GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	3562	None	29	Human	Functional	pAC50	=	8.9	8.9	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3000322.0	3562	None	29	Human	Functional	pAC50	=	8.9	8.9	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3562	None	29	Human	Functional	pAC50	=	8.9	8.9	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3562	None	29	Human	Functional	pAC50	=	8.9	8.9	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3562	None	29	Human	Functional	pAC50	=	8.9	8.9	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11693	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494.0	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193.0	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1827	None	12	Human	Functional	pAC50	=	8	8.0	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	367	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427.0	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3824	None	10	Human	Functional	pAC50	=	8	8.0	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	3775	14481	None	19	Human	Functional	pAC50	=	8	8.0	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	3775.0	14481	None	19	Human	Functional	pAC50	=	8	8.0	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	14481	None	19	Human	Functional	pAC50	=	8	8.0	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB01625	14481	None	19	Human	Functional	pAC50	=	8	8.0	-1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	1613	2348	None	42	Human	Functional	pAC50	=	5	5.0	-169	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	None	42	Human	Functional	pAC50	=	5	5.0	-169	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	None	42	Human	Functional	pAC50	=	5	5.0	-169	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964.0	2348	None	42	Human	Functional	pAC50	=	5	5.0	-169	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	None	42	Human	Functional	pAC50	=	5	5.0	-169	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	None	42	Human	Functional	pAC50	=	5	5.0	-169	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2136	3095	None	24	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	None	24	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768.0	3095	None	24	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	None	24	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	None	24	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	None	24	Human	Functional	pAC50	=	5	5.0	-199	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	5280343	188382	None	69	Human	Functional	pAC50	=	5	5.0	-63	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL1520590	188382	None	69	Human	Functional	pAC50	=	5	5.0	-63	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL50	188382	None	69	Human	Functional	pAC50	=	5	5.0	-63	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Functional	pAC50	=	5.0	5.0	-323	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	4614	5393	None	62	Human	Functional	pAC50	=	5.0	5.0	-131	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	CHEMBL1071	5393	None	62	Human	Functional	pAC50	=	5.0	5.0	-131	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	47936	193531	None	56	Human	Functional	pAC50	=	5.0	5.0	-97	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193531	None	56	Human	Functional	pAC50	=	5.0	5.0	-97	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-309	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4940	14476	None	26	Human	Functional	pAC50	=	6.0	6.0	-18	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14476	None	26	Human	Functional	pAC50	=	6.0	6.0	-18	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	5573	67602	None	59	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	5573.0	67602	None	59	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1325297	67602	None	59	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL190044	67602	None	59	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	DB09089	67602	None	59	Human	Functional	pAC50	=	5.9	5.9	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	4919	208692	None	16	Human	Functional	pAC50	=	5.9	5.9	-5	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	4919.0	208692	None	16	Human	Functional	pAC50	=	5.9	5.9	-5	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	208692	None	16	Human	Functional	pAC50	=	5.9	5.9	-5	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00387	208692	None	16	Human	Functional	pAC50	=	5.9	5.9	-5	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3316	31768	None	42	Human	Functional	pAC50	=	4.9	4.9	-22	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31768	None	42	Human	Functional	pAC50	=	4.9	4.9	-22	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	21109	75025	None	48	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL203266	75025	None	48	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	26248	161633	None	72	Human	Functional	pAC50	=	4.9	4.9	1	11	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161633	None	72	Human	Functional	pAC50	=	4.9	4.9	1	11	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	4413	98126	None	43	Human	Functional	pAC50	=	4.9	4.9	-3	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98126	None	43	Human	Functional	pAC50	=	4.9	4.9	-3	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	9429	204590	None	44	Human	Functional	pAC50	=	4.9	4.9	-588	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	9429.0	204590	None	44	Human	Functional	pAC50	=	4.9	4.9	-588	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	204590	None	44	Human	Functional	pAC50	=	4.9	4.9	-588	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	DB01622	204590	None	44	Human	Functional	pAC50	=	4.9	4.9	-588	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3658	4107	None	38	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	None	38	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	None	38	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709.0	4107	None	38	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	None	38	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	None	38	Human	Functional	pAC50	=	4.9	4.9	-1258	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	2220	3134	None	58	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	None	58	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400.0	3134	None	58	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	None	58	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	None	58	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	None	58	Human	Functional	pAC50	=	6.9	6.9	-30	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	68873	43578	None	39	Human	Functional	pAC50	=	4.9	4.9	1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43578	None	39	Human	Functional	pAC50	=	4.9	4.9	1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	443955	206828	None	60	Human	Functional	pAC50	=	4.9	4.9	-11	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	206828	None	60	Human	Functional	pAC50	=	4.9	4.9	-11	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	21158560	112856	None	8	Human	Functional	pAC50	=	4.9	4.9	-3090	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL3305985	112856	None	8	Human	Functional	pAC50	=	4.9	4.9	-3090	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	656603	194645	None	3	Human	Functional	pAC50	=	7.8	7.8	-29	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL5292015	194645	None	3	Human	Functional	pAC50	=	7.8	7.8	-29	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	41684	31229	None	62	Human	Functional	pAC50	=	5.9	5.9	-3	32	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31229	None	62	Human	Functional	pAC50	=	5.9	5.9	-3	32	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4477	36546	None	57	Human	Functional	pAC50	=	5.9	5.9	-12	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL1448	36546	None	57	Human	Functional	pAC50	=	5.9	5.9	-12	4	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	5284550	41735	None	12	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	5284550.0	41735	None	12	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL108947	41735	None	12	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41735	None	12	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	DB09167	41735	None	12	Human	Functional	pAC50	=	5.9	5.9	-74	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	3149	12618	None	11	Human	Functional	pAC50	=	4.9	4.9	-38	26	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12618	None	11	Human	Functional	pAC50	=	4.9	4.9	-38	26	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	2333	142422	None	66	Human	Functional	pAC50	=	4.9	4.9	1	14	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142422	None	66	Human	Functional	pAC50	=	4.9	4.9	1	14	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2713	207729	None	57	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	207729	None	57	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	207729	None	57	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	207729	None	57	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	207729	None	57	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	207729	None	57	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	207729	None	57	Human	Functional	pAC50	=	4.9	4.9	-28	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	154257	178724	None	43	Human	Functional	pAC50	=	4.8	4.8	-42	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178724	None	43	Human	Functional	pAC50	=	4.8	4.8	-42	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	68617	207985	None	33	Human	Functional	pAC50	=	4.8	4.8	-18	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	207985	None	33	Human	Functional	pAC50	=	4.8	4.8	-18	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	207985	None	33	Human	Functional	pAC50	=	4.8	4.8	-18	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	216416	111644	None	40	Human	Functional	pAC50	=	4.8	4.8	-177	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111644	None	40	Human	Functional	pAC50	=	4.8	4.8	-177	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	5048	3133	None	50	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	8924	3133	None	