58	None	-	5	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3152	188387	103	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188387	103	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	22530	56100	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1600878	56100	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1625607	56100	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	5351322	94762	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL25336	94762	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	708857	56154	44	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1626223	56154	44	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
	9400	14459	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
	CHEMBL1201302	14459	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
	2726	916	68	None	-79	73	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-79	73	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-79	73	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-79	73	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-79	73	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	3180	14441	41	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201217	14441	41	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	1712095	195369	30	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
	CHEMBL551978	195369	30	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
	25295	13588	37	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1194287	13588	37	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	31101	726	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-	36	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	22323	15267	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15267	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15267	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	4098	32475	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1255739	32475	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1411979	32475	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	316	2816	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	317	2816	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	71183	2816	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3140030	2816	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL376897	2816	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB00462	2816	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	2039	2961	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	5749	2961	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	7257	2961	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	CHEMBL1201286	2961	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	DB00219	2961	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	2293	3164	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	329	3164	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	4934	3164	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	CHEMBL1180725	3164	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	DB00782	3164	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	25897919	55622	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55622	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1464005	55622	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55622	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6917866	167413	5	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL4297364	167413	5	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	2784	949	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	351	949	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	366	949	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	676	949	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL620	949	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	DB00771	949	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	174174	521	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	260	521	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	320	521	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	CHEMBL517712	521	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	DB00572	521	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	2286	3161	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	68778	115179	68	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL334491	115179	68	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	1548955	88552	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2800	88552	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2355051	88552	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	100	3776	58	None	-19	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3776	58	None	-19	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3776	58	None	-19	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3776	58	None	-19	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3776	58	None	-19	56	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	242	469	124	None	-295	52	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-295	52	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-295	52	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-295	52	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-295	52	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	3607	36352	72	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
	CHEMBL144673	36352	72	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
	93154	5404	29	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL107360	5404	29	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2898	32621	73	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL141305	32621	73	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
	2805	161866	38	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL415087	161866	38	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	12555	17929	53	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL12610	17929	53	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	6726	1269	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7151	1269	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	749	1269	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL648	1269	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB01176	1269	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2749	343	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	5574	343	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7237	343	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL829	343	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01246	343	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	132999	179077	47	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
	CHEMBL471737	179077	47	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
	3354	41754	50	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	CHEMBL1493	41754	50	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	3166	169396	23	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL442444	169396	23	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	5354	155632	21	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL404849	155632	21	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	6075	150084	42	None	-7	16	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL395110	150084	42	None	-7	16	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	191	402	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	402	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	402	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	402	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	402	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	213046	2370	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	115163	57273	44	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
	CHEMBL1650818	57273	44	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
	5583	13012	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL119	13012	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
	4601	206724	35	None	-2	17	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201023	206724	35	None	-2	17	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL900	206724	35	None	-2	17	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	160883	55234	9	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1618102	55234	9	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	16960	14455	23	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1201287	14455	23	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	5511	5456	40	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1076211	5456	40	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	2333	142310	97	None	-	2	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142310	97	None	-	2	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	124087	1377	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	16362	3103	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-	30	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3055	1421	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	313	1421	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	7163	1421	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL936	1421	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB01231	1421	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	135	2515	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-25	58	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	60663	175645	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1421212	175645	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1534525	175645	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL45816	175645	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	3000322	3536	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3536	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3536	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3536	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3053	205111	95	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL780	205111	95	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	43082	60253	37	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1742452	60253	37	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	11519069	3908	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	11519070	3908	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4816	3908	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7354	3908	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187833	3908	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB09076	3908	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	11693	1814	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1814	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1814	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1814	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1814	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1814	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	10470	2471	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	1689	2471	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4057	2471	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL524004	2471	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB04843	2471	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	180	400	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4886	14078	28	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1198	14078	28	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	4919	206211	23	None	-3	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	206211	23	None	-3	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	6918558	14482	41	None	-1	5	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201764	14482	41	None	-1	5	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	2771	194994	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	40	1535	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	77993	1535	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	995	1535	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1510	1535	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	DB00216	1535	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
	1909	2803	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	2559	2803	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	4474	2803	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL1484	2803	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL3302409	2803	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	DB00622	2803	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	54697325	58949	35	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58949	35	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	7019	167952	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL1308088	167952	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL43184	167952	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	3474	38071	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	CHEMBL146095	38071	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	104903	56314	17	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1630578	56314	17	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
	1530	2169	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2169	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2169	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2169	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2169	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	5330286	67541	104	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
	CHEMBL189963	67541	104	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
	2580	78366	18	None	-	2	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL2110775	78366	18	None	-	2	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	3634	84079	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL22077	84079	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	2398	951	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1427	2000	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2000	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2000	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2000	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2000	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4908	188782	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	CHEMBL506	188782	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
	1086	1577	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	3290	1577	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	7181	1577	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	CHEMBL1206	1577	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	DB00392	1577	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	187	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	10071196	3102	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	5142	3102	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	8423	3102	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	CHEMBL2111101	3102	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	DB05316	3102	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	187	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	319	1312	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1312	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1312	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1312	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1312	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1312	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	2762	3834	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	5587	3834	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	7318	3834	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL1241	3834	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	DB00792	3834	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
	11057	176125	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	3468	176125	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL459265	176125	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL64894	176125	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	187	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2993	114666	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL121663	114666	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL333826	114666	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	70695647	78184	0	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL2105618	78184	0	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	11154555	797	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	5037	797	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	7671	797	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL2028019	797	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL3085826	797	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB06016	797	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	5328940	100188	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100188	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	25151352	140581	67	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	CHEMBL3813873	140581	67	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	4167	14468	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1201342	14468	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	4167	14468	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1201342	14468	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	174174	521	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	260	521	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	320	521	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	CHEMBL517712	521	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	DB00572	521	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	277	1289	62	None	-10	46	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2913	1289	62	None	-10	46	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	765	1289	62	None	-10	46	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL516	1289	62	None	-10	46	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB00434	1289	62	None	-10	46	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2710	84279	31	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL22150	84279	31	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	4921596	98754	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
	60063	98754	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
	CHEMBL278255	98754	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
	3601	14471	9	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1201349	14471	9	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	16351	102703	47	None	-	6	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102703	47	None	-	6	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	1210	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	90475904	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	915	51	None	-162	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	5039	63153	17	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	CHEMBL1790041	63153	17	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	2337	3232	77	None	-31	63	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-31	63	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-31	63	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-31	63	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-31	63	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	3158	56237	27	None	-630	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-630	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	135565596	109242	70	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
	CHEMBL3218576	109242	70	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
	2107	3033	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	4747	3033	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	9216	3033	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL251940	3033	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB01608	3033	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	3158	56237	27	None	-630	20	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-630	20	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2220	3112	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3112	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3112	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3112	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3112	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	5568	197477	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	66069	197477	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL1201102	197477	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL570	197477	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	11976	917	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	917	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	917	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	917	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	3162	4204	43	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1004	4204	43	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	5328940	100188	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100188	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	21722	17960	31	None	-	6	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17960	31	None	-	6	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	3336	94972	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1405922	94972	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL254832	94972	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1273	1741	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	3450	1741	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	356	1741	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	6172	1741	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	67425	1741	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL360055	1741	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	DB00483	1741	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	2905	14466	50	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201338	14466	50	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	65863	14433	57	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1201196	14433	57	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	2774	3839	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3839	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3839	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3839	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3839	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3839	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	2865	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	1935	3707	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	2551	3707	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	6687	3707	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL95	3707	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00382	3707	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
	1971	2846	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3157	1458	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1458	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1458	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1458	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1458	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	2600	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	19861	207500	50	None	-	1	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207500	50	None	-	1	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	4976	203556	29	None	-1	12	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203556	29	None	-1	12	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	448537	160226	89	None	-	25	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160226	89	None	-	25	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	71329	179245	102	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL473	179245	102	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	27901	78178	22	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2105458	78178	22	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4822	45002	47	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL152408	45002	47	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	26987	946	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	3236	67579	43	None	1	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	67579	43	None	1	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	1371	1910	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	24199	1910	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	323	1910	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1201325	1910	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	DB06787	1910	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
	3047788	78167	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2105148	78167	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
	2865	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-1659	54	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	5329102	194703	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194703	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	135398737	955	93	None	-22	92	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-22	92	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-22	92	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-22	92	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-22	92	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1613	2333	53	None	-42	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-42	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-42	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-42	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-42	45	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	115368	3034	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	2112	3034	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	7556	3034	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1472975	3034	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	DB08922	3034	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	124087	1377	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	1979	77297	70	None	-2	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL20835	77297	70	None	-2	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	12488	1644	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	941361	1644	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	CHEMBL30008	1644	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	DB04841	1644	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	3033538	1307	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	7155	1307	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	781	1307	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1201216	1307	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	DB00298	1307	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	237	204842	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL546257	204842	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL554190	204842	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL7568	204842	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	21855	84217	42	None	-7	6	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL22108	84217	42	None	-7	6	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	2771	194994	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	34040	28054	72	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	CHEMBL1372950	28054	72	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	6834	205529	45	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL811	205529	45	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	3000322	3536	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3536	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3536	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3536	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	2705	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	2705	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3813	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	1605	2327	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	3957	2327	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	7216	2327	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	CHEMBL998	2327	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	DB00455	2327	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	1224	1420	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1420	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1420	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1420	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1420	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1420	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	2551	791	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	791	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	791	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	791	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	791	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2683	102861	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL305906	102861	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL334255	102861	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-38	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-38	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-38	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-38	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	5205	78158	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL2104895	78158	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	1227	2472	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	2331	2472	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	3957	2472	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	4992	2472	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL511	2472	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	DB06691	2472	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
	2337	3232	77	None	-31	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-31	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-31	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-31	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-31	63	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	1560	2296	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	5359371	2296	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	7209	2296	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1254682	2296	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	DB00504	2296	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
	1353	1898	93	None	-5011	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-5011	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-5011	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-5011	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-5011	86	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2028	2958	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	359	2958	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	4634	2958	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	CHEMBL1231	2958	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	DB01062	2958	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	1400	1944	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1944	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1944	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1944	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1944	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1944	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	180	400	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	98941	46920	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL154126	46920	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	9880	30910	61	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL139835	30910	61	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	54697325	58949	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58949	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	26987	946	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	25102847	78192	93	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78192	93	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	3055	1421	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	313	1421	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	7163	1421	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL936	1421	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB01231	1421	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
	5832	14428	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1201146	14428	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	9417	133487	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133487	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133487	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	135	2515	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-25	58	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1726	2480	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	1993	2480	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	7438	2480	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	CHEMBL978	2480	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	DB06709	2480	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	2520	203985	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	203985	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	203985	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	2284	3160	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3160	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3160	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3160	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3160	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	10104167	2046	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	6937	2046	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	CHEMBL3121473	2046	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	10104167	2046	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	6937	2046	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	CHEMBL3121473	2046	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
	405242	11935	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1182967	11935	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL274413	11935	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	23657685	13787	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1195729	13787	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1203986	13787	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	23657685	13787	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1195729	13787	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1203986	13787	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
	44435840	13788	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1195736	13788	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL555247	13788	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	44435840	13788	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1195736	13788	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL555247	13788	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	11600184	12271	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
	CHEMBL1184960	12271	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
	CHEMBL380572	12271	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
	23657683	13716	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1195234	13716	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1203985	13716	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	23657683	13716	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1195234	13716	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1203985	13716	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
	44435838	13035	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1190118	13035	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1203984	13035	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	44435838	13035	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1190118	13035	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	CHEMBL1203984	13035	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
	23657687	13034	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1190117	13034	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL540132	13034	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	23657687	13034	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL1190117	13034	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	CHEMBL540132	13034	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
	10653182	99111	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
	CHEMBL265482	99111	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
	CHEMBL281080	99111	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
	2370	620	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	297	620	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	358	620	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	CHEMBL1482	620	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	DB01019	620	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	167962	4038	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
	362	4038	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
	CHEMBL31599	4038	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
	10653182	99111	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
	CHEMBL265482	99111	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
	CHEMBL281080	99111	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
	2166	3101	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	305	3101	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	5910	3101	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	CHEMBL550	3101	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	DB01085	3101	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
	10437519	106894	0	None	-	0	Pig	5.0	pEC50	=	5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31475	106894	0	None	-	0	Pig	5.0	pEC50	=	5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	76328902	106491	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121475	106491	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140248	106491	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL5287096	194590	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	CHEMBL5315302	194590	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	44408941	11783	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1182020	11783	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL206666	11783	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	118714969	120817	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3337859	120817	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3558417	120817	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	46878254	14206	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1199299	14206	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL607178	14206	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	60138187	106421	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138192	106421	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121479	106421	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139879	106421	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	135544402	113081	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	135597270	113081	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202147	113081	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33142	113081	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	11613432	12276	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1184988	12276	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL382243	12276	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	44265572	98644	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL262448	98644	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL27743	98644	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	44265572	98644	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL262448	98644	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL27743	98644	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	10077281	104080	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL30939	104080	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8653	104080	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	44318743	105922	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
	CHEMBL312920	105922	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
	118714976	120819	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337863	120819	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558421	120819	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	76328902	106491	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121475	106491	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140248	106491	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	118714976	120819	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337863	120819	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558421	120819	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	187	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	11828809	11926	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL1182934	11926	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL273255	11926	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	134207697	174255	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	CHEMBL4549515	174255	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	10438106	99629	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202149	99629	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL284370	99629	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	44279262	106047	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
	CHEMBL31336	106047	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
	10795567	99807	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
	CHEMBL285598	99807	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
	CHEMBL303052	99807	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
	10795567	99807	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
	CHEMBL285598	99807	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
	CHEMBL303052	99807	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
	187	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	167962	4038	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
	362	4038	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
	CHEMBL31599	4038	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
	405252	11902	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1182747	11902	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL263972	11902	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	1273	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	3450	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	356	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	6172	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	67425	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	CHEMBL360055	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	DB00483	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	1273	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	3450	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	356	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	6172	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	67425	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	CHEMBL360055	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	DB00483	1741	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
	168294767	192995	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	192995	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	192995	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	10865495	18038	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL126655	18038	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL8898	18038	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	10865495	18038	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL126655	18038	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8898	18038	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	167962	4038	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
	362	4038	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
	CHEMBL31599	4038	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
	10699850	100000	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL168760	100000	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL286892	100000	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL5272950	193716	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	166	2	1	3	0.5	O=C1C[C@@H](Cc2cnc[nH]2)CO1	10.1021/acs.jnatprod.2c01079
	10699850	100000	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL168760	100000	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL286892	100000	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	60138189	106493	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138190	106493	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121476	106493	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140252	106493	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	11007357	11053	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1177962	11053	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL8721	11053	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	10795468	11705	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181455	11705	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL171664	11705	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	170332	160952	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2370	620	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	297	620	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	358	620	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	CHEMBL1482	620	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	DB01019	620	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
	167962	4038	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
	362	4038	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
	CHEMBL31599	4038	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
	170332	160952	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	167962	4038	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	362	4038	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	CHEMBL31599	4038	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	405254	106155	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL269205	106155	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL31380	106155	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	167962	4038	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	362	4038	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	CHEMBL31599	4038	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	405254	106155	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL269205	106155	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31380	106155	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	44319261	12313	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL1185324	12313	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL407440	12313	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	10629136	102324	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
	CHEMBL30376	102324	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
	CHEMBL68151	102324	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
	10629136	102324	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
	CHEMBL30376	102324	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
	CHEMBL68151	102324	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
	10985389	11942	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1183013	11942	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL275988	11942	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	187	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	294	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	65	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	8593	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	CHEMBL667	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	DB03128	255	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
	44408892	75123	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL203627	75123	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	44265578	17930	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL126103	17930	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL268194	17930	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	44265578	17930	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL126103	17930	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL268194	17930	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	137629935	160996	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	10257778	116757	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202150	116757	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33774	116757	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	137629935	160996	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44318815	12319	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL1185416	12319	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL412670	12319	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	10974720	17953	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL126199	17953	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	CHEMBL9071	17953	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
	10974720	17953	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL126199	17953	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL9071	17953	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	76325356	106485	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3120178	106485	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140233	106485	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	405246	11937	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1182976	11937	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL274564	11937	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	302	2956	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
	4630	2956	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
	CHEMBL7634	2956	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
	187	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	10676698	11704	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181450	11704	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL171388	11704	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	187	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	10604576	105301	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
	CHEMBL303002	105301	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31162	105301	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
	10604576	105301	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
	CHEMBL303002	105301	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
	CHEMBL31162	105301	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
	21158560	112766	7	None	-	4	Pig	8.7	pEC50	=	8.7	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3305985	112766	7	None	-	4	Pig	8.7	pEC50	=	8.7	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	11527805	12275	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
	CHEMBL1184985	12275	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
	CHEMBL381913	12275	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
	11535022	11775	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
	CHEMBL1181943	11775	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
	CHEMBL199636	11775	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
	60138188	106423	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138191	106423	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121478	106423	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139897	106423	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	44265574	11055	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1177964	11055	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8764	11055	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	405250	11807	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
	CHEMBL1182178	11807	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
	CHEMBL216974	11807	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
	76328904	106424	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121480	106424	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139898	106424	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	11585610	12277	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1184995	12277	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL382659	12277	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	11757557	100085	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
	CHEMBL1202151	100085	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
	CHEMBL287536	100085	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
	44279470	102298	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
	CHEMBL30361	102298	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
	11094083	11056	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
	CHEMBL1177968	11056	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
	CHEMBL8855	11056	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
	11613432	12276	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1184988	12276	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL382243	12276	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	10747747	99049	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
	CHEMBL280535	99049	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
	CHEMBL304129	99049	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
	10747747	99049	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
	CHEMBL280535	99049	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
	CHEMBL304129	99049	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
	44408941	11783	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1182020	11783	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL206666	11783	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	10483419	111319	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL32689	111319	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL539621	111319	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	10771150	11706	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181457	11706	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL171776	11706	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	44278967	99742	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL285136	99742	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	137629935	160996	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44279153	106984	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31533	106984	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	137629935	160996	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	2230	464	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	296	464	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	CHEMBL7303	464	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	DB04365	464	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
	9987754	11049	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1177947	11049	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL8449	11049	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	10007510	109668	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL1202152	109668	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL32278	109668	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL5287159	194596	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
	CHEMBL5315392	194596	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
	118714979	120820	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337866	120820	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558422	120820	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	10319023	111316	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	CHEMBL32688	111316	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
	118714979	120820	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337866	120820	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558422	120820	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	10770828	107564	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL165814	107564	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31895	107564	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10770828	107564	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL165814	107564	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31895	107564	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	154734599	2486	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	327	2486	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	4108	2486	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	CHEMBL27673	2486	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
	44319052	12038	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1183674	12038	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL311649	12038	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	44319054	12042	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1183713	12042	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL314491	12042	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	11115491	11893	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL1182715	11893	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL262449	11893	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
	44265538	11057	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL1177969	11057	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8900	11057	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	2520	203985	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
	CHEMBL1280	203985	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
	CHEMBL6966	203985	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
	118720626	120826	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355097	120826	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558555	120826	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	44318760	12309	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL1185295	12309	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL405691	12309	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	44279242	105555	0	None	-	0	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
	CHEMBL31221	105555	0	None	-	0	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
	118720626	120826	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355097	120826	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558555	120826	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	118714974	120818	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337862	120818	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558420	120818	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	44265563	99832	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
	CHEMBL285811	99832	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
	CHEMBL8491	99832	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
	44265563	99832	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL285811	99832	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8491	99832	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	118714974	120818	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337862	120818	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558420	120818	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	44265563	99832	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL285811	99832	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8491	99832	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	118714971	120813	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
	CHEMBL3337860	120813	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
	CHEMBL3558367	120813	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
	44319263	12322	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
	CHEMBL1185419	12322	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
	CHEMBL412718	12322	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
	10556700	12207	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184494	12207	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL352356	12207	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10843180	11701	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181400	11701	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169638	11701	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	118714981	120821	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337867	120821	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558423	120821	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	11828771	16706	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL124330	16706	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8729	16706	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	118714981	120821	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337867	120821	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558423	120821	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	11115442	12310	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1185309	12310	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL406431	12310	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	11828771	16706	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL124330	16706	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8729	16706	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	168057	1201	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	7634	1201	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	CHEMBL28407	1201	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
	44318758	12285	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1185047	12285	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL385915	12285	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	76321739	106422	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121477	106422	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139896	106422	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	10699593	99385	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL282782	99385	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL353262	99385	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10699593	99385	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL282782	99385	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL353262	99385	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	168057	1201	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	7634	1201	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	CHEMBL28407	1201	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
	44279691	99713	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL284962	99713	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10909212	12339	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
	CHEMBL1185516	12339	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
	CHEMBL418702	12339	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
	44319178	12375	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1185797	12375	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL433343	12375	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	405242	11935	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1182967	11935	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL274413	11935	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	23657556	13033	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1190116	13033	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL540131	13033	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	118714972	114563	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	CHEMBL3337861	114563	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	10442337	203925	2	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	CHEMBL69305	203925	2	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	118714972	114563	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	CHEMBL3337861	114563	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
	10461289	112677	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL1202148	112677	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33044	112677	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	10442081	102581	9	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
	CHEMBL304142	102581	9	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
	168927	140144	7	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
	CHEMBL380352	140144	7	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
	168927	140144	7	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
	CHEMBL380352	140144	7	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
	10009514	202146	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
	CHEMBL609382	202146	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
	10974913	11059	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
	CHEMBL1177971	11059	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
	CHEMBL9017	11059	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
	44408892	75123	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	CHEMBL203627	75123	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
	44279471	99965	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
	CHEMBL286686	99965	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
	10032676	11700	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181399	11700	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169633	11700	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10077592	116556	1	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL33656	116556	1	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	44265498	111296	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL32676	111296	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL8669	111296	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	44265498	111296	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL32676	111296	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL8669	111296	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	76328904	106424	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121480	106424	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139898	106424	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
	10009225	96484	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL262632	96484	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8531	96484	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
	10009225	96484	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL262632	96484	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8531	96484	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
	10747449	12214	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184538	12214	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL354750	12214	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10461019	12208	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184498	12208	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL352486	12208	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10101670	1497	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
	7635	1497	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
	CHEMBL32985	1497	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
	118720628	120827	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355098	120827	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558556	120827	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	10509176	12213	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184534	12213	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL354673	12213	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	118720628	120827	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3355098	120827	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558556	120827	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
	23657556	13033	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL1190116	13033	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	CHEMBL540131	13033	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
	76325356	106485	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3120178	106485	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140233	106485	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	11505653	12278	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1185000	12278	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL382846	12278	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	118714977	114564	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	CHEMBL3337865	114564	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	118714977	114564	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	CHEMBL3337865	114564	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
	10963807	11048	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL1177938	11048	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	CHEMBL7902	11048	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
	44319265	12312	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL1185319	12312	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	CHEMBL407071	12312	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
	10794637	11696	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181384	11696	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169133	11696	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	44381306	11697	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181388	11697	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169342	11697	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10843237	12212	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1184525	12212	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL354103	12212	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	11104735	11050	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1177953	11050	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL8518	11050	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	10676884	11699	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181392	11699	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL169475	11699	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	10509365	106854	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31452	106854	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL352323	106854	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10509365	106854	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31452	106854	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL352323	106854	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL5285668	194607	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	CHEMBL5315497	194607	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
	10069369	99676	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL284672	99676	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10348407	16264	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL122499	16264	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL267482	16264	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	10348407	16264	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL122499	16264	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL267482	16264	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	10818763	106960	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL169001	106960	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31518	106960	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10818763	106960	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL169001	106960	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31518	106960	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	11422540	202111	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
	CHEMBL609120	202111	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
	10261985	203926	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	CHEMBL69306	203926	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
	11671915	11771	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1181935	11771	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL197604	11771	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	134207690	174621	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	CHEMBL4558206	174621	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	11756054	110837	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	CHEMBL32609	110837	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
	10747380	104840	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
	CHEMBL31103	104840	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
	CHEMBL68393	104840	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
	10747380	104840	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
	CHEMBL31103	104840	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
	CHEMBL68393	104840	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
	10077281	104080	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL30939	104080	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL8653	104080	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10509354	11695	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL1181373	11695	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	CHEMBL168613	11695	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
	1935	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	2551	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	6687	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	CHEMBL95	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	DB00382	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	11083080	11054	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
	CHEMBL1177963	11054	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
	CHEMBL8763	11054	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
	1935	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	2551	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	6687	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	CHEMBL95	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	DB00382	3707	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
	53382542	86284	0	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	CHEMBL2313377	86284	0	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	134207682	173620	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	CHEMBL4534301	173620	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
	10055492	106150	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL31376	106150	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL3350263	106150	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	11504244	106492	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138185	106492	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121474	106492	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140249	106492	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	10055492	106150	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL31376	106150	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL3350263	106150	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	10818794	102140	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
	CHEMBL30264	102140	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
	CHEMBL73114	102140	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
	10818794	102140	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
	CHEMBL30264	102140	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
	CHEMBL73114	102140	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
	71717892	89049	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL2311018	89049	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	CHEMBL2365146	89049	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
	76321739	106422	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3121477	106422	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	CHEMBL3139896	106422	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
	60138189	106493	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138190	106493	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121476	106493	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140252	106493	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138187	106421	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138192	106421	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121479	106421	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139879	106421	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	405244	12311	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL1185313	12311	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	CHEMBL406691	12311	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
	60138188	106423	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	60138191	106423	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121478	106423	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3139897	106423	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
	11768033	11919	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1182845	11919	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL269592	11919	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	10843266	110536	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
	CHEMBL32530	110536	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
	CHEMBL68936	110536	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
	10985526	18789	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL127933	18789	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	CHEMBL8983	18789	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
	10985526	18789	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL127933	18789	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	CHEMBL8983	18789	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
	10843266	110536	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
	CHEMBL32530	110536	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
	CHEMBL68936	110536	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
	11353863	202112	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL609124	202112	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	2551	791	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	298	791	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	488	791	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	CHEMBL965	791	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	DB00411	791	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
	132986	99585	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
	CHEMBL284055	99585	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
	405248	11913	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
	CHEMBL1182821	11913	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
	CHEMBL268195	11913	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
	10509706	96411	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
	CHEMBL262124	96411	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
	CHEMBL303624	96411	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
	10509706	96411	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
	CHEMBL262124	96411	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
	CHEMBL303624	96411	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
	10348116	104791	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
	CHEMBL31097	104791	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
	44319180	12046	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL1183728	12046	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	CHEMBL315340	12046	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
	118714967	120816	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3337858	120816	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	CHEMBL3558416	120816	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
	46878256	14132	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL1198561	14132	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	CHEMBL607179	14132	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
	11115574	11052	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL1177955	11052	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	CHEMBL8532	11052	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
	2230	464	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	296	464	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	CHEMBL7303	464	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	DB04365	464	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
	11636025	11777	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL1181949	11777	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	CHEMBL201016	11777	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
	170332	160952	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	170332	160952	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	10748143	99634	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL2111531	99634	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	CHEMBL284393	99634	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
	10748143	99634	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL2111531	99634	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	CHEMBL284393	99634	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
	11504244	106492	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	60138185	106492	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3121474	106492	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	CHEMBL3140249	106492	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
	10767691	107732	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL171215	107732	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	CHEMBL31915	107732	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
	10767691	107732	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL171215	107732	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	CHEMBL31915	107732	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
	10050814	109766	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
	CHEMBL32329	109766	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
	102070733	120815	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3337857	120815	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	CHEMBL3558415	120815	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
	44340802	62101	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
	CHEMBL177732	62101	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
	11331580	202113	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
	CHEMBL609125	202113	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
	367	3795	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	5487427	3795	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	8592	3795	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	CHEMBL1900528	3795	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	CHEMBL3305968	3795	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	CHEMBL4650755	3795	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	DB01409	3795	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
	367	3795	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	5487427	3795	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	8592	3795	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	CHEMBL1900528	3795	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	CHEMBL3305968	3795	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	CHEMBL4650755	3795	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	DB01409	3795	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
	11434515	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	11519741	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	4484	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	7449	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	CHEMBL1194325	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	DB08897	261	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
	10143956	13879	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL1196359	13879	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL556635	13879	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	11693	1814	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	3494	1814	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	4302	1814	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	7459	1814	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	CHEMBL1201335	1814	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	DB00986	1814	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
	11434515	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	11519741	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	4484	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	7449	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	CHEMBL1194325	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	DB08897	261	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	44233403	13869	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL1196247	13869	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL556222	13869	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	44233401	13592	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
	CHEMBL1194321	13592	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
	CHEMBL551327	13592	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
	11852298	13994	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1197251	13994	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL564057	13994	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	155566290	176556	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176556	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176556	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	367	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	5487427	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	8592	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	CHEMBL1900528	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	CHEMBL3305968	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	CHEMBL4650755	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	DB01409	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
	367	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	5487427	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	8592	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL1900528	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL3305968	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL4650755	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	DB01409	3795	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	44232930	196670	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL564747	196670	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	44232931	196358	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL562642	196358	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	44232927	195314	8	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL551729	195314	8	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	44236098	195625	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL556426	195625	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	44233177	13868	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1196246	13868	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL556221	13868	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44232685	13997	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL1197273	13997	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	CHEMBL564765	13997	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
	20735153	13591	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1194314	13591	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL551063	13591	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
	11489419	13586	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL1194274	13586	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL549784	13586	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	44233173	13988	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1197216	13988	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL562890	13988	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44236340	13760	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1195513	13760	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL554725	13760	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	688566	195860	24	None	-	3	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	CHEMBL558910	195860	24	None	-	3	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	49800047	14451	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201024	14451	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201268	14451	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	44232683	13594	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	CHEMBL1194336	13594	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	CHEMBL551731	13594	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
	44236336	13981	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL1197131	13981	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	CHEMBL560327	13981	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
	11693	1814	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	3494	1814	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	4302	1814	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	7459	1814	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	CHEMBL1201335	1814	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	DB00986	1814	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
	9913341	82129	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL216927	82129	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL553058	82129	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	44236101	13996	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1197261	13996	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL564515	13996	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44236099	195532	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL554699	195532	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	10007638	120850	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401648	120850	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559195	120850	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	67548926	120852	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401649	120852	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559201	120852	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	9809330	115973	0	None	-1	5	Human	9.2	pIC50	=	9.2	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	CHEMBL335542	115973	0	None	-1	5	Human	9.2	pIC50	=	9.2	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	44232681	13983	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1197156	13983	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL561187	13983	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