50	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	9948102	3133	None	50	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	9948102.0	3133	None	50	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL462605	3133	None	50	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB11642	3133	None	50	Human	Functional	pAC50	=	4.8	4.8	-10000	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	107771	120312	None	42	Human	Functional	pAC50	=	4.8	4.8	1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	120312	None	42	Human	Functional	pAC50	=	4.8	4.8	1	9	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	5803	162321	None	58	Human	Functional	pAC50	=	4.8	4.8	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162321	None	58	Human	Functional	pAC50	=	4.8	4.8	-3	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	6127	14505	None	4	Human	Functional	pAC50	=	6.8	6.8	1	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	6127.0	14505	None	4	Human	Functional	pAC50	=	6.8	6.8	1	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14505	None	4	Human	Functional	pAC50	=	6.8	6.8	1	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13720	14505	None	4	Human	Functional	pAC50	=	6.8	6.8	1	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72093	35070	None	5	Human	Functional	pAC50	=	4.8	4.8	-14	28	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35070	None	5	Human	Functional	pAC50	=	4.8	4.8	-14	28	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35070	None	5	Human	Functional	pAC50	=	4.8	4.8	-14	28	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	20628	96601	None	25	Human	Functional	pAC50	=	4.8	4.8	-40	13	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96601	None	25	Human	Functional	pAC50	=	4.8	4.8	-40	13	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	447715	199383	None	50	Human	Functional	pAC50	=	4.8	4.8	-19	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	199383	None	50	Human	Functional	pAC50	=	4.8	4.8	-19	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	1024	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	5359318	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	5359318.0	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	556	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	65326	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	65326.0	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294.0	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL1523964	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL211456	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL2146102	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	DB01364	1571	None	12	Human	Functional	pAC50	=	4.8	4.8	-1	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	13314	84267	None	11	Human	Functional	pAC50	=	4.8	4.8	-2	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL22097	84267	None	11	Human	Functional	pAC50	=	4.8	4.8	-2	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	4450	178333	None	41	Human	Functional	pAC50	=	4.8	4.8	-26	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178333	None	41	Human	Functional	pAC50	=	4.8	4.8	-26	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-16	34	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	1816	2540	None	64	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	None	64	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205.0	2540	None	64	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	None	64	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	None	64	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	None	64	Human	Functional	pAC50	=	4.8	4.8	-2754	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4976	206037	None	20	Human	Functional	pAC50	=	5.8	5.8	-123	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	206037	None	20	Human	Functional	pAC50	=	5.8	5.8	-123	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	3036780	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3036780.0	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	46780481	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970.0	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL504548	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	DB06216	107587	None	16	Human	Functional	pAC50	=	4.7	4.7	-95499	15	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	5210	33346	None	22	Human	Functional	pAC50	=	4.7	4.7	-18	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	33346	None	22	Human	Functional	pAC50	=	4.7	4.7	-18	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	33346	None	22	Human	Functional	pAC50	=	4.7	4.7	-18	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	47936	193531	None	56	Human	Functional	pAC50	=	5.7	5.7	-97	6	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193531	None	56	Human	Functional	pAC50	=	5.7	5.7	-97	6	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	1530	2182	None	36	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2182	None	36	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827.0	2182	None	36	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2182	None	36	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2182	None	36	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2182	None	36	Human	Functional	pAC50	=	5.7	5.7	-63	25	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	1971	2866	None	32	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	None	32	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	None	32	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543.0	2866	None	32	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	None	32	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	None	32	Human	Functional	pAC50	=	5.7	5.7	-1023	32	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3000322	3562	None	29	Human	Functional	pAC50	=	7.7	7.7	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3000322.0	3562	None	29	Human	Functional	pAC50	=	7.7	7.7	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3562	None	29	Human	Functional	pAC50	=	7.7	7.7	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3562	None	29	Human	Functional	pAC50	=	7.7	7.7	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3562	None	29	Human	Functional	pAC50	=	7.7	7.7	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3108	209745	None	64	Human	Functional	pAC50	=	5.7	5.7	1	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	209745	None	64	Human	Functional	pAC50	=	5.7	5.7	1	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	13789	38388	None	45	Human	Functional	pAC50	=	4.7	4.7	-1	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL1463345	38388	None	45	Human	Functional	pAC50	=	4.7	4.7	-1	2	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	26987	949	None	27	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	26987.0	949	None	27	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	None	27	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	None	27	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	None	27	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	None	27	Human	Functional	pAC50	=	6.7	6.7	-204	34	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	213046	2385	None	44	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	213046.0	2385	None	44	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	None	44	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	None	44	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	None	44	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	None	44	Human	Functional	pAC50	=	5.7	5.7	-173	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	43815	187026	None	38	Human	Functional	pAC50	=	5.7	5.7	-10	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	187026	None	38	Human	Functional	pAC50	=	5.7	5.7	-10	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	187026	None	38	Human	Functional	pAC50	=	5.7	5.7	-10	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	3081361	93987	None	66	Human	Functional	pAC50	=	4.7	4.7	-33	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93987	None	66	Human	Functional	pAC50	=	4.7	4.7	-33	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Functional	pAC50	=	5.7	5.7	-89	38	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	1056	3371	None	67	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	None	67	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	None	67	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	None	67	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	None	67	Human	Functional	pAC50	=	4.7	4.7	-39	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	60753	194796	None	31	Human	Functional	pAC50	=	4.7	4.7	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	194796	None	31	Human	Functional	pAC50	=	4.7	4.7	-6	6	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	187	255	None	24	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	187.0	255	None	24	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	None	24	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	None	24	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	None	24	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	None	24	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	None	24	Human	Functional	pAC50	=	7.7	7.7	-3	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2131	57423	None	16	Human	Functional	pAC50	=	5.7	5.7	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1652	57423	None	16	Human	Functional	pAC50	=	5.7	5.7	-3	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	3236	67630	None	28	Human	Functional	pAC50	=	5.7	5.7	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	67630	None	28	Human	Functional	pAC50	=	5.7	5.7	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	4832	55436	None	14	Human	Functional	pAC50	=	7.6	7.6	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1619528	55436	None	14	Human	Functional	pAC50	=	7.6	7.6	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	2705	3842	None	44	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3842	None	44	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3842	None	44	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879.0	3842	None	44	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3842	None	44	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3842	None	44	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	124	2981	None	32	Human	Functional	pAC50	=	4.6	4.6	-11481	24	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	None	32	Human	Functional	pAC50	=	4.6	4.6	-11481	24	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	None	32	Human	Functional	pAC50	=	4.6	4.6	-11481	24	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636.0	2981	None	32	Human	Functional	pAC50	=	4.6	4.6	-11481	24	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	None	32	Human	Functional	pAC50	=	4.6	4.6	-11481	24	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	None	32	Human	Functional	pAC50	=	4.6	4.6	-11481	24	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2402	3370	None	38	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	None	38	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095.0	3370	None	38	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	None	38	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	None	38	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	None	38	Human	Functional	pAC50	=	4.6	4.6	-851	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10184653	11001	None	62	Human	Functional	pAC50	=	4.6	4.6	-26	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	CHEMBL1173655	11001	None	62	Human	Functional	pAC50	=	4.6	4.6	-26	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	127151	35339	None	12	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	3022645	35339	None	12	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL14370	35339	None	12	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	19675	51685	None	37	Human	Functional	pAC50	=	4.6	4.6	-1862	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51685	None	37	Human	Functional	pAC50	=	4.6	4.6	-1862	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3949	100668	None	35	Human	Functional	pAC50	=	4.6	4.6	-25	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100668	None	35	Human	Functional	pAC50	=	4.6	4.6	-25	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	54697325	58996	None	30	Human	Functional	pAC50	=	4.6	4.6	2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	58996	None	30	Human	Functional	pAC50	=	4.6	4.6	2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	25382	9159	None	27	Human	Functional	pAC50	=	6.6	6.6	-6	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9159	None	27	Human	Functional	pAC50	=	6.6	6.6	-6	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Functional	pAC50	=	5.6	5.6	-891	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Functional	pAC50	=	5.6	5.6	-891	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Functional	pAC50	=	5.6	5.6	-891	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Functional	pAC50	=	5.6	5.6	-891	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	1210	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036.0	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	918	None	42	Human	Functional	pAC50	=	4.6	4.6	-1047	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	5833	30492	None	42	Human	Functional	pAC50	=	4.6	4.6	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30492	None	42	Human	Functional	pAC50	=	4.6	4.6	-2	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	2165	206241	None	47	Human	Functional	pAC50	=	4.6	4.6	-17	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	206241	None	47	Human	Functional	pAC50	=	4.6	4.6	-17	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	206241	None	47	Human	Functional	pAC50	=	4.6	4.6	-17	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	2564	208642	None	37	Human	Functional	pAC50	=	4.6	4.6	-239	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL864	208642	None	37	Human	Functional	pAC50	=	4.6	4.6	-239	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	16363	596	None	33	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16363.0	596	None	33	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	None	33	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	None	33	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	None	33	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	None	33	Human	Functional	pAC50	=	5.6	5.6	-501	21	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	10133	910	None	49	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	910	None	49	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	910	None	49	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	910	None	49	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	910	None	49	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	910	None	49	Human	Functional	pAC50	=	4.6	4.6	-8	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	60606	61580	None	50	Human	Functional	pAC50	=	4.6	4.6	-13	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	60606.0	61580	None	50	Human	Functional	pAC50	=	4.6	4.6	-13	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61580	None	50	Human	Functional	pAC50	=	4.6	4.6	-13	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	DB00758	61580	None	50	Human	Functional	pAC50	=	4.6	4.6	-13	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2726	919	None	48	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2726.0	919	None	48	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	None	48	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	None	48	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	None	48	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	None	48	Human	Functional	pAC50	=	5.6	5.6	-794	42	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2333	142422	None	66	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142422	None	66	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2895	206050	None	27	Human	Functional	pAC50	=	5.6	5.6	-38	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2895.0	206050	None	27	Human	Functional	pAC50	=	5.6	5.6	-38	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	206050	None	27	Human	Functional	pAC50	=	5.6	5.6	-38	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	206050	None	27	Human	Functional	pAC50	=	5.6	5.6	-38	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-10232	29	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	131411	15398	None	50	Human	Functional	pAC50	=	4.6	4.6	-10	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	15398	None	50	Human	Functional	pAC50	=	4.6	4.6	-10	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	15398	None	50	Human	Functional	pAC50	=	4.6	4.6	-10	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	5591	157623	None	57	Human	Functional	pAC50	=	4.6	4.6	-13	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157623	None	57	Human	Functional	pAC50	=	4.6	4.6	-13	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	2905	14504	None	36	Human	Functional	pAC50	=	6.5	6.5	-10	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	2905.0	14504	None	36	Human	Functional	pAC50	=	6.5	6.5	-10	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201338	14504	None	36	Human	Functional	pAC50	=	6.5	6.5	-10	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	DB00979	14504	None	36	Human	Functional	pAC50	=	6.5	6.5	-10	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	8612	11264	None	26	Human	Functional	pAC50	=	4.5	4.5	-7	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1179047	11264	None	26	Human	Functional	pAC50	=	4.5	4.5	-7	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	2381	663	None	30	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	2381.0	663	None	30	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	374	663	None	30	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7128	663	None	30	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1101	663	None	30	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00810	663	None	30	Human	Functional	pAC50	=	6.5	6.5	-25	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	123603	883	None	21	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	2684	883	None	21	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	2684.0	883	None	21	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	584	883	None	21	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	9658	883	None	21	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	CHEMBL168815	883	None	21	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	DB00185	883	None	21	Human	Functional	pAC50	=	5.5	5.5	-22	5	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	23480	124157	None	21	Human	Functional	pAC50	=	5.5	5.5	-4	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL363295	124157	None	21	Human	Functional	pAC50	=	5.5	5.5	-4	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	2286	3183	None	36	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	None	36	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927.0	3183	None	36	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	None	36	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	None	36	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	None	36	Human	Functional	pAC50	=	6.5	6.5	-19	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2551	794	None	13	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2551.0	794	None	13	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	794	None	13	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	794	None	13	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	794	None	13	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	794	None	13	Human	Functional	pAC50	=	6.5	6.5	-2	13	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	4942	5720	None	27	Human	Functional	pAC50	=	5.4	5.4	-4	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4942.0	5720	None	27	Human	Functional	pAC50	=	5.4	5.4	-4	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5720	None	27	Human	Functional	pAC50	=	5.4	5.4	-4	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB12278	5720	None	27	Human	Functional	pAC50	=	5.4	5.4	-4	11	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135398745	2914	None	65	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135398745.0	2914	None	65	