	10325942	120853	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401650	120853	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559202	120853	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	10143954	13587	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL1194286	13587	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL549986	13587	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	44236332	13985	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL1197183	13985	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL561870	13985	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	10143718	63104	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779131	63104	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789435	63104	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	44235871	196549	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL563887	196549	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	50925542	19145	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289653	19145	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	10165877	63100	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779133	63100	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789396	63100	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	11725334	117750	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401641	117750	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	155566290	176556	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176556	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176556	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	9928017	62309	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779033	62309	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	11569908	13969	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL1197028	13969	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL559106	13969	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	1201549	594	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	594	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	594	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	594	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	594	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	594	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	52942402	19187	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289983	19187	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	44303019	100919	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL294082	100919	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10229167	63095	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779136	63095	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789385	63095	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	14590398	101839	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL300660	101839	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590401	187954	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL49721	187954	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054136	60329	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17460	60329	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	13810575	98554	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
	CHEMBL276771	98554	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
	14590398	101839	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL300660	101839	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	14590401	187954	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL49721	187954	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	44333541	4720	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL103785	4720	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	60691	101524	26	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	CHEMBL29835	101524	26	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	24739387	188133	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	CHEMBL498556	188133	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	CHEMBL4639128	213999	17	None	-	0	Human	5.0	pIC50	=	5	Binding	Cross screening panelCross screening panel	ChEMBL		None	None	None		COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1	10.6019/CHEMBL4630907
	44275628	11962	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183229	11962	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL285803	11962	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
	10354348	98854	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
	CHEMBL279105	98854	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
	67549179	117754	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3401645	117754	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
	10784004	13355	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1192621	13355	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL543890	13355	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	137630050	161016	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	2774	3839	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	5593	3839	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	7319	3839	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	CHEMBL1200604	3839	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB00809	3839	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB01199	3839	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	1224	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	100	3776	58	None	-19	56	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3776	58	None	-19	56	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3776	58	None	-19	56	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3776	58	None	-19	56	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3776	58	None	-19	56	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	124087	1377	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1377	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1377	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1377	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1377	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	135	2515	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2515	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2515	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2515	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2515	43	None	-25	58	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	10782321	12092	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
	CHEMBL1184098	12092	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
	CHEMBL332405	12092	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
	10080742	206343	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL87485	206343	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	2284	3160	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3160	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3160	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3160	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3160	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	10594386	11386	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180249	11386	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL118553	11386	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	2230	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	296	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	CHEMBL7303	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	DB04365	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	9946632	62319	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779043	62319	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
	44302901	101029	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
	CHEMBL294726	101029	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
	6726	1269	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1269	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1269	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1269	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1269	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	2683	102861	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102861	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102861	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	10547222	114760	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333940	114760	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44236338	13878	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1196358	13878	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL556634	13878	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	52948443	19161	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289758	19161	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	2551	791	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	298	791	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	488	791	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	CHEMBL965	791	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	DB00411	791	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	3652	4066	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	57	4066	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	60809	4066	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	CHEMBL21536	4066	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	DB15357	4066	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	14590397	187673	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL49525	187673	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054141	162460	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	CHEMBL416723	162460	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	9815331	203084	1	None	1	8	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203084	1	None	1	8	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	14590397	187673	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL49525	187673	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	9815331	203084	1	None	-1	8	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203084	1	None	-1	8	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	11793999	12083	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184074	12083	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL331516	12083	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	18456768	63105	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779134	63105	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789445	63105	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	2200	3109	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	328	3109	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	4848	3109	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	CHEMBL9967	3109	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	DB00670	3109	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
	13271739	98498	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL276282	98498	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	14054138	98798	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL278701	98798	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	53853235	78652	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	CHEMBL2112432	78652	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	10829928	12370	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
	CHEMBL1185758	12370	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
	CHEMBL431688	12370	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
	15730	71089	80	None	-2	10	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	CHEMBL195437	71089	80	None	-2	10	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	10827157	11405	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL1180317	11405	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL121552	11405	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	52947552	19075	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289201	19075	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52943921	19092	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289315	19092	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52942610	19295	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290635	19295	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	46891076	6676	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	CHEMBL1083618	6676	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	441383	20301	57	None	-7	17	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL1306	20301	57	None	-7	17	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	9944783	62313	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779037	62313	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	2551	791	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	791	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	791	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	791	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	791	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2551	791	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	791	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	791	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	791	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	791	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	10567372	12099	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12099	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12099	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12099	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44302788	200599	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL59939	200599	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	122203596	155782	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10760249	11391	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
	CHEMBL1180285	11391	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
	CHEMBL120119	11391	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
	10760249	11391	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL1180285	11391	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL120119	11391	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	67547950	120851	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3401655	120851	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3559199	120851	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	54586723	62314	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779038	62314	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10686494	100510	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	CHEMBL291351	100510	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	10393952	63099	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779140	63099	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789389	63099	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	9798900	63106	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1779047	63106	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1789446	63106	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
	107867	2953	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	309	2953	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	CHEMBL17045	2953	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	13578548	101335	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296988	101335	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	107867	2953	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	309	2953	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	CHEMBL17045	2953	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	13578548	101335	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296988	101335	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	67548544	120856	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3401656	120856	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3559205	120856	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
	3088389	23082	3	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL13308	23082	3	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	2551	791	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	298	791	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	488	791	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	CHEMBL965	791	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	DB00411	791	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
	2247	504	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	44303294	201133	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60331	201133	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	4735	195092	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL361506	195092	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL55	195092	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	11057	176125	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	3468	176125	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL459265	176125	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL64894	176125	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	2812	4747	101	None	-33	34	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4747	101	None	-33	34	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	10518821	12095	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184108	12095	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL332645	12095	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	44302793	199706	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
	CHEMBL59347	199706	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
	10664532	12080	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184064	12080	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL330892	12080	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	52945272	19176	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289866	19176	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	52943721	19257	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290410	19257	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	379653	101656	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL299344	101656	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	13578572	186875	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL48980	186875	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054140	98912	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL279528	98912	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	5487543	205623	4	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	CHEMBL81878	205623	4	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	24750278	89395	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
	CHEMBL237067	89395	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
	379653	101656	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL299344	101656	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13578572	186875	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL48980	186875	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	14590400	177438	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL46390	177438	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	3071772	98392	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL275537	98392	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	14590400	177438	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL46390	177438	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	10638050	11383	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL116601	11383	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180202	11383	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10848032	206070	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85645	206070	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	44342270	9898	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	CHEMBL114484	9898	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	3652	4066	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	57	4066	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809	4066	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	CHEMBL21536	4066	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	DB15357	4066	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	44303286	201295	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL60419	201295	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	3071780	18758	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
	CHEMBL12781	18758	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
	44275648	11952	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183077	11952	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL278618	11952	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	13621567	98132	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL27384	98132	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL440085	98132	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	10757736	14472	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL120135	14472	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	10567372	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10567372	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12099	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44302834	202687	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61700	202687	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	4098	32475	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32475	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32475	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	10516408	11409	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180330	11409	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL122353	11409	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10240891	206075	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85678	206075	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	44303424	200464	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL59862	200464	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
	9815331	203084	1	None	1	8	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203084	1	None	1	8	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	9815331	203084	1	None	-1	8	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203084	1	None	-1	8	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	324	1912	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
	6436265	1912	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
	CHEMBL277642	1912	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
	10300661	63107	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779135	63107	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789451	63107	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	13578571	101097	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
	CHEMBL295214	101097	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
	13578571	101097	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
	CHEMBL295214	101097	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
	10610375	11390	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL1180284	11390	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL120109	11390	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
	10610375	11390	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
	CHEMBL1180284	11390	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
	CHEMBL120109	11390	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
	11820032	98196	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL274329	98196	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	3013846	188215	2	None	-4	5	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	CHEMBL499519	188215	2	None	-4	5	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	2745	3832	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	5572	3832	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	66007	3832	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	7315	3832	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	CHEMBL1490	3832	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	DB00376	3832	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
	306	3430	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	3536	3430	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	53930639	3430	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	9577995	3430	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	CHEMBL134641	3430	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
	2230	464	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	296	464	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	CHEMBL7303	464	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	DB04365	464	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
	44275626	11133	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178434	11133	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL28033	11133	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	163388532	190334	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
	CHEMBL5177023	190334	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
	CHEMBL4800073	214031	5	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2	ChEMBL		None	None	None		C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4cnccc4c3)ccc2[nH]1	10.6019/CHEMBL5212743
	44356367	118466	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
	CHEMBL341447	118466	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
	122203596	155782	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	137630050	161016	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	10684720	12062	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1183926	12062	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL324712	12062	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	2551	791	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	298	791	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	488	791	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	CHEMBL965	791	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	DB00411	791	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
	19816	57555	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	CHEMBL166736	57555	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	52946249	19056	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289082	19056	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	10420458	206245	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL86903	206245	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	71454411	78420	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL2111621	78420	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	44302741	202632	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61412	202632	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	4011	82379	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82379	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	10521205	11397	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180298	11397	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL120599	11397	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	9903030	62318	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779042	62318	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
	46871844	6780	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	CHEMBL1083925	6780	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	46871665	6563	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
	CHEMBL1083108	6563	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
	1273	1741	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	3450	1741	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	356	1741	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	6172	1741	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	67425	1741	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	CHEMBL360055	1741	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	DB00483	1741	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	25897919	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	657309	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	CHEMBL1464005	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	CHEMBL1621597	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
	44236334	13980	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL1197117	13980	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL559931	13980	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
	44233175	13987	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL1197209	13987	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	CHEMBL562655	13987	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
	25897919	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	657309	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1464005	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1621597	55622	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	52947320	19216	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290184	19216	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
	939077	195045	2	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	CHEMBL549577	195045	2	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
	44303323	163218	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL418491	163218	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10785471	113689	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL332320	113689	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	14590403	188371	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
	CHEMBL50176	188371	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
	13810574	59664	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17228	59664	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	14590403	188371	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
	CHEMBL50176	188371	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
	302	2956	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	4630	2956	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL7634	2956	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	24739886	187845	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	CHEMBL496376	187845	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
	14590396	172518	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL44838	172518	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590396	172518	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL44838	172518	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	19716	9235	6	None	-	1	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL11081	9235	6	None	-	1	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	10356006	205626	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81895	205626	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	10515352	106148	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL313749	106148	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	122203596	155782	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10019339	102599	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL304247	102599	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	1935	3707	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3707	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3707	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3707	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3707	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	1935	3707	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	2551	3707	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	6687	3707	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	CHEMBL95	3707	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	DB00382	3707	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
	2750	204038	76	None	-4	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204038	76	None	-4	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	5282593	55228	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1319362	55228	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1618018	55228	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	10808719	12100	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184120	12100	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL333125	12100	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	10399393	205763	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL83074	205763	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	4212	198656	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL1417019	198656	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL58	198656	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	154734599	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	327	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	4108	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	CHEMBL27673	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
	154734599	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	327	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	4108	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	CHEMBL27673	2486	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
	10546275	15170	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL121059	15170	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	10133281	62316	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779040	62316	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	9857572	62312	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779036	62312	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	13578549	101247	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296317	101247	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	10678449	22621	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	CHEMBL132698	22621	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	13578549	101247	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296317	101247	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	10846833	49775	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
	CHEMBL15675	49775	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
	3071773	19376	3	None	-	0	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL12937	19376	3	None	-	0	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	44275683	99254	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL281944	99254	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL541666	99254	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	10593954	13044	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1190178	13044	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL540316	13044	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
	10358345	11410	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1180331	11410	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL122354	11410	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	9996901	117751	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401642	117751	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	3236	67579	43	None	1	2	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	CHEMBL1902981	67579	43	None	1	2	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	10641009	11394	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180292	11394	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL120472	11394	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
	10726038	119406	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
	CHEMBL344892	119406	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
	44333603	109620	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	CHEMBL322378	109620	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
	3072503	4834	6	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL104355	4834	6	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	3072518	5214	4	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL106344	5214	4	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	2398	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	10663572	13127	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1190784	13127	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL541584	13127	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	44303396	201213	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60374	201213	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	9974222	11889	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1182709	11889	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL262198	11889	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	10778750	163934	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL420781	163934	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	52942628	19055	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289081	19055	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52942401	19186	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289982	19186	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	44275767	97589	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL27096	97589	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL540136	97589	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	52945255	19275	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290520	19275	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	46891179	6385	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	CHEMBL1082365	6385	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
	118728611	117753	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401644	117753	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	10267601	12097	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1184116	12097	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL332980	12097	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	44302775	202773	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL62247	202773	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	10573693	11398	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL1180305	11398	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL120963	11398	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	3158	56237	27	None	-630	20	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56237	27	None	-630	20	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	10220392	205982	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL84893	205982	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	4841	67397	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1889399	67397	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1909073	67397	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	44303314	100906	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL293982	100906	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	54585743	62320	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779044	62320	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	44275682	11959	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183197	11959	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL284208	11959	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	191	402	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	402	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	402	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	402	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	402	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	3823	50191	42	None	-44	11	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	76973198	50191	42	None	-44	11	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL157101	50191	42	None	-44	11	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	44302900	202775	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
	CHEMBL62251	202775	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
	44302813	101903	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL301041	101903	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	137630050	161016	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	2028	2958	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2958	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2958	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2958	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2958	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	44303327	162987	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL417560	162987	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	10539130	106703	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL314420	106703	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	10567192	12064	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1183934	12064	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL324936	12064	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	10567372	12099	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1160977	12099	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184119	12099	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL333065	12099	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	10777692	11395	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180296	11395	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL120539	11395	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	68617	205504	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205504	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205504	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	54585742	62307	1	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779031	62307	1	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	54582845	63101	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779139	63101	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789405	63101	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	10451242	203091	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL64029	203091	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10262466	98316	0	None	-	5	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL275104	98316	0	None	-	5	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	122203596	155782	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10538337	12079	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL1184062	12079	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
	CHEMBL330885	12079	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
	67547652	117756	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
	CHEMBL3401647	117756	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
	154734599	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	327	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	4108	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	CHEMBL27673	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
	11678378	120860	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3401654	120860	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3559211	120860	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	54586745	63110	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779138	63110	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789461	63110	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	134688371	14397	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	13765	14397	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	CHEMBL1200623	14397	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	3652	46214	70	None	-2	9	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	CHEMBL1535	46214	70	None	-2	9	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	50925541	19127	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289545	19127	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	50925543	19146	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289654	19146	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	10119939	63098	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1777827	63098	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789388	63098	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	155522355	176385	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176385	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176385	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	9967590	62111	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1777826	62111	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	174174	521	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	260	521	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	320	521	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	CHEMBL517712	521	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	DB00572	521	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	2551	791	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	298	791	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	488	791	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	CHEMBL965	791	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	DB00411	791	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
	10208972	63102	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779129	63102	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789429	63102	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	52942458	19215	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290183	19215	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	10094518	101366	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL297224	101366	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	10096508	176999	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
	CHEMBL46315	176999	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
	11725107	100585	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL291872	100585	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10094518	101366	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL297224	101366	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	10096508	176999	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
	CHEMBL46315	176999	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
	3072508	107461	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL318517	107461	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	14054145	98600	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL277078	98600	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL5076569	214426	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2cccnc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
	44302727	101891	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL300987	101891	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	10176679	133584	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	CHEMBL37132	133584	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	10797864	26113	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
	CHEMBL135645	26113	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
	52947254	19175	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289865	19175	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
	52949961	19316	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290752	19316	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	3072505	108545	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL320291	108545	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	2551	791	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	791	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	791	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	791	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	791	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2551	791	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	791	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	791	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	791	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	791	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2274	3151	58	None	-100	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3151	58	None	-100	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3151	58	None	-100	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3151	58	None	-100	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3151	58	None	-100	32	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	3652	4066	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	57	4066	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	60809	4066	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	CHEMBL21536	4066	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	DB15357	4066	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	24882193	188625	0	None	-	2	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
	CHEMBL503468	188625	0	None	-	2	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
	3198	205490	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	54586743	63111	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
	CHEMBL1779130	63111	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
	CHEMBL1789462	63111	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
	13578551	101257	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296405	101257	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	13578551	101257	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296405	101257	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	9882189	167410	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
	CHEMBL4297224	167410	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
	9882189	167410	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
	CHEMBL4297224	167410	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
	3072510	5333	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL106936	5333	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	10761219	11399	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1180309	11399	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL121298	11399	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
	2337	3232	77	None	-31	63	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3232	77	None	-31	63	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3232	77	None	-31	63	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3232	77	None	-31	63	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3232	77	None	-31	63	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	2745	3832	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	5572	3832	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	66007	3832	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	7315	3832	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	CHEMBL1490	3832	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	DB00376	3832	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	2551	791	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	298	791	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	488	791	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	CHEMBL965	791	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	DB00411	791	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	154734599	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	327	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	4108	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	CHEMBL27673	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
	154734599	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	327	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	4108	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	CHEMBL27673	2486	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
	24996645	70397	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
	CHEMBL1945848	70397	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
	44275767	97589	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL27096	97589	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL540136	97589	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	290	2456	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	4022	2456	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	5926	2456	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	CHEMBL40554	2456	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	CHEMBL74300	2456	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
	15685990	58053	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	CHEMBL167335	58053	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	11498	2997	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
	4995951	2997	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
	CHEMBL59898	2997	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
	1971	2846	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2846	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2846	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2846	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2846	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	11695697	117755	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	CHEMBL3401646	117755	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
	54583839	62311	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779035	62311	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	277	1289	62	None	-10	46	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1289	62	None	-10	46	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1289	62	None	-10	46	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1289	62	None	-10	46	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1289	62	None	-10	46	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2286	3161	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3161	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3161	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3161	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3161	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	118728610	117749	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401640	117749	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
	3067217	61268	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
	CHEMBL17671	61268	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
	3072506	5292	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL106782	5292	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	3072512	5331	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL106932	5331	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	10639739	11617	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
	CHEMBL1181055	11617	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
	CHEMBL154087	11617	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
	6918276	15579	7	None	-131	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15579	7	None	-131	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	10759393	84356	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL2112589	84356	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL2219563	84356	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	25014630	83510	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
	CHEMBL2203713	83510	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
	44275648	11952	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183077	11952	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL278618	11952	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	1548953	207656	27	None	-6	17	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	207656	27	None	-6	17	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	154734599	2486	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	327	2486	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	4108	2486	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	CHEMBL27673	2486	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	3072515	5162	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL106082	5162	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	202718	87295	22	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
	CHEMBL2332280	87295	22	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
	4601	206724	35	None	-2	17	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	206724	35	None	-2	17	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	206724	35	None	-2	17	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	3072507	5217	2	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	CHEMBL106348	5217	2	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
	1726	2480	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2480	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2480	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2480	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2480	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1726	2480	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2480	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2480	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2480	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2480	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	13621567	98132	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL27384	98132	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	CHEMBL440085	98132	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
	10595006	11413	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL1180343	11413	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL123099	11413	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	10595006	11413	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL1180343	11413	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL123099	11413	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	10777343	206146	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL86288	206146	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	52946359	19091	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289314	19091	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	44275683	99254	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL281944	99254	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	CHEMBL541666	99254	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
	9308	17722	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17722	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17722	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17722	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	9308	17722	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17722	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17722	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17722	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	10611310	12091	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1184096	12091	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL332335	12091	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	316	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	46890977	6700	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
	CHEMBL1083723	6700	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
	46871666	7037	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	CHEMBL1084993	7037	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	10208897	63097	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779049	63097	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789387	63097	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10246307	117752	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401643	117752	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
	316	2816	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	317	2816	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	71183	2816	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	CHEMBL3140030	2816	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	CHEMBL376897	2816	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	DB00462	2816	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
	11306852	13993	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
	CHEMBL1197250	13993	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
	CHEMBL563996	13993	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
	11539632	70532	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	CHEMBL194837	70532	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	9946010	62310	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779034	62310	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10053614	120854	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401651	120854	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559203	120854	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	14075467	101453	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL297818	101453	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14075467	101453	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL297818	101453	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	107867	2953	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	309	2953	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	CHEMBL17045	2953	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	302	2956	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
	4630	2956	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
	CHEMBL7634	2956	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
	3071778	163261	3	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL418712	163261	3	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	3072509	5540	3	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107673	5540	3	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	107867	2953	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	309	2953	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	CHEMBL17045	2953	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	10333583	206027	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85264	206027	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10686988	12157	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
	CHEMBL1184244	12157	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
	CHEMBL340780	12157	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
	155522355	176385	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176385	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176385	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	10852843	11892	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1182713	11892	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL262303	11892	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
	44304805	202999	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
	CHEMBL345233	202999	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
	CHEMBL63325	202999	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
	10132599	62308	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779032	62308	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10755733	11396	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL1180297	11396	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	CHEMBL120581	11396	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
	4189	206899	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	316	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2816	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	44275682	11959	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1183197	11959	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL284208	11959	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	3072514	5387	3	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107254	5387	3	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	19718	204801	7	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	CHEMBL75358	204801	7	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
	9308	17722	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17722	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17722	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17722	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	10688349	12104	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184138	12104	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL334194	12104	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
	54583840	62321	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779045	62321	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
	10591874	13284	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1192001	13284	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL543177	13284	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
	2230	464	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	296	464	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	CHEMBL7303	464	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	DB04365	464	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
	11811722	10033	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
	CHEMBL115280	10033	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
	5310989	200854	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL60142	200854	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	3042	1402	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1402	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1402	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1402	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1402	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	44275680	11131	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178406	11131	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL26932	11131	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	10660	14384	58	None	-4	12	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14384	58	None	-4	12	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	10826990	206133	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL86197	206133	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	44302879	202695	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61774	202695	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
	10522202	11402	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180312	11402	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL121385	11402	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
	44303018	202000	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60833	202000	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	3055247	18899	6	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL12858	18899	6	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	10755732	12089	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1184092	12089	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL332181	12089	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	5747382	109176	3	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321605	109176	3	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	10549581	11417	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL1180349	11417	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	CHEMBL123198	11417	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
	135398737	955	93	None	-22	92	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	955	93	None	-22	92	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	955	93	None	-22	92	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	955	93	None	-22	92	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	955	93	None	-22	92	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	167962	4038	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4038	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4038	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	10563152	206047	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL85460	206047	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	72548703	161543	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161543	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	10082470	52687	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
	CHEMBL15944	52687	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
	CHEMBL308608	52687	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
	9804849	67426	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL189118	67426	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	44275626	11133	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178434	11133	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL28033	11133	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	10522336	15098	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL120972	15098	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	44303397	102261	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL303360	102261	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	9308	17722	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17722	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17722	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17722	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	44275680	11131	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL1178406	11131	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	CHEMBL26932	11131	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
	107867	2953	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	309	2953	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	CHEMBL17045	2953	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
	14054139	161743	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	CHEMBL413966	161743	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
	107867	2953	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	309	2953	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	CHEMBL17045	2953	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
	52950036	19126	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289544	19126	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52943879	19317	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290753	19317	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
	11569926	63103	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779048	63103	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789434	63103	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	14054137	98857	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL279135	98857	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	44268378	21919	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
	CHEMBL13206	21919	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
	14590394	180862	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL47575	180862	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590394	180862	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL47575	180862	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	316	2816	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2816	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2816	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2816	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2816	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2816	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	176	397	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	154734599	2486	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	327	2486	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	4108	2486	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	CHEMBL27673	2486	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	10937901	9878	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	CHEMBL114379	9878	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	10058347	105904	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL312823	105904	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10035533	205680	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL82378	205680	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10854880	11389	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1180282	11389	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL120080	11389	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	3071774	21516	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL13166	21516	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	1726	2480	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2480	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2480	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2480	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2480	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1726	2480	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2480	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2480	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2480	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2480	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	5487543	205623	4	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81878	205623	4	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	43815	186896	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL1708	186896	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL490	186896	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	3071777	163262	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL418714	163262	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	10636001	11393	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1180290	11393	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL120329	11393	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	5648	78382	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2107687	78382	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2111176	78382	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	1734	116	10	None	-9	13	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	307	116	10	None	-9	13	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	CHEMBL168067	116	10	None	-9	13	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	3071779	16790	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
	CHEMBL12472	16790	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
	15685982	56496	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL163661	56496	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	13578552	160153	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
	CHEMBL410928	160153	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
	13578552	160153	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
	CHEMBL410928	160153	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
	9905467	11404	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1180316	11404	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL121520	11404	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	6075	150084	42	None	-7	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	150084	42	None	-7	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	3072501	107242	6	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL316973	107242	6	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	154059	3610	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	2457	3610	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	7483	3610	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1734	3610	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	DB01591	3610	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	2335	11816	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	8478	11816	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL1182210	11816	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL221753	11816	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	3071775	97187	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL268499	97187	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	3071771	21062	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
	CHEMBL13122	21062	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
	2230	464	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	296	464	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	CHEMBL7303	464	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	DB04365	464	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
	44575653	181620	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
	CHEMBL477542	181620	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
	52943696	19233	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290294	19233	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	14374296	101626	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL299142	101626	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	13578554	172401	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
	CHEMBL44773	172401	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
	14374296	101626	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL299142	101626	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13578554	172401	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
	CHEMBL44773	172401	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
	6410685	109229	3	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321808	109229	3	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
	13578555	176656	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
	CHEMBL45983	176656	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
	14590399	101251	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL296365	101251	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14054144	60403	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17519	60403	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	14590399	101251	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL296365	101251	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13578555	176656	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
	CHEMBL45983	176656	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
	10851853	12156	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1184242	12156	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL340561	12156	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	71450872	78650	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL2112418	78650	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	10058744	206359	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL87622	206359	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10397133	107035	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL315676	107035	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	10487582	28198	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	CHEMBL137384	28198	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	24180125	95627	71	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
	CHEMBL257991	95627	71	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
	44303017	200810	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60101	200810	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	52947553	19076	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289202	19076	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	122203596	155782	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	3072513	6230	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL108163	6230	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	78319901	159210	35	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
	CHEMBL4098877	159210	35	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
	118728611	117753	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401644	117753	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
	60691	101524	26	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	CHEMBL29835	101524	26	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
	15685977	120317	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL353023	120317	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	2726	916	68	None	-79	73	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-79	73	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-79	73	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-79	73	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-79	73	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	137630050	161016	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	10499832	12103	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184134	12103	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	CHEMBL334093	12103	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
	10782462	12082	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL1184068	12082	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	CHEMBL330999	12082	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
	14660293	52623	3	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
	CHEMBL15936	52623	3	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
	3072504	5780	7	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107892	5780	7	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	44333819	4681	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL103529	4681	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
	2200	3109	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	328	3109	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	4848	3109	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	CHEMBL9967	3109	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	DB00670	3109	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
	10707175	206128	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL86150	206128	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	1210	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	1213	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	2725	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	33036	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	4411	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	616	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	6976	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	716121	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	90475904	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1201353	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1554789	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL505	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB01114	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB13679	915	51	None	-162	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	10187216	63108	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779128	63108	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789452	63108	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	14590402	101060	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	CHEMBL294919	101060	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
	14590402	101060	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	CHEMBL294919	101060	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
	13269694	59418	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17120	59418	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	14054135	61488	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17709	61488	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	10511551	25799	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	CHEMBL135328	25799	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
	3072502	4894	13	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL104681	4894	13	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	24871823	92500	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
	CHEMBL2431819	92500	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
	3071776	24517	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	CHEMBL13426	24517	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
	10806268	12105	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL1184139	12105	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	CHEMBL334245	12105	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
	15181802	12133	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
	CHEMBL1184199	12133	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
	CHEMBL338611	12133	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
	10666533	11400	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL1180310	11400	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	CHEMBL121299	11400	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
	14058518	11130	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL1178388	11130	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL25649	11130	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	10592484	11403	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180314	11403	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL121476	11403	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	1212	1649	50	None	-1380	66	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1649	50	None	-1380	66	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1649	50	None	-1380	66	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1649	50	None	-1380	66	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1649	50	None	-1380	66	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	11256587	2445	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	8580	2445	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	CHEMBL518924	2445	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	DB05501	2445	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
	9966959	62317	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	CHEMBL1779041	62317	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
	44333822	4633	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL103189	4633	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	10048670	107431	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	CHEMBL318316	107431	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
	57345320	3803	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
	9882	3803	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
	CHEMBL3091687	3803	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
	3055	1421	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	313	1421	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	7163	1421	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	CHEMBL936	1421	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	DB01231	1421	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	44302755	202653	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL61494	202653	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	10854879	11385	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL1180239	11385	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	CHEMBL118241	11385	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
	1273	1741	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	3450	1741	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	356	1741	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	6172	1741	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	67425	1741	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	CHEMBL360055	1741	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	DB00483	1741	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	1016	3720	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	3191	102831	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102831	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	44303293	201403	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60479	201403	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	44235638	195291	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
	CHEMBL551525	195291	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
	52945165	19109	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	CHEMBL1289432	19109	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
	52942497	19234	3	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290295	19234	3	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	3233138	19256	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290409	19256	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	52949883	19294	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290634	19294	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
	57396813	71516	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1949930	71516	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1963007	71516	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	10085070	205961	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL84726	205961	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	52946068	19201	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
	CHEMBL1290077	19201	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
	52947416	19274	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
	CHEMBL1290519	19274	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
	46891488	7141	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	CHEMBL1085507	7141	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
	14054142	59488	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	CHEMBL17155	59488	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
	10143858	63109	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779132	63109	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789454	63109	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
	10164137	63096	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779137	63096	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	CHEMBL1789386	63096	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
	2200	3109	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	328	3109	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	4848	3109	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	CHEMBL9967	3109	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	DB00670	3109	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
	14590395	101491	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
	CHEMBL298078	101491	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
	14590395	101491	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
	CHEMBL298078	101491	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
	16005860	187382	7	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
	CHEMBL493677	187382	7	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
	67547662	120859	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401653	120859	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559210	120859	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
	42636350	82564	41	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
	CHEMBL2178953	82564	41	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
	9990434	106312	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL313918	106312	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
	180	400	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	400	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	400	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	400	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	400	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	1530	2169	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2169	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2169	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2169	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2169	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	10778462	205985	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	CHEMBL84919	205985	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