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	None	65	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	None	65	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	None	65	Human	Functional	pAC50	=	6.4	6.4	-16	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2166	3123	None	33	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	3123	None	33	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	3123	None	33	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910.0	3123	None	33	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	3123	None	33	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	3123	None	33	Human	Functional	pAC50	=	5.4	5.4	-28	10	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2370	623	None	23	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	2370.0	623	None	23	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	297	623	None	23	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	358	623	None	23	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	CHEMBL1482	623	None	23	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	DB01019	623	None	23	Human	Functional	pAC50	=	5.4	5.4	-19	3	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	319	1324	None	32	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1324	None	32	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1324	None	32	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031.0	1324	None	32	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1324	None	32	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1324	None	32	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1324	None	32	Human	Functional	pAC50	=	6.4	6.4	-436	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	6450551	19218	None	60	Human	Functional	pAC50	=	5.4	5.4	1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	CHEMBL1289926	19218	None	60	Human	Functional	pAC50	=	5.4	5.4	1	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	1427	2013	None	42	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2013	None	42	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2013	None	42	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2013	None	42	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2013	None	42	Human	Functional	pAC50	=	5.4	5.4	-1778	30	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2200	3131	None	31	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3131	None	31	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3131	None	31	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848.0	3131	None	31	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3131	None	31	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3131	None	31	Human	Functional	pAC50	=	6.4	6.4	-114	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	2540	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-660	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-660	28	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	124087	1389	None	72	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	124087.0	1389	None	72	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	None	72	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	None	72	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	None	72	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	None	72	Human	Functional	pAC50	=	6.3	6.3	-2	27	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2995	206863	None	31	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2995.0	206863	None	31	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	206863	None	31	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	206863	None	31	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB01151	206863	None	31	Human	Functional	pAC50	=	5.3	5.3	-1737	18	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4746	207349	None	24	Human	Functional	pAC50	=	5.3	5.3	-4	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	207349	None	24	Human	Functional	pAC50	=	5.3	5.3	-4	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	207349	None	24	Human	Functional	pAC50	=	5.3	5.3	-4	19	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	11504295	2923	None	40	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	11504295.0	2923	None	40	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	None	40	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	None	40	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	None	40	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	None	40	Human	Functional	pAC50	=	5.3	5.3	-38904	8	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2583	3776	None	69	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	None	69	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	None	69	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999.0	3776	None	69	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	None	69	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	None	69	Human	Functional	pAC50	=	5.3	5.3	-2884	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	4153	None	44	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	None	44	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	None	44	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	None	44	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	None	44	Human	Functional	pAC50	=	5.3	5.3	-489	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1224	1432	None	51	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	None	51	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100.0	1432	None	51	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	None	51	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	None	51	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	None	51	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	None	51	Human	Functional	pAC50	=	5.3	5.3	-575	22	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	5453	206077	None	58	Human	Functional	pAC50	=	6.2	6.2	-13	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	206077	None	58	Human	Functional	pAC50	=	6.2	6.2	-13	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	3652	4097	None	50	Human	Functional	pAC50	=	6.2	6.2	-30	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4097	None	50	Human	Functional	pAC50	=	6.2	6.2	-30	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4097	None	50	Human	Functional	pAC50	=	6.2	6.2	-30	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809.0	4097	None	50	Human	Functional	pAC50	=	6.2	6.2	-30	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4097	None	50	Human	Functional	pAC50	=	6.2	6.2	-30	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4097	None	50	Human	Functional	pAC50	=	6.2	6.2	-30	15	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	135	2532	None	33	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	None	33	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	None	33	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184.0	2532	None	33	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	None	33	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	None	33	Human	Functional	pAC50	=	5.2	5.2	-1047	33	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	5284632	67423	None	10	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	5284632.0	67423	None	10	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	67423	None	10	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	67423	None	10	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00209	67423	None	10	Human	Functional	pAC50	=	8.2	8.2	-1	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	154417	23189	None	39	Human	Functional	pAC50	=	8.2	8.2	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23189	None	39	Human	Functional	pAC50	=	8.2	8.2	-2	7	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-100000	23	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	71496458	115628	None	61	Human	Functional	pAC50	=	6.2	6.2	-1	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115628	None	61	Human	Functional	pAC50	=	6.2	6.2	-1	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	657202	12534	None	3	Human	Functional	pAC50	=	6.2	6.2	-17	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1186610	12534	None	3	Human	Functional	pAC50	=	6.2	6.2	-17	4	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	54682461	84720	None	41	Human	Functional	pAC50	=	5.2	5.2	-1	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84720	None	41	Human	Functional	pAC50	=	5.2	5.2	-1	12	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	154257	178724	None	43	Human	Functional	pAC50	=	5.2	5.2	-42	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178724	None	43	Human	Functional	pAC50	=	5.2	5.2	-42	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	1385580	29284	None	49	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29284	None	49	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615.0	29284	None	49	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29284	None	49	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB12877	29284	None	49	Human	Functional	pAC50	=	5.2	5.2	-776	19	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16351	102785	None	36	Human	Functional	pAC50	=	5.2	5.2	-309	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	16351.0	102785	None	36	Human	Functional	pAC50	=	5.2	5.2	-309	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102785	None	36	Human	Functional	pAC50	=	5.2	5.2	-309	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB13256	102785	None	36	Human	Functional	pAC50	=	5.2	5.2	-309	17	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	4066	207084	None	54	Human	Functional	pAC50	=	7.2	7.2	-4	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4066.0	207084	None	54	Human	Functional	pAC50	=	7.2	7.2	-4	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	207084	None	54	Human	Functional	pAC50	=	7.2	7.2	-4	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	DB01071	207084	None	54	Human	Functional	pAC50	=	7.2	7.2	-4	16	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4642	42000	None	22	Human	Functional	pAC50	=	7.2	7.2	-2	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	4642.0	42000	None	22	Human	Functional	pAC50	=	7.2	7.2	-2	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	42000	None	22	Human	Functional	pAC50	=	7.2	7.2	-2	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00383	42000	None	22	Human	Functional	pAC50	=	7.2	7.2	-2	3	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	2774	3868	None	59	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3868	None	59	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593.0	3868	None	59	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3868	None	59	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3868	None	59	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3868	None	59	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3868	None	59	Human	Functional	pAC50	=	6.1	6.1	-19	5	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Functional	pAC50	=	6.1	6.1	-229	43	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	24826799	10802	None	64	Human	Functional	pAC50	=	5.1	5.1	-24	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10802	None	64	Human	Functional	pAC50	=	5.1	5.1	-24	20	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	19861	209982	None	33	Human	Functional	pAC50	=	7.1	7.1	-3	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	19861.0	209982	None	33	Human	Functional	pAC50	=	7.1	7.1	-3	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	209982	None	33	Human	Functional	pAC50	=	7.1	7.1	-3	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	DB00719	209982	None	33	Human	Functional	pAC50	=	7.1	7.1	-3	10	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	4150	788	None	26	Human	Functional	pAC50	=	5.1	5.1	-123	16	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	None	26	Human	Functional	pAC50	=	5.1	5.1	-123	16	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	None	26	Human	Functional	pAC50	=	5.1	5.1	-123	16	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019.0	788	None	26	Human	Functional	pAC50	=	5.1	5.1	-123	16	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	None	26	Human	Functional	pAC50	=	5.1	5.1	-123	16	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	None	26	Human	Functional	pAC50	=	5.1	5.1	-123	16	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	3294	2006	None	61	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	None	61	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360.0	2006	None	61	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	None	61	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	None	61	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	None	61	Human	Functional	pAC50	=	5.1	5.1	-4466	23	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2337	3256	None	51	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	None	51	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	None	51	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002.0	3256	None	51	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	None	51	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	None	51	Human	Functional	pAC50	=	5.1	5.1	-177	29	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	3042	1414	None	26	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	3042.0	1414	None	26	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1414	None	26	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1414	None	26	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1414	None	26	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1414	None	26	Human	Functional	pAC50	=	5.1	5.1	-263	17	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	1201549	597	None	17	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1201549.0	597	None	17	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	None	17	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	None	17	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	None	17	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	None	17	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	None	17	Human	Functional	pAC50	=	7.0	7.0	-26	26	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24821094	67115	None	58	Human	Functional	pAC50	=	5.0	5.0	-4	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67115	None	58	Human	Functional	pAC50	=	5.0	5.0	-4	8	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	636403	188375	None	19	Human	Functional	pAC50	=	5	5.0	-3	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188375	None	19	Human	Functional	pAC50	=	5	5.0	-3	7	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	2267	559	None	45	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2267.0	559	None	45	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	None	45	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	None	45	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	None	45	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	None	45	Human	Functional	pAC50	=	5	5.0	-416	14	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	129456	209630	None	12	Human	Functional	pEC50	=	10.4	10.4	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	209630	None	12	Human	Functional	pEC50	=	10.4	10.4	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	10104167	2059	None	2	Human	Functional	pEC50	=	9.6	9.6	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	6937	2059	None	2	Human	Functional	pEC50	=	9.6	9.6	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL3121473	2059	None	2	Human	Functional	pEC50	=	9.6	9.6	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	42599070	16085	None	0	Human	Functional	pEC50	=	7	7.0	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223804	16085	None	0	Human	Functional	pEC50	=	7	7.0	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	137630848	161210	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061390	161210	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117131	161210	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	10386	161262	None	12	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092348	161262	None	12	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117554	161262	None	12	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	2230	465	None	43	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	296	465	None	43	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	CHEMBL7303	465	None	43	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	DB04365	465	None	43	Human	Functional	pEC50	=	5	5.0	1	9	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	2551	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	2551.0	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	298	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	488	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	CHEMBL965	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	DB00411	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	49799920	10545	None	0	Human	Functional	pEC50	=	6.0	6.0	-6	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL1169506	10545	None	0	Human	Functional	pEC50	=	6.0	6.0	-6	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	11120503	4196	None	0	Human	Functional	pEC50	=	6.0	6.0	-16	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100163	4196	None	0	Human	Functional	pEC50	=	6.0	6.0	-16	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	137629935	161114	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161114	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161114	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44329977	111473	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL327269	111473	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	44589681	185394	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	CHEMBL485913	185394	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	22745278	187169	None	1	Human	Functional	pEC50	=	7.9	7.9	-5	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	CHEMBL491209	187169	None	1	Human	Functional	pEC50	=	7.9	7.9	-5	5	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	2551	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	2551.0	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	298	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	488	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	CHEMBL965	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	DB00411	794	None	13	Human	Functional	pEC50	=	7.0	7.0	-2	13	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	10104047	21644	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21644	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	137629935	161114	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161114	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161114	None	0	Human	Functional	pEC50	=	5.0	5.0	-1	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191002	123679	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	CHEMBL3618445	123679	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	170332	161070	None	0	Human	Functional	pEC50	=	4.9	4.9	-2	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	161070	None	0	Human	Functional	pEC50	=	4.9	4.9	-2	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	161070	None	0	Human	Functional	pEC50	=	4.9	4.9	-2	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3652	4097	None	50	Human	Functional	pEC50	=	6.9	6.9	-30	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	57	4097	None	50	Human	Functional	pEC50	=	6.9	6.9	-30	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	60809	4097	None	50	Human	Functional	pEC50	=	6.9	6.9	-30	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	60809.0	4097	None	50	Human	Functional	pEC50	=	6.9	6.9	-30	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	CHEMBL21536	4097	None	50	Human	Functional	pEC50	=	6.9	6.9	-30	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	DB15357	4097	None	50	Human	Functional	pEC50	=	6.9	6.9	-30	15	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	44303017	203289	None	0	Human	Functional	pEC50	=	5.9	5.9	-19	2	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60101	203289	None	0	Human	Functional	pEC50	=	5.9	5.9	-19	2	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	42598829	16087	None	0	Human	Functional	pEC50	=	5.9	5.9	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223806	16087	None	0	Human	Functional	