	302	2956	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	4630	2956	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	CHEMBL7634	2956	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
	302	2956	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
	4630	2956	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
	CHEMBL7634	2956	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
	44265375	206124	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL8610	206124	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL5070958	214226	3	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
	54584800	62315	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779039	62315	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
	2166	3101	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	305	3101	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	5910	3101	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	CHEMBL550	3101	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	DB01085	3101	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
	10610448	206102	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	CHEMBL85936	206102	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
	13271741	59502	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17162	59502	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	13271742	59621	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	CHEMBL17213	59621	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
	10392705	120855	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3401652	120855	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	CHEMBL3559204	120855	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
	2230	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	296	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	CHEMBL7303	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	DB04365	464	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
	44303408	201923	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60777	201923	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	49853884	90654	0	None	-	0	Human	4.0	pIC50	=	4.0	Binding	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
	CHEMBL2391353	90654	0	None	-	0	Human	4.0	pIC50	=	4.0	Binding	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
	44302728	198690	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL58228	198690	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
	14058518	11130	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL1178388	11130	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	CHEMBL25649	11130	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
	44302776	102323	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	CHEMBL303758	102323	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
	10614695	12125	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL1184188	12125	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	CHEMBL338280	12125	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
	10569816	11427	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL1180367	11427	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	CHEMBL124173	11427	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
	10248541	182875	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
	CHEMBL479224	182875	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
	237	204842	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL546257	204842	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL554190	204842	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL7568	204842	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	2200	3109	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	328	3109	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	4848	3109	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	CHEMBL9967	3109	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	DB00670	3109	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
	25147683	62322	37	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	CHEMBL1779046	62322	37	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
	164612037	185353	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	CHEMBL4860528	185353	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	168290235	192944	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5201074	192944	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222491	192944	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	168294767	192995	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	192995	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	192995	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	168295528	193007	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	193007	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	193007	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	10457079	9998	0	None	-4	2	Human	9.8	pKd	=	9.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	9998	0	None	-4	2	Human	9.8	pKd	=	9.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	688566	195860	24	None	-1	3	Rat	9.7	pKd	=	9.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
	CHEMBL558910	195860	24	None	-1	3	Rat	9.7	pKd	=	9.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
	137630050	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137630050	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137630050	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137630050	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	10387775	78463	0	None	-3	2	Rat	9.4	pKd	=	9.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	CHEMBL2111842	78463	0	None	-3	2	Rat	9.4	pKd	=	9.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	156015807	178275	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162677523	183650	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4756833	183650	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4802932	183650	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	10387775	78463	0	None	-3	2	Rat	9.2	pKd	=	9.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	CHEMBL2111842	78463	0	None	-3	2	Rat	9.2	pKd	=	9.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
	162649253	183621	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4748004	183621	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4802611	183621	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	156015900	178297	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643273	178297	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651104	178297	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	156015900	178297	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643273	178297	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651104	178297	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155782	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	156015807	178275	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155782	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	122203596	155782	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	4120	5902	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL107979	5902	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL293927	5902	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	156015807	178275	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	137630050	161016	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	162677523	183650	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4756833	183650	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4802932	183650	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	156014820	178281	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4646116	178281	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4650998	178281	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	156015978	178299	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	14753629	13636	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1194660	13636	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL553066	13636	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	10101246	9514	0	None	-81	2	Human	8.8	pKd	=	8.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9514	0	None	-81	2	Human	8.8	pKd	=	8.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	162654942	183647	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4754371	183647	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802913	183647	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	162649253	183621	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4748004	183621	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4802611	183621	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	156016041	178223	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162645430	183603	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4744233	183603	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802409	183603	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	324	1912	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
	6436265	1912	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
	CHEMBL277642	1912	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
	14753632	13476	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1193564	13476	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL544993	13476	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	14753634	13695	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1195059	13695	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL553783	13695	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	156015153	178283	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178283	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178283	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10125445	75999	0	None	-25	5	Human	7.0	pKd	=	7	Binding	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	CHEMBL205654	75999	0	None	-25	5	Human	7.0	pKd	=	7	Binding	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	71716224	86927	0	None	-1	3	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323444	86927	0	None	-1	3	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	14753624	13704	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1195123	13704	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL553894	13704	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	156016041	178223	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	156016041	178223	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	15038486	85739	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
	CHEMBL22923	85739	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
	15038486	85739	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	CHEMBL22923	85739	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	71718669	86929	0	None	2	3	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323446	86929	0	None	2	3	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	44457850	98930	0	None	-1	2	Rat	7.8	pKd	=	7.8	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL279712	98930	0	None	-1	2	Rat	7.8	pKd	=	7.8	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	167962	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	167962	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	76315655	106178	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	76315655	106178	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261153	106178	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261153	106178	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3138747	106178	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3138747	106178	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	11957991	106419	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	11957991	106419	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261155	106419	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261155	106419	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3139843	106419	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3139843	106419	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	167962	4038	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4038	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4038	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	162654942	183647	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4754371	183647	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802913	183647	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	156015153	178283	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178283	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178283	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	156015978	178299	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44457838	161857	0	None	2	2	Rat	8.7	pKd	=	8.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL415038	161857	0	None	2	2	Rat	8.7	pKd	=	8.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	156014820	178281	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4646116	178281	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	CHEMBL4650998	178281	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
	162677513	183720	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4789147	183720	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4803695	183720	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	156015153	178283	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178283	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178283	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	174174	521	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	260	521	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	320	521	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	CHEMBL517712	521	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	DB00572	521	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
	5861	11253	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL1179176	11253	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	CHEMBL63452	11253	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
	156015978	178299	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44457835	83357	0	None	-11	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL21942	83357	0	None	-11	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	44457839	83965	0	None	-4	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL22071	83965	0	None	-4	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	3636	11115	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1178342	11115	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL21823	11115	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	14753627	13674	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1194941	13674	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL553562	13674	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	44373048	52500	0	None	2	2	Rat	6.6	pKd	=	6.6	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
	CHEMBL159189	52500	0	None	2	2	Rat	6.6	pKd	=	6.6	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
	44457833	94758	0	None	-7	2	Rat	7.6	pKd	=	7.6	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
	CHEMBL25334	94758	0	None	-7	2	Rat	7.6	pKd	=	7.6	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
	167962	4038	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4038	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4038	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	76312112	106413	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	76312112	106413	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2261148	106413	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261148	106413	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139732	106413	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139732	106413	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	76315655	106308	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	76315655	106308	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261152	106308	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261152	106308	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3139166	106308	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3139166	106308	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	76312110	106410	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	76312110	106410	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2261144	106410	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261144	106410	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139691	106410	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139691	106410	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	10365181	18525	0	None	-38	3	Rat	7.5	pKd	=	7.5	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	CHEMBL127587	18525	0	None	-38	3	Rat	7.5	pKd	=	7.5	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	44373347	119539	0	None	1	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
	CHEMBL346049	119539	0	None	1	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
	137628879	160948	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160948	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160948	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160948	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	44457825	163169	0	None	-1	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL418189	163169	0	None	-1	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	324	1912	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	6436265	1912	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	CHEMBL277642	1912	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	11968014	12726	5	None	-3	9	Rat	8.5	pKd	=	8.5	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
	CHEMBL1187846	12726	5	None	-3	9	Rat	8.5	pKd	=	8.5	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
	156015978	178299	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44457832	85594	0	None	-2	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL22829	85594	0	None	-2	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	162645430	183603	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4744233	183603	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802409	183603	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	162645520	183604	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4742721	183604	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802414	183604	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	44457828	161856	0	None	-1	2	Rat	7.5	pKd	=	7.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL415037	161856	0	None	-1	2	Rat	7.5	pKd	=	7.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	44373093	54073	0	None	-2	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
	CHEMBL160666	54073	0	None	-2	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
	57664406	2383	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	6938	2383	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089376	2383	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	156016041	178223	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162677513	183720	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4789147	183720	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	CHEMBL4803695	183720	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
	156016041	178223	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162645520	183604	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4742721	183604	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	CHEMBL4802414	183604	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
	137628879	160948	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160948	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160948	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160948	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	324	1912	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	6436265	1912	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	CHEMBL277642	1912	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	156015807	178275	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10055202	11501	1	None	5	2	Human	6.4	pKd	=	6.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
	CHEMBL11805	11501	1	None	5	2	Human	6.4	pKd	=	6.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
	10365181	18525	0	None	-38	3	Rat	7.4	pKd	=	7.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	CHEMBL127587	18525	0	None	-38	3	Rat	7.4	pKd	=	7.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
	15038486	85739	0	None	-3	3	Human	5.4	pKd	=	5.4	Binding	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	CHEMBL22923	85739	0	None	-3	3	Human	5.4	pKd	=	5.4	Binding	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
	167962	4038	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4038	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4038	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	44373067	51875	0	None	5	2	Rat	6.3	pKd	=	6.3	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	CHEMBL158589	51875	0	None	5	2	Rat	6.3	pKd	=	6.3	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	9979830	13015	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
	9979830	13015	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL1190002	13015	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL1190002	13015	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL539879	13015	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL539879	13015	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
	156015807	178275	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	156015978	178299	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11957991	106414	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	11957991	106414	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL2261154	106414	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL2261154	106414	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	CHEMBL3139733	106414	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
	CHEMBL3139733	106414	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
	76319430	106416	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2262220	106416	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139826	106416	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	76330179	106417	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261145	106417	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139827	106417	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	14753637	13457	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL1193366	13457	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	CHEMBL544759	13457	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
	324	1912	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	6436265	1912	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	CHEMBL277642	1912	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
	71720488	86924	0	None	2	3	Guinea pig	6.2	pKd	=	6.2	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323441	86924	0	None	2	3	Guinea pig	6.2	pKd	=	6.2	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	44457844	85786	0	None	1	2	Rat	6.2	pKd	=	6.2	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
	CHEMBL22962	85786	0	None	1	2	Rat	6.2	pKd	=	6.2	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
	44457834	84688	0	None	-1	2	Rat	8.1	pKd	=	8.1	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	CHEMBL22278	84688	0	None	-1	2	Rat	8.1	pKd	=	8.1	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
	137628879	160948	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160948	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160948	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160948	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	156015153	178283	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178283	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178283	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	76308444	106411	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	76308444	106411	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL2261149	106411	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL2261149	106411	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	CHEMBL3139712	106411	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
	CHEMBL3139712	106411	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
	71716836	86925	0	None	4	3	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323442	86925	0	None	4	3	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	10318189	54201	0	None	9	2	Rat	7.1	pKd	=	7.1	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
	CHEMBL160755	54201	0	None	9	2	Rat	7.1	pKd	=	7.1	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
	324	1912	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
	6436265	1912	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
	CHEMBL277642	1912	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
	44373049	52536	0	None	4	2	Rat	7.0	pKd	=	7.0	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	CHEMBL159237	52536	0	None	4	2	Rat	7.0	pKd	=	7.0	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
	9916852	204896	0	None	-	1	Human	11.0	pKi	=	11	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	CHEMBL76164	204896	0	None	-	1	Human	11.0	pKi	=	11	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	9916852	204896	0	None	-	1	Human	11.0	pKi	=	11	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL76164	204896	0	None	-	1	Human	11.0	pKi	=	11	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	367	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	5487427	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	8592	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	CHEMBL1900528	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	CHEMBL3305968	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	CHEMBL4650755	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	DB01409	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
	367	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	5487427	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	8592	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL1900528	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL3305968	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL4650755	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	DB01409	3795	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	59291417	112796	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298595	112796	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307168	112796	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	688566	195860	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
	CHEMBL558910	195860	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
	71452756	79512	0	None	2	4	Human	10.5	pKi	=	10.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114068	79512	0	None	2	4	Human	10.5	pKi	=	10.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	44378845	57127	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL164705	57127	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
	44378762	119902	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL349497	119902	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	44324892	111538	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328094	111538	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	688566	195860	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
	CHEMBL558910	195860	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
	688566	195860	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
	CHEMBL558910	195860	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
	44325018	206851	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90700	206851	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44378811	120075	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL350956	120075	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	23056	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	318	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	3260	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL12980	112	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
	25005841	112793	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298599	112793	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307130	112793	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	16065402	67898	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
	CHEMBL1910848	67898	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
	71454563	79627	0	None	5	4	Human	10.2	pKi	=	10.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL2115128	79627	0	None	5	4	Human	10.2	pKi	=	10.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	10143956	13879	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL1196359	13879	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	CHEMBL556635	13879	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
	367	3795	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	5487427	3795	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	8592	3795	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL1900528	3795	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL3305968	3795	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	CHEMBL4650755	3795	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	DB01409	3795	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
	155566290	176556	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176556	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176556	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155550632	176505	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4540949	176505	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597071	176505	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155566290	176556	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176556	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176556	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	316	2816	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2816	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2816	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2816	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2816	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2816	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	44343733	13400	0	None	-	1	Rat	10.2	pKi	=	10.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	CHEMBL119294	13400	0	None	-	1	Rat	10.2	pKi	=	10.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	9827782	103526	0	None	41	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL308566	103526	0	None	41	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
	15407089	207429	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL94189	207429	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	10457079	9998	0	None	-4	2	Human	10.1	pKi	=	10.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	9998	0	None	-4	2	Human	10.1	pKi	=	10.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	155566290	176556	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176556	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176556	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	164611865	188452	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4856113	188452	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028107	188452	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	155525097	170926	0	None	18	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4455570	170926	0	None	18	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155567380	176384	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4589047	176384	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596064	176384	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155521894	176401	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451383	176401	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596183	176401	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	155550436	176477	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4569639	176477	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596780	176477	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	11434515	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	11519741	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	4484	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	7449	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	CHEMBL1194325	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	DB08897	261	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
	11852298	13994	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL1197251	13994	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	CHEMBL564057	13994	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
	44378875	57159	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL164935	57159	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44379051	58058	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL167396	58058	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	10461523	120223	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL352291	120223	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44379021	120234	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL352380	120234	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	367	3795	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	5487427	3795	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	8592	3795	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL1900528	3795	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL3305968	3795	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	CHEMBL4650755	3795	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	DB01409	3795	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
	44274333	11114	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
	CHEMBL1178341	11114	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
	CHEMBL21812	11114	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
	11431874	74251	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
	CHEMBL2023762	74251	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
	CHEMBL2023764	74251	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
	155566290	176556	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4582879	176556	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4597498	176556	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164622681	188538	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4864727	188538	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028712	188538	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164616463	188490	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
	CHEMBL4859378	188490	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
	CHEMBL5028381	188490	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
	137630050	161016	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	9827782	103526	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL308566	103526	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	9827782	103526	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL308566	103526	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	15453419	207438	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL94247	207438	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	9827782	103526	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL308566	103526	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	140844407	176608	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4519930	176608	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597916	176608	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	155539713	176336	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4515788	176336	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595691	176336	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44431393	87995	0	None	1	3	Human	9.9	pKi	=	9.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234440	87995	0	None	1	3	Human	9.9	pKi	=	9.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
	59291241	112788	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298596	112788	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307116	112788	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	9809330	115973	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	CHEMBL335542	115973	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
	15407088	206970	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL91404	206970	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44292486	181487	0	None	-	1	Rat	9.9	pKi	=	9.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL47650	181487	0	None	-	1	Rat	9.9	pKi	=	9.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	16065403	67906	23	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
	CHEMBL1910856	67906	23	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
	316	2816	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2816	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2816	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2816	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2816	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2816	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	44610056	123965	0	None	1	5	Human	9.9	pKi	=	9.9	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
	CHEMBL3629360	123965	0	None	1	5	Human	9.9	pKi	=	9.9	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
	10274019	204228	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL71124	204228	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44378846	57137	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL164762	57137	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	164622945	188541	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL4871700	188541	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL5028723	188541	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	155523648	176569	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4454300	176569	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597576	176569	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	15463388	165668	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL424530	165668	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	49800047	14451	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201024	14451	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	CHEMBL1201268	14451	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
	367	3795	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	5487427	3795	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	8592	3795	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	CHEMBL1900528	3795	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	CHEMBL3305968	3795	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	CHEMBL4650755	3795	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	DB01409	3795	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
	11519069	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	4816	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	7354	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	CHEMBL1187833	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	DB09076	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	164615275	188483	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4861252	188483	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028304	188483	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	367	3795	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	5487427	3795	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	8592	3795	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	CHEMBL1900528	3795	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	CHEMBL3305968	3795	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	CHEMBL4650755	3795	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	DB01409	3795	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
	25195533	78357	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2103803	78357	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2110584	78357	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	9984928	204660	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL73893	204660	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44325048	111530	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328059	111530	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	9984928	204660	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL73893	204660	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44379026	120276	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL352739	120276	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	14537188	136521	0	None	1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
	CHEMBL37372	136521	0	None	1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
	9867847	204235	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL71147	204235	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	9867847	204235	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL71147	204235	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
	25195533	78357	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
	CHEMBL2103803	78357	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
	CHEMBL2110584	78357	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
	155556290	176432	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4554682	176432	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596434	176432	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44337753	108974	0	None	-	1	Rat	9.8	pKi	=	9.8	Binding	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
	CHEMBL321214	108974	0	None	-	1	Rat	9.8	pKi	=	9.8	Binding	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
	316	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	317	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	71183	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL3140030	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL376897	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	DB00462	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	164626501	188572	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4874955	188572	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028936	188572	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	316	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	317	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	71183	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	CHEMBL3140030	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	CHEMBL376897	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	DB00462	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
	316	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	317	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	71183	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL3140030	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL376897	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	DB00462	2816	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	140844416	176582	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4516342	176582	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597717	176582	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	23056	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	318	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	3260	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	CHEMBL12980	112	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
	156014450	178227	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4636083	178227	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650652	178227	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	164617895	188501	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852868	188501	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028466	188501	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164627113	188578	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4878646	188578	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028981	188578	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164611189	188447	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4851514	188447	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028061	188447	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164614083	188467	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4855492	188467	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028231	188467	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015648	178291	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4641328	178291	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4651078	178291	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL5074599	214296	2	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL		None	None	None		COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CNC(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)s2)cc1OC	10.1021/acs.jmedchem.1c00204
	9937474	170446	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4448933	170446	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
	9937474	170446	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4448933	170446	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44378842	57393	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL165375	57393	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44378601	168559	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL435849	168559	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	15407074	57394	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL165377	57394	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44379050	161484	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL412814	161484	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	10109130	132990	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370232	132990	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	9894236	60199	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL174070	60199	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	15392110	105458	0	None	6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL312085	105458	0	None	6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	164618444	188505	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852186	188505	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028499	188505	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164625454	188567	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862735	188567	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028885	188567	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	11798681	11117	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
	CHEMBL1178344	11117	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
	CHEMBL21905	11117	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
	59291493	112795	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298600	112795	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307158	112795	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	164627445	188583	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4876453	188583	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028997	188583	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164628529	188590	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL4876725	188590	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL5029058	188590	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	10101246	9514	0	None	-81	2	Human	9.6	pKi	=	9.6	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9514	0	None	-81	2	Human	9.6	pKi	=	9.6	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	164624669	188562	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4870127	188562	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028837	188562	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	688566	195860	24	None	-1	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL558910	195860	24	None	-1	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	164624066	188556	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4864987	188556	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028806	188556	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	155560305	176229	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4568151	176229	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4594890	176229	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	164610746	188443	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188443	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188443	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164621305	188528	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4863285	188528	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028642	188528	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015900	178297	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643273	178297	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651104	178297	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
	10324012	204683	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL74117	204683	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	10324012	204683	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL74117	204683	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	132947	3835	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
	361	3835	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
	CHEMBL265256	3835	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
	155519740	170382	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
	CHEMBL4448108	170382	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
	156015724	178250	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4643159	178250	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650839	178250	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	164610955	188445	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL4858398	188445	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	CHEMBL5028048	188445	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
	132947	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	361	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	CHEMBL265256	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	164619001	188512	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4871153	188512	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028529	188512	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	132947	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	361	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	CHEMBL265256	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	44311771	164208	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL421113	164208	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311771	164208	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL421113	164208	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311771	164208	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL421113	164208	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
	164628352	188589	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4878717	188589	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029051	188589	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44312007	169141	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL440491	169141	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44312007	169141	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL440491	169141	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	15463387	56505	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL163777	56505	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	44378810	57401	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL165439	57401	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	44378876	58106	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL167816	58106	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44378952	119874	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL349142	119874	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	132947	3835	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
	361	3835	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
	CHEMBL265256	3835	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
	132947	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	361	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	CHEMBL265256	3835	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	164612662	188458	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4847898	188458	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028154	188458	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44292836	101290	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	CHEMBL296633	101290	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	372625	101120	11	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL295388	101120	11	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	164613559	188462	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4856659	188462	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028196	188462	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	372625	101120	11	None	-1	5	Rat	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL295388	101120	11	None	-1	5	Rat	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	367	3795	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	5487427	3795	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	8592	3795	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	CHEMBL1900528	3795	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	CHEMBL3305968	3795	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	CHEMBL4650755	3795	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	DB01409	3795	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
	316	2816	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2816	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2816	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2816	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2816	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2816	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	164619973	188517	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862996	188517	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028571	188517	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	174174	521	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	260	521	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	320	521	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	CHEMBL517712	521	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	DB00572	521	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
	44311784	204456	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72408	204456	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	174174	521	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	260	521	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	320	521	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	CHEMBL517712	521	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	DB00572	521	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	44311784	204456	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72408	204456	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	137630050	161016	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089543	161016	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4097258	161016	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4116470	161016	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	164617401	188496	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL4852646	188496	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	CHEMBL5028427	188496	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
	155543944	176310	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4567026	176310	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595467	176310	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44311717	204466	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72494	204466	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311717	204466	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72494	204466	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	155535606	172028	0	None	4	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
	CHEMBL4471882	172028	0	None	4	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
	9953227	204174	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	CHEMBL70828	204174	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
	10628017	21684	0	None	1	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL131865	21684	0	None	1	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	44311718	204448	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72363	204448	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311760	204476	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72551	204476	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44292858	101320	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
	CHEMBL296895	101320	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
	44311718	204448	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72363	204448	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311760	204476	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72551	204476	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	164623076	188543	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872608	188543	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028732	188543	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	939077	195045	2	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL549577	195045	2	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	9809222	114066	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL332703	114066	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44378764	57216	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
	CHEMBL165035	57216	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
	10291977	72869	0	None	-5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200401	72869	0	None	-5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44344122	110390	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL324484	110390	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	15870384	59207	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
	CHEMBL170298	59207	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
	134272442	176464	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4457734	176464	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596671	176464	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	137630050	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	44312024	204538	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72957	204538	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	137630050	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	44312024	204538	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72957	204538	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	25897919	55622	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	657309	55622	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1464005	55622	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1621597	55622	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	155554568	176585	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4548432	176585	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597724	176585	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	316	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	6604314	30948	3	None	-3	2	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
	CHEMBL1398637	30948	3	None	-3	2	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
	11434515	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	11519741	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	4484	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	7449	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	CHEMBL1194325	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	DB08897	261	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
	316	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2816	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	11766733	155730	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202003	155730	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL405739	155730	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	44344164	10953	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117351	10953	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44311823	204181	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL70860	204181	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311823	204181	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL70860	204181	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	688520	35385	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL1437876	35385	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL3289390	35385	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	44311987	204579	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL73245	204579	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	59291402	112759	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298588	112759	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305766	112759	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	44311987	204579	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL73245	204579	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	16116083	12264	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL1184884	12264	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL375969	12264	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	129486	100127	6	None	-5	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
	CHEMBL287868	100127	6	None	-5	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
	25897919	55622	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	657309	55622	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1464005	55622	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	CHEMBL1621597	55622	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
	367	3795	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	5487427	3795	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	8592	3795	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	CHEMBL1900528	3795	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	CHEMBL3305968	3795	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	CHEMBL4650755	3795	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	DB01409	3795	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
	155520948	176405	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4450188	176405	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596191	176405	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44379040	120086	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL351079	120086	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	302	2956	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2956	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2956	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	302	2956	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2956	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2956	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	9851621	59149	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL170033	59149	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	44382606	120769	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355511	120769	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	44232952	103356	0	None	-10	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084650	103356	0	None	-10	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10009554	204688	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
	CHEMBL74141	204688	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
	10009554	204688	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
	CHEMBL74141	204688	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
	44215377	12060	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL118391	12060	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	137630050	161016	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089543	161016	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4097258	161016	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	CHEMBL4116470	161016	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
	156015807	178275	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178275	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178275	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44344216	13198	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL119131	13198	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44344106	113045	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL331214	113045	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44343862	10479	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL116777	10479	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	10771937	21661	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202004	21661	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL131846	21661	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	316	2816	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2816	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2816	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2816	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2816	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2816	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	164616706	188491	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4850130	188491	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028391	188491	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015042	178210	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
	CHEMBL4645845	178210	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650549	178210	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
	44311785	204714	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL74352	204714	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311785	204714	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL74352	204714	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44312451	104759	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL310912	104759	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
	15407073	119934	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL349720	119934	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44379055	120489	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
	CHEMBL354534	120489	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
	44312451	104759	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL310912	104759	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44312450	204813	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL75448	204813	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	154734599	2486	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	327	2486	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	4108	2486	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	CHEMBL27673	2486	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
	CHEMBL5289667	194452	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	959	21	2	5	13.8	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	156015978	178299	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178299	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178299	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	25006208	112798	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298763	112798	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307197	112798	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	44431384	148836	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL394137	148836	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44344145	10984	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117414	10984	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	56667296	176617	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4461243	176617	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597972	176617	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	10470	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	1689	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	4057	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	CHEMBL524004	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	DB04843	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
	155512178	176465	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4436930	176465	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596672	176465	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	174174	521	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	260	521	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	320	521	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	CHEMBL517712	521	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	DB00572	521	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
	174174	521	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	260	521	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	320	521	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	CHEMBL517712	521	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	DB00572	521	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	10393100	56501	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL163714	56501	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44267748	12903	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11892	12903	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	137628879	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	137628879	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4068393	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4079233	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	CHEMBL4115977	160948	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
	44324655	168115	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL433011	168115	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44343761	111265	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL326561	111265	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	134272452	176650	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4448944	176650	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4598232	176650	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	316	2816	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2816	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2816	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2816	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2816	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2816	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	11223598	106498	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
	CHEMBL3084413	106498	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
	CHEMBL3140264	106498	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
	16125331	136937	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374452	136937	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	122203596	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	174174	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	260	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	320	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	CHEMBL517712	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	DB00572	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
	174174	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	260	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	320	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	CHEMBL517712	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	DB00572	521	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
	122203596	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	16115945	12265	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1184886	12265	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376057	12265	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	303	2957	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2957	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2957	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2957	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	44344132	110333	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL324116	110333	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	25897919	55622	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	657309	55622	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL1464005	55622	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL1621597	55622	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	9946298	72798	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200171	72798	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10291366	140674	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381623	140674	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	25897919	55622	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	657309	55622	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	CHEMBL1464005	55622	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	CHEMBL1621597	55622	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
	122203596	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
	CHEMBL4059733	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
	CHEMBL4066481	155782	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
	156016041	178223	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178223	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178223	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10291366	140674	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL381623	140674	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	456615	102719	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL305026	102719	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44378689	56495	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL163658	56495	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	44378958	9217	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL110744	9217	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	456615	102719	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL305026	102719	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44312083	204464	0	None	13	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL72455	204464	0	None	13	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	59291259	112446	1	None	-3	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298591	112446	1	None	-3	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	174174	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	260	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	320	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	CHEMBL517712	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	DB00572	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	10919522	78889	0	None	-3	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
	CHEMBL2112957	78889	0	None	-3	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
	44325017	206834	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90638	206834	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	59291413	112760	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298589	112760	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305767	112760	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	44325047	207239	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL93017	207239	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	16115947	11817	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182214	11817	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL222259	11817	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	164620907	188524	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4865939	188524	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028619	188524	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	10474247	101377	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL297276	101377	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	44344078	110744	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL326057	110744	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9894173	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	CHEMBL12098	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	10163651	163209	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL418446	163209	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
	9894173	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	CHEMBL12098	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	9894173	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
	CHEMBL12098	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
	10163651	163209	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL418446	163209	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	9894173	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
	CHEMBL12098	15118	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
	15407073	119934	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL349720	119934	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	44267782	98492	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL276239	98492	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267782	98492	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	CHEMBL276239	98492	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	20689406	111334	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	CHEMBL326990	111334	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
	174174	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	260	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	320	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	CHEMBL517712	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	DB00572	521	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
	134272503	176387	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4545504	176387	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596068	176387	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	174174	521	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	521	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	521	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	521	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	521	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	10486393	141677	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202000	141677	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL385625	141677	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL5270870	193633	0	None	-6	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	507	12	2	4	6.8	NCCCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	164618698	188509	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862098	188509	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028512	188509	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015645	178274	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4638411	178274	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650970	178274	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11691950	12730	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL1187853	12730	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL524097	12730	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	16116085	11814	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182201	11814	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219786	11814	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	44311786	103023	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL307234	103023	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311786	103023	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL307234	103023	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	463517	203679	1	None	436	2	Human	9.0	pKi	=	9	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL67563	203679	1	None	436	2	Human	9.0	pKi	=	9	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	10180872	103102	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL307810	103102	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44378951	57400	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL165434	57400	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	44267696	10999	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11756	10999	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44343902	11104	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117817	11104	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9938599	58683	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL168483	58683	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	174174	521	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	260	521	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	320	521	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	CHEMBL517712	521	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	DB00572	521	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
	10180872	103102	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL307810	103102	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	155522355	176385	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4451030	176385	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4596065	176385	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	134272501	176557	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4483083	176557	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597500	176557	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44325052	206937	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL91232	206937	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	25897919	55622	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	657309	55622	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1464005	55622	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	CHEMBL1621597	55622	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
	137630050	161016	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161016	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161016	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161016	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	127044	78881	1	None	-3	3	Rat	9.0	pKi	=	9.0	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
	CHEMBL2112942	78881	1	None	-3	3	Rat	9.0	pKi	=	9.0	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
	16115797	138130	0	None	-3	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376870	138130	0	None	-3	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	155522355	176385	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176385	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176385	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	155522355	176385	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176385	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176385	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	122203596	155782	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	10437400	194262	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL52852	194262	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	44344248	114065	0	None	-	1	Rat	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL332702	114065	0	None	-	1	Rat	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9872651	165090	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL422740	165090	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL5289601	194449	0	None	-1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	973	22	2	5	14.1	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	145148382	176590	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4590868	176590	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597793	176590	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
	316	2816	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2816	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2816	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2816	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2816	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2816	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	44311762	163448	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL420008	163448	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
	44311762	163448	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL420008	163448	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
	5284632	67372	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
	CHEMBL1888176	67372	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
	CHEMBL3084748	67372	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
	316	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	317	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	71183	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL3140030	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	CHEMBL376897	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	DB00462	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
	164620270	188518	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4869723	188518	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028587	188518	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44343901	110287	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL323850	110287	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	59291327	112790	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3298597	112790	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3307126	112790	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
	59291513	112791	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3298598	112791	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
	CHEMBL3307127	112791	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
	316	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	317	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	71183	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL3140030	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	CHEMBL376897	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	DB00462	2816	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
	44325034	206816	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90507	206816	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	25897919	55622	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	657309	55622	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	CHEMBL1464005	55622	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	CHEMBL1621597	55622	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
	10275847	203976	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL69595	203976	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44378597	57386	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL165337	57386	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44379052	120405	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	CHEMBL353842	120405	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
	10119364	43220	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL150624	43220	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	44406481	72846	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200319	72846	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	71462570	82537	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
	CHEMBL2178569	82537	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
	44337326	7936	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
	CHEMBL109051	7936	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
	174174	521	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	260	521	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	320	521	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	CHEMBL517712	521	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	DB00572	521	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
	156015153	178283	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178283	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178283	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	118719922	115749	0	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354068	115749	0	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	44343900	10480	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL116781	10480	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	59291527	112436	1	None	-11	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298333	112436	1	None	-11	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL5281043	194076	0	None	-17	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	479	10	2	4	6.1	NCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	155530273	176327	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
	CHEMBL4463636	176327	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
	CHEMBL4595649	176327	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
	156014880	178207	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636351	178207	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650536	178207	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	174174	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	260	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	320	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	CHEMBL517712	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	DB00572	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
	44311716	165108	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL422770	165108	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311716	165108	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL422770	165108	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	174174	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	260	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	320	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	CHEMBL517712	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	DB00572	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
	16115943	11815	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182205	11815	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL220393	11815	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	155560140	176323	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4565234	176323	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595575	176323	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	174174	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	260	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	320	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	CHEMBL517712	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	DB00572	521	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
	44343735	11058	1	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL117797	11058	1	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	44378807	58120	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	CHEMBL167932	58120	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	4134	72657	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL1996652	72657	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2106570	72657	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	10269503	167056	0	None	-7	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL428962	167056	0	None	-7	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	14939896	82058	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201996	82058	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216566	82058	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10096939	164796	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL421864	164796	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44295932	189321	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51256	189321	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	44344156	10097	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL115681	10097	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9807612	59042	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL169565	59042	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	44383342	59454	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL171411	59454	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	16065135	67896	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
	CHEMBL1910846	67896	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
	11693	1814	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	3494	1814	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	4302	1814	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	7459	1814	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	CHEMBL1201335	1814	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	DB00986	1814	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	140844401	176663	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4539799	176663	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4598363	176663	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	174174	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	260	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	320	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	CHEMBL517712	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	DB00572	521	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	16125541	137182	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374989	137182	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	155513986	176463	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4439675	176463	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596667	176463	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	101882890	115750	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354069	115750	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	14939894	10264	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL116172	10264	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	302	2956	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	4630	2956	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	CHEMBL7634	2956	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	CHEMBL5284000	194216	0	None	-6	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	493	11	2	4	6.6	NCCCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	71128	96781	25	None	-3	8	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	CHEMBL26505	96781	25	None	-3	8	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	14210083	156688	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	CHEMBL4070155	156688	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	44378763	120477	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL354461	120477	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44344215	13249	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL119168	13249	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	16721019	87957	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234258	87957	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	10061124	78877	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
	CHEMBL2112938	78877	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
	44324891	111537	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328093	111537	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	155559741	176263	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4562770	176263	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595125	176263	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	444015	13984	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1197177	13984	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	44295617	189625	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51510	189625	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	44431389	146126	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL391977	146126	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	174174	521	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	260	521	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	320	521	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	CHEMBL517712	521	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	DB00572	521	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
	59291421	112750	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298592	112750	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305620	112750	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	164609302	188439	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4846958	188439	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5027951	188439	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14210083	156688	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4070155	156688	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	324	1912	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
	6436265	1912	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
	CHEMBL277642	1912	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
	324	1912	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	6436265	1912	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	CHEMBL277642	1912	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	324	1912	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
	6436265	1912	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
	CHEMBL277642	1912	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
	10104167	2046	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2046	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2046	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44627746	14010	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197392	14010	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569760	14010	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	122203596	155782	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155782	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155782	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	52941205	55239	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
	CHEMBL1256938	55239	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
	CHEMBL1618160	55239	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
	316	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	317	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	71183	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL3140030	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	CHEMBL376897	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	DB00462	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
	156015246	178215	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4648144	178215	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650567	178215	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	71452793	79626	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2115127	79626	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	444015	13984	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL1197177	13984	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118719921	115748	0	None	-2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354067	115748	0	None	-2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	455657	203982	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	CHEMBL69642	203982	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	455656	203987	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL69670	203987	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	24841480	183875	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL481153	183875	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	135398737	955	93	None	-22	92	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	38	955	93	None	-22	92	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	722	955	93	None	-22	92	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	CHEMBL42	955	93	None	-22	92	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	DB00363	955	93	None	-22	92	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	135398745	2893	112	None	-38	66	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	47	2893	112	None	-38	66	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	CHEMBL715	2893	112	None	-38	66	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	DB00334	2893	112	None	-38	66	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	44406527	140624	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381469	140624	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	2551	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	298	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	488	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	CHEMBL965	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	DB00411	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
	46855274	113691	12	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323285	113691	12	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	155536739	172191	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	CHEMBL4473985	172191	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	44385509	61033	11	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
	CHEMBL176400	61033	11	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
	2551	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	298	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	488	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	CHEMBL965	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	DB00411	791	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	16086067	81288	0	None	-63	5	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	CHEMBL215894	81288	0	None	-63	5	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	10248403	103393	0	None	-25	2	Rat	6.0	pKi	=	6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
	CHEMBL3084867	103393	0	None	-25	2	Rat	6.0	pKi	=	6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
	44309209	204300	0	None	-38	3	Human	6.0	pKi	=	6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71483	204300	0	None	-38	3	Human	6.0	pKi	=	6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	301	2517	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	9571002	2517	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	CHEMBL151938	2517	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	118500	156975	63	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4073256	156975	63	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	25147647	182115	0	None	2	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
	CHEMBL478226	182115	0	None	2	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
	11798126	41942	0	None	-288	3	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL149484	41942	0	None	-288	3	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	137630848	161092	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061390	161092	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117131	161092	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	302	2956	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	4630	2956	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL7634	2956	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	302	2956	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	4630	2956	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL7634	2956	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	56593934	65665	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
	CHEMBL1834350	65665	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
	73352414	92503	0	None	-1	5	Human	6.0	pKi	=	6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
	CHEMBL2432038	92503	0	None	-1	5	Human	6.0	pKi	=	6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
	16125648	84706	0	None	-44	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222874	84706	0	None	-44	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	15065550	205094	2	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
	CHEMBL77793	205094	2	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
	72064	78372	14	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL2110892	78372	14	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
	11131099	120235	0	None	3	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	CHEMBL352404	120235	0	None	3	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	302	2956	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	4630	2956	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	CHEMBL7634	2956	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	44593619	187436	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493980	187436	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	73346334	92512	0	None	-1	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
	CHEMBL2432048	92512	0	None	-1	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
	44295616	188769	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50584	188769	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267766	161295	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	CHEMBL412421	161295	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	44267766	161295	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
	CHEMBL412421	161295	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
	134688371	14397	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	13765	14397	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	CHEMBL1200623	14397	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
	164621085	188525	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4869980	188525	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028630	188525	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	639794	98741	1	None	1	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL278129	98741	1	None	1	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	3652	46214	70	None	-2	9	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	CHEMBL1535	46214	70	None	-2	9	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
	44400175	67739	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL190815	67739	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	44295878	191766	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51982	191766	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	71128	96781	25	None	-17	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL26505	96781	25	None	-17	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	16124706	137497	0	None	-61	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL375420	137497	0	None	-61	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
	303	2957	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	4629	2957	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	8595	2957	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	CHEMBL44674	2957	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	10871551	120485	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL354523	120485	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	44593618	187435	0	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493979	187435	0	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	71718669	86929	0	None	-8	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323446	86929	0	None	-8	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	11012712	57799	2	None	1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	CHEMBL167027	57799	2	None	1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	167962	4038	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4038	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4038	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	9931930	108573	0	None	-537	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL320465	108573	0	None	-537	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	11079969	163833	0	None	-70	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL420662	163833	0	None	-70	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	44267713	15573	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12215	15573	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	16125400	84634	0	None	-35	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222449	84634	0	None	-35	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	71456286	79569	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2114430	79569	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	10380647	154410	1	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
	CHEMBL39900	154410	1	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
	15050949	203953	0	None	1	3	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL69458	203953	0	None	1	3	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	11498	2997	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
	4995951	2997	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
	CHEMBL59898	2997	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
	15888011	204290	0	None	-11	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71431	204290	0	None	-11	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	44267718	16981	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12542	16981	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL5285607	194281	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1052	21	1	13	10.0	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	155521383	176402	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4450522	176402	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596184	176402	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	71741394	120809	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120809	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120809	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	10474247	101377	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL297276	101377	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	15678852	102190	0	None	1	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL302923	102190	0	None	1	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	3652	4066	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	57	4066	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	60809	4066	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	CHEMBL21536	4066	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	DB15357	4066	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	2028	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	359	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	4634	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	CHEMBL1231	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	DB01062	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
	14964495	12581	1	None	4	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12581	1	None	4	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	11526446	201781	0	None	-13	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
	CHEMBL606904	201781	0	None	-13	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
	16086064	79931	0	None	-213	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL212645	79931	0	None	-213	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	5747382	109176	3	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321605	109176	3	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	44309208	165625	0	None	-77	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL424416	165625	0	None	-77	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	14964496	8932	0	None	1	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8932	0	None	1	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	10339062	36257	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	CHEMBL144580	36257	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	474188	31619	2	None	-28	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL140490	31619	2	None	-28	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10595006	11413	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL1180343	11413	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL123099	11413	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	53414666	159277	8	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099673	159277	8	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	574782	102124	2	None	-3	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
	CHEMBL302557	102124	2	None	-3	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
	2274	3151	58	None	-100	32	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3151	58	None	-100	32	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3151	58	None	-100	32	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3151	58	None	-100	32	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3151	58	None	-100	32	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	44379508	58134	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
	CHEMBL168145	58134	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
	11034265	120347	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
	CHEMBL353290	120347	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
	162353386	180956	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758635	180956	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	46227555	14099	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL1198062	14099	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL594376	14099	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	44443734	94210	0	None	-16	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL250031	94210	0	None	-16	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	36014865	182646	2	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	CHEMBL4789054	182646	2	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	16125682	84260	0	None	-239	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	CHEMBL221401	84260	0	None	-239	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	44299635	100541	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL291562	100541	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	164623185	188546	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4864101	188546	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028743	188546	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	137640511	157042	0	None	-44	8	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4074104	157042	0	None	-44	8	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	16125593	84712	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222916	84712	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	3198	205490	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	73345823	89786	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377392	89786	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
	11722587	12904	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1189204	12904	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL538266	12904	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
	26987	946	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	6063	946	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	671	946	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	CHEMBL1626	946	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	DB00283	946	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
	71575447	86173	0	None	-19	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	CHEMBL2312361	86173	0	None	-19	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	44299599	167781	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL430587	167781	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	44313166	103074	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL307628	103074	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	2337	3232	77	None	-31	63	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3232	77	None	-31	63	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3232	77	None	-31	63	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3232	77	None	-31	63	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3232	77	None	-31	63	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	11061341	78890	0	None	-25	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112958	78890	0	None	-25	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	44295787	189062	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50998	189062	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267759	11718	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11816	11718	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	10163651	163209	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL418446	163209	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	15870389	120768	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355510	120768	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	277	1289	62	None	-10	46	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1289	62	None	-10	46	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1289	62	None	-10	46	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1289	62	None	-10	46	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1289	62	None	-10	46	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2286	3161	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3161	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3161	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3161	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3161	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	2745	3832	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	5572	3832	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	66007	3832	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	7315	3832	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	CHEMBL1490	3832	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	DB00376	3832	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
	44431388	87290	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233202	87290	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44431380	87956	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234257	87956	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	16065136	67897	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
	CHEMBL1910847	67897	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
	140844418	176386	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4576060	176386	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596067	176386	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	140844397	176574	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4567385	176574	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597612	176574	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	140844405	176618	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4474694	176618	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597973	176618	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	10316726	11996	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	11996	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	11996	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	164614994	188478	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4850553	188478	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028287	188478	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	155528270	176367	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4461081	176367	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595943	176367	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44325080	111544	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328120	111544	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44392966	66069	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL183903	66069	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	11808040	168371	0	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL434684	168371	0	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	75167447	178262	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634230	178262	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650933	178262	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44233190	103375	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084679	103375	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	324	1912	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
	6436265	1912	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
	CHEMBL277642	1912	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
	154417	93231	60	None	-18	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93231	60	None	-18	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	10418181	9554	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112500	9554	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201995	9554	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	205895	11836	2	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11836	2	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	154059	3610	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	2457	3610	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	7483	3610	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	CHEMBL1734	3610	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	DB01591	3610	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
	3652	4066	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	57	4066	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	60809	4066	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	CHEMBL21536	4066	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	DB15357	4066	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
	155515662	169940	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4441786	169940	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	2200	3109	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	328	3109	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848	3109	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	CHEMBL9967	3109	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	DB00670	3109	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	154059	3610	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	2457	3610	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	7483	3610	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	CHEMBL1734	3610	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	DB01591	3610	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
	44308910	203719	0	None	-39	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL67814	203719	0	None	-39	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	9794266	157127	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4075227	157127	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
	44318817	169090	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL440138	169090	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	16086065	79768	0	None	-426	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL211976	79768	0	None	-426	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	3072501	107242	6	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL316973	107242	6	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	5747382	109176	3	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL321605	109176	3	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	71716224	86927	0	None	-13	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323444	86927	0	None	-13	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	71451002	79681	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	CHEMBL2115494	79681	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	71451002	79681	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	CHEMBL2115494	79681	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
	657347	5044	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL105457	5044	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL387632	5044	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	72190449	92243	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426676	92243	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	657347	5044	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL105457	5044	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL387632	5044	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	44274302	77038	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL20732	77038	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	2166	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	305	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	5910	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	CHEMBL550	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	DB01085	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
	44448419	12304	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185266	12304	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL403592	12304	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	44295713	189724	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51588	189724	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	71459604	83764	0	None	-2	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205811	83764	0	None	-2	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	463319	119370	1	None	-102	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL344607	119370	1	None	-102	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	1971	2846	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2846	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2846	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2846	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2846	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	14967772	13381	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1192807	13381	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL544107	13381	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
	688567	63004	4	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL1788199	63004	4	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	10251468	94040	0	None	-20	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	CHEMBL249006	94040	0	None	-20	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	2551	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	298	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	488	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	CHEMBL965	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	DB00411	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
	12963076	196602	4	None	-2951	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL564226	196602	4	None	-2951	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	109018479	181794	1	None	2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	CHEMBL4778178	181794	1	None	2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	2551	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	298	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	488	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	CHEMBL965	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	DB00411	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	2551	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	298	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	488	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	CHEMBL965	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	DB00411	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
	2551	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	298	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	488	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL965	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	DB00411	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
	2551	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	298	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	488	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	CHEMBL965	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	DB00411	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
	145961125	161522	0	None	-3	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128667	161522	0	None	-3	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	71463063	83772	0	None	-2	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205825	83772	0	None	-2	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	44318928	205740	0	None	-28	2	Human	6.9	pKi	=	6.9	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	CHEMBL82859	205740	0	None	-28	2	Human	6.9	pKi	=	6.9	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	250	3361	8	None	-35481	13	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
	5311416	3361	8	None	-35481	13	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
	CHEMBL69733	3361	8	None	-35481	13	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
	24865895	95976	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL259662	95976	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL390842	95976	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	44274469	80579	1	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21509	80579	1	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	44406321	72749	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL199981	72749	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	6918276	15579	7	None	-131	8	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15579	7	None	-131	8	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	60138186	120810	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120810	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120810	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120810	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	44267712	161999	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL415975	161999	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	1548953	207656	27	None	-6	17	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	207656	27	None	-6	17	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	71452387	83774	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
	CHEMBL2205829	83774	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
	71452387	83774	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
	CHEMBL2205829	83774	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
	11006792	78893	0	None	-5	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112961	78893	0	None	-5	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	11501540	133578	0	None	-16	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	CHEMBL371293	133578	0	None	-16	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	44406598	72996	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200957	72996	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44383238	120601	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL354636	120601	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
	59291452	112749	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298590	112749	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305615	112749	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL5279174	193992	0	None	-16	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.7	C#CCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	155541812	173026	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
	CHEMBL4519301	173026	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
	164623942	188555	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4873621	188555	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028796	188555	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	156020548	178154	0	None	-9	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4649224	178154	0	None	-9	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	10759971	65223	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL182761	65223	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	44627748	14062	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL1197705	14062	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL583027	14062	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	15050960	102300	0	None	-4	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL303622	102300	0	None	-4	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	2381	660	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	374	660	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	7128	660	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL1101	660	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	DB00810	660	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
	156021441	178130	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648939	178130	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44308912	102806	0	None	-61	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL305531	102806	0	None	-61	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
	155562285	175818	0	None	-16	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
	CHEMBL4585326	175818	0	None	-16	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
	44296044	194647	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL53190	194647	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	14964499	169365	3	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169365	3	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	15196354	119244	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	CHEMBL343697	119244	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	2551	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	298	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	488	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	CHEMBL965	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	DB00411	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
	137630994	161116	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4103375	161116	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4117267	161116	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	10421982	206018	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	CHEMBL85190	206018	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	16086061	80189	0	None	-1412	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	CHEMBL213709	80189	0	None	-1412	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	10597259	119231	0	None	-67	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
	CHEMBL343644	119231	0	None	-67	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
	14964499	169365	3	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169365	3	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	14964506	113289	1	None	-6	2	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113289	1	None	-6	2	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	137629935	160996	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	118710670	120807	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120807	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120807	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	2551	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	298	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	488	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	CHEMBL965	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	DB00411	791	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
	164612852	188459	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852544	188459	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028161	188459	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	164627387	188582	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4874785	188582	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028995	188582	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	162353369	180771	0	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756442	180771	0	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	19021478	192673	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
	CHEMBL5219452	192673	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
	3497	1172	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
	5311123	1172	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
	CHEMBL1628706	1172	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
	457875	5197	1	None	-22	3	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
	CHEMBL106247	5197	1	None	-22	3	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
	44267754	15221	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12115	15221	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267714	97346	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL269645	97346	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	4601	206724	35	None	-2	17	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	206724	35	None	-2	17	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	206724	35	None	-2	17	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	73350398	89769	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377262	89769	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
	15678859	102748	0	None	-1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL305197	102748	0	None	-1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	71463061	83766	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205813	83766	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	156015968	178221	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648657	178221	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650620	178221	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	10874119	4875	0	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
	CHEMBL104574	4875	0	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
	10862395	4994	0	None	-338	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105148	4994	0	None	-338	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	44312468	204564	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL73145	204564	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
	44443732	94209	0	None	-41	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL250030	94209	0	None	-41	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	15050940	102800	0	None	1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL305501	102800	0	None	1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	13773338	79560	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114395	79560	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	13773338	79560	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114395	79560	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	44382125	120390	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL353689	120390	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	164617650	188497	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4860171	188497	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028445	188497	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	156014875	178217	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4640846	178217	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650577	178217	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	46227413	14108	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198087	14108	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL595265	14108	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
	44267728	14715	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	CHEMBL12064	14715	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	2028	2958	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	359	2958	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	4634	2958	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	CHEMBL1231	2958	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	DB01062	2958	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
	44382652	58996	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL169313	58996	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	90645361	112789	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298601	112789	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3307123	112789	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
	10373706	57379	0	None	-2	4	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	CHEMBL165220	57379	0	None	-2	4	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	154734599	2486	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	327	2486	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	4108	2486	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	CHEMBL27673	2486	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
	44324848	206757	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL90199	206757	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	154734599	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	327	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	4108	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL27673	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	71741394	120809	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120809	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120809	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	154734599	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	327	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	4108	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	CHEMBL27673	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
	154734599	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	327	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	4108	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL27673	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	164611187	188446	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4851265	188446	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028060	188446	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	6338102	100437	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL290723	100437	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL59587	100437	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	11552283	71661	0	None	-15	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
	CHEMBL196481	71661	0	None	-15	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
	137630667	161068	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4100938	161068	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116890	161068	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	11796409	38361	0	None	-89	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	CHEMBL146351	38361	0	None	-89	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	155515982	169986	0	None	-56234	17	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	CHEMBL4442460	169986	0	None	-56234	17	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	170332	160952	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	137629919	160985	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4095626	160985	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116258	160985	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	10386	161144	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092348	161144	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117554	161144	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	10810094	119534	0	None	-52	3	Human	4.9	pKi	=	4.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL345985	119534	0	None	-52	3	Human	4.9	pKi	=	4.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	9976808	103415	0	None	-11	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	CHEMBL3084892	103415	0	None	-11	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	156015895	178257	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4643290	178257	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650874	178257	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	44627742	198354	0	None	-10	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL576707	198354	0	None	-10	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	44593623	187856	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496503	187856	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539373	187856	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	44450622	95804	0	None	4	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL258907	95804	0	None	4	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	167962	4038	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4038	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4038	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	44274432	80098	0	None	3	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21328	80098	0	None	3	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	58438475	92244	0	None	-1548	2	Human	4.9	pKi	=	4.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426677	92244	0	None	-1548	2	Human	4.9	pKi	=	4.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	24894635	169783	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
	CHEMBL443939	169783	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
	CHEMBL527880	169783	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
	44443721	94233	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL250203	94233	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	11012653	120794	0	None	6	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL355769	120794	0	None	6	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	164617938	188502	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854179	188502	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028470	188502	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	10969696	132079	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL369575	132079	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	44593621	193273	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524061	193273	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	10160219	4898	0	None	-1445	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	CHEMBL104693	4898	0	None	-1445	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	72190451	92247	0	None	-524	2	Human	4.8	pKi	=	4.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426680	92247	0	None	-524	2	Human	4.8	pKi	=	4.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	24894632	189395	2	None	1	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
	CHEMBL513277	189395	2	None	1	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
	10020614	204744	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
	CHEMBL74736	204744	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
	13773342	79653	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115341	79653	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	302	2956	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	4630	2956	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL7634	2956	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
	CHEMBL4520788	213952	10	None	-69	25	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
	10870954	120284	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL352779	120284	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	44384327	59759	0	None	10	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL172646	59759	0	None	10	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	71457690	83769	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205817	83769	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	9976807	103408	1	None	-36	3	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL3084884	103408	1	None	-36	3	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	71455894	83773	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205827	83773	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	71455894	83773	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	CHEMBL2205827	83773	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	10336462	103407	0	None	-13	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	CHEMBL3084883	103407	0	None	-13	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	44295789	189414	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL51339	189414	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	14964496	8932	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8932	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	11561621	201780	0	None	-15	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
	CHEMBL606903	201780	0	None	-15	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
	9894922	120268	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	CHEMBL352660	120268	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	154734599	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	327	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	4108	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	CHEMBL27673	2486	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
	54757332	67895	0	None	-7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
	CHEMBL1910845	67895	0	None	-7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
	410345	89774	4	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL2377269	89774	4	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
	11748799	165387	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL423831	165387	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	10226457	12943	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL1189471	12943	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL538793	12943	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	9909908	13487	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
	CHEMBL1193635	13487	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
	CHEMBL545077	13487	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
	11071537	26465	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL136027	26465	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	174174	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	260	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	320	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	CHEMBL517712	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	DB00572	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	302	2956	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	4630	2956	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	CHEMBL7634	2956	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
	44267695	10692	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11710	10692	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	14964507	114328	1	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114328	1	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	303	2957	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2957	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2957	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2957	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	14685523	37724	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
	CHEMBL14580	37724	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
	15196236	119174	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	CHEMBL343236	119174	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	44415886	79806	0	None	-630	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL212141	79806	0	None	-630	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	44309108	103067	0	None	-52	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL307554	103067	0	None	-52	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	10830843	203940	0	None	-48	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL69383	203940	0	None	-48	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	44308799	204006	0	None	-19	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69765	204006	0	None	-19	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44285557	100125	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL287834	100125	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	137636830	161200	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061384	161200	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117956	161200	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	73356869	92239	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426672	92239	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	118710660	120805	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120805	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120805	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	11740181	103398	0	None	-281	2	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
	CHEMBL3084873	103398	0	None	-281	2	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
	44274468	80577	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21508	80577	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	13773336	79654	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115342	79654	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	10025038	168803	0	None	-26	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL437781	168803	0	None	-26	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	164626977	188575	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4874412	188575	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028969	188575	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	4189	206899	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	72190452	92249	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426682	92249	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	145961126	161529	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128764	161529	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	11523051	96260	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2093084	96260	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL261194	96260	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	45266386	194893	0	None	1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL541424	194893	0	None	1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	23352279	207557	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	CHEMBL94921	207557	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	15105211	172852	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL451542	172852	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	16125398	85088	0	None	-20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL224783	85088	0	None	-20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	9969695	160864	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
	CHEMBL411514	160864	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
	187	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	294	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	65	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	8593	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	CHEMBL667	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	DB03128	255	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
	145961495	161422	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4127373	161422	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	11536903	2382	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	3262	2382	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	CHEMBL3770346	2382	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	16094810	137861	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
	CHEMBL376295	137861	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
	71456285	79566	0	None	1	2	Rat	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
	CHEMBL2114426	79566	0	None	1	2	Rat	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
	24865895	95976	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL259662	95976	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL390842	95976	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	24865895	95976	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL259662	95976	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL390842	95976	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	44274433	99482	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL283320	99482	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	24894516	172684	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
	CHEMBL450463	172684	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
	15196233	121089	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL357404	121089	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
	44378753	120256	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	CHEMBL352607	120256	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
	2028	2958	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	359	2958	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634	2958	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	CHEMBL1231	2958	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	DB01062	2958	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	3042	1402	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1402	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1402	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1402	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1402	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	44392933	166279	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
	CHEMBL427145	166279	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
	118710660	120805	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120805	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120805	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118710662	120804	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120804	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120804	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	56965018	77152	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042552	77152	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078967	77152	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	164621443	188530	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4867483	188530	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028653	188530	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015141	178243	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4642045	178243	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650774	178243	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
	174174	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	260	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	320	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	CHEMBL517712	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	DB00572	521	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
	302	2956	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2956	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2956	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	15196236	119174	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	CHEMBL343236	119174	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
	199230	163111	21	None	37	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163111	21	None	37	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	6098192	201778	14	None	-3	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606901	201778	14	None	-3	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL306462	102938	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	211	2	1	4	1.1	CCO/C(O)=C1\CN2CCCC(C2)C1=O	10.1021/jm020572p
	44318930	106145	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	CHEMBL313738	106145	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	53391301	92245	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426678	92245	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	462902	119827	1	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL348667	119827	1	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10660	14384	58	None	-4	12	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14384	58	None	-4	12	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	24894109	189004	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL509202	189004	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL551563	189004	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	162353376	180403	0	None	3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4752380	180403	0	None	3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	14925759	158014	6	None	-5754	13	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4085780	158014	6	None	-5754	13	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	46227415	14097	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198050	14097	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL593871	14097	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	16125683	84621	0	None	-36	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL222403	84621	0	None	-36	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
	939078	63039	2	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL1788286	63039	2	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	2562	204576	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL1256696	204576	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL73234	204576	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	462573	29498	1	None	-316	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL138502	29498	1	None	-316	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	16125506	84750	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL223187	84750	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
	463210	164891	1	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL422326	164891	1	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	135398737	955	93	None	-22	92	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	955	93	None	-22	92	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	955	93	None	-22	92	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	955	93	None	-22	92	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	955	93	None	-22	92	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	9968046	198140	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL57485	198140	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	44450637	155172	0	None	12	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL402473	155172	0	None	12	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	162353379	180938	0	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4758449	180938	0	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	44386115	131412	0	None	-8	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL369062	131412	0	None	-8	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	44295977	192707	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL52203	192707	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267762	15406	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12150	15406	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	9889312	78401	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78401	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44312066	164357	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL421304	164357	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	302	2956	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	4630	2956	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	CHEMBL7634	2956	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	71459971	79510	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114066	79510	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44627852	14007	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197387	14007	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569712	14007	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	10314131	103397	0	None	-8	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
	CHEMBL3084872	103397	0	None	-8	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
	164627575	188584	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4873979	188584	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029004	188584	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44593625	188106	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498358	188106	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539120	188106	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44383415	120740	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355299	120740	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	11819545	37375	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL145488	37375	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
	11819883	120965	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL356321	120965	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
	46878242	201788	0	None	-154	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606962	201788	0	None	-154	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	146025727	171661	0	None	-63	27	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171661	0	None	-63	27	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44328561	207344	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	CHEMBL93709	207344	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	10105296	205899	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	CHEMBL84113	205899	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	155552185	174037	0	None	-30902	16	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	CHEMBL4544086	174037	0	None	-30902	16	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	45786849	157781	34	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4083241	157781	34	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	10718110	39885	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	CHEMBL147778	39885	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	10671167	121473	0	None	-602	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL358289	121473	0	None	-602	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	190868	13110	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
	CHEMBL1190617	13110	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
	CHEMBL541284	13110	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
	2200	3109	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	328	3109	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	4848	3109	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	CHEMBL9967	3109	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	DB00670	3109	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
	73346332	92506	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432041	92506	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	44299616	195685	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL55698	195685	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	92218234	120801	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
	CHEMBL3309718	120801	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
	CHEMBL3558072	120801	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
	46227411	14089	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL1198027	14089	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL593443	14089	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	15678857	204009	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL69796	204009	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	156010212	178213	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634066	178213	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650562	178213	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	302	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	4630	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	CHEMBL7634	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	137635734	156088	0	None	-61	8	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4063176	156088	0	None	-61	8	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	44296007	101937	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL301354	101937	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267703	14926	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12085	14926	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44344029	10088	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL115642	10088	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	15050957	203571	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL66914	203571	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	118710660	120805	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120805	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120805	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	174174	521	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	521	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	521	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	521	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	521	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	118710660	120805	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120805	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120805	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	14939895	82090	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201997	82090	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216629	82090	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10404824	103404	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	CHEMBL3084880	103404	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	44392906	12228	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL1184677	12228	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL363895	12228	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
	55005	104748	8	None	-1	3	Rat	6.8	pKi	=	6.8	Binding	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104748	8	None	-1	3	Rat	6.8	pKi	=	6.8	Binding	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	11610557	72002	0	None	-85	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL197588	72002	0	None	-85	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	10619926	39772	0	None	-35	3	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL147672	39772	0	None	-35	3	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	176	397	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	10033774	56516	0	None	-4	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	CHEMBL163901	56516	0	None	-4	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
	16125257	144651	0	None	-7	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
	CHEMBL390839	144651	0	None	-7	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
	57326142	77151	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2042401	77151	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2078965	77151	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	46227457	14102	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL1198075	14102	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL594801	14102	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	16125621	84334	0	None	-22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL221829	84334	0	None	-22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	2200	3109	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	328	3109	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	4848	3109	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	CHEMBL9967	3109	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	DB00670	3109	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	44383064	120281	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL352756	120281	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	10807270	100429	0	None	5	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
	CHEMBL290675	100429	0	None	5	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
	162667844	182509	0	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4787283	182509	0	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	16124707	138121	0	None	-67	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	CHEMBL376781	138121	0	None	-67	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	44382841	59372	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL170977	59372	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	43815	186896	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL1708	186896	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	CHEMBL490	186896	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
	5648	78382	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2107687	78382	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	CHEMBL2111176	78382	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
	16086063	80533	0	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL214898	80533	0	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	71741394	120809	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120809	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120809	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	164613685	188465	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4861655	188465	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028207	188465	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	15157138	99597	0	None	-6	4	Human	7.7	pKi	=	7.7	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL284137	99597	0	None	-6	4	Human	7.7	pKi	=	7.7	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	155557119	176487	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4555411	176487	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4596899	176487	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	155557119	176487	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4555411	176487	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596899	176487	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	10155850	96713	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL264414	96713	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44627860	14003	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197371	14003	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL568870	14003	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	10789183	104340	0	None	-25	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310132	104340	0	None	-25	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319009	106909	0	None	-15	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL314831	106909	0	None	-15	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44318782	206110	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85996	206110	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	154734599	2486	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	327	2486	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	4108	2486	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	CHEMBL27673	2486	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	44318851	104699	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL310558	104699	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	164608958	188436	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4846447	188436	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5027936	188436	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14964511	12069	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1183954	12069	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL325473	12069	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	10465050	36157	2	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144493	36157	2	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
	162353393	179415	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	CHEMBL4740422	179415	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	137661377	159185	0	None	-363	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4098720	159185	0	None	-363	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	24894630	188945	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL508347	188945	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL555475	188945	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
	156016047	178236	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4647816	178236	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650722	178236	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	44267758	12348	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11856	12348	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44400218	67599	0	None	-2	2	Rat	5.7	pKi	=	5.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
	CHEMBL190459	67599	0	None	-2	2	Rat	5.7	pKi	=	5.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
	73352415	92509	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432044	92509	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	44593622	187772	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL495888	187772	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL556390	187772	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	156015809	178294	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4645019	178294	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651096	178294	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	11833737	120313	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	CHEMBL352966	120313	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	73347725	92241	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426674	92241	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	24894633	176876	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
	CHEMBL461709	176876	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
	73355415	92504	0	None	1	13	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
	CHEMBL2432039	92504	0	None	1	13	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
	10852782	168256	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
	CHEMBL43398	168256	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
	5281825	107521	11	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
	CHEMBL318849	107521	11	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
	44329347	208065	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
	CHEMBL97765	208065	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
	11504244	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	3652	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	156010398	178212	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4633895	178212	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650561	178212	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	156011112	178251	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4633679	178251	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650842	178251	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	145960427	161426	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4127428	161426	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	42853214	206431	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL88078	206431	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	25025581	201973	0	None	-3	8	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
	CHEMBL608151	201973	0	None	-3	8	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
	10663237	147202	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
	CHEMBL39284	147202	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
	71459909	78586	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL2112313	78586	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	73350846	92237	0	None	1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426670	92237	0	None	1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	46227455	14138	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198609	14138	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL608985	14138	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
	44406573	72945	0	None	-6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200693	72945	0	None	-6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406690	74964	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL203249	74964	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	9871871	120732	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL355169	120732	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	9843814	127223	0	None	25	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	CHEMBL36583	127223	0	None	25	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	44431383	87993	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234439	87993	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	16125370	84617	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL222387	84617	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
	155522355	176385	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176385	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176385	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44295965	189556	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51459	189556	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	10470	2471	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	1689	2471	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	4057	2471	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	CHEMBL524004	2471	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	DB04843	2471	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
	140844422	176417	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4452706	176417	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596309	176417	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	10104167	2046	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2046	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2046	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44311704	204178	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL70848	204178	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44311704	204178	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL70848	204178	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
	688566	195860	24	None	-1	3	Rat	8.7	pKi	=	8.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL558910	195860	24	None	-1	3	Rat	8.7	pKi	=	8.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	10107360	78878	28	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
	CHEMBL2112939	78878	28	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