pEC50	=	5.9	5.9	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	45786849	157897	None	29	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4083241	157897	None	29	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	44330073	210889	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL99884	210889	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44209166	59575	None	0	Human	Functional	pEC50	=	7.9	7.9	7	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL171721	59575	None	0	Human	Functional	pEC50	=	7.9	7.9	7	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	44303408	204403	None	0	Human	Functional	pEC50	=	5.8	5.8	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60777	204403	None	0	Human	Functional	pEC50	=	5.8	5.8	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10451242	205572	None	0	Human	Functional	pEC50	=	5.8	5.8	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL64029	205572	None	0	Human	Functional	pEC50	=	5.8	5.8	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	122189496	123403	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616500	123403	None	0	Human	Functional	pEC50	=	6.8	6.8	-4	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	89777356	155972	None	0	Human	Functional	pEC50	=	5.8	5.8	-72	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4060475	155972	None	0	Human	Functional	pEC50	=	5.8	5.8	-72	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	53385782	74339	None	0	Human	Functional	pEC50	=	5.8	5.8	-56	3	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	CHEMBL2024331	74339	None	0	Human	Functional	pEC50	=	5.8	5.8	-56	3	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	424727	161268	None	0	Human	Functional	pEC50	=	4.8	4.8	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4095774	161268	None	0	Human	Functional	pEC50	=	4.8	4.8	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117601	161268	None	0	Human	Functional	pEC50	=	4.8	4.8	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	129456	209630	None	12	Human	Functional	pEC50	=	7.7	7.7	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	209630	None	12	Human	Functional	pEC50	=	7.7	7.7	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	24967746	16062	None	0	Human	Functional	pEC50	=	7.7	7.7	-50	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223754	16062	None	0	Human	Functional	pEC50	=	7.7	7.7	-50	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9820835	116839	None	3	Human	Functional	pEC50	=	5.7	5.7	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL337676	116839	None	3	Human	Functional	pEC50	=	5.7	5.7	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	9927975	4190	None	0	Human	Functional	pEC50	=	8.7	8.7	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100147	4190	None	0	Human	Functional	pEC50	=	8.7	8.7	-10	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	156246205	195343	None	2	Human	Functional	pEC50	=	6.7	6.7	-32	3	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	384	4	0	4	2.9	COc1ccccc1C1CCN(C2CCC3(C2)CN(C(=O)C2COC2)C3)CC1	10.1021/acsmedchemlett.3c00331
	CHEMBL5401679	195343	None	2	Human	Functional	pEC50	=	6.7	6.7	-32	3	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	384	4	0	4	2.9	COc1ccccc1C1CCN(C2CCC3(C2)CN(C(=O)C2COC2)C3)CC1	10.1021/acsmedchemlett.3c00331
	156246132	196237	None	3	Human	Functional	pEC50	=	6.7	6.7	-32	3	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	398	5	0	4	3.3	CCOc1ccccc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1	10.1021/acsmedchemlett.3c00331
	CHEMBL5419462	196237	None	3	Human	Functional	pEC50	=	6.7	6.7	-32	3	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	398	5	0	4	3.3	CCOc1ccccc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1	10.1021/acsmedchemlett.3c00331
	145973726	164725	None	0	Human	Functional	pEC50	=	5.7	5.7	-36	2	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	CHEMBL4216213	164725	None	0	Human	Functional	pEC50	=	5.7	5.7	-36	2	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	137629935	161114	None	0	Human	Functional	pEC50	=	4.7	4.7	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161114	None	0	Human	Functional	pEC50	=	4.7	4.7	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161114	None	0	Human	Functional	pEC50	=	4.7	4.7	-1	3	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191003	123680	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618446	123680	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	137635723	156174	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4062934	156174	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	187	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	187.0	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	294	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	65	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	8593	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	DB03128	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	187	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	187.0	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	294	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	65	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	8593	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	DB03128	255	None	24	Human	Functional	pEC50	=	6.7	6.7	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	137630667	161186	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4100938	161186	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116890	161186	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	57230548	173336	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524085	173336	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	44330080	107776	None	0	Human	Functional	pEC50	=	6.6	6.6	-8	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL319109	107776	None	0	Human	Functional	pEC50	=	6.6	6.6	-8	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303018	204480	None	0	Human	Functional	pEC50	=	5.6	5.6	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60833	204480	None	0	Human	Functional	pEC50	=	5.6	5.6	-218	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137631026	161244	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4093215	161244	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117321	161244	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	137628799	161087	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4064668	161087	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116150	161087	None	0	Human	Functional	pEC50	=	4.6	4.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189499	123404	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	CHEMBL3616504	123404	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	10686494	100592	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	CHEMBL291351	100592	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	10686494	100592	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	CHEMBL291351	100592	None	0	Human	Functional	pEC50	=	6.6	6.6	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	122191007	123683	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618449	123683	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	42598357	16112	None	0	Human	Functional	pEC50	=	5.6	5.6	-794	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223863	16112	None	0	Human	Functional	pEC50	=	5.6	5.6	-794	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42598359	16113	None	0	Human	Functional	pEC50	=	5.6	5.6	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223864	16113	None	0	Human	Functional	pEC50	=	5.6	5.6	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25207745	16133	None	0	Human	Functional	pEC50	=	5.6	5.6	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223941	16133	None	0	Human	Functional	pEC50	=	5.6	5.6	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	89777060	157213	None	0	Human	Functional	pEC50	=	5.6	5.6	-114	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4074908	157213	None	0	Human	Functional	pEC50	=	5.6	5.6	-114	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	5487543	208104	None	2	Human	Functional	pEC50	=	4.6	4.6	-162	6	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	CHEMBL81878	208104	None	2	Human	Functional	pEC50	=	4.6	4.6	-162	6	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	11725107	100667	None	0	Human	Functional	pEC50	=	5.6	5.6	-134	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL291872	100667	None	0	Human	Functional	pEC50	=	5.6	5.6	-134	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629887	161104	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4065555	161104	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116259	161104	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	10375002	24154	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL133905	24154	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	44158142	188777	None	42	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	CHEMBL503735	188777	None	42	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	5487543	208104	None	2	Human	Functional	pEC50	=	4.6	4.6	-162	6	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	CHEMBL81878	208104	None	2	Human	Functional	pEC50	=	4.6	4.6	-162	6	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	650899	54430	None	6	Human	Functional	pEC50	=	4.6	4.6	-10	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1535797	54430	None	6	Human	Functional	pEC50	=	4.6	4.6	-10	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1609153	54430	None	6	Human	Functional	pEC50	=	4.6	4.6	-10	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	44158142	188777	None	42	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	CHEMBL503735	188777	None	42	Rat	Functional	pEC50	=	5.6	5.6	-1	4	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	57088082	173337	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524086	173337	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	53414666	159395	None	3	Human	Functional	pEC50	=	4.5	4.5	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099673	159395	None	3	Human	Functional	pEC50	=	4.5	4.5	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	178030	21378	None	26	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	CHEMBL131428	21378	None	26	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	129456	209630	None	12	Human	Functional	pEC50	=	8.5	8.5	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	209630	None	12	Human	Functional	pEC50	=	8.5	8.5	8	2	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	156246105	195266	None	3	Human	Functional	pEC50	=	7.5	7.5	-18	4	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	402	4	0	4	3.0	COc1ccc(F)cc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1	10.1021/acsmedchemlett.3c00331