	164614388	188473	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4848683	188473	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028251	188473	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44343736	110559	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL325451	110559	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	134272561	176403	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4540604	176403	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4596189	176403	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44627858	14006	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197382	14006	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569307	14006	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	16125642	141985	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL387546	141985	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	154734599	2486	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	327	2486	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	4108	2486	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	CHEMBL27673	2486	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
	14939891	169340	0	None	-3	4	Rat	8.6	pKi	=	8.6	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL442014	169340	0	None	-3	4	Rat	8.6	pKi	=	8.6	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44296054	189132	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51096	189132	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	10119364	43220	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL150624	43220	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	44431381	148997	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL394254	148997	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	164616974	188494	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4857722	188494	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028407	188494	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44378765	56514	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	CHEMBL163887	56514	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
	44344030	10121	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL115807	10121	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	174174	521	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	521	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	521	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	521	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	521	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	10104167	2046	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2046	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2046	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	10109563	158516	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL409151	158516	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	16094788	141890	0	None	5	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL386983	141890	0	None	5	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	10606253	157249	0	None	1	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL407678	157249	0	None	1	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	13981865	112785	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL3289391	112785	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	CHEMBL3306998	112785	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
	1201549	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	333	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	7601	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	CHEMBL1201203	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	CHEMBL438151	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	DB00245	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
	44378862	58089	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
	CHEMBL167629	58089	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
	16065268	67899	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
	CHEMBL1910849	67899	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
	155542840	176369	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4521993	176369	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595947	176369	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	9815331	203084	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL64000	203084	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	9815331	203084	1	None	1	8	Rat	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203084	1	None	1	8	Rat	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	9815331	203084	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64000	203084	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
	9815331	203084	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
	CHEMBL64000	203084	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
	154417	93231	60	None	-10	9	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
	CHEMBL2449003	93231	60	None	-10	9	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
	155538050	172325	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4475862	172325	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
	44295618	165103	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	CHEMBL422763	165103	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	44267706	163225	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL418530	163225	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	10119364	43220	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL150624	43220	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	9889312	78401	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78401	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	2705	3813	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	360	3813	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	443879	3813	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	CHEMBL1382	3813	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	DB01036	3813	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
	2705	3813	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	360	3813	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	443879	3813	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	CHEMBL1382	3813	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	DB01036	3813	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
	16115796	137192	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL375073	137192	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	16115951	141618	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL385328	141618	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	12872437	12026	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL1183585	12026	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL306182	12026	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	9889312	78401	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2111540	78401	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	154417	93231	60	None	-18	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93231	60	None	-18	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	118710664	120806	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120806	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120806	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118710664	120806	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120806	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120806	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	57326235	77156	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042405	77156	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079009	77156	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	9871136	207092	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL92110	207092	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	164621814	188532	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4867301	188532	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028667	188532	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44311835	204514	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL72787	204514	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
	44311835	204514	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL72787	204514	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
	44267725	11292	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11794	11292	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267772	15762	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	CHEMBL12228	15762	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
	10269504	134348	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL371734	134348	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406268	140771	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381878	140771	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44213237	101894	0	None	-16	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL300998	101894	0	None	-16	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	9889312	78401	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78401	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	2551	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	298	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	488	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	CHEMBL965	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	DB00411	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	15050956	102901	0	None	3	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL306201	102901	0	None	3	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	2551	791	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	791	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	791	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	791	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	791	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	2551	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	298	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	488	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	CHEMBL965	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	DB00411	791	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
	10557581	21742	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202001	21742	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL131913	21742	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10398843	36377	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
	CHEMBL144693	36377	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
	137629935	160996	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	10622033	42752	0	None	-323	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	CHEMBL150219	42752	0	None	-323	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
	208598	35898	5	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL144247	35898	5	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
	6075	150084	42	None	-7	16	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	150084	42	None	-7	16	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	16125529	137181	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374987	137181	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	463892	31847	1	None	-18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	CHEMBL140706	31847	1	None	-18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	44392898	123062	0	None	7	2	Human	6.7	pKi	=	6.7	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL360988	123062	0	None	7	2	Human	6.7	pKi	=	6.7	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	71575027	86194	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	CHEMBL2312389	86194	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
	463616	32020	1	None	-2884	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	CHEMBL140827	32020	1	None	-2884	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	2335	11816	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	8478	11816	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL1182210	11816	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	CHEMBL221753	11816	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
	306	3430	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	3536	3430	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	53930639	3430	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	9577995	3430	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	CHEMBL134641	3430	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
	11504244	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106492	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	10236758	115746	5	None	-208	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
	CHEMBL3354065	115746	5	None	-208	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
	137655636	158712	0	None	-95	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4093527	158712	0	None	-95	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	44437249	11840	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
	CHEMBL1182436	11840	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
	CHEMBL238825	11840	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
	137629935	160996	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	160996	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	160996	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	16125372	84625	0	None	-74	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL222424	84625	0	None	-74	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	118719927	115755	0	None	-2	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354074	115755	0	None	-2	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
	6603753	108675	1	None	5	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL320820	108675	1	None	5	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
	44422692	11821	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182296	11821	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL228144	11821	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	24865895	95976	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL259662	95976	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	CHEMBL390842	95976	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
	44383595	166091	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	CHEMBL426032	166091	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	10476118	123801	0	None	-4	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
	CHEMBL362438	123801	0	None	-4	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
	134271233	176515	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4591883	176515	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4597134	176515	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	118710664	120806	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120806	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120806	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	164622170	188536	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4863723	188536	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028687	188536	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44593626	187829	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496306	187829	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539121	187829	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	15050953	102312	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL303684	102312	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	101676031	97299	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16175987	97299	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201998	97299	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL269272	97299	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16664965	84873	0	None	-28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223668	84873	0	None	-28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	44308733	102163	0	None	-138	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL302809	102163	0	None	-138	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	611037	203671	1	None	-3	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL67532	203671	1	None	-3	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
	14956862	13703	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
	CHEMBL1195116	13703	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
	CHEMBL553865	13703	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
	14964513	11387	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1180268	11387	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL119508	11387	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	14964497	14259	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119985	14259	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	10622718	38372	0	None	-1174	3	Human	4.7	pKi	=	4.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL146359	38372	0	None	-1174	3	Human	4.7	pKi	=	4.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	15086397	13688	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1195036	13688	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL553755	13688	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
	3652	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4066	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	118719928	115756	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354075	115756	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
	156013536	178287	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4639297	178287	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651058	178287	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	108993439	179836	1	None	3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4745429	179836	1	None	3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	71452382	83765	0	None	-6	10	Human	6.7	pKi	=	6.7	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205812	83765	0	None	-6	10	Human	6.7	pKi	=	6.7	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	44593617	187407	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493795	187407	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	11048067	5547	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL107679	5547	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	135430667	4926	0	None	-35	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
	CHEMBL104803	4926	0	None	-35	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
	11143997	4990	0	None	-309	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105122	4990	0	None	-309	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	10225881	107594	0	None	-724	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	CHEMBL318995	107594	0	None	-724	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
	58438451	92256	0	None	-2089	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426689	92256	0	None	-2089	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	44437298	11855	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL1182460	11855	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL239436	11855	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
	9998202	69137	0	None	-2	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69137	0	None	-2	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	44267749	12916	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11893	12916	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267693	169160	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL440601	169160	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	11595794	135676	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	CHEMBL372983	135676	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	44313630	204796	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL75217	204796	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	10525412	41944	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
	CHEMBL149486	41944	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
	15050961	203799	0	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL68446	203799	0	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	155525065	176530	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4456524	176530	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597243	176530	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	1935	3707	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3707	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3707	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3707	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3707	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	44568347	191627	0	None	-10	15	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL519609	191627	0	None	-10	15	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	155518181	170237	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4446039	170237	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	16085999	80263	0	None	-457	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL214029	80263	0	None	-457	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	10646906	119207	0	None	-63	3	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
	CHEMBL343449	119207	0	None	-63	3	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
	44309089	102983	0	None	-128	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL306903	102983	0	None	-128	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	10061123	36860	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL145081	36860	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
	44207909	16667	3	None	-8	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
	CHEMBL1242923	16667	3	None	-8	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
	44328540	207759	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	CHEMBL96042	207759	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
	14964499	169365	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169365	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	137630043	161013	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099667	161013	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116455	161013	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44400185	69297	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL192885	69297	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	44295977	192707	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	CHEMBL52203	192707	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
	1273944	202572	20	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	CHEMBL612034	202572	20	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	73352329	92236	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426669	92236	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	156015719	178234	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4646457	178234	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650699	178234	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	156011605	178259	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4638067	178259	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650888	178259	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	10101246	9514	0	None	-81	2	Human	4.7	pKi	=	4.7	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9514	0	None	-81	2	Human	4.7	pKi	=	4.7	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	9998202	69137	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69137	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	44382865	120255	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL352596	120255	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	16125620	84618	0	None	-93	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL222388	84618	0	None	-93	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	15105209	103592	1	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL308707	103592	1	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	16125371	84730	0	None	-28	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	CHEMBL223017	84730	0	None	-28	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	53324553	56825	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	CHEMBL1643900	56825	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	53324553	56825	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	CHEMBL1643900	56825	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	11013666	59402	1	None	-5	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL171102	59402	1	None	-5	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	44593616	193190	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL523518	193190	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	162649767	180078	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4748337	180078	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	44448500	12302	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185248	12302	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL402282	12302	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	145961152	161567	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4129382	161567	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	162658112	181047	0	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4759774	181047	0	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	73347827	92515	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432052	92515	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	14964494	11925	1	None	2	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11925	1	None	2	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL5287315	194356	0	None	-12	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	460	8	1	3	6.5	C#CCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	1734	116	10	None	-9	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	307	116	10	None	-9	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	CHEMBL168067	116	10	None	-9	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
	214124	169667	2	None	-5	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL443780	169667	2	None	-5	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	164619478	188515	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872882	188515	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028552	188515	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	14210083	156688	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	CHEMBL4070155	156688	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	137629887	160986	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4065555	160986	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116259	160986	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	14964507	114328	1	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114328	1	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	2551	791	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	298	791	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	488	791	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL965	791	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	DB00411	791	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL5279691	194013	0	None	-2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	Cc1cc(C(F)(F)F)nc(Nc2ccccc2-c2nnn[nH]2)n1	10.1021/acs.jmedchem.2c01997
	10716120	38253	0	None	-208	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
	CHEMBL146249	38253	0	None	-208	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
	44364174	121959	0	None	-128	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
	CHEMBL359220	121959	0	None	-128	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
	2726	916	68	None	-79	73	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-79	73	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-79	73	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-79	73	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-79	73	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	10880435	59029	0	None	6	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL169494	59029	0	None	6	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	11015312	5242	0	None	-34	5	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106505	5242	0	None	-34	5	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	44448538	12387	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185855	12387	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL436850	12387	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	44267740	98294	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	CHEMBL274999	98294	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	1353	1898	93	None	-338	86	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	3559	1898	93	None	-338	86	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	86	1898	93	None	-338	86	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	CHEMBL54	1898	93	None	-338	86	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	DB00502	1898	93	None	-338	86	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
	155565286	176242	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4579642	176242	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595003	176242	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	156012936	178272	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4639004	178272	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650969	178272	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	11092603	4829	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL104332	4829	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	73355325	92238	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426671	92238	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	137642607	158494	0	None	-1230	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4091231	158494	0	None	-1230	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	9817231	158212	22	None	-2	7	Human	4.6	pKi	=	4.6	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
	CHEMBL4088272	158212	22	None	-2	7	Human	4.6	pKi	=	4.6	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
	10693031	120961	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
	CHEMBL356305	120961	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
	15678851	102646	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL304582	102646	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	15888010	203823	0	None	-79	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL68584	203823	0	None	-79	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	14964498	13855	0	None	6	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13855	0	None	6	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	15050941	203644	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL67381	203644	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
	2230	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	296	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	CHEMBL7303	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	DB04365	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
	137630995	161117	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4102555	161117	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117268	161117	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44328347	207528	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
	CHEMBL94772	207528	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
	44318817	169090	0	None	-7	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL440138	169090	0	None	-7	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	10836338	39303	0	None	-186	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147105	39303	0	None	-186	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	10573458	119236	0	None	-218	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
	CHEMBL343659	119236	0	None	-218	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
	14537192	100196	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL288482	100196	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	44267796	98073	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL273439	98073	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44326538	13234	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL1191560	13234	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	164622564	188537	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862221	188537	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028706	188537	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	2230	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	296	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	CHEMBL7303	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	DB04365	464	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
	164614732	188474	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4860752	188474	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028266	188474	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	162353371	181626	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4775999	181626	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	10916286	5070	0	None	-1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
	CHEMBL105593	5070	0	None	-1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
	15157141	92772	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL24369	92772	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	71449188	79656	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
	CHEMBL2115359	79656	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
	15157140	99846	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL285898	99846	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	1210	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	1213	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	2725	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	33036	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	4411	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	616	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	6976	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	716121	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	90475904	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1201353	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL1554789	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	CHEMBL505	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB01114	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	DB13679	915	51	None	-162	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	nan
	9880462	72875	0	None	-39	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	CHEMBL200416	72875	0	None	-39	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	9308	17722	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL1255785	17722	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL12587	17722	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL292911	17722	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	10066369	120232	0	None	8	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL352375	120232	0	None	8	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	10269504	134348	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL371734	134348	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44319342	205695	0	None	-31	2	Human	7.6	pKi	=	7.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82512	205695	0	None	-31	2	Human	7.6	pKi	=	7.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	511332	109601	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	CHEMBL322251	109601	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	44267694	12695	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11877	12695	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	511332	109601	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL322251	109601	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	135409468	2022	69	None	-114	40	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
	333	2022	69	None	-114	40	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
	CHEMBL845	2022	69	None	-114	40	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
	464036	9714	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	CHEMBL113436	9714	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
	14964506	113289	1	None	-6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113289	1	None	-6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	464036	9714	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL113436	9714	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10012596	188990	2	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	CHEMBL50898	188990	2	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	1353	1898	93	None	-338	86	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	3559	1898	93	None	-338	86	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	86	1898	93	None	-338	86	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	CHEMBL54	1898	93	None	-338	86	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	DB00502	1898	93	None	-338	86	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
	15050947	102570	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL304109	102570	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	44406572	72813	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200208	72813	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406346	136125	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL373256	136125	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	2200	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	328	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	4848	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	CHEMBL9967	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	DB00670	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
	164611279	188449	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854472	188449	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028067	188449	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44319010	205803	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83363	205803	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	50898777	56410	0	None	-23442	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	CHEMBL1632158	56410	0	None	-23442	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	15050950	204034	0	None	-3	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70003	204034	0	None	-3	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	44267715	14512	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12029	14512	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	462989	33074	1	None	-14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL141699	33074	1	None	-14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	44267750	15216	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12112	15216	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44267697	16285	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12268	16285	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	11011757	59193	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
	CHEMBL170221	59193	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
	10104167	2046	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2046	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2046	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44448496	11880	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182637	11880	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL257547	11880	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	15157139	99783	0	None	-8	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL285440	99783	0	None	-8	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	44267751	98358	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	CHEMBL275347	98358	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
	154734599	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	327	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	4108	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	CHEMBL27673	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
	44383065	120354	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL353311	120354	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
	44312152	204123	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL70531	204123	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL5268503	193543	0	None	-10	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.7	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	CHEMBL5283759	194205	0	None	-7	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1024	19	1	13	9.4	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	15678850	102981	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL306875	102981	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	15157137	99867	0	None	-17	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	CHEMBL286008	99867	0	None	-17	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
	71741394	120809	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323287	120809	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558239	120809	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	44267799	16318	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12291	16318	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	14964499	169365	3	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL442206	169365	3	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	10421982	206018	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	CHEMBL85190	206018	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
	10812455	39757	0	None	-109	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147653	39757	0	None	-109	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	15196354	119244	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	CHEMBL343697	119244	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
	23352285	96750	2	None	-2	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	CHEMBL264747	96750	2	None	-2	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
	137628850	160945	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4097248	160945	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4115965	160945	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
	10957754	59014	0	None	2	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL169401	59014	0	None	2	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	46905988 91930079	10384	0	None	-3	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL1162964	10384	0	None	-3	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	15050946	102619	0	None	1	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL304391	102619	0	None	1	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	1212	1649	50	None	-1380	66	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1649	50	None	-1380	66	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1649	50	None	-1380	66	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1649	50	None	-1380	66	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1649	50	None	-1380	66	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	2200	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	328	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	4848	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	CHEMBL9967	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	DB00670	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
	2200	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	328	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	4848	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	CHEMBL9967	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	DB00670	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
	2200	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	328	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	4848	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	CHEMBL9967	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	DB00670	3109	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
	13773340	79561	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114396	79561	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	16125698	84527	0	None	-102	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222054	84527	0	None	-102	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	70682037	75852	20	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048820	75852	20	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	3652	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	57	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	60809	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	CHEMBL21536	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	DB15357	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	24894637	188695	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL504733	188695	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	CHEMBL553434	188695	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
	44296020	194812	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL53965	194812	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	154734599	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	327	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	4108	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	CHEMBL27673	2486	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
	156578	141464	5	None	81	2	Rat	7.6	pKi	=	7.6	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
	CHEMBL38441	141464	5	None	81	2	Rat	7.6	pKi	=	7.6	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
	16125335	138133	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL376900	138133	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	462772	102284	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	CHEMBL303503	102284	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	44385809	61436	0	None	-81	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL177040	61436	0	None	-81	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	2200	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	328	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	4848	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	CHEMBL9967	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	DB00670	3109	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
	9991939	119326	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL344327	119326	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	11796509	40667	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	CHEMBL148450	40667	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	10354430	37141	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL145301	37141	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	9839491	163185	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
	CHEMBL41830	163185	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
	CHEMBL554874	163185	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
	10035281	100955	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL294273	100955	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	10035281	100955	0	None	-1	8	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	CHEMBL294273	100955	0	None	-1	8	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	10035281	100955	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	CHEMBL294273	100955	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
	14964506	113289	1	None	-6	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113289	1	None	-6	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	15196232	165347	3	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL423746	165347	3	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
	137628858	160947	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4074319	160947	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115967	160947	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3055	1421	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	313	1421	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	7163	1421	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	CHEMBL936	1421	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	DB01231	1421	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
	44384258	128648	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	CHEMBL366819	128648	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
	3652	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4066	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60138186	120810	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120810	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120810	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120810	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	11504244	106492	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106492	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106492	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106492	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	44448646	11876	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182612	11876	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
	CHEMBL254586	11876	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
	10035281	100955	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
	CHEMBL294273	100955	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
	46227483	14093	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198039	14093	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL593685	14093	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	9868297	94085	0	None	-13	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249205	94085	0	None	-13	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	1016	3720	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	73347826	92513	0	None	-2	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
	CHEMBL2432049	92513	0	None	-2	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
	3191	102831	97	None	-8	25	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102831	97	None	-8	25	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	44308861	203505	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL66400	203505	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	44404147	169066	12	None	-19	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL439867	169066	12	None	-19	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL5282659	194144	0	None	-14	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	465	9	2	4	5.8	NCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	11968014	12726	5	None	-4	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12726	5	None	-4	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	24936155	94593	0	None	-46	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
	CHEMBL252258	94593	0	None	-46	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
	44309151	203560	0	None	-60	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL66820	203560	0	None	-60	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	10103909	203281	3	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL64779	203281	3	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
	275176	89784	1	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
	CHEMBL2377388	89784	1	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
	3055	1421	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	313	1421	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	7163	1421	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	CHEMBL936	1421	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	DB01231	1421	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
	67407161	92255	0	None	-1819	2	Human	4.6	pKi	=	4.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426688	92255	0	None	-1819	2	Human	4.6	pKi	=	4.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	57326237	77154	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042407	77154	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078985	77154	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	44384326	59846	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
	CHEMBL172969	59846	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
	109013312	180110	1	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4748774	180110	1	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	11530307	78313	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2093082	78313	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2109993	78313	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	7141654	175765	8	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
	CHEMBL458416	175765	8	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
	180	400	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	400	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	400	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	400	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	400	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	44627739	198349	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL576663	198349	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	44308818	102054	0	None	-30	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
	CHEMBL302145	102054	0	None	-30	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
	14964495	12581	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12581	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	199230	163111	21	None	37	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163111	21	None	37	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	137630127	161025	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4084607	161025	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116537	161025	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	16125443	84620	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
	CHEMBL222402	84620	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
	44274400	98910	0	None	-1	5	Human	4.5	pKi	=	4.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL279520	98910	0	None	-1	5	Human	4.5	pKi	=	4.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	3675988	176811	66	None	-2	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
	CHEMBL461087	176811	66	None	-2	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
	16125437	84319	0	None	-19	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL221713	84319	0	None	-19	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	16125568	97301	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
	CHEMBL269280	97301	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
	7333	99329	79	None	-3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
	CHEMBL282433	99329	79	None	-3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
	1530	2169	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2169	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2169	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2169	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2169	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	10410916	94041	0	None	-9	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249007	94041	0	None	-9	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	44378598	58107	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
	CHEMBL167838	58107	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
	156014820	178281	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4646116	178281	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4650998	178281	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
	11968014	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	10225340	204311	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL71531	204311	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	174174	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	25034182	172560	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL448870	172560	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL540359	172560	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	25010559	96740	0	None	-10	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL264676	96740	0	None	-10	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	9936450	35125	0	None	-4	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
	CHEMBL143469	35125	0	None	-4	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
	44406597	72880	0	None	-12	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200432	72880	0	None	-12	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406686	140886	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL382213	140886	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44382699	59110	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL169876	59110	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	129989	450	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	8584	450	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	CHEMBL43383	450	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	44292486	181487	0	None	-	1	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	CHEMBL47650	181487	0	None	-	1	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
	11968014	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	11968014	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	118710670	120807	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120807	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120807	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	16115801	12263	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL1184882	12263	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL375851	12263	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	9883040	100509	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL291339	100509	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL542622	100509	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	156011965	177268	0	None	-51	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
	CHEMBL4636528	177268	0	None	-51	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
	70685504	74425	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
	CHEMBL2021478	74425	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
	CHEMBL2027846	74425	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
	11968014	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	CHEMBL1187846	12726	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
	164625419	188566	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4862087	188566	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028881	188566	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	71461681	79511	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114067	79511	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	59291461	112748	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298334	112748	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305613	112748	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	23983764	10301	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
	CHEMBL1162116	10301	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
	154417	93231	60	None	-18	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93231	60	None	-18	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	1201549	594	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	594	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	594	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	594	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	594	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	594	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	9892600	58466	0	None	-1	2	Rat	8.4	pKi	=	8.4	Binding	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
	CHEMBL168329	58466	0	None	-1	2	Rat	8.4	pKi	=	8.4	Binding	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
	14939897	96520	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201994	96520	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL262913	96520	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44311761	102823	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	CHEMBL305607	102823	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
	9889312	78401	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78401	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	9798900	63106	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL1779047	63106	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	CHEMBL1789446	63106	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
	44311761	102823	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	CHEMBL305607	102823	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
	1734	116	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	307	116	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	CHEMBL168067	116	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	69058946	106448	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084658	106448	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140110	106448	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44233192	106455	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084643	106455	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140141	106455	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	70687661	74424	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2021476	74424	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2027845	74424	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	1734	116	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
	307	116	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
	CHEMBL168067	116	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
	11039424	78887	1	None	-97	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112955	78887	1	None	-97	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	155529196	171386	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	CHEMBL4462631	171386	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
	155554149	175423	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4576768	175423	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	10500741	38516	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL146464	38516	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	10104	3540	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
	6604866	3540	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
	CHEMBL1493369	3540	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
	132712	171774	19	None	5	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4468100	171774	19	None	5	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
	73353378	89773	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
	CHEMBL2377268	89773	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
	44309231	169474	0	None	-301	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL443267	169474	0	None	-301	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44308913	203944	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69402	203944	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	155511167	169534	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	CHEMBL4435641	169534	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
	10105296	205899	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	CHEMBL84113	205899	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
	10244370	121499	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL358505	121499	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	16086003	80402	0	None	-724	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL214642	80402	0	None	-724	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	14964497	14259	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119985	14259	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	15749863	154587	5	None	-3	2	Human	4.5	pKi	=	4.5	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL39922	154587	5	None	-3	2	Human	4.5	pKi	=	4.5	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	156009611	178233	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634605	178233	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650698	178233	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	156015730	178292	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4644389	178292	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651081	178292	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	16125508	84303	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
	CHEMBL221660	84303	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
	16125680	136612	0	None	-70	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	CHEMBL373994	136612	0	None	-70	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
	44593621	193273	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524061	193273	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	611101	203856	3	None	-2	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL68771	203856	3	None	-2	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	10315426	101021	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL294663	101021	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	118710666	120803	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323282	120803	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558210	120803	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	155559291	176635	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4563530	176635	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4598099	176635	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	24894514	172710	3	None	1	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
	CHEMBL450729	172710	3	None	1	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
	463493	203613	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL67172	203613	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	44400323	68640	0	None	-2	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	CHEMBL192065	68640	0	None	-2	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	9859365	8465	2	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL109405	8465	2	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	16125589	84670	0	None	-16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222636	84670	0	None	-16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	167962	4038	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4038	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4038	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	44449463	96076	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL260228	96076	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44627744	14008	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL1197389	14008	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL569729	14008	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	167962	4038	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4038	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4038	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	6472	202724	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
	CHEMBL61946	202724	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
	44318736	106994	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	CHEMBL315428	106994	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	16086066	139210	0	None	-794	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	CHEMBL378872	139210	0	None	-794	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	10503358	38656	0	None	-354	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL146567	38656	0	None	-354	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	10647703	120942	0	None	-123	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
	CHEMBL356181	120942	0	None	-123	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
	44318851	104699	0	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL310558	104699	0	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	10984804	98448	0	None	-30	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL275914	98448	0	None	-30	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	10835518	40297	0	None	-257	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL148129	40297	0	None	-257	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	44383554	120764	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
	CHEMBL355475	120764	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
	44406476	140499	0	None	-15	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381020	140499	0	None	-15	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	9913892	205814	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83459	205814	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319006	206149	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL86309	206149	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	10044685	206310	6	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL87302	206310	6	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	10109893	82136	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL216983	82136	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL544840	82136	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	44406342	72141	0	None	-5	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL197973	72141	0	None	-5	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	11536903	2382	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	3262	2382	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	CHEMBL3770346	2382	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
	10164480	43315	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	CHEMBL150707	43315	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	6472	202724	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	CHEMBL61946	202724	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	9985181	120332	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	CHEMBL353140	120332	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	44383653	120825	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL355854	120825	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
	10969390	59647	0	None	-4	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL172233	59647	0	None	-4	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	9843967	155434	1	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
	CHEMBL40391	155434	1	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
	10092649	193049	56	None	-28	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
	CHEMBL522460	193049	56	None	-28	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
	11794901	119557	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL346194	119557	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	611066	157485	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL407975	157485	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
	10043954	82249	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21716	82249	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	302	2956	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
	4630	2956	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
	CHEMBL7634	2956	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
	3652	4066	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4066	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4066	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4066	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4066	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	164624458	188559	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4863121	188559	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028823	188559	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164625211	188564	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4869865	188564	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028864	188564	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	171578	12272	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
	CHEMBL1184962	12272	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
	CHEMBL380759	12272	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
	162353374	180019	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4747590	180019	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	118719925	115753	0	None	-43	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
	CHEMBL3354072	115753	0	None	-43	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
	44627856	197466	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569953	197466	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	290	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	4022	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	5926	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	CHEMBL40554	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	CHEMBL74300	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
	7141656	176813	7	None	3	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
	CHEMBL461089	176813	7	None	3	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
	290	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	4022	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	5926	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	CHEMBL40554	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	CHEMBL74300	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
	290	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	4022	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	5926	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	CHEMBL40554	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	CHEMBL74300	2456	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
	156015484	178267	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4645254	178267	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650952	178267	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	11101362	5093	0	None	-8	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
	CHEMBL105674	5093	0	None	-8	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
	16125567	84729	0	None	-104	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	CHEMBL223016	84729	0	None	-104	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	16125507	166155	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL426393	166155	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
	44312464	204633	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL73661	204633	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	11759212	57862	0	None	-40	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL167223	57862	0	None	-40	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
	10316726	11996	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	11996	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	11996	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	155554262	176531	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582069	176531	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597244	176531	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	57326233	77157	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042406	77157	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079010	77157	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	145960466	161499	0	None	-7	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128341	161499	0	None	-7	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	10058649	36095	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL144434	36095	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	10670917	165040	0	None	-102	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL422665	165040	0	None	-102	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	14964495	12581	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12581	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	10739662	42246	0	None	-194	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL149769	42246	0	None	-194	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	10066972	98726	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL278074	98726	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	109035013	180451	1	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	CHEMBL4752973	180451	1	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	162353383	182553	0	None	2	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	CHEMBL4787944	182553	0	None	2	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	71449073	78553	0	None	-8	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
	CHEMBL2112217	78553	0	None	-8	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
	631645	164852	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL422053	164852	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	44443731	94183	0	None	-36	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249830	94183	0	None	-36	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	24882532	95088	0	None	-26	5	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255523	95088	0	None	-26	5	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	10160073	111162	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL326450	111162	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	156015465	178300	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4640926	178300	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651115	178300	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	46227485	14091	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198034	14091	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL593620	14091	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	10160073	111162	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
	CHEMBL326450	111162	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
	10381417	68639	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL192061	68639	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	44312460	204598	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL73410	204598	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
	44382247	30470	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	CHEMBL139311	30470	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
	44325051	111670	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328659	111670	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	10623721	38321	0	None	-162	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	CHEMBL146307	38321	0	None	-162	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
	237	204842	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL546257	204842	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL554190	204842	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	CHEMBL7568	204842	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
	15050951	164901	0	None	1	2	Rat	4.5	pKi	=	4.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL422407	164901	0	None	1	2	Rat	4.5	pKi	=	4.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	162353381	180005	0	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4747438	180005	0	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	462395	115176	1	None	-128	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	CHEMBL334470	115176	1	None	-128	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
	422063	196054	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377384	196054	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL560649	196054	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	44443724	93960	0	None	-51	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL248614	93960	0	None	-51	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
	456319	204053	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL70124	204053	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44296053	189632	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51515	189632	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
	205895	11836	2	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11836	2	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	155565770	175600	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
	CHEMBL4580590	175600	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
	11567493	201779	13	None	-15	3	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606902	201779	13	None	-15	3	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	461838	203625	1	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	CHEMBL67281	203625	1	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
	44382858	59186	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL170205	59186	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	145963288	161591	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4129723	161591	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	56672197	66532	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
	CHEMBL1824785	66532	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
	CHEMBL1852489	66532	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
	44450621	95803	0	None	3	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL258906	95803	0	None	3	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	57664406	2383	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2383	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2383	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	162353375	179871	0	None	4	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4745885	179871	0	None	4	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	44448575	11885	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182650	11885	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL258161	11885	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
	73355419	92520	0	None	-3	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL2432059	92520	0	None	-3	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	44400800	165786	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL424832	165786	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	44312455	204537	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL72956	204537	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
	154734599	2486	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	327	2486	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	4108	2486	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	CHEMBL27673	2486	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
	1687	104382	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL310310	104382	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL540034	104382	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	44318736	106994	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	CHEMBL315428	106994	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
	44318766	205728	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	CHEMBL82754	205728	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	44308798	204024	0	None	-19	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL69904	204024	0	None	-19	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	10925451	58742	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
	CHEMBL168707	58742	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
	25067048	12301	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185245	12301	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL402207	12301	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	44627855	197348	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569212	197348	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	162353377	181141	0	None	2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760904	181141	0	None	2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353372	181363	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4763422	181363	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	71450996	79658	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2115361	79658	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	10408304	103417	0	None	-11	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	CHEMBL3084896	103417	0	None	-11	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
	13773342	79653	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115341	79653	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	44312081	204224	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
	CHEMBL71088	204224	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
	2774	3839	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	5593	3839	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	7319	3839	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	CHEMBL1200604	3839	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB00809	3839	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	DB01199	3839	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
	10646948	37852	0	None	-30	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL145913	37852	0	None	-30	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44379281	57516	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	CHEMBL166385	57516	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	10041771	103405	0	None	-13	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	CHEMBL3084881	103405	0	None	-13	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	16086004	139212	0	None	-1000	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	CHEMBL378885	139212	0	None	-1000	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
	25070031	65355	18	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
	CHEMBL1829335	65355	18	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
	10397468	188940	2	None	-1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	CHEMBL50831	188940	2	None	-1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	10501523	40491	0	None	-169	3	Human	4.4	pKi	=	4.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	CHEMBL148310	40491	0	None	-169	3	Human	4.4	pKi	=	4.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	10951142	5190	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106219	5190	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	24894628	179099	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
	CHEMBL471942	179099	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
	CHEMBL554532	179099	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
	1273	1741	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	3450	1741	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	356	1741	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	6172	1741	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	67425	1741	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	CHEMBL360055	1741	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	DB00483	1741	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	24865895	95976	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL259662	95976	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL390842	95976	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
	1224	1420	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1420	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1420	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1420	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1420	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1420	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	44382840	120712	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
	CHEMBL354934	120712	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
	2200	3109	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	328	3109	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	4848	3109	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	CHEMBL9967	3109	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	DB00670	3109	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
	44437227	11846	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL1182447	11846	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL239017	11846	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
	124087	1377	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1377	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1377	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1377	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1377	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	100	3776	58	None	-19	56	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3776	58	None	-19	56	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3776	58	None	-19	56	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3776	58	None	-19	56	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3776	58	None	-19	56	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2733638	11882	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	6508731	11882	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	8030329	11882	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL1182640	11882	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL257643	11882	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	2551	791	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	298	791	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	488	791	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	CHEMBL965	791	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	DB00411	791	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
	44593620	187912	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496915	187912	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	187	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	10248845	122745	0	None	-3	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	CHEMBL360491	122745	0	None	-3	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	3652	4066	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4066	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4066	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4066	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4066	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	187	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	14964507	114328	1	None	-5	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114328	1	None	-5	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	10443767	13850	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
	CHEMBL1196108	13850	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
	CHEMBL555955	13850	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
	9911615	99003	0	None	-1905	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
	CHEMBL280220	99003	0	None	-1905	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
	44286172	144448	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL39067	144448	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
	135	2515	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2515	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2515	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2515	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2515	43	None	-25	58	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	2284	3160	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3160	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3160	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3160	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3160	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	108993425	181734	1	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4777543	181734	1	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	44274477	165544	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
	CHEMBL424214	165544	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
	11595794	135676	0	None	-3	3	Rat	7.4	pKi	=	7.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	CHEMBL372983	135676	0	None	-3	3	Rat	7.4	pKi	=	7.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
	59291324	112751	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298593	112751	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305622	112751	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	44443730	94004	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL248811	94004	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	10340096	103406	0	None	-10	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	CHEMBL3084882	103406	0	None	-10	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	10269809	159357	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL410061	159357	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	44593616	193190	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL523518	193190	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	167962	4038	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	362	4038	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	CHEMBL31599	4038	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
	44418764	82130	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	CHEMBL216928	82130	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	16094791	83228	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL218755	83228	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	16094783	136542	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL373888	136542	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	15196234	118479	3	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL341476	118479	3	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
	3941250	13305	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1192187	13305	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
	CHEMBL543382	13305	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
	187	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44309090	203726	0	None	-43	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	CHEMBL67873	203726	0	None	-43	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
	137644950	158468	0	None	-1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091032	158468	0	None	-1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	11099206	120761	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL355455	120761	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	44319008	205739	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82850	205739	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44339685	110437	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	CHEMBL324725	110437	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	9978073	94039	0	None	-7	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249005	94039	0	None	-7	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	44448385	11878	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182633	11878	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL257174	11878	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	44318781	106951	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL315127	106951	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11759058	120823	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL355851	120823	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	57326146	77158	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042403	77158	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079020	77158	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
	2551	791	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	298	791	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	488	791	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL965	791	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	DB00411	791	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	55005	104748	8	None	-1	3	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104748	8	None	-1	3	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	2705	3813	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	360	3813	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879	3813	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	CHEMBL1382	3813	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	DB01036	3813	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	44406662	166259	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL427013	166259	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44378914	120004	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	CHEMBL350332	120004	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
	155560013	176276	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4564922	176276	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595198	176276	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44593618	187435	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493979	187435	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	10073079	101493	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	CHEMBL298085	101493	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	16115798	137853	0	None	-3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376255	137853	0	None	-3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	155516383	176649	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4443219	176649	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4598230	176649	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	129989	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	8584	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	CHEMBL43383	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	14939893	9502	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112244	9502	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44267730	16455	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12354	16455	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44383653	120825	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL355854	120825	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	44378982	57550	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL166685	57550	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	16115799	83413	0	None	-4	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219825	83413	0	None	-4	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	156015254	178263	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4649420	178263	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650938	178263	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	70681307	74427	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2021479	74427	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2027890	74427	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	10365639	120833	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	CHEMBL355874	120833	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
	324	1912	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
	6436265	1912	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
	CHEMBL277642	1912	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
	11968014	12726	5	None	-3	9	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
	CHEMBL1187846	12726	5	None	-3	9	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
	154417	93231	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93231	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	44627853	197658	0	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL571121	197658	0	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	324	1912	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	6436265	1912	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	CHEMBL277642	1912	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
	44378599	58108	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
	CHEMBL167839	58108	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
	44344075	110462	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL324832	110462	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	16115950	136357	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	CHEMBL373515	136357	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
	14210083	156688	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4070155	156688	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
	174174	521	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	521	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	521	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	521	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	521	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	10104167	2046	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	6937	2046	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL3121473	2046	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	44400180	68979	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	CHEMBL192337	68979	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	44296022	194901	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL54155	194901	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44267734	10498	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11690	10498	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44406316	72693	0	None	-15	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	CHEMBL199821	72693	0	None	-15	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
	44406689	141260	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL383248	141260	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44299477	100689	0	None	95	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
	CHEMBL292574	100689	0	None	95	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
	18342968	167945	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL431787	167945	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44437270	12296	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL1185211	12296	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL398043	12296	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
	2230	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	296	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	CHEMBL7303	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	DB04365	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	2230	464	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	296	464	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	CHEMBL7303	464	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	DB04365	464	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	2230	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	296	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	CHEMBL7303	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	DB04365	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
	2230	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	296	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	CHEMBL7303	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	DB04365	464	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
	118710666	120803	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323282	120803	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558210	120803	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	164627658	188585	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4875268	188585	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029013	188585	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	10242813	36447	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144751	36447	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
	15169865	11231	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL1179079	11231	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL59085	11231	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	68764898	669	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
	9430	669	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
	CHEMBL3577945	669	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
	167962	4038	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4038	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4038	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	72190450	92246	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426679	92246	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	109032820	182851	1	None	1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4791819	182851	1	None	1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	156015045	178241	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648218	178241	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650765	178241	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	11729182	5199	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106259	5199	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	162353387	181207	0	None	2	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4761549	181207	0	None	2	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353380	182470	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4786868	182470	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	44437303	12294	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
	CHEMBL1185162	12294	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
	CHEMBL394329	12294	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
	44308899	203983	0	None	-37	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69648	203983	0	None	-37	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
	2683	102861	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102861	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102861	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	44431376	87288	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233200	87288	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44593623	187856	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496503	187856	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539373	187856	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	10428089	103420	0	None	-5	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
	CHEMBL3084899	103420	0	None	-5	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
	10330893	121095	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL357444	121095	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL69452	203951	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
	2551	791	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	298	791	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	488	791	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL965	791	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB00411	791	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	16125505	84749	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL223186	84749	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
	6726	1269	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1269	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1269	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1269	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1269	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	9998508	80081	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21321	80081	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	54816802	181248	2	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4762056	181248	2	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	118719929	115757	0	None	-3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354076	115757	0	None	-3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
	156015051	178304	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4643329	178304	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651139	178304	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	156009660	178305	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4634475	178305	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651150	178305	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
	10982070	5134	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105945	5134	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	137636308	156178	0	None	-13	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4064222	156178	0	None	-13	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	44274317	83343	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL21937	83343	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	24894631	176740	3	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
	CHEMBL460470	176740	3	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
	10404406	100173	0	None	19	2	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
	CHEMBL288285	100173	0	None	19	2	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
	10381417	68639	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	CHEMBL192061	68639	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
	14537189	162619	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL416974	162619	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	10066369	120232	0	None	8	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL352375	120232	0	None	8	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	44309135	96539	0	None	-54	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL263040	96539	0	None	-54	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	10467755	121074	2	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL357200	121074	2	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
	137628855	160946	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4103087	160946	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115966	160946	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
	9998202	69137	0	None	-2	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69137	0	None	-2	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	145961981	161507	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4128497	161507	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	4715419	188717	34	None	4	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
	CHEMBL505086	188717	34	None	4	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
	44392960	66271	0	None	9	2	Human	7.4	pKi	=	7.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL184843	66271	0	None	9	2	Human	7.4	pKi	=	7.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	15050959	204059	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70154	204059	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	164627253	188579	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4876651	188579	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028989	188579	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	156015390	178218	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648229	178218	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650585	178218	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	14964494	11925	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11925	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	14964494	11925	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11925	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	14956867	204805	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
	CHEMBL75380	204805	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
	12739458	66521	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
	CHEMBL1824784	66521	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
	CHEMBL1852447	66521	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
	15086396	13260	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1191773	13260	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL542915	13260	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
	49783209	17577	0	None	-758	27	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258223	17577	0	None	-758	27	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	164614364	188471	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4847458	188471	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028248	188471	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44448380	11883	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182644	11883	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	CHEMBL257804	11883	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
	156011518	178314	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4637731	178314	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651208	178314	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
	162353394	180746	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756237	180746	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	11828362	78891	0	None	-57	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112959	78891	0	None	-57	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	44431372	87286	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	CHEMBL233198	87286	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	21855	84217	42	None	-7	6	Human	7.4	pKi	=	7.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
	CHEMBL22108	84217	42	None	-7	6	Human	7.4	pKi	=	7.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
	11834199	58741	0	None	10	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL168704	58741	0	None	10	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
	10651844	115463	0	None	-4	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL335115	115463	0	None	-4	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	11695960	72366	0	None	-52	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL198669	72366	0	None	-52	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
	10024068	131324	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
	CHEMBL368792	131324	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
	137630891	161105	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4085451	161105	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	CHEMBL4117201	161105	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
	10035281	100955	0	None	-1	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	CHEMBL294273	100955	0	None	-1	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
	574989	204047	2	None	-	1	Rat	5.4	pKi	=	5.4	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70082	204047	2	None	-	1	Rat	5.4	pKi	=	5.4	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	73353884	92293	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
	CHEMBL2429890	92293	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
	44378600	56497	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
	CHEMBL163686	56497	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
	15730	71089	80	None	-2	10	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	CHEMBL195437	71089	80	None	-2	10	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
	164616776	188492	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL4852133	188492	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL5028394	188492	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	3652	4066	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	57	4066	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	60809	4066	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	CHEMBL21536	4066	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	DB15357	4066	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
	44392967	65577	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
	CHEMBL183331	65577	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
	164620290	188519	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4870729	188519	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028589	188519	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164621861	188533	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4868124	188533	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028673	188533	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14964511	12069	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1183954	12069	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL325473	12069	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	16086060	168919	0	None	-1148	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL438822	168919	0	None	-1148	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	70693619	73114	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
	CHEMBL2011502	73114	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
	483747	105382	3	None	-177	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL311795	105382	3	None	-177	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10139614	4999	0	None	-323	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL105160	4999	0	None	-323	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	441383	20301	57	None	-7	17	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL1306	20301	57	None	-7	17	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	135398737	955	93	None	-6	92	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	38	955	93	None	-6	92	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	722	955	93	None	-6	92	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	CHEMBL42	955	93	None	-6	92	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	DB00363	955	93	None	-6	92	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
	155552923	176283	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4544820	176283	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4595245	176283	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	44379080	58135	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	CHEMBL168149	58135	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
	3072504	5780	7	None	-	1	Mouse	6.3	pKi	=	6.3	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107892	5780	7	None	-	1	Mouse	6.3	pKi	=	6.3	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	10429011	36098	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
	CHEMBL144435	36098	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
	9910802	120984	0	None	-141	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL356505	120984	0	None	-141	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44312132	102275	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
	CHEMBL303443	102275	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
	10572657	40509	0	None	-45	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL148328	40509	0	None	-45	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	137639541	156679	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4070061	156679	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	9906447	195554	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL2031738	195554	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL555146	195554	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	1273	1741	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	3450	1741	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	356	1741	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	6172	1741	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	67425	1741	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	CHEMBL360055	1741	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	DB00483	1741	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
	2719	914	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	5535	914	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	607	914	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	CHEMBL76	914	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	DB00608	914	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
	46227487	14095	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198047	14095	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL593861	14095	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
	319	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	321	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	444031	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	784	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	CHEMBL1346	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	DB00496	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
	3042	1402	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	355	1402	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	868	1402	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	CHEMBL1123	1402	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	DB00804	1402	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
	16125585	84723	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222976	84723	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	73352330	92156	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2424680	92156	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	118710666	120803	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323282	120803	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558210	120803	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	16125619	84694	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
	CHEMBL222804	84694	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
	14964506	113289	1	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL331556	113289	1	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	66561966	74674	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
	CHEMBL2030625	74674	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
	44437308	12295	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
	CHEMBL1185188	12295	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
	CHEMBL396845	12295	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
	73350931	92505	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432040	92505	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	118719930	115758	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354077	115758	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
	10474335	194669	23	None	-165	10	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
	CHEMBL53325	194669	23	None	-165	10	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
	162658421	181077	0	None	3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4760150	181077	0	None	3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	137644962	158469	0	None	-239	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4091058	158469	0	None	-239	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	44448457	11881	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182638	11881	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL257586	11881	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	24894515	176846	4	None	1	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
	CHEMBL461502	176846	4	None	1	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
	44267709	16610	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12419	16610	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	44431369	87954	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	CHEMBL234253	87954	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
	324	1912	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
	6436265	1912	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
	CHEMBL277642	1912	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
	3929516	107343	4	None	-5	4	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	CHEMBL317757	107343	4	None	-5	4	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
	11610557	72002	0	None	-85	3	Rat	6.3	pKi	=	6.3	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	CHEMBL197588	72002	0	None	-85	3	Rat	6.3	pKi	=	6.3	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
	10551354	39727	0	None	-190	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147611	39727	0	None	-190	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44304818	203283	0	None	-1	7	Rat	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64788	203283	0	None	-1	7	Rat	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	44304818	203283	0	None	-1	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	CHEMBL64788	203283	0	None	-1	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
	137629673	161135	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4094819	161135	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117396	161135	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
	456293	204035	1	None	-17	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL70010	204035	1	None	-17	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44383489	128447	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL366640	128447	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	73346336	92516	0	None	1	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432054	92516	0	None	1	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	9308	17722	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	CHEMBL1255785	17722	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	CHEMBL12587	17722	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	CHEMBL292911	17722	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
	11809446	59649	0	None	1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL172234	59649	0	None	1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
	44422692	11821	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182296	11821	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL228144	11821	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	44446841	12306	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL1185281	12306	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	CHEMBL404557	12306	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
	162657652	180961	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758742	180961	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	44431375	87287	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233199	87287	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44431370	87955	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234254	87955	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	9308	17722	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	CHEMBL1255785	17722	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	CHEMBL12587	17722	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	CHEMBL292911	17722	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
	16086059	80746	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
	CHEMBL215180	80746	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
	16125618	168653	0	None	-19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
	CHEMBL436492	168653	0	None	-19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
	16086059	80746	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215180	80746	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	9821459	200420	11	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	CHEMBL59836	200420	11	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
	15105207	169171	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL440686	169171	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
	14537191	147964	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL39342	147964	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	474465	203048	2	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL63757	203048	2	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
	44420791	84675	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
	CHEMBL222689	84675	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
	44325013	207171	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	CHEMBL92569	207171	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
	44295954	162871	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL417369	162871	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44295712	189485	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51400	189485	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44406521	73877	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL201933	73877	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10199963	141290	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL383389	141290	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10299489	204118	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL70464	204118	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
	129989	450	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	8584	450	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	CHEMBL43383	450	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	129989	450	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	8584	450	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	CHEMBL43383	450	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
	154417	93231	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL2449003	93231	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
	10049361	206098	0	None	-10	2	Human	8.3	pKi	=	8.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85892	206098	0	None	-10	2	Human	8.3	pKi	=	8.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44325013	207171	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL92569	207171	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	44431391	146396	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL392186	146396	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
	118710662	120804	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120804	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120804	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	119357	303	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	3264	303	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	368	303	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	CHEMBL279453	303	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
	118710662	120804	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120804	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120804	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	155548586	176573	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4537517	176573	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597611	176573	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	70683405	74446	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2021477	74446	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	CHEMBL2027984	74446	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
	315401	89783	4	None	-4	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377387	89783	4	None	-4	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	44420795	11818	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL1182222	11818	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223055	11818	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	14537188	136521	0	None	-1	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL37372	136521	0	None	-1	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	10770914	25029	0	None	-19	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL134692	25029	0	None	-19	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	42596929	77159	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042404	77159	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079021	77159	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	688567	63004	4	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	CHEMBL1788199	63004	4	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
	425249	89768	8	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
	CHEMBL2377261	89768	8	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
	CHEMBL5277670	193919	0	None	-2	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	930	19	2	5	13.0	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	319	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	321	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	784	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	CHEMBL1346	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	DB00496	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	44406406	133512	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370862	133512	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406520	135233	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL372566	135233	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406395	140255	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL380583	140255	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	24809738	11857	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL1182466	11857	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
	CHEMBL239655	11857	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
	15050958	203773	0	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL68292	203773	0	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	3652	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	57	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	60809	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	CHEMBL21536	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	DB15357	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
	118710668	120808	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120808	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120808	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	44319043	206036	0	None	-17	2	Human	7.3	pKi	=	7.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85391	206036	0	None	-17	2	Human	7.3	pKi	=	7.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	3652	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	57	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	60809	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	CHEMBL21536	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	DB15357	4066	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
	5387	94850	31	None	-19	6	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
	CHEMBL253978	94850	31	None	-19	6	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
	44313489	204607	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL73501	204607	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	2551	791	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	298	791	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	488	791	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL965	791	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	DB00411	791	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
	15196235	119167	2	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
	CHEMBL343182	119167	2	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
	15749864	100435	3	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL290715	100435	3	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	137629259	160980	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092769	160980	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116203	160980	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44406387	72814	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200209	72814	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	2247	504	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	71455896	83776	0	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205832	83776	0	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
	11819782	95857	0	None	10	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	CHEMBL259131	95857	0	None	10	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
	6604789	101020	5	None	-199	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	CHEMBL294649	101020	5	None	-199	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	10337773	101558	0	None	-125	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	CHEMBL298612	101558	0	None	-125	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
	162670602	182913	0	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4792675	182913	0	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	4735	195092	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL361506	195092	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	CHEMBL55	195092	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
	11057	176125	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	3468	176125	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL459265	176125	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	CHEMBL64894	176125	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
	44344077	10418	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	CHEMBL116404	10418	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
	9974229	120260	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL352618	120260	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	11808947	59423	0	None	4	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL171216	59423	0	None	4	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	10203251	5192	0	None	-257	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
	CHEMBL106224	5192	0	None	-257	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
	11004046	5422	0	None	-33	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL107444	5422	0	None	-33	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	15678856	103754	0	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL308893	103754	0	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	3652	46214	70	None	-2	9	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
	CHEMBL1535	46214	70	None	-2	9	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
	162353388	180955	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4758633	180955	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	162353384	181066	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4760037	181066	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	11515739	78303	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2092736	78303	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2109804	78303	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	16124705	84600	0	None	-77	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	CHEMBL222207	84600	0	None	-77	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	2812	4747	101	None	-33	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4747	101	None	-33	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	107867	2953	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
	309	2953	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
	CHEMBL17045	2953	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
	137645406	157878	0	None	-6	13	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4084262	157878	0	None	-6	13	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	164628906	188592	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4877107	188592	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5029079	188592	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44382974	59483	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL171520	59483	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	16124708	137311	0	None	-28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
	CHEMBL375277	137311	0	None	-28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
	14964513	11387	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1180268	11387	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL119508	11387	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	2200	3109	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	328	3109	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	4848	3109	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	CHEMBL9967	3109	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	DB00670	3109	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
	44450620	95802	0	None	3	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL258905	95802	0	None	3	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	44422697	11820	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182277	11820	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL227429	11820	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	12259685	201525	11	None	-6	4	Rat	6.3	pKi	=	6.3	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
	CHEMBL60542	201525	11	None	-6	4	Rat	6.3	pKi	=	6.3	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
	44378769	120016	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
	CHEMBL350404	120016	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
	156009698	178312	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4634575	178312	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651200	178312	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
	9846311	203988	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
	CHEMBL69678	203988	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
	9846311	203988	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	CHEMBL69678	203988	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
	44309107	102148	0	None	-8	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
	CHEMBL302720	102148	0	None	-8	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
	10176401	154944	19	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	CHEMBL40121	154944	19	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
	10344314	94084	0	None	-12	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	CHEMBL249204	94084	0	None	-12	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
	11498	2997	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
	4995951	2997	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
	CHEMBL59898	2997	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
	11011332	120776	1	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL355560	120776	1	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	156010362	178308	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4633296	178308	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651171	178308	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	11112362	4927	0	None	-4	5	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
	CHEMBL104804	4927	0	None	-4	5	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
	9998829	103392	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
	CHEMBL3084866	103392	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
	118710660	120805	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323279	120805	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558230	120805	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	46682613	181132	1	None	2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760823	181132	1	None	2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	156014205	178268	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4635385	178268	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650957	178268	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	71575652	86169	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	CHEMBL2312352	86169	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
	44308831	204372	0	None	-44	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71933	204372	0	None	-44	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44593627	193275	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524071	193275	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL541671	193275	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44448417	11877	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182629	11877	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL256923	11877	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	57664406	2383	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	6938	2383	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089376	2383	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
	44308832	203790	0	None	-45	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL68384	203790	0	None	-45	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	14964495	12581	1	None	4	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118700	12581	1	None	4	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	2733619	11879	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	6508725	11879	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL1182634	11879	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	CHEMBL257431	11879	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
	10475156	121497	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	CHEMBL358493	121497	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
	15086393	13259	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL1191772	13259	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
	CHEMBL542914	13259	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
	71457691	83770	0	None	-1	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205823	83770	0	None	-1	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	16125640	84713	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222917	84713	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	205895	11836	2	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11836	2	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	10457079	9998	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	9998	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	137645938	157559	0	None	-407	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4080675	157559	0	None	-407	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
	44593617	187407	0	None	-2	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493795	187407	0	None	-2	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	44443733	154760	0	None	-45	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL400167	154760	0	None	-45	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	202119	12003	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL1183388	12003	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL294470	12003	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	71461700	79565	0	None	7	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
	CHEMBL2114425	79565	0	None	7	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
	15678860	102356	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL303876	102356	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	44593627	193275	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524071	193275	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL541671	193275	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	145961161	161582	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4129580	161582	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	44382880	120734	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
	CHEMBL355193	120734	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
	137629744	161151	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4071109	161151	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117602	161151	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44392984	12225	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL1184654	12225	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL362864	12225	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	483747	105382	3	None	-177	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL311795	105382	3	None	-177	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	10066369	120232	0	None	8	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL352375	120232	0	None	8	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	133640439	181349	1	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4763304	181349	1	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	611107	203921	1	None	-1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL69287	203921	1	None	-1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	71458134	79659	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2115362	79659	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	11120347	120703	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	CHEMBL354841	120703	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
	15678858	102122	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL302544	102122	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	59291578	112758	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3298594	112758	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	CHEMBL3305763	112758	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
	1726	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1726	2480	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	1993	2480	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	7438	2480	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	CHEMBL978	2480	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	DB06709	2480	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
	44383305	59323	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL170739	59323	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	4098	32475	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32475	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32475	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	44383373	59360	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL170922	59360	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	44295953	189012	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50927	189012	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	44382739	120370	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL353465	120370	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	9905731	168484	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL435353	168484	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	119357	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	3264	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	368	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	CHEMBL279453	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
	44428745	92148	0	None	3	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
	CHEMBL242345	92148	0	None	3	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
	119357	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	3264	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	368	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	CHEMBL279453	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
	46188794	178295	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4645580	178295	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4651099	178295	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44267747	10029	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	CHEMBL11527	10029	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
	118710670	120807	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120807	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120807	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	11531644	176389	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
	CHEMBL4560341	176389	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
	CHEMBL4596085	176389	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
	44431382	87992	0	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234438	87992	0	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	199230	163111	21	None	37	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163111	21	None	37	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	10086238	78879	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
	CHEMBL2112940	78879	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
	66875589	103363	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084662	103363	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10155225	95811	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	CHEMBL258959	95811	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
	14210083	156688	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	CHEMBL4070155	156688	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
	118710670	120807	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120807	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120807	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	10163651	163209	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL418446	163209	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
	CHEMBL5273907	193761	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	945	20	2	5	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	44627740	198735	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL583051	198735	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	10497101	70440	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
	CHEMBL194628	70440	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
	13773336	79654	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2115342	79654	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	9894136	166212	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	CHEMBL426761	166212	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
	939077	195045	2	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL549577	195045	2	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	2705	3813	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	360	3813	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	443879	3813	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	CHEMBL1382	3813	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	DB01036	3813	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
	118710668	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	2028	2958	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	359	2958	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	4634	2958	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	CHEMBL1231	2958	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	DB01062	2958	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
	302	2956	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	4630	2956	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL7634	2956	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
	303	2957	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2957	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2957	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2957	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	44627854	197686	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL571341	197686	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	156015971	178258	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4648444	178258	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650880	178258	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
	9991979	119132	1	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL342958	119132	1	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
	14964507	114328	1	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	CHEMBL333107	114328	1	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
	75356563	156933	23	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	CHEMBL4072787	156933	23	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	118719926	115754	0	None	-138	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
	CHEMBL3354073	115754	0	None	-138	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
	11001809	59051	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL169594	59051	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
	46227461	14104	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198077	14104	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL594803	14104	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	631644	204054	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL70133	204054	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	118710664	120806	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120806	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120806	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	60138186	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	145960827	161356	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	CHEMBL4126290	161356	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
	2200	3109	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	328	3109	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	4848	3109	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	CHEMBL9967	3109	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	DB00670	3109	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
	1353	1898	93	None	-338	86	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	3559	1898	93	None	-338	86	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	86	1898	93	None	-338	86	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	CHEMBL54	1898	93	None	-338	86	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	DB00502	1898	93	None	-338	86	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
	502259	116772	1	None	-61	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL337820	116772	1	None	-61	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	909982	202071	10	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	CHEMBL608828	202071	10	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
	162353390	180925	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4758316	180925	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	109035056	181299	1	None	7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	CHEMBL4762755	181299	1	None	7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	164609373	188440	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL4846035	188440	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL5027958	188440	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	162353378	182887	0	None	3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4792360	182887	0	None	3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	44446841	12306	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1185281	12306	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL404557	12306	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	11819882	17411	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL125764	17411	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
	16124769	84751	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
	CHEMBL223188	84751	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
	319	1312	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	321	1312	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	444031	1312	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	784	1312	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	CHEMBL1346	1312	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	DB00496	1312	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
	10125445	75999	0	None	-25	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	CHEMBL205654	75999	0	None	-25	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
	164615651	188487	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188487	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188487	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	16094793	83293	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
	CHEMBL219118	83293	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
	9799291	160096	0	None	-169	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL410890	160096	0	None	-169	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	14964497	14259	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119985	14259	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	3013846	188215	2	None	-4	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	CHEMBL499519	188215	2	None	-4	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
	137631178	161180	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4081662	161180	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117768	161180	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44443728	94003	0	None	-25	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	CHEMBL248809	94003	0	None	-25	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
	44318969	206057	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85568	206057	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319016	206114	0	None	-25	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL86012	206114	0	None	-25	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319017	206286	0	None	-19	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL87132	206286	0	None	-19	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	10418420	70244	0	None	-47	4	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
	CHEMBL194216	70244	0	None	-47	4	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
	11169365	112485	0	None	-99	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298986	112485	0	None	-99	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	137630084	161021	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4070055	161021	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116507	161021	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
	57326140	77150	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2042400	77150	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	CHEMBL2078962	77150	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
	44406451	72913	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200566	72913	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	542182	102134	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL302604	102134	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	71460014	79657	0	None	4	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
	CHEMBL2115360	79657	0	None	4	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
	44400887	70969	0	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	CHEMBL195169	70969	0	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
	60138186	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120810	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	44627741	197659	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	CHEMBL571123	197659	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
	44593619	187436	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL493980	187436	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44308746	203828	0	None	-138	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL68609	203828	0	None	-138	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	10572658	121954	0	None	-33	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL359197	121954	0	None	-33	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	167962	4038	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4038	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4038	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	162675053	183234	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4796491	183234	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	44578707	182117	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
	CHEMBL478227	182117	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
	57664406	2383	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2383	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2383	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	164618644	188507	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL4872142	188507	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	CHEMBL5028508	188507	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
	57326144	77162	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042402	77162	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2079061	77162	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
	10457079	9998	0	None	-4	2	Human	4.2	pKi	=	4.2	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL115078	9998	0	None	-4	2	Human	4.2	pKi	=	4.2	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	162353389	181500	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
	CHEMBL4765133	181500	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
	44443735	94354	0	None	-52	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL250834	94354	0	None	-52	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	9998202	69137	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192485	69137	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
	44420821	84259	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
	CHEMBL221400	84259	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
	44383352	59662	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	CHEMBL172272	59662	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
	10096017	103418	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	CHEMBL3084897	103418	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
	118719920	115747	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354066	115747	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	44593620	187912	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496915	187912	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	302	2956	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	4630	2956	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	CHEMBL7634	2956	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
	2551	791	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	298	791	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	488	791	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	CHEMBL965	791	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	DB00411	791	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	71450550	83778	0	None	-1	16	Human	6.2	pKi	=	6.2	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205836	83778	0	None	-1	16	Human	6.2	pKi	=	6.2	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	156017826	177834	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4644285	177834	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	10408160	13018	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	CHEMBL1190020	13018	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	CHEMBL540013	13018	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
	44299589	196374	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL56275	196374	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	44450624	95907	0	None	12	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	CHEMBL259344	95907	0	None	12	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
	11045444	59159	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL170088	59159	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	11000399	59065	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL169680	59065	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	463209	121106	1	None	-6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	CHEMBL357557	121106	1	None	-6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
	134272502	176284	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4514058	176284	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595246	176284	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	44392974	64510	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	CHEMBL181447	64510	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
	16086062	80762	0	None	-128	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215189	80762	0	None	-128	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	44308809	204358	0	None	-123	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL71799	204358	0	None	-123	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	56963799	74866	0	None	-1698	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
	CHEMBL2031737	74866	0	None	-1698	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
	132060812	162012	0	None	-1778	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	CHEMBL4160064	162012	0	None	-1778	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	4011	82379	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82379	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	44593622	187772	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL495888	187772	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL556390	187772	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
	10647553	39688	0	None	-407	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147554	39688	0	None	-407	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	44422699	11819	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL1182272	11819	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	CHEMBL227378	11819	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
	10473919	204708	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
	CHEMBL74305	204708	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
	16125571	85121	0	None	-79	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	CHEMBL225074	85121	0	None	-79	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
	66561967	74675	0	None	-1	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
	CHEMBL2030626	74675	0	None	-1	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
	44295888	188233	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL49975	188233	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	9815331	203084	1	None	-1	8	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	CHEMBL64000	203084	1	None	-1	8	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
	174174	521	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	521	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	521	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	521	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	521	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	118710668	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	118710668	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120808	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	140844410	176368	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4436947	176368	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595946	176368	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	71454562	79625	0	None	6	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2115126	79625	0	None	6	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	44431387	87289	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL233201	87289	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	164609510	188441	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4846562	188441	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5027965	188441	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	10204457	204380	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL71971	204380	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	174174	521	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	260	521	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	320	521	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	CHEMBL517712	521	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	DB00572	521	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
	13567081	11202	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1178839	11202	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL45454	11202	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	44292563	187756	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	CHEMBL49576	187756	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
	71449148	79509	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	CHEMBL2114064	79509	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
	155523889	176500	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4454134	176500	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597014	176500	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	14939893	9502	0	None	-1	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL112244	9502	0	None	-1	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL5270925	193636	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.9	C#CCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	24846938	89772	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
	CHEMBL2377267	89772	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
	10030021	169855	12	None	6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4440484	169855	12	None	6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	9913341	82129	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL216927	82129	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	CHEMBL553058	82129	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
	156014269	177192	0	None	-10	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4635500	177192	0	None	-10	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
	44319071	205996	0	None	-7	2	Human	8.1	pKi	=	8.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL84993	205996	0	None	-7	2	Human	8.1	pKi	=	8.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	9913341	82129	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL216927	82129	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL553058	82129	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	9818955	9311	1	None	2	2	Rat	8.1	pKi	=	8.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	CHEMBL111224	9311	1	None	2	2	Rat	8.1	pKi	=	8.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	205895	11836	2	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	CHEMBL118240	11836	2	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
	55005	104748	8	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104748	8	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	199230	163111	21	None	37	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	CHEMBL41779	163111	21	None	37	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
	10262466	98316	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
	CHEMBL275104	98316	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
	10621363	121664	0	None	-48	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	CHEMBL358726	121664	0	None	-48	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
	44593625	188106	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498358	188106	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539120	188106	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	10449632	103419	0	None	-56	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	CHEMBL3084898	103419	0	None	-56	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
	71458105	79567	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL2114427	79567	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
	145962050	161608	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4130037	161608	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	10949838	5189	0	None	-234	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL106218	5189	0	None	-234	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	73346226	92235	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426668	92235	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	164621361	188529	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4865137	188529	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028648	188529	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	14964498	13855	0	None	6	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13855	0	None	6	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	10405613	202495	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
	CHEMBL611476	202495	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
	14964496	8932	0	None	1	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8932	0	None	1	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	10354969	13540	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
	CHEMBL1194009	13540	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
	CHEMBL545506	13540	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
	1273	1741	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	3450	1741	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	356	1741	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	6172	1741	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	67425	1741	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	CHEMBL360055	1741	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	DB00483	1741	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
	10088338	103411	0	None	-15	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
	CHEMBL3084888	103411	0	None	-15	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
	44400375	69145	0	None	-2	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	CHEMBL192537	69145	0	None	-2	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
	11767229	78888	0	None	-72	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	CHEMBL2112956	78888	0	None	-72	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
	9308	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL1255785	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL12587	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	CHEMBL292911	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
	57339144	92209	78	None	1	6	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
	CHEMBL2426364	92209	78	None	1	6	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
	3652	4066	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	57	4066	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	60809	4066	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	CHEMBL21536	4066	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	DB15357	4066	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
	162353391	180797	0	None	1	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	CHEMBL4756873	180797	0	None	1	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	44448606	11886	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1182652	11886	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL258385	11886	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	10114698	4801	0	None	-660	5	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	CHEMBL104210	4801	0	None	-660	5	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
	46227481	14107	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL1198081	14107	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	CHEMBL595022	14107	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
	16086001	139189	0	None	-426	5	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL378772	139189	0	None	-426	5	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	16125373	84761	0	None	-28	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL223267	84761	0	None	-28	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	44318930	106145	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	CHEMBL313738	106145	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
	16086000	80327	0	None	-1412	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	CHEMBL214342	80327	0	None	-1412	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
	9802631	111970	1	None	-3467	5	Rat	5.1	pKi	=	5.1	Binding	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
	CHEMBL328866	111970	1	None	-3467	5	Rat	5.1	pKi	=	5.1	Binding	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
	130442480	175246	0	None	-89	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-89	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	44400762	70539	0	None	-2	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	CHEMBL194870	70539	0	None	-2	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
	3028236	102572	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL2377383	102572	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	CHEMBL3041159	102572	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
	10336882	103421	0	None	-10	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
	CHEMBL3084900	103421	0	None	-10	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
	939078	63039	2	None	-12	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	CHEMBL1788286	63039	2	None	-12	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
	44313626	204545	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	CHEMBL73017	204545	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
	164611347	188450	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4856090	188450	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028070	188450	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	44576913	193290	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL524186	193290	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL557808	193290	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	44274441	99065	0	None	1	5	Human	5.1	pKi	=	5.1	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL280684	99065	0	None	1	5	Human	5.1	pKi	=	5.1	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	24894625	9746	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
	CHEMBL113580	9746	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
	CHEMBL553155	9746	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
	156014813	178260	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4649668	178260	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650897	178260	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	5282593	55228	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1319362	55228	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	CHEMBL1618018	55228	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
	9308	17722	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17722	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17722	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17722	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	9308	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL1255785	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL12587	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	CHEMBL292911	17722	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
	11504244	106492	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106492	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106492	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106492	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	164623530	188549	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872632	188549	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028763	188549	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	2750	204038	76	None	-4	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	CHEMBL7002	204038	76	None	-4	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
	44627958	14004	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197374	14004	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL569089	14004	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	11718570	72173	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
	CHEMBL198065	72173	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
	456292	96720	1	None	-42	2	Human	6.1	pKi	=	6.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	CHEMBL264442	96720	1	None	-42	2	Human	6.1	pKi	=	6.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
	44309153	203491	0	None	-69	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL66322	203491	0	None	-69	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44378888	56815	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	CHEMBL164385	56815	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
	44593626	187829	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL496306	187829	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL539121	187829	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	4212	198656	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL1417019	198656	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	CHEMBL58	198656	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