	CHEMBL5399732	195266	None	3	Human	Functional	pEC50	=	7.5	7.5	-18	4	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	402	4	0	4	3.0	COc1ccc(F)cc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1	10.1021/acsmedchemlett.3c00331
	137629935	161114	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161114	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161114	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	137629935	161114	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	161114	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	161114	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191006	123682	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618448	123682	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	3652	4097	None	50	Human	Functional	pEC50	=	6.4	6.4	-30	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	57	4097	None	50	Human	Functional	pEC50	=	6.4	6.4	-30	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809	4097	None	50	Human	Functional	pEC50	=	6.4	6.4	-30	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809.0	4097	None	50	Human	Functional	pEC50	=	6.4	6.4	-30	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	CHEMBL21536	4097	None	50	Human	Functional	pEC50	=	6.4	6.4	-30	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	DB15357	4097	None	50	Human	Functional	pEC50	=	6.4	6.4	-30	15	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	42598360	16111	None	0	Human	Functional	pEC50	=	6.4	6.4	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223862	16111	None	0	Human	Functional	pEC50	=	6.4	6.4	-158	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	87934	98134	None	15	Human	Functional	pEC50	=	6.4	6.4	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL273308	98134	None	15	Human	Functional	pEC50	=	6.4	6.4	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL542883	98134	None	15	Human	Functional	pEC50	=	6.4	6.4	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	122191004	123400	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616497	123400	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	122191001	123678	None	0	Human	Functional	pEC50	=	6.4	6.4	-9	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618444	123678	None	0	Human	Functional	pEC50	=	6.4	6.4	-9	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	187	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187.0	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	647412	27327	None	5	Human	Functional	pEC50	=	4.3	4.3	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	CHEMBL1367424	27327	None	5	Human	Functional	pEC50	=	4.3	4.3	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	187	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187.0	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	137639541	156795	None	0	Human	Functional	pEC50	=	4.3	4.3	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4070061	156795	None	0	Human	Functional	pEC50	=	4.3	4.3	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	42598358	16109	None	0	Human	Functional	pEC50	=	6.3	6.3	-501	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223860	16109	None	0	Human	Functional	pEC50	=	6.3	6.3	-501	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	187	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187.0	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187.0	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	24	Human	Functional	pEC50	=	6.3	6.3	-3	8	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44303293	203883	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60479	203883	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	53382542	86347	None	0	Human	Functional	pEC50	=	6.3	6.3	-7	6	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	CHEMBL2313377	86347	None	0	Human	Functional	pEC50	=	6.3	6.3	-7	6	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	187	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187.0	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	255	None	24	Human	Functional	pEC50	=	7.3	7.3	-3	8	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	122191005	123681	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618447	123681	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	2551	794	None	13	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	2551.0	794	None	13	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	794	None	13	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	794	None	13	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	794	None	13	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	794	None	13	Human	Functional	pEC50	=	4.2	4.2	-2	13	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	10426487	2841	None	7	Human	Functional	pEC50	=	7.2	7.2	-3	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	291	2841	None	7	Human	Functional	pEC50	=	7.2	7.2	-3	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	CHEMBL99521	2841	None	7	Human	Functional	pEC50	=	7.2	7.2	-3	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	306	3456	None	17	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	3536	3456	None	17	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	53930639	3456	None	17	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	9577995	3456	None	17	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	CHEMBL134641	3456	None	17	Human	Functional	pEC50	=	7.2	7.2	-1	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	42598591	16084	None	0	Human	Functional	pEC50	=	7.2	7.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223803	16084	None	0	Human	Functional	pEC50	=	7.2	7.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599068	16086	None	0	Human	Functional	pEC50	=	6.2	6.2	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223805	16086	None	0	Human	Functional	pEC50	=	6.2	6.2	-199	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25230693	16132	None	0	Human	Functional	pEC50	=	6.2	6.2	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223940	16132	None	0	Human	Functional	pEC50	=	6.2	6.2	-251	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	16071018	16061	None	16	Human	Functional	pEC50	=	6.2	6.2	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL1223753	16061	None	16	Human	Functional	pEC50	=	6.2	6.2	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16038385	80489	None	0	Human	Functional	pEC50	=	6.2	6.2	-10	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL2146598	80489	None	0	Human	Functional	pEC50	=	6.2	6.2	-10	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16123945	80490	None	10	Human	Functional	pEC50	=	6.2	6.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	CHEMBL2146599	80490	None	10	Human	Functional	pEC50	=	6.2	6.2	-125	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	170332	161070	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	161070	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	161070	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2166	3123	None	33	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	305	3123	None	33	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	5910	3123	None	33	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	5910.0	3123	None	33	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	CHEMBL550	3123	None	33	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	DB01085	3123	None	33	Human	Functional	pEC50	=	4.2	4.2	-28	10	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	170332	161070	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	161070	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	161070	None	0	Human	Functional	pEC50	=	5.2	5.2	-2	3	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189495	123402	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616499	123402	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122191008	123684	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618450	123684	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303397	102343	None	0	Human	Functional	pEC50	=	6.2	6.2	-75	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL303360	102343	None	0	Human	Functional	pEC50	=	6.2	6.2	-75	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10104047	21644	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21644	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	10019339	102681	None	0	Human	Functional	pEC50	=	6.2	6.2	-138	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL304247	102681	None	0	Human	Functional	pEC50	=	6.2	6.2	-138	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	5441	2426	None	12	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	9893054	2426	None	12	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL3616501	2426	None	12	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	187	255	None	24	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	187.0	255	None	24	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	294	255	None	24	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	65	255	None	24	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	8593	255	None	24	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL667	255	None	24	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	DB03128	255	None	24	Human	Functional	pEC50	=	8.2	8.2	-3	8	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	2551	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	2551.0	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	298	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	488	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	CHEMBL965	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	DB00411	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	2551	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	2551.0	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	298	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	488	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	CHEMBL965	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	DB00411	794	None	13	Human	Functional	pEC50	=	6.2	6.2	-2	13	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	59654579	123674	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618440	123674	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122190994	123671	None	0	Human	Functional	pEC50	=	6.1	6.1	-14	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618436	123671	None	0	Human	Functional	pEC50	=	6.1	6.1	-14	3	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303294	203613	None	0	Human	Functional	pEC50	=	6.1	6.1	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60331	203613	None	0	Human	Functional	pEC50	=	6.1	6.1	-16	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	3652	4097	None	50	Human	Functional	pEC50	=	6.1	6.1	-30	15	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acsmedchemlett.3c00331