	75201901	166401	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71720489	86930	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323447	86930	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	11588241	155715	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2092735	155715	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL405612	155715	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
	45266385	195469	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL553241	195469	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	7047822	176812	15	None	-3	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
	CHEMBL461088	176812	15	None	-3	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
	10026270	94086	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL249206	94086	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
	44295668	188931	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL50822	188931	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	10336644	161649	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
	CHEMBL41313	161649	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
	14956860	13670	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL1194903	13670	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL553520	13670	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	44406480	72815	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200210	72815	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10834711	121384	0	None	-21	3	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL358193	121384	0	None	-21	3	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	155551903	176433	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4569929	176433	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596435	176433	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	118719931	115759	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
	CHEMBL3354078	115759	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
	44319339	205884	0	None	-44	2	Human	7.1	pKi	=	7.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83982	205884	0	None	-44	2	Human	7.1	pKi	=	7.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	137631026	161126	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4093215	161126	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117321	161126	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	2200	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	328	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	4848	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	CHEMBL9967	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	DB00670	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
	12310489	208371	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
	CHEMBL99618	208371	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
	2200	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	328	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	4848	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	CHEMBL9967	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	DB00670	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
	137640201	156937	2	None	-630	13	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	CHEMBL4072818	156937	2	None	-630	13	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
	42853213	104317	7	None	-7	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310016	104317	7	None	-7	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	2396803	206103	3	None	-10	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85950	206103	3	None	-10	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	2200	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	328	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	4848	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	CHEMBL9967	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	DB00670	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
	2200	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	328	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	4848	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	CHEMBL9967	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	DB00670	3109	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
	9818955	9311	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	CHEMBL111224	9311	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
	2736067	87501	73	None	-93	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
	CHEMBL2335158	87501	73	None	-93	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
	57326239	77153	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042551	77153	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078974	77153	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
	2551	791	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	298	791	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	488	791	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	CHEMBL965	791	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	DB00411	791	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
	350	3530	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
	9867750	3530	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
	CHEMBL73341	3530	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
	2028	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	359	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	4634	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	CHEMBL1231	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	DB01062	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
	164619081	188513	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4872720	188513	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028531	188513	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
	118710668	120808	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3323283	120808	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3558234	120808	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	3652	4066	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	57	4066	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	60809	4066	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	CHEMBL21536	4066	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	DB15357	4066	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
	118710664	120806	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323281	120806	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558231	120806	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	10963509	18464	1	None	1	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	CHEMBL127273	18464	1	None	1	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	44267744	15416	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL12153	15416	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	11155732	10515	17	None	-26	3	Rat	8.1	pKi	=	8.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL1169543	10515	17	None	-26	3	Rat	8.1	pKi	=	8.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
	10104167	2046	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	6937	2046	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	CHEMBL3121473	2046	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
	44431386	149001	0	None	1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL394255	149001	0	None	1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	16125587	84734	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223028	84734	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	118710670	120807	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3323284	120807	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	CHEMBL3558233	120807	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
	55005	104748	8	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	CHEMBL310852	104748	8	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
	14964496	8932	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL109815	8932	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL69452	203951	0	None	2	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
	11718536	137820	0	None	-41	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL376000	137820	0	None	-41	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	574784	103568	2	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
	CHEMBL308650	103568	2	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
	10354968	13043	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
	CHEMBL1190173	13043	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
	CHEMBL540310	13043	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
	107867	2953	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
	309	2953	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
	CHEMBL17045	2953	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
	164614830	188476	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4858774	188476	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028275	188476	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	130442572	171884	0	None	-173	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-173	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	10365534	154936	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
	CHEMBL401154	154936	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
	11530307	78313	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2093082	78313	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2109993	78313	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	45266386	194893	0	None	1	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL541424	194893	0	None	1	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	44286173	144462	0	None	3	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL39068	144462	0	None	3	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	16125223	168875	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	CHEMBL438427	168875	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
	44308900	203973	0	None	-85	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	CHEMBL69582	203973	0	None	-85	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
	44318929	106835	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	CHEMBL314493	106835	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	CHEMBL5092328	215336	5	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysis	ChEMBL		None	None	None		CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N	10.1021/acs.jmedchem.1c00935
	3236	67579	43	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	CHEMBL1902981	67579	43	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
	36381	12910	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
	CHEMBL1189234	12910	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
	36381	12910	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
	CHEMBL1189234	12910	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
	302	2956	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
	4630	2956	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
	CHEMBL7634	2956	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
	15050954	203980	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL69620	203980	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	71718048	86926	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323443	86926	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	9948957	204469	1	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	CHEMBL72506	204469	1	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
	118719924	115752	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354071	115752	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	44593624	188105	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498357	188105	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL554916	188105	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	9842753	201789	0	None	-24	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	CHEMBL606963	201789	0	None	-24	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
	10101246	9514	0	None	-81	2	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	CHEMBL112297	9514	0	None	-81	2	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
	44299564	199064	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL58824	199064	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
	11759379	120751	0	None	2	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL355392	120751	0	None	2	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	167962	4038	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	362	4038	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	CHEMBL31599	4038	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
	302	2956	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	4630	2956	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	CHEMBL7634	2956	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
	123603	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	2684	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	584	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	9658	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	CHEMBL168815	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
	2398	951	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	951	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	951	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	951	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	951	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	10574041	39792	0	None	-281	3	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL147695	39792	0	None	-281	3	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
	CHEMBL308924	103760	0	None	-2	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	268	4	1	5	1.0	CCO/C(O)=C1\CN2CC(CCC2CN(C)C)C1=O	10.1021/jm020572p
	71716225	86928	0	None	1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323445	86928	0	None	1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	16125325	84544	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222090	84544	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	2229	463	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
	295	463	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
	CHEMBL128365	463	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
	44627956	14002	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL1197362	14002	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	CHEMBL568775	14002	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
	1687	104382	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL310310	104382	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	CHEMBL540034	104382	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
	3072501	107242	6	None	-	1	Mouse	6.1	pKi	=	6.1	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL316973	107242	6	None	-	1	Mouse	6.1	pKi	=	6.1	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	53390181	92242	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426675	92242	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	53390538	92248	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426681	92248	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	44448421	12305	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL1185269	12305	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	CHEMBL403773	12305	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
	156013387	178237	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4638935	178237	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650725	178237	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	156012563	178224	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4637485	178224	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650635	178224	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
	156013998	178245	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4635148	178245	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	CHEMBL4650787	178245	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
	11672895	77776	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL2092737	77776	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	71452384	83768	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205816	83768	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
	71452384	83768	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
	CHEMBL2205816	83768	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
	44437295	11861	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
	CHEMBL1182472	11861	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
	CHEMBL239866	11861	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
	16125704	84635	0	None	-54	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222450	84635	0	None	-54	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	71720488	86924	0	None	-13	3	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323441	86924	0	None	-13	3	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	15050952	203473	0	None	1	3	Rat	5.1	pKi	=	5.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	CHEMBL66177	203473	0	None	1	3	Rat	5.1	pKi	=	5.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
	16125531	84327	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL221775	84327	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	73355416	92508	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	CHEMBL2432043	92508	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
	15050955	102571	0	None	1	4	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	CHEMBL304112	102571	0	None	1	4	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
	164622017	188534	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4871563	188534	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028681	188534	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	109014373	179778	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4744856	179778	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	118719923	115751	0	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	CHEMBL3354070	115751	0	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
	14964498	13855	0	None	6	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13855	0	None	6	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	11694119	115461	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	CHEMBL3351105	115461	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
	46227417	14096	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL1198048	14096	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	CHEMBL593864	14096	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
	44296096	101870	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	CHEMBL300845	101870	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
	44295763	188791	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	CHEMBL50618	188791	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
	44296006	189707	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	CHEMBL51574	189707	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
	15407072	56836	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	CHEMBL164397	56836	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
	9889312	78401	0	None	2	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	CHEMBL2111540	78401	0	None	2	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
	44455198	97629	0	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
	CHEMBL271108	97629	0	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
	44455198	97629	0	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
	CHEMBL271108	97629	0	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
	44292834	101429	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	CHEMBL297683	101429	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
	44325003	111615	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	CHEMBL328550	111615	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
	10865439	20593	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	CHEMBL130835	20593	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
	140844398	176337	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4470924	176337	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	CHEMBL4595692	176337	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
	71128	96781	25	None	-17	8	Human	8.0	pKi	=	8.0	Binding	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
	CHEMBL26505	96781	25	None	-17	8	Human	8.0	pKi	=	8.0	Binding	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
	CHEMBL5265833	193433	0	None	-28	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	488	10	1	3	7.1	C#CCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
	155543345	176662	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4543584	176662	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4598362	176662	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	101720828	97091	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	16147087	97091	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202002	97091	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL267643	97091	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	4841	67397	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1889399	67397	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	CHEMBL1909073	67397	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
	11968014	12726	5	None	-4	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
	CHEMBL1187846	12726	5	None	-4	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
	10302719	43478	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	CHEMBL150845	43478	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
	CHEMBL5271406	193657	0	None	-10	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1159	27	3	10	12.8	CC1(C)C(/C=C/C=C/C=C2/N(CCCCS(=O)(=O)O)c3ccccc3C2(C)C)=[N+](CCCCCC(=O)NCCCCCCCCN2CCC(OC(=O)Nc3ccc(F)cc3-c3ccc(F)c(Cl)c3)CC2)c2ccc(S(=O)(=O)[O-])cc21	10.1021/acs.jmedchem.2c01376
	2028	2958	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2958	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2958	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2958	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2958	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	118710662	120804	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120804	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120804	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	118710662	120804	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3323280	120804	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	CHEMBL3558229	120804	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
	57326326	77149	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042553	77149	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078942	77149	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	57326326	77149	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2042553	77149	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2078942	77149	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL5267836	193514	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.8	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
	CHEMBL5289083	194435	0	None	-5	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1002	24	3	6	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCNCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
	16125591	84669	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222634	84669	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
	14964494	11925	1	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	CHEMBL118292	11925	1	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
	155672	5005	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL105198	5005	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	CHEMBL56734	5005	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
	44431367	87953	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	CHEMBL234252	87953	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
	44318766	205728	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	CHEMBL82754	205728	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
	16124710	85156	0	None	-54	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL225387	85156	0	None	-54	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	60138186	120810	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	60138193	120810	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3323288	120810	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	CHEMBL3558240	120810	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
	11504244	106492	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	60138185	106492	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3121474	106492	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	CHEMBL3140249	106492	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
	303	2957	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	4629	2957	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	8595	2957	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	CHEMBL44674	2957	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
	170332	160952	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	11024241	120275	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	CHEMBL352723	120275	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
	73346227	92240	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426673	92240	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
	162353382	181710	0	None	4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	CHEMBL4777127	181710	0	None	4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	44274417	98866	0	None	2	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	CHEMBL279225	98866	0	None	2	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
	57664406	2383	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2383	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2383	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	170332	160952	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	160952	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	160952	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3158	56237	27	None	-630	20	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56237	27	None	-630	20	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL5274390	193789	0	None	-32	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	366	3	2	3	4.6	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OC1CCNCC1	10.1021/acs.jmedchem.2c01376
	44318929	106835	0	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	CHEMBL314493	106835	0	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
	10105880	37421	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	CHEMBL145533	37421	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
	137628800	160970	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4089027	160970	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116151	160970	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
	44267699	13643	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	CHEMBL11947	13643	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
	199230	163111	21	None	37	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	CHEMBL41779	163111	21	None	37	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
	16125509	169318	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
	CHEMBL441873	169318	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
	11501540	133578	0	None	-16	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	CHEMBL371293	133578	0	None	-16	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
	137628788	160968	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4085150	160968	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116149	160968	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
	10670961	40602	0	None	-66	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
	CHEMBL148404	40602	0	None	-66	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
	14964498	13855	0	None	6	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	CHEMBL119615	13855	0	None	6	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
	191	402	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	402	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	402	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	402	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	402	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	44275807	98942	0	None	-851	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
	CHEMBL27979	98942	0	None	-851	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
	11653112	78304	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2092820	78304	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	CHEMBL2109828	78304	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
	45266386	194893	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	CHEMBL541424	194893	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
	57664406	2383	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	6938	2383	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	CHEMBL4089376	2383	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
	11110049	58210	0	None	-2	4	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	CHEMBL168223	58210	0	None	-2	4	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
	13773340	79561	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	CHEMBL2114396	79561	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
	3823	50191	42	None	-44	11	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	76973198	50191	42	None	-44	11	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	CHEMBL157101	50191	42	None	-44	11	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
	16086005	139206	0	None	-77	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	CHEMBL378859	139206	0	None	-77	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
	16125646	136946	0	None	-50	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL374513	136946	0	None	-50	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	10598540	38299	0	None	-134	3	Human	5.0	pKi	=	5.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	CHEMBL146291	38299	0	None	-134	3	Human	5.0	pKi	=	5.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
	44443722	154896	0	None	-29	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
	CHEMBL400953	154896	0	None	-29	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
	10360219	101983	0	None	1	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	CHEMBL301670	101983	0	None	1	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
	57326325	77155	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2042554	77155	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	CHEMBL2078987	77155	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
	44593624	188105	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL498357	188105	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	CHEMBL554916	188105	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
	57326325	77155	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2042554	77155	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL2078987	77155	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	145960592	161337	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	CHEMBL4126071	161337	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
	17621	60567	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	CHEMBL176012	60567	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
	3072504	5780	7	None	-	1	Mouse	5.0	pKi	=	5.0	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	CHEMBL107892	5780	7	None	-	1	Mouse	5.0	pKi	=	5.0	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
	71718668	86770	0	None	-1	2	Rat	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2321893	86770	0	None	-1	2	Rat	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	300	2493	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
	4141	2493	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
	CHEMBL92387	2493	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
	2904292	183556	13	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4800495	183556	13	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	46227459	14103	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL1198076	14103	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	CHEMBL594802	14103	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
	16125681	84739	0	None	-141	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	CHEMBL223079	84739	0	None	-141	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
	10243426	121890	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL359027	121890	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	16125374	84703	0	None	-36	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	CHEMBL222860	84703	0	None	-36	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
	15050948	102790	0	None	1	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	CHEMBL305403	102790	0	None	1	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
	10451634	204427	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
	CHEMBL72219	204427	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
	11808946	120610	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	CHEMBL354678	120610	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
	47358375	180738	1	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756164	180738	1	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	87934	98053	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL273308	98053	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	CHEMBL542883	98053	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
	21862266	141988	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	CHEMBL38756	141988	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
	10468535	98101	1	None	-1	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
	CHEMBL273586	98101	1	None	-1	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
	14964513	11387	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL1180268	11387	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	CHEMBL119508	11387	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
	289	242	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
	9948320	242	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
	CHEMBL1242950	242	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
	137628799	160969	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4064668	160969	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116150	160969	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2166	3101	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	305	3101	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	5910	3101	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	CHEMBL550	3101	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	DB01085	3101	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
	71716836	86925	0	None	-11	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	CHEMBL2323442	86925	0	None	-11	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
	68617	205504	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205504	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205504	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	462571	118769	1	None	-97	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	CHEMBL342137	118769	1	None	-97	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
	10466231	36045	0	None	-2	2	Human	7.0	pKi	=	7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144385	36045	0	None	-2	2	Human	7.0	pKi	=	7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
	10421689	35761	0	None	-2	2	Human	6.0	pKi	=	6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
	CHEMBL144123	35761	0	None	-2	2	Human	6.0	pKi	=	6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
	1935	3707	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3707	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3707	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3707	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3707	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	154059	3610	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	2457	3610	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	7483	3610	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	CHEMBL1734	3610	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	DB01591	3610	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	306	3430	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	3536	3430	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	53930639	3430	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	9577995	3430	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	CHEMBL134641	3430	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
	2745	3832	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3832	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3832	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3832	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3832	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3832	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	3652	4066	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4066	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4066	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4066	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4066	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	2824	3962	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	345	3962	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	71203	3962	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	CHEMBL1892145	3962	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	DB13793	3962	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
	92112	21673	18	None	1	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
	CHEMBL1318553	21673	18	None	1	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
	2360	3667	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	2484	3667	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	347	3667	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	441071	3667	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	CHEMBL227934	3667	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	DB15954	3667	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
	15376	3963	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	349	3963	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	3643	3963	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	CHEMBL1165342	3963	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	DB13374	3963	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
	21158560	112766	7	None	-1	4	Human	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	CHEMBL3305985	112766	7	None	-1	4	Human	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	2381	660	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	374	660	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	7128	660	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	CHEMBL1101	660	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	DB00810	660	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	11968014	12726	5	None	-3	9	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	CHEMBL1187846	12726	5	None	-3	9	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	656598	12700	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1187724	12700	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL516476	12700	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	367	3795	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	5487427	3795	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	8592	3795	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	CHEMBL1900528	3795	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	CHEMBL3305968	3795	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	CHEMBL4650755	3795	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	DB01409	3795	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
	23056	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	23056	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	318	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	318	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	3260	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	3260	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	CHEMBL12980	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
	CHEMBL12980	112	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
	11536903	2382	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
	3262	2382	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
	CHEMBL3770346	2382	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
	57664406	2383	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
	57664406	2383	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
	6938	2383	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
	6938	2383	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
	CHEMBL4089376	2383	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
	CHEMBL4089376	2383	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
	1273	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	1273	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	3450	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	3450	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	356	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	356	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	6172	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	6172	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	67425	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	67425	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	CHEMBL360055	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	CHEMBL360055	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	DB00483	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
	DB00483	1741	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
	341	339	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
	341	339	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
	341	339	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
	5311001	339	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
	5311001	339	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
	5311001	339	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
	167962	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	167962	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
	362	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	362	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
	CHEMBL31599	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	CHEMBL31599	4038	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
	168057	1201	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
	168057	1201	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
	7634	1201	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
	7634	1201	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
	CHEMBL28407	1201	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
	CHEMBL28407	1201	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
	2381	660	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	374	660	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	7128	660	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	CHEMBL1101	660	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	DB00810	660	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
	10350027	1416	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	364	1416	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	365	1416	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	303	2957	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	4629	2957	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	8595	2957	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	CHEMBL44674	2957	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
	187	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	294	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	65	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	8593	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	CHEMBL667	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	DB03128	255	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
	119357	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	119357	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	119357	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	3264	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	3264	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	3264	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	368	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	368	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	368	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	CHEMBL279453	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
	CHEMBL279453	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
	CHEMBL279453	303	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
	316	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	316	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	316	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	316	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	316	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	316	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	316	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	317	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	317	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	317	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	317	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	317	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	317	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	317	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	71183	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	71183	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	71183	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	71183	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	71183	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	71183	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	71183	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	CHEMBL3140030	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	CHEMBL3140030	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	CHEMBL3140030	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	CHEMBL3140030	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	CHEMBL3140030	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	CHEMBL3140030	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	CHEMBL3140030	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	CHEMBL376897	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	CHEMBL376897	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	CHEMBL376897	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	CHEMBL376897	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	CHEMBL376897	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	CHEMBL376897	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	CHEMBL376897	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	DB00462	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
	DB00462	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
	DB00462	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
	DB00462	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
	DB00462	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
	DB00462	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
	DB00462	2816	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
	21123938	730	0	None	-1	5	Human	3.5	pKd	None	3.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
	343	730	0	None	-1	5	Human	3.5	pKd	None	3.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
	348	3774	0	None	-3	4	Human	3.9	pKd	None	3.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
	66706	3774	0	None	-3	4	Human	3.9	pKd	None	3.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
	2824	3962	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	345	3962	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	71203	3962	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	CHEMBL1892145	3962	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	DB13793	3962	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
	342	729	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	442021	729	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	CHEMBL501756	729	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	342	729	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
	342	729	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	442021	729	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
	442021	729	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	CHEMBL501756	729	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
	CHEMBL501756	729	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
	344	2729	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
	44358908	2729	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
	CHEMBL139677	2729	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
	332	2021	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
	44358893	2021	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
	CHEMBL343796	2021	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
	2360	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	2360	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	2360	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	2484	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	2484	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	2484	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	347	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	347	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	347	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	441071	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	441071	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	441071	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	CHEMBL227934	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	CHEMBL227934	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	CHEMBL227934	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	DB15954	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
	DB15954	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
	DB15954	3667	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
	335	1823	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
	3500	1823	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
	CHEMBL157822	1823	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
	346	3663	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	44259	3663	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	CHEMBL388978	3663	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	DB02010	3663	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
	15376	3963	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	349	3963	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	3643	3963	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	CHEMBL1165342	3963	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	DB13374	3963	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
	15118529	4052	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
	340	4052	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
	CHEMBL1256845	4052	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
	108152	2189	0	None	-1	2	Human	5.7	pKd	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
	338	2189	0	None	-1	2	Human	5.7	pKd	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
	339	4050	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
	9803245	4050	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
	CHEMBL2206331	4050	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
	2784	949	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	351	949	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	366	949	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	676	949	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	CHEMBL620	949	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	DB00771	949	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	316	2816	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	317	2816	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	71183	2816	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	CHEMBL3140030	2816	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	CHEMBL376897	2816	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	DB00462	2816	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
	2784	949	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	351	949	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	366	949	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	676	949	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	CHEMBL620	949	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	DB00771	949	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
	23056	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	318	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	3260	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	CHEMBL12980	112	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	23056	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	318	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	3260	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	CHEMBL12980	112	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
	44431393	87995	0	UNDEFINED	1	3	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
	CHEMBL234440	87995	0	UNDEFINED	1	3	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
	1427	2000	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	132947	3835	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
	361	3835	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
	CHEMBL265256	3835	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
	325	2049	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	3746	2049	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	657308	2049	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	CHEMBL1615433	2049	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	DB00332	2049	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	187	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	131632304	216011	0	3H-QNB	-6	13	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	12057539	208018	42	3H-MQNB(-)	-2	21	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-MQNB(-)	-2	21	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-MQNB(-)	-2	21	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	44431384	148836	0	UNDEFINED	2	3	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
	CHEMBL394137	148836	0	UNDEFINED	2	3	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
	12057539	208018	42	3H-PIRENZEPINE	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-PIRENZEPINE	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-PIRENZEPINE	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-MQNB(-)	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-MQNB(-)	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-MQNB(-)	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-NMS	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-NMSP	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-QNB	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-NMS	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-NMSP	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-QNB	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-NMS	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-NMSP	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-QNB	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-NMS	-2	21	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-NMS	-2	21	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-NMS	-2	21	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-MQNB(-)	-2	21	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-MQNB(-)	-2	21	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-MQNB(-)	-2	21	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-Arachidonic Acid	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-NMS	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-Arachidonic Acid	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-NMS	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-Arachidonic Acid	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-NMS	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	24835791	216078	0	3H-MQNB(-)	1	2	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	5831	215938	0	3H-QNB	-29	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	42470	216157	0	3H-NMS	-3	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	345	10	0	3	4.9	CCN(CCCC(=O)C1CCCCC1)C(C)CC2=CC=C(C=C2)OC	None
	3246155	215937	0	3H-QNB	-6	17	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
	131632304	216011	0	3H-NMS	-10	13	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	325	2049	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	3746	2049	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	657308	2049	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	CHEMBL1615433	2049	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	DB00332	2049	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
	12057539	208018	42	3H-NMS	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-QNB	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	3H-MQNB(-)	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-NMS	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-QNB	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-MQNB(-)	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-NMS	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-QNB	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-MQNB(-)	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	24835791	216078	0	3H-MQNB(-)	-1	2	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	12057539	208018	42	3H-QNB	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	3H-QNB	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	3H-QNB	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	16721019	87957	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
	CHEMBL234258	87957	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
	44431389	146126	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
	CHEMBL391977	146126	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
	1734	116	10	3H-PIRENZEPINE	-12	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-PIRENZEPINE	-12	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-PIRENZEPINE	-12	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	135398737	955	93	3H-NMS	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-QNB	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-NMS	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-QNB	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-NMS	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-QNB	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-NMS	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-QNB	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-NMS	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-QNB	-6	92	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	154825138	216012	0	3H-4-DAMP	-1	12	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154825138	216012	0	3H-NMS	-1	12	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	11434515	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	11519741	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	4484	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	7449	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	CHEMBL1194325	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	DB08897	261	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
	154825138	216012	0	3H-MQNB(-)	-1	12	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	2381	660	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	374	660	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	7128	660	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	CHEMBL1101	660	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	DB00810	660	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	71202	216346	0	3H-NMS	-3	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	340	3	0	3	4.9	CC1(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)SCCN(C)C)C	None
	202	1496	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1496	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1496	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1496	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1496	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	5656	203043	87	UNDEFINED	-25	43	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203043	87	UNDEFINED	-25	43	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	54841	203104	52	UNDEFINED	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	CHEMBL641	203104	52	UNDEFINED	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	11957621	216013	0	3H-NMS	-12	10	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
	11957621	216013	0	3H-NMS	-12	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
	3075702	217305	0	3H-AF-DX384	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
	145	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	179	399	115	3H-QNB	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-QNB	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-QNB	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-QNB	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-QNB	-4365	51	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	141	1415	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1415	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1415	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1415	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	119376	1828	48	3H-NMS	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	247	1828	48	3H-NMS	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	CHEMBL33884	1828	48	3H-NMS	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	1353	1898	93	3H-QNB	-5011	86	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-QNB	-5011	86	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-QNB	-5011	86	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-QNB	-5011	86	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-QNB	-5011	86	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1588	2311	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	290	2456	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	4022	2456	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	5926	2456	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	CHEMBL40554	2456	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	CHEMBL74300	2456	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
	15897	2840	0	3H-QNB	-204	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-QNB	-204	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-QNB	-204	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	2166	3101	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3101	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3101	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3101	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3101	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	2200	3109	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	119570	3137	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3137	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3137	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3137	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3137	96	3H-QNB	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2389	3306	118	3H-QNB	-2818	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-QNB	-2818	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-QNB	-2818	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-QNB	-2818	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-QNB	-2818	68	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	128563	3438	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	1666	3438	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	CHEMBL445332	3438	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	DB12327	3438	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	6917970	3665	61	3H-QNB	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	8370	3665	61	3H-QNB	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	CHEMBL487387	3665	61	3H-QNB	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	1267	3775	49	3H-NMS	-4168	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	3035905	3775	49	3H-NMS	-4168	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	CHEMBL260374	3775	49	3H-NMS	-4168	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
	213	3824	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	3H-QNB	-912	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	185	3975	60	3H-QNB	-30902	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3975	60	3H-QNB	-30902	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3975	60	3H-QNB	-30902	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3975	60	3H-QNB	-30902	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	2865	4112	73	3H-QNB	-1659	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-QNB	-1659	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-QNB	-1659	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-QNB	-1659	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-QNB	-1659	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	103	4122	61	3H-QNB	-177	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-QNB	-177	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-QNB	-177	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-QNB	-177	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-QNB	-177	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2662	11352	131	3H-QNB	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11352	131	3H-QNB	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	5090	15529	106	3H-QNB	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	15529	106	3H-QNB	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	10297	27081	30	3H-QNB	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	CHEMBL136560	27081	30	3H-QNB	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	156391	46770	99	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL1200806	46770	99	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL154	46770	99	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	115237	55555	119	3H-QNB	-42657	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	3H-QNB	-42657	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	10624	70271	19	3H-QNB	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	70271	19	3H-QNB	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	70271	19	3H-QNB	-776	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	1979	77297	70	3H-cAMP	-14	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77297	70	3H-cAMP	-14	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	2244	94204	100	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	CHEMBL25	94204	100	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	3025067	99354	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	65853	99354	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	CHEMBL282614	99354	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
	3663	99939	83	3H-QNB	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	CHEMBL286494	99939	83	3H-QNB	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	37632	111565	28	3H-QNB	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
	CHEMBL328250	111565	28	3H-QNB	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
	3452843	119499	15	3H-NMS	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
	CHEMBL345686	119499	15	3H-NMS	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
	446220	133496	14	3H-QNB	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	CHEMBL370805	133496	14	3H-QNB	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	44208932	140682	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
	CHEMBL381689	140682	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
	1615	167767	24	3H-QNB	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167767	24	3H-QNB	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	5280343	188251	124	3H-QNB	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL1520590	188251	124	3H-QNB	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL50	188251	124	3H-QNB	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	3672	192509	136	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	CHEMBL521	192509	136	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	54676228	193591	112	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	CHEMBL527	193591	112	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	4495	196512	92	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	CHEMBL56367	196512	92	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	54677470	200528	115	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL1256873	200528	115	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL599	200528	115	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	162265	202251	22	3H-QNB	-239	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	202251	22	3H-QNB	-239	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	202251	22	3H-QNB	-239	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	5281600	203002	92	3H-QNB	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	CHEMBL63354	203002	92	3H-QNB	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	5656	203043	87	3H-QNB	-25	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203043	87	3H-QNB	-25	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	1973	203460	15	3H-AF-DX384	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL1394464	203460	15	3H-AF-DX384	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL66089	203460	15	3H-AF-DX384	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	202478	204664	20	3H-QNB	-97	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
	CHEMBL7393	204664	20	3H-QNB	-97	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
	5311189	204818	11	3H-QNB	-194	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
	CHEMBL7549	204818	11	3H-QNB	-194	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
	4158	205318	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL1722	205318	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL796	205318	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	4054	205478	72	3H-QNB	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL1699	205478	72	3H-QNB	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL807	205478	72	3H-QNB	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	119607	206180	113	3H-QNB	-97	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	CHEMBL865	206180	113	3H-QNB	-97	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	3337	206344	27	3H-QNB	-120	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-QNB	-120	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-QNB	-120	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-QNB	-120	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-QNB	-120	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	444	206643	53	3H-QNB	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
	CHEMBL894	206643	53	3H-QNB	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
	16231	207486	57	3H-NMS	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
	CHEMBL945	207486	57	3H-NMS	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
	5831	215938	0	3H-NMS	-29	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	11954259	215954	0	3H-QNB	-15135	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	104911	215994	0	3H-QNB	-41686	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	None	216001	0	3H-NMS	-6309	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
	24835791	216078	0	3H-MQNB(-)	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	None	216109	0	3H-QNB	-10471	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
	40589	216118	0	3H-QNB	-407	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	377	7	0	6	2.5	CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl	None
	25137849	216153	0	3H-QNB	-4	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	216153	0	3H-QNB	-4	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	None	216213	0	3H-QNB	-95499	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
	None	216285	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
	None	216286	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
	None	216287	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
	None	216288	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
	None	216289	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
	None	216290	0	3H-QNB	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
	None	216291	0	3H-QNB	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
	None	216292	0	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
	None	216299	0	3H-QNB	-13	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
	1576	216300	0	3H-QNB	-16	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
	None	216301	0	3H-QNB	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
	4978	216302	0	3H-QNB	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
	None	216303	0	3H-QNB	-3	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
	None	216304	0	3H-QNB	-281	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
	None	216305	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
	135269	216363	0	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
	23681059	216364	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
	5018304	216365	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
	84003	216366	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
	119828	216368	0	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
	None	216369	0	3H-QNB	-7	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
	None	216462	0	3H-QNB	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
	None	216466	0	3H-NMS	-10471285	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	372	2	1	3	4.4	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl	None
	None	216467	0	3H-NMS	-1	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
	20980871	216403	0	3H-QNB	-27	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
	367	3795	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	5487427	3795	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	8592	3795	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL1900528	3795	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL3305968	3795	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL4650755	3795	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	DB01409	3795	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	9399	216080	0	3H-MQNB(-)	-	1	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	493	3	2	4	-1.1	C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C.[Br-]	None
	180	400	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	1971	2846	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	2404	2846	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	4543	2846	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	CHEMBL445	2846	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	DB00540	2846	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	44431388	87290	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
	CHEMBL233202	87290	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
	44431380	87956	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
	CHEMBL234257	87956	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
	154825138	216012	0	3H-MQNB(-)	-1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154825138	216012	0	3H-NMS	-1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154825138	216012	0	3H-NMS	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154734599	2486	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	154734599	2486	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	1224	1420	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	3100	1420	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	8980	1420	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	916	1420	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	CHEMBL657	1420	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	DB01075	1420	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	310	1909	0	3H-NMS	-25	11	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	3602	1909	0	3H-NMS	-25	11	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	CHEMBL3545990	1909	0	3H-NMS	-25	11	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	1353	1898	93	3H-NMS	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1898	93	3H-QNB	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-NMS	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-QNB	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-NMS	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-QNB	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-NMS	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-QNB	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-NMS	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-QNB	-338	86	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3652	4066	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4066	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4066	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4066	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4066	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	None	216231	0	3H-4-DAMP	-8	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
	1734	116	10	3H-NMS	-12	13	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-NMS	-12	13	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-NMS	-12	13	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	154734599	2486	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	2745	3832	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3832	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3832	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3832	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3832	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3832	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	None	216231	0	3H-NMS	-8	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
	2337	3232	77	3H-QNB	-31	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-QNB	-31	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-QNB	-31	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-QNB	-31	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-QNB	-31	63	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135398737	955	93	3H-QNB	-22	92	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-QNB	-22	92	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-QNB	-22	92	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-QNB	-22	92	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-QNB	-22	92	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	100	3776	58	3H-QNB	-19	56	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-QNB	-19	56	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-QNB	-19	56	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-QNB	-19	56	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-QNB	-19	56	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	4066	204603	78	3H-QNB	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	CHEMBL73451	204603	78	3H-QNB	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	154825138	216012	0	3H-MQNB(-)	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	154734599	2486	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	103	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	103	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-QNB	-177	54	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	4601	206724	35	3H-NMS	-6	17	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	206724	35	3H-NMS	-6	17	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	206724	35	3H-NMS	-6	17	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	4839	216349	0	3H-NMS	-3	5	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	323	5	0	3	3.8	CCN1CCCC(C1)OC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	None
	2274	3151	58	3H-QNB	-100	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	3H-QNB	-100	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	3H-QNB	-100	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	3H-QNB	-100	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	3H-QNB	-100	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	1712	2475	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2475	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2475	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2475	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2475	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	154825138	216012	0	3H-NMS	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	2270	3149	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4811	3149	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4913	3149	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	CHEMBL640	3149	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	DB01035	3149	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	2726	916	68	3H-QNB	-79	73	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-QNB	-79	73	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-QNB	-79	73	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-QNB	-79	73	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-QNB	-79	73	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	3012003	216119	0	3H-QNB	-1	12	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
	308	2047	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	3603	2047	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	CHEMBL1256682	2047	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	154734599	2486	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	5387	94850	31	3H-NMS	-19	6	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
	CHEMBL253978	94850	31	3H-NMS	-19	6	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
	1225	1459	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1459	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1459	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1459	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1459	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	73707487	216348	0	3H-NMS	-23	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
	1273	1741	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1741	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1741	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1741	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1741	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1741	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1741	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	308	2047	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	3603	2047	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	CHEMBL1256682	2047	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	135398745	2893	112	3H-NMS	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	3H-QNB	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-NMS	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-QNB	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-NMS	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-QNB	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-NMS	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-QNB	-9	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	101	3793	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	55752	3793	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL35057	3793	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	2448	99295	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99295	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	2448	99295	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99295	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	5831	215938	0	3H-MQNB(-)	-29	12	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	3337	206344	27	3H-QNB	-120	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-QNB	-120	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-QNB	-120	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-QNB	-120	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-QNB	-120	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	154734599	2486	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	None	216228	0	3H-NMS	-1659	21	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
	2200	3109	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	44431383	87993	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
	CHEMBL234439	87993	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
	131632304	216011	0	3H-QNB	-6	13	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
	2230	464	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	296	464	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	CHEMBL7303	464	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	DB04365	464	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	44431381	148997	0	UNDEFINED	1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
	CHEMBL394254	148997	0	UNDEFINED	1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
	None	216230	0	3H-NMS	-5	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
	124226	1908	0	3H-NMS	-19	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	322	1908	0	3H-NMS	-19	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	5831	215938	0	3H-MQNB(-)	-190	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	135398737	955	93	3H-NMS	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	955	93	3H-NMSP	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-NMS	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-NMSP	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-NMS	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-NMSP	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-NMS	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-NMSP	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-NMS	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-NMSP	-22	92	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	5831	215938	0	3H-MQNB(-)	-190	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	68617	205504	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	205504	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	205504	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	11954259	215954	0	3H-QNB	-15135	44	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	4601	206724	35	3H-QNB	-2	17	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	206724	35	3H-QNB	-2	17	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	206724	35	3H-QNB	-2	17	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	2726	916	68	3H-MQNB(-)	-79	73	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-MQNB(-)	-79	73	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-MQNB(-)	-79	73	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-MQNB(-)	-79	73	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-MQNB(-)	-79	73	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1212	1649	50	3H-QNB	-1380	66	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-QNB	-1380	66	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-QNB	-1380	66	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-QNB	-1380	66	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-QNB	-1380	66	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	214	3831	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3831	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3831	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3831	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3831	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3831	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2200	3109	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	2200	3109	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1979	77297	70	3H-cAMP	-2	4	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77297	70	3H-cAMP	-2	4	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	302	2956	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	4630	2956	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	CHEMBL7634	2956	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	15387	45792	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45792	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	15387	45792	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45792	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	3042	1402	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1402	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1402	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1402	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1402	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	5831	215938	0	3H-cAMP	-190	12	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	310	1909	0	3H-NMS	-56	11	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	3602	1909	0	3H-NMS	-56	11	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	CHEMBL3545990	1909	0	3H-NMS	-56	11	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	10921	13013	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	2968	13013	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	CHEMBL1190	13013	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	4919	206211	23	3H-QNB	-3	9	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	CHEMBL86715	206211	23	3H-QNB	-3	9	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	2865	4112	73	3H-QNB	-1659	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-QNB	-1659	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-QNB	-1659	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-QNB	-1659	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-QNB	-1659	54	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	100	3776	58	3H-QNB	-19	56	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-QNB	-19	56	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-QNB	-19	56	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-QNB	-19	56	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-QNB	-19	56	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	1273	1741	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1741	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1741	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1741	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1741	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1741	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1741	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	2905	14466	50	3H-NMS	-16	5	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
	CHEMBL1201338	14466	50	3H-NMS	-16	5	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
	2200	3109	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1209	1645	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	2726	916	68	3H-QNB	-79	73	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-QNB	-79	73	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-QNB	-79	73	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-QNB	-79	73	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-QNB	-79	73	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	11976	917	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	209	3035	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	3035	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	3035	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	3035	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	3035	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	302	2956	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	4630	2956	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	CHEMBL7634	2956	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	1192	147	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	1794	147	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	CHEMBL501701	147	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
	2028	2958	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2958	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2958	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2958	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2958	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	154734599	2486	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	1734	116	10	3H-QNB	-12	13	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-QNB	-12	13	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-QNB	-12	13	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	1734	116	10	3H-NMS	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-NMS	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-NMS	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	3246155	215937	0	3H-NMS	-16	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
	1734	116	10	3H-4-DAMP	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-4-DAMP	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-4-DAMP	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	308	2047	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	3603	2047	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	CHEMBL1256682	2047	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
	1613	2333	53	3H-QNB	-42	45	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-QNB	-42	45	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-QNB	-42	45	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-QNB	-42	45	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-QNB	-42	45	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	2865	4112	73	3H-QNB	-1659	54	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-QNB	-1659	54	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-QNB	-1659	54	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-QNB	-1659	54	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-QNB	-1659	54	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	3042	1402	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1402	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1402	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1402	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1402	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	7534	216347	0	3H-NMS	-3	5	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	291	3	1	4	2.5	CC1CC(CC(N1C)(C)C)OC(=O)C(C2=CC=CC=C2)O	None
	3947	206372	53	3H-QNB	-6	16	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	CHEMBL87708	206372	53	3H-QNB	-6	16	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	114743	216075	0	3H-QNB	-1	8	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	291	1	1	1	4.9	C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N	None
	2200	3109	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	5831	215938	0	3H-cAMP	-29	12	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	3294	1993	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-NMS	-194	45	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	15897	2840	0	3H-QNB	-204	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-QNB	-204	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-QNB	-204	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	187	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	43815	186896	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL1708	186896	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL490	186896	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	187	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	130169	3578	0	3H-NMS	-26	5	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
	331	3578	0	3H-NMS	-26	5	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
	242	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-QNB	-295	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2389	3306	118	3H-QNB	-2818	68	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-QNB	-2818	68	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-QNB	-2818	68	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-QNB	-2818	68	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-QNB	-2818	68	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2200	3109	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	3337	206344	27	3H-QNB	-120	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-QNB	-120	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-QNB	-120	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-QNB	-120	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-QNB	-120	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	442108	84607	6	3H-QNB	-3	12	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
	CHEMBL222287	84607	6	3H-QNB	-3	12	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
	2370	620	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	297	620	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	358	620	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	CHEMBL1482	620	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	DB01019	620	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	5831	215938	0	3H-NMS	-29	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	129989	450	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
	8584	450	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
	CHEMBL43383	450	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
	10938	1689	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	299	1689	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	3256	1689	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	CHEMBL2110739	1689	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
	154734599	2486	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	154825138	216012	0	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	1734	116	10	3H-MQNB(-)	-9	13	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-MQNB(-)	-9	13	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-MQNB(-)	-9	13	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	71128	96781	25	3H-NMS	-3	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
	CHEMBL26505	96781	25	3H-NMS	-3	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
	44431376	87288	0	UNDEFINED	-2	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
	CHEMBL233200	87288	0	UNDEFINED	-2	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
	135409468	2022	69	3H-QNB	-114	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	2022	69	3H-QNB	-114	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	2022	69	3H-QNB	-114	40	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	2200	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	62865	1263	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1263	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1263	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1263	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1263	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	154734599	2486	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4919	206211	23	3H-NMS	-9	9	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	CHEMBL86715	206211	23	3H-NMS	-9	9	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	187	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	2726	916	68	3H-QNB	-79	73	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-QNB	-79	73	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-QNB	-79	73	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-QNB	-79	73	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-QNB	-79	73	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1979	77297	70	3H-cAMP	-14	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77297	70	3H-cAMP	-14	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	154734599	2486	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	44431372	87286	0	UNDEFINED	1	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	CHEMBL233198	87286	0	UNDEFINED	1	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	2200	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1830	2572	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2572	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2572	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2572	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2572	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	5831	215938	0	3H-MQNB(-)	-190	12	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	208	2843	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	4541	2843	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL1494	2843	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	2200	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	None	216202	0	3H-NMS	-56	6	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	426	7	1	3	4.0	C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5	None
	135398745	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2200	3109	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	10090005	215961	0	3H-QNB	-588	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	361	1	0	3	4.4	CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42	None
	135398737	955	93	3H-QNB	-22	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-QNB	-22	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-QNB	-22	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-QNB	-22	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-QNB	-22	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398745	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-QNB	-38	66	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	44431369	87954	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	CHEMBL234253	87954	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
	302	2956	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	4630	2956	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	CHEMBL7634	2956	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
	2745	3832	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3832	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3832	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3832	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3832	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3832	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	154734599	2486	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	44431375	87287	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
	CHEMBL233199	87287	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
	44431370	87955	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
	CHEMBL234254	87955	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
	2166	3101	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3101	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3101	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3101	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3101	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	3823	50191	42	None	-44	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	76973198	50191	42	None	-44	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	CHEMBL157101	50191	42	None	-44	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	44431391	146396	0	UNDEFINED	-1	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
	CHEMBL392186	146396	0	UNDEFINED	-1	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
	3389	217683	0	None	1	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
	2812	4747	101	None	-33	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	CHEMBL104	4747	101	None	-33	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	2719	914	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	5535	914	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	607	914	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	CHEMBL76	914	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	DB00608	914	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
	441383	20301	57	None	-7	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	CHEMBL1306	20301	57	None	-7	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
	2389	3306	118	None	-2818	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	None	-2818	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	None	-2818	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	None	-2818	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	None	-2818	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	242	469	124	None	-295	52	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	None	-295	52	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	None	-295	52	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	None	-295	52	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	None	-295	52	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	3294	1993	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	None	-194	45	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	1016	3720	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3720	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3720	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3720	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3720	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3720	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	1209	1645	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1212	1649	50	None	-1380	66	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	None	-1380	66	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	None	-1380	66	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	None	-1380	66	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	None	-1380	66	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66265	93984	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL248702	93984	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	1210	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	915	51	None	-162	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1273	1741	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1741	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1741	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1741	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1741	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1741	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1741	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	15387	45792	55	None	-16	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	CHEMBL1531134	45792	55	None	-16	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
	212	3777	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	2639	3777	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	941651	3777	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	CHEMBL1201	3777	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	DB01623	3777	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	68617	205504	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	205504	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	205504	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	176	397	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	397	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	397	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	397	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	397	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2448	99295	70	None	-72	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL28218	99295	70	None	-72	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
	4189	206899	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1559	206899	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL91	206899	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	1548955	88552	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	2800	88552	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	CHEMBL2355051	88552	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	3198	205490	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1201049	205490	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL808	205490	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	2274	3151	58	None	-100	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	None	-100	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	None	-100	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	None	-100	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	None	-100	32	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	3652	46214	70	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
	CHEMBL1535	46214	70	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
	72064	78372	14	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
	CHEMBL2110892	78372	14	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
	2774	3839	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	5593	3839	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	7319	3839	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	CHEMBL1200604	3839	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB00809	3839	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB01199	3839	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	310	1909	0	3H-QNB	-25	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	3602	1909	0	3H-QNB	-25	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	CHEMBL3545990	1909	0	3H-QNB	-25	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
	2200	3109	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	183782	3373	20	3H-NMS	-1202	15	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	237	3373	20	3H-NMS	-1202	15	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL85251	3373	20	3H-NMS	-1202	15	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
	2200	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1613	2333	53	3H-QNB	-42	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-QNB	-42	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-QNB	-42	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-QNB	-42	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-QNB	-42	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	1353	1898	93	3H-QNB	-5011	86	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-QNB	-5011	86	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-QNB	-5011	86	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-QNB	-5011	86	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-QNB	-5011	86	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2230	464	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	296	464	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	CHEMBL7303	464	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	DB04365	464	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
	2200	3109	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	2995	204382	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	15897	2840	0	3H-QNB	-204	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-QNB	-204	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-QNB	-204	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	108107	79915	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	156592250	79915	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	CHEMBL1256878	79915	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	CHEMBL212579	79915	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
	1613	2333	53	3H-QNB	-42	45	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	3H-QNB	-42	45	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	3H-QNB	-42	45	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	3H-QNB	-42	45	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	3H-QNB	-42	45	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	9905731	168484	0	UNDEFINED	1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
	CHEMBL435353	168484	0	UNDEFINED	1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
	191	402	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	None	216232	0	3H-NMS	1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	574	9	3	7	4.0	CCCN(CCC)CC1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4.CS(=O)(=O)O	None
	2337	3232	77	None	-31	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	None	-31	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	None	-31	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	None	-31	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	None	-31	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	3236	67579	43	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
	CHEMBL1902981	67579	43	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
	1273	1741	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1741	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1741	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1741	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1741	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1741	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1741	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	4011	82379	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	CHEMBL21731	82379	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	44431382	87992	0	UNDEFINED	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
	CHEMBL234438	87992	0	UNDEFINED	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
	4098	32475	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1255739	32475	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1411979	32475	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	2995	204382	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	11057	176125	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	3468	176125	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	CHEMBL459265	176125	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	CHEMBL64894	176125	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
	4735	195092	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
	CHEMBL361506	195092	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
	CHEMBL55	195092	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
	2247	504	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	504	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	504	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	504	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	504	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2381	660	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	374	660	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	7128	660	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	CHEMBL1101	660	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	DB00810	660	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
	1530	2169	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	3827	2169	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	7206	2169	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	CHEMBL534	2169	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	DB00920	2169	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	6726	1269	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	7151	1269	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	749	1269	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	CHEMBL648	1269	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	DB01176	1269	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	1613	2333	53	None	-42	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2333	53	None	-42	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2333	53	None	-42	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2333	53	None	-42	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2333	53	None	-42	45	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	6918558	14482	41	None	-1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
	CHEMBL1201764	14482	41	None	-1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
	2284	3160	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	4926	3160	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	7281	3160	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	CHEMBL564	3160	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	DB00420	3160	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	135	2515	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	None	-25	58	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	237	204842	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	CHEMBL546257	204842	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	CHEMBL554190	204842	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	CHEMBL7568	204842	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
	3947	206372	53	None	-6	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	CHEMBL87708	206372	53	None	-6	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
	187	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	3191	102831	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	CHEMBL305660	102831	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	3055	1421	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	313	1421	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	7163	1421	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	CHEMBL936	1421	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	DB01231	1421	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
	3042	1402	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1402	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1402	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1402	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1402	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	1353	1898	93	None	-338	86	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-338	86	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-338	86	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-338	86	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-338	86	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1935	3707	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3707	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3707	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3707	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3707	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2335	11816	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	8478	11816	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	CHEMBL1182210	11816	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	CHEMBL221753	11816	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
	6075	150084	42	None	-7	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	CHEMBL395110	150084	42	None	-7	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	26987	946	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	6063	946	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	671	946	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	CHEMBL1626	946	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	DB00283	946	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	1734	116	10	3H-MQNB(-)	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-MQNB(-)	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-MQNB(-)	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	43815	186896	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL1708	186896	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL490	186896	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	2726	916	68	None	-79	73	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-79	73	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-79	73	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-79	73	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-79	73	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	2200	3109	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	2562	204576	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
	CHEMBL1256696	204576	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
	CHEMBL73234	204576	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
	1225	1459	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1459	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1459	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1459	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1459	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	103	4122	61	None	-177	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	None	-177	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	None	-177	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	None	-177	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	None	-177	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	4601	206724	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	206724	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	206724	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	4976	203556	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	CHEMBL668	203556	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	154059	3610	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	2457	3610	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	7483	3610	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	CHEMBL1734	3610	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	DB01591	3610	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
	3652	4066	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4066	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4066	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4066	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4066	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	2200	3109	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	1224	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	3100	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	8980	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	916	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	CHEMBL657	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	DB01075	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	1971	2846	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	2404	2846	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	4543	2846	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	CHEMBL445	2846	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	DB00540	2846	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	5284550	41691	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
	CHEMBL1492500	41691	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
	134688371	14397	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
	13765	14397	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
	CHEMBL1200623	14397	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
	134	2497	24	3H-QNB	-154	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-QNB	-154	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-QNB	-154	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-QNB	-154	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-QNB	-154	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1979	77297	70	3H-cAMP	-2	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77297	70	3H-cAMP	-2	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	2389	3306	118	3H-QNB	-2818	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-QNB	-2818	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-QNB	-2818	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-QNB	-2818	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-QNB	-2818	68	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	6450478	215987	0	3H-QNB	-1	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	340	0	0	6	3.4	CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42	None
	135398745	2893	112	35S-GTPGammaS	-38	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	35S-GTPGammaS	-38	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	35S-GTPGammaS	-38	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	35S-GTPGammaS	-38	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2337	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3232	77	3H-NMS	-70	63	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-NMS	-70	63	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-NMS	-70	63	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-NMS	-70	63	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-NMS	-70	63	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-QNB	-31	63	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	1712	2475	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2475	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2475	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2475	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2475	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	277	1289	62	3H-QNB	-10	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-QNB	-10	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-QNB	-10	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-QNB	-10	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-QNB	-10	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2745	3832	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3832	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3832	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3832	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3832	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3832	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	129894468	216079	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
	2398	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	2801	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	701	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	CHEMBL415	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	DB01242	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	1734	116	10	3H-NMS	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	307	116	10	3H-NMS	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	CHEMBL168067	116	10	3H-NMS	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
	2745	3832	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	5572	3832	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	66007	3832	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	7315	3832	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	CHEMBL1490	3832	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	DB00376	3832	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
	135398745	2893	112	None	-38	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	None	-38	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	None	-38	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	None	-38	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	4212	198656	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
	CHEMBL1417019	198656	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
	CHEMBL58	198656	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
	73707487	216348	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
	319	1312	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	321	1312	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	444031	1312	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	784	1312	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	CHEMBL1346	1312	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	DB00496	1312	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	44431387	87289	0	UNDEFINED	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
	CHEMBL233201	87289	0	UNDEFINED	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
	1726	2480	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	1993	2480	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	7438	2480	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	CHEMBL978	2480	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	DB06709	2480	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	1726	2480	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	1993	2480	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	7438	2480	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	CHEMBL978	2480	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	DB06709	2480	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
	135398737	955	93	None	-22	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-22	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-22	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-22	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-22	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	3042	1402	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1402	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1402	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1402	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1402	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	135398737	955	93	None	-6	92	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-6	92	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-6	92	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-6	92	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-6	92	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	21855	84217	42	None	-7	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
	CHEMBL22108	84217	42	None	-7	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
	62865	1263	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1263	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1263	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1263	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1263	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	2774	3839	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	5593	3839	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	7319	3839	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	CHEMBL1200604	3839	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB00809	3839	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	DB01199	3839	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
	6472	202724	35	None	-4	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
	CHEMBL61946	202724	35	None	-4	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
	24096961	216081	0	3H-MQNB(-)	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
	319	1312	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	321	1312	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	444031	1312	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	784	1312	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	CHEMBL1346	1312	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	DB00496	1312	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
	124087	1377	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	7157	1377	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	814	1377	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	CHEMBL1172	1377	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	DB00967	1377	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	1371	1910	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	24199	1910	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	323	1910	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	CHEMBL1201325	1910	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	DB06787	1910	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
	10921	13013	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	2968	13013	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	CHEMBL1190	13013	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
	4919	206211	23	None	-3	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	CHEMBL86715	206211	23	None	-3	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
	5648	78382	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
	CHEMBL2107687	78382	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
	CHEMBL2111176	78382	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
	2270	3149	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4811	3149	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	4913	3149	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	CHEMBL640	3149	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	DB01035	3149	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
	1712	2475	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2475	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2475	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2475	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2475	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	100	3776	58	None	-19	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	None	-19	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	None	-19	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	None	-19	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	None	-19	56	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2286	3161	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	4927	3161	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	7282	3161	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	CHEMBL643	3161	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	DB01069	3161	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	154825138	216012	0	3H-PIRENZEPINE	-1	12	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
	187	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	294	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	65	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	8593	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	CHEMBL667	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	DB03128	255	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
	279	1648	26	3H-QNB	-14	18	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	49381	1648	26	3H-QNB	-14	18	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	CHEMBL63756	1648	26	3H-QNB	-14	18	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	1212	1649	50	3H-QNB	-1380	66	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	3H-QNB	-1380	66	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	3H-QNB	-1380	66	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	3H-QNB	-1380	66	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	3H-QNB	-1380	66	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	None	216230	0	3H-NMS	-5	5	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
	154734599	2486	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	327	2486	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	4108	2486	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	CHEMBL27673	2486	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
	135398745	2893	112	3H-QNB	-38	66	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-QNB	-38	66	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-QNB	-38	66	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-QNB	-38	66	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	11976	917	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	2200	3109	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	277	1289	62	None	-10	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	None	-10	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	None	-10	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	None	-10	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	None	-10	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1427	2000	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	2028	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2958	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	5831	215938	0	None	-1	12	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	180	400	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2028	2958	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2958	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2958	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2958	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2958	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	1086	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	3290	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	7181	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	CHEMBL1206	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	DB00392	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
	4904	155497	48	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
	CHEMBL404215	155497	48	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
	2028	2958	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2958	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2958	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2958	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2958	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	2705	3813	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	360	3813	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	443879	3813	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	CHEMBL1382	3813	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	DB01036	3813	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	5831	215938	0	None	-190	12	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	2705	3813	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	360	3813	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	443879	3813	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	CHEMBL1382	3813	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	DB01036	3813	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
	1201549	594	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	333	594	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	7601	594	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL1201203	594	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL438151	594	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	DB00245	594	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	24835791	216078	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	44431386	149001	0	UNDEFINED	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
	CHEMBL394255	149001	0	UNDEFINED	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
	25897919	55622	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	657309	55622	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1464005	55622	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1621597	55622	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	1201549	594	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	333	594	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	7601	594	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL1201203	594	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL438151	594	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	DB00245	594	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	11968014	12726	5	None	-4	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	CHEMBL1187846	12726	5	None	-4	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
	24835791	216078	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	123134663	217700	0	None	-1	3	Dog	8.1	pKi	=	8.1	Binding	radioligand ([3H]QNB) displacement assayradioligand ([3H]QNB) displacement assay	Drug Central	330	2	0	2	5.4	C[N@+]12CCCC[C@@H]1CCC(C2)=C(C1=CC=CS1)C1=CC=CS1	None
	12057539	208018	42	None	-2	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	None	-2	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	None	-2	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	135398737	955	93	3H-QNB	-22	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-QNB	-22	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-QNB	-22	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-QNB	-22	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-QNB	-22	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	100	3776	58	3H-QNB	-19	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	3H-QNB	-19	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	3H-QNB	-19	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	3H-QNB	-19	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	3H-QNB	-19	56	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	1427	2000	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	2000	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	2000	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	2000	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	2000	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	25897919	55622	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	657309	55622	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1464005	55622	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL1621597	55622	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
	12057539	208018	42	None	-2	21	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	None	-2	21	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	None	-2	21	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	10470	2471	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	1689	2471	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	4057	2471	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	CHEMBL524004	2471	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	DB04843	2471	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
	11693	1814	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	3494	1814	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	4302	1814	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	7459	1814	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	CHEMBL1201335	1814	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	DB00986	1814	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
	154417	23149	60	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
	CHEMBL1331216	23149	60	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
	12057539	208018	42	None	-17	21	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	3661	208018	42	None	-17	21	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	CHEMBL9751	208018	42	None	-17	21	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
	2293	3164	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	329	3164	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	4934	3164	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	CHEMBL1180725	3164	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	DB00782	3164	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
	10129	3297	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	11753673	3297	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	5303	3297	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	CHEMBL3833319	3297	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	DB11855	3297	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
	316	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	317	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	71183	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL3140030	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL376897	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	DB00462	2816	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	367	3795	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	5487427	3795	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	8592	3795	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL1900528	3795	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL3305968	3795	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	CHEMBL4650755	3795	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	DB01409	3795	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
	11519069	3908	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	11519070	3908	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	4816	3908	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	7354	3908	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	CHEMBL1187833	3908	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	DB09076	3908	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
	44431367	87953	0	UNDEFINED	-4	3	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
	CHEMBL234252	87953	0	UNDEFINED	-4	3	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
	2200	3109	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	328	3109	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	4848	3109	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	CHEMBL9967	3109	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	DB00670	3109	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
	24835791	216078	0	3H-MQNB(-)	1	2	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
	11954224	215928	0	3H-QNB	-1047	60	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	46780481	107504	20	3H-NMS	-436	54	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	3H-NMS	-436	54	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	3H-NMS	-436	54	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	3H-NMS	-436	54	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	135398745	2893	112	3H-NMS	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2893	112	3H-NMSP	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-NMS	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-NMSP	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-NMS	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-NMSP	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-NMS	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-NMSP	-38	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	129894468	216079	0	3H-MQNB(-)	-	1	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
	10104	3540	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
	6604866	3540	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
	CHEMBL1493369	3540	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
	10129	3297	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	11753673	3297	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	5303	3297	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	CHEMBL3833319	3297	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	DB11855	3297	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
	1201549	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	333	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	7601	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	CHEMBL1201203	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	CHEMBL438151	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	DB00245	594	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
	1086	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	3290	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	7181	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	CHEMBL1206	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	DB00392	1577	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
	123603	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	2684	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	584	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	9658	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	CHEMBL168815	880	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
	367	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	367	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	367	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	367	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	5487427	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	5487427	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	5487427	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	5487427	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	8592	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	8592	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	8592	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	8592	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	CHEMBL1900528	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	CHEMBL1900528	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	CHEMBL1900528	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	CHEMBL1900528	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	CHEMBL3305968	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	CHEMBL3305968	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	CHEMBL3305968	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	CHEMBL3305968	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	CHEMBL4650755	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	CHEMBL4650755	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	CHEMBL4650755	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	CHEMBL4650755	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	DB01409	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
	DB01409	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
	DB01409	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
	DB01409	3795	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
	8598	1261	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	91827377	1261	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	2370	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	2370	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	297	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	297	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	358	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	358	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	CHEMBL1482	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	CHEMBL1482	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	DB01019	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
	DB01019	620	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
	2166	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	2166	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	305	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	305	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	5910	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	5910	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	CHEMBL550	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	CHEMBL550	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	DB01085	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
	DB01085	3101	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
	2551	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	2551	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	298	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	298	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	488	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	488	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	CHEMBL965	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	CHEMBL965	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	DB00411	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
	DB00411	791	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
	2230	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	2230	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	2230	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	296	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	296	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	296	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	CHEMBL7303	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	CHEMBL7303	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	CHEMBL7303	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	DB04365	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
	DB04365	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
	DB04365	464	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
	129786	1878	0	None	-141	4	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
	3276	1878	0	None	-141	4	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
	187	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	187	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	187	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	294	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	294	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	294	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	65	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	65	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	65	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	8593	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	8593	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	8593	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	CHEMBL667	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	CHEMBL667	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	CHEMBL667	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	DB03128	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
	DB03128	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
	DB03128	255	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
	302	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
	302	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
	4630	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
	4630	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
	CHEMBL7634	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
	CHEMBL7634	2956	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
	24768606	3999	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
	3274	3999	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
	CHEMBL1628667	3999	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	2200	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	328	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	4848	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	CHEMBL9967	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
	DB00670	3109	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	1273	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	1273	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	1273	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	3450	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	3450	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	3450	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	356	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	356	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	356	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	6172	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	6172	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	6172	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	67425	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	67425	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	67425	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	CHEMBL360055	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	CHEMBL360055	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	CHEMBL360055	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	DB00483	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
	DB00483	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
	DB00483	1741	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	107867	2953	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
	107867	2953	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	309	2953	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
	309	2953	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	CHEMBL17045	2953	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
	CHEMBL17045	2953	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	5282426	1454	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	7549	1454	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	CHEMBL108947	1454	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
	154059	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	154059	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	2457	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	2457	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	7483	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	7483	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	CHEMBL1734	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	CHEMBL1734	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	DB01591	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
	DB01591	3610	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
	3652	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	3652	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	3652	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	57	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	57	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	57	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	60809	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	60809	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	60809	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	CHEMBL21536	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	CHEMBL21536	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	CHEMBL21536	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	DB15357	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
	DB15357	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
	DB15357	4066	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	2774	3839	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	5593	3839	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	7319	3839	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	CHEMBL1200604	3839	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	DB00809	3839	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	DB01199	3839	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
	1726	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	1726	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	1993	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	1993	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	7438	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	7438	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	CHEMBL978	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	CHEMBL978	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	DB06709	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
	DB06709	2480	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
	319	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	319	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	319	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	321	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	321	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	321	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	444031	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	444031	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	444031	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	784	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	784	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	784	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	CHEMBL1346	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	CHEMBL1346	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	CHEMBL1346	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	DB00496	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
	DB00496	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
	DB00496	1312	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
	129140	3903	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
	129140	3903	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
	8583	3903	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
	8583	3903	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
	154734599	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	154734599	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	154734599	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	154734599	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	154734599	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	154734599	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	327	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	327	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	327	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	327	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	327	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	327	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	4108	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	4108	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	4108	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	4108	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	4108	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	4108	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	CHEMBL27673	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
	CHEMBL27673	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
	CHEMBL27673	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
	CHEMBL27673	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
	CHEMBL27673	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
	CHEMBL27673	2486	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	180	400	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	200	400	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	2160	400	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	CHEMBL629	400	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	DB00321	400	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
	2028	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	359	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	4634	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	CHEMBL1231	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	DB01062	2958	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	2028	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	2028	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	359	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	359	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	4634	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	4634	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	CHEMBL1231	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	CHEMBL1231	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	DB01062	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
	DB01062	2958	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
	324	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
	324	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
	324	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
	324	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	6436265	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
	6436265	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
	6436265	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
	6436265	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	CHEMBL277642	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
	CHEMBL277642	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
	CHEMBL277642	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
	CHEMBL277642	1912	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	119357	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	119357	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	3264	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	3264	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	368	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	368	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	CHEMBL279453	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
	CHEMBL279453	303	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
	1734	116	10	None	-9	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
	307	116	10	None	-9	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
	CHEMBL168067	116	10	None	-9	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
	129989	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
	129989	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
	8584	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
	8584	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
	CHEMBL43383	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
	CHEMBL43383	450	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
	2705	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	2705	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	360	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	360	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	443879	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	443879	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	CHEMBL1382	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	CHEMBL1382	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	DB01036	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
	DB01036	3813	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
	174174	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	174174	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	174174	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	174174	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	260	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	260	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	260	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	260	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	320	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	320	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	320	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	320	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	CHEMBL517712	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	CHEMBL517712	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	CHEMBL517712	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	CHEMBL517712	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	DB00572	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
	DB00572	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
	DB00572	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
	DB00572	521	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
	8586	300	0	None	-19	4	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
	9862598	300	0	None	-19	4	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
	3000322	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	3000322	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	330	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	330	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	CHEMBL569713	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	CHEMBL569713	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	DB00747	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
	DB00747	3536	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
	8600	341	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	91827379	341	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
	30843	1390	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	354	1390	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	831	1390	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	CHEMBL1908364	1390	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	DB08997	1390	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	10470	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	1689	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	4057	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	CHEMBL524004	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	DB04843	2471	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
	2293	3164	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	329	3164	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	4934	3164	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	CHEMBL1180725	3164	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	DB00782	3164	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
	11354367	3787	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
	3255	3787	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
	325	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	325	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	3746	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	3746	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	657308	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	657308	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	CHEMBL1615433	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	CHEMBL1615433	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	DB00332	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
	DB00332	2049	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
	132947	3835	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
	361	3835	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
	CHEMBL265256	3835	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
	11519069	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	11519069	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	11519070	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	11519070	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	4816	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	4816	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	7354	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	7354	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	CHEMBL1187833	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	CHEMBL1187833	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	DB09076	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
	DB09076	3908	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
	42519285	2560	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
	8591	2560	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
	CHEMBL3185781	2560	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
	314	2673	0	None	-1122018	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10799315
	313	2672	0	None	-407	6	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7925952
	134	2497	24	None	-154	68	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	None	-154	68	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	None	-154	68	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	None	-154	68	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	None	-154	68	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2865	4112	73	None	-1659	54	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	None	-1659	54	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	None	-1659	54	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	None	-1659	54	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	None	-1659	54	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	3337	206344	27	None	-120	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	None	-120	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	None	-120	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	None	-120	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	None	-120	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	46780481	107504	20	None	-436	54	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	None	-436	54	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	None	-436	54	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	None	-436	54	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	11954224	215928	0	None	-1047	60	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	3012003	216119	0	None	-1	12	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
	2895	203569	41	None	-1	8	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	CHEMBL669	203569	41	None	-1	8	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	11976	917	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	917	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	917	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	917	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	4066	204603	78	None	-1	7	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	CHEMBL73451	204603	78	None	-1	7	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
	24096961	216081	0	None	-	1	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
	11757797	2822	0	None	1	5	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	292	2822	0	None	1	5	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	10938	1689	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	299	1689	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	3256	1689	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	CHEMBL2110739	1689	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
	30844	2297	0	None	-1	2	Rat	4.8	pKi	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	358	2297	0	None	-1	2	Rat	4.8	pKi	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	300	2493	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
	4141	2493	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
	CHEMBL92387	2493	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
	303	2957	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	4629	2957	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	8595	2957	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	CHEMBL44674	2957	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
	30844	2297	0	None	1	2	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	358	2297	0	None	1	2	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	290	2456	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	4022	2456	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	5926	2456	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	CHEMBL40554	2456	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	CHEMBL74300	2456	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
	22991950	2314	0	None	-3	6	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
	326	2314	0	None	-3	6	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
	1273	1741	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	3450	1741	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	356	1741	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	6172	1741	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	67425	1741	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	CHEMBL360055	1741	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	DB00483	1741	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
	2229	463	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
	295	463	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
	CHEMBL128365	463	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
	2551	791	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	298	791	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	488	791	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	CHEMBL965	791	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	DB00411	791	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
	107867	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
	107867	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
	107867	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	309	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
	309	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
	309	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	CHEMBL17045	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
	CHEMBL17045	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
	CHEMBL17045	2953	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
	2200	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	2200	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	2200	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	328	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	328	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	328	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	4848	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	4848	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	4848	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	CHEMBL9967	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	CHEMBL9967	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	CHEMBL9967	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	DB00670	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
	DB00670	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
	DB00670	3109	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
	308	2047	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
	308	2047	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
	3603	2047	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
	3603	2047	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
	CHEMBL1256682	2047	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
	CHEMBL1256682	2047	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
	187	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	294	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	65	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	8593	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	CHEMBL667	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	DB03128	255	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
	302	2956	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
	4630	2956	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
	CHEMBL7634	2956	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
	3042	1402	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	355	1402	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	868	1402	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	CHEMBL1123	1402	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	DB00804	1402	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
	310	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	310	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
	310	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	3602	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	3602	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
	3602	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	CHEMBL3545990	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	CHEMBL3545990	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
	CHEMBL3545990	1909	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	124226	1908	0	None	-19	5	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	322	1908	0	None	-19	5	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
	310	1909	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
	310	1909	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	3602	1909	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
	3602	1909	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	CHEMBL3545990	1909	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
	CHEMBL3545990	1909	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
	1427	2000	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	357	2000	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	3696	2000	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	CHEMBL11	2000	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	DB00458	2000	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
	10259588	4048	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
	363	4048	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
	10426487	2821	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
	291	2821	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
	CHEMBL99521	2821	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
	154734599	2486	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	327	2486	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	4108	2486	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	CHEMBL27673	2486	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
	130169	3578	0	None	-26	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
	331	3578	0	None	-26	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
	1371	1910	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	24199	1910	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	323	1910	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	CHEMBL1201325	1910	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	DB06787	1910	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
	167962	4038	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	362	4038	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	CHEMBL31599	4038	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
	324	1912	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	6436265	1912	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	CHEMBL277642	1912	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
	10062394	3025	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
	304	3025	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
	CHEMBL130715	3025	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
	1734	116	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
	1734	116	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
	307	116	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
	307	116	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
	CHEMBL168067	116	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
	CHEMBL168067	116	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
	293	2823	0	None	-2	5	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	9985526	2823	0	None	-2	5	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
	10350027	1416	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	364	1416	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	365	1416	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
	350	3530	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
	9867750	3530	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
	CHEMBL73341	3530	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
	30843	1390	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	354	1390	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	831	1390	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	CHEMBL1908364	1390	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	DB08997	1390	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
	174174	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	174174	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	260	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	260	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	320	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	320	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	CHEMBL517712	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	CHEMBL517712	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
	DB00572	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
	DB00572	521	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790

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Ligand source activities (1 row/activity)