	57	4097	None	50	Human	Functional	pEC50	=	6.1	6.1	-30	15	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acsmedchemlett.3c00331
	60809	4097	None	50	Human	Functional	pEC50	=	6.1	6.1	-30	15	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acsmedchemlett.3c00331
	60809.0	4097	None	50	Human	Functional	pEC50	=	6.1	6.1	-30	15	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acsmedchemlett.3c00331
	CHEMBL21536	4097	None	50	Human	Functional	pEC50	=	6.1	6.1	-30	15	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acsmedchemlett.3c00331
	DB15357	4097	None	50	Human	Functional	pEC50	=	6.1	6.1	-30	15	Activation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assayActivation of human cloned muscarinic M2 receptor expressed in CHO-K1 cells by Calcium flux assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acsmedchemlett.3c00331
	170332	161070	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	161070	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	161070	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44303286	203775	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL60419	203775	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	44303286	203775	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	CHEMBL60419	203775	None	0	Human	Functional	pEC50	=	6.1	6.1	-48	3	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	170332	161070	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	161070	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	161070	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	3	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44253016	80488	None	1	Human	Functional	pEC50	=	7.1	7.1	-6	4	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	CHEMBL2146597	80488	None	1	Human	Functional	pEC50	=	7.1	7.1	-6	4	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	44303019	101000	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL294082	101000	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	16071018	16061	None	16	Human	Functional	pEC50	=	6.1	6.1	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223753	16061	None	16	Human	Functional	pEC50	=	6.1	6.1	-112	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	42598828	16110	None	0	Human	Functional	pEC50	=	6.1	6.1	-630	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223861	16110	None	0	Human	Functional	pEC50	=	6.1	6.1	-630	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599071	16131	None	0	Human	Functional	pEC50	=	6.1	6.1	-316	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223939	16131	None	0	Human	Functional	pEC50	=	6.1	6.1	-316	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9883040	100591	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL291339	100591	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL542622	100591	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44303396	203693	None	0	Human	Functional	pEC50	=	7.1	7.1	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60374	203693	None	0	Human	Functional	pEC50	=	7.1	7.1	1	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	118500	157091	None	38	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4073256	157091	None	38	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	44303323	163337	None	0	Human	Functional	pEC50	=	7.1	7.1	-18	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL418491	163337	None	0	Human	Functional	pEC50	=	7.1	7.1	-18	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10104047	21644	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	21644	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	71792	78437	None	32	Human	Functional	pEC50	=	6.1	6.1	-2	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	CHEMBL2111051	78437	None	32	Human	Functional	pEC50	=	6.1	6.1	-2	5	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	44303327	163106	None	0	Human	Functional	pEC50	=	6.1	6.1	-31	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL417560	163106	None	0	Human	Functional	pEC50	=	6.1	6.1	-31	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	2551	794	None	13	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	2551.0	794	None	13	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	298	794	None	13	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	488	794	None	13	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL965	794	None	13	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB00411	794	None	13	Human	Functional	pEC50	=	6.1	6.1	-2	13	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44330081	210622	None	0	Human	Functional	pEC50	=	8.1	8.1	-17	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL98255	210622	None	0	Human	Functional	pEC50	=	8.1	8.1	-17	2	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303314	100987	None	0	Human	Functional	pEC50	=	6.0	6.0	-363	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL293982	100987	None	0	Human	Functional	pEC50	=	6.0	6.0	-363	3	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629744	161269	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4071109	161269	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117602	161269	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	644390	40425	None	2	Human	Functional	pEC50	=	4.0	4.0	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	CHEMBL1482157	40425	None	2	Human	Functional	pEC50	=	4.0	4.0	-3	4	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	25010776	55971	None	1	Human	Functional	pEC50	=	4.0	4.0	-44	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1559151	55971	None	1	Human	Functional	pEC50	=	4.0	4.0	-44	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1624037	55971	None	1	Human	Functional	pEC50	=	4.0	4.0	-44	5	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	137646732	157884	None	0	Human	Functional	pEC50	=	6.0	6.0	-12	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4083081	157884	None	0	Human	Functional	pEC50	=	6.0	6.0	-12	2	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	75356563	157049	None	24	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	CHEMBL4072787	157049	None	24	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	44372610	52559	None	0	Human	Functional	pED50	=	9.1	9.1	181	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL159208	52559	None	0	Human	Functional	pED50	=	9.1	9.1	181	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372301	49816	None	0	Human	Functional	pED50	=	8.7	8.7	40	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL156749	49816	None	0	Human	Functional	pED50	=	8.7	8.7	40	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372633	50322	None	0	Human	Functional	pED50	=	8.0	8.0	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL157197	50322	None	0	Human	Functional	pED50	=	8.0	8.0	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44372232	119884	None	0	Human	Functional	pED50	=	8.0	8.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348412	119884	None	0	Human	Functional	pED50	=	8.0	8.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	10058744	208840	None	0	Human	Functional	pED50	=	8.0	8.0	1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL87622	208840	None	0	Human	Functional	pED50	=	8.0	8.0	1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372253	50024	None	0	Human	Functional	pED50	=	7.9	7.9	21	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156925	50024	None	0	Human	Functional	pED50	=	7.9	7.9	21	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	9795428	96541	None	4	Human	Functional	pED50	=	5.9	5.9	-30	5	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	CHEMBL262455	96541	None	4	Human	Functional	pED50	=	5.9	5.9	-30	5	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	5487543	208104	None	2	Human	Functional	pED50	=	5.9	5.9	-162	6	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81878	208104	None	2	Human	Functional	pED50	=	5.9	5.9	-162	6	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	10266025	120230	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL351561	120230	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372580	119845	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348079	119845	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372492	155814	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL405426	155814	None	0	Human	Functional	pED50	=	8.6	8.6	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	794	None	13	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	2551.0	794	None	13	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	298	794	None	13	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	488	794	None	13	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	CHEMBL965	794	None	13	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	DB00411	794	None	13	Human	Functional	pED50	=	7.6	7.6	-2	13	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	10420458	208726	None	0	Human	Functional	pED50	=	7.6	7.6	7	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL86903	208726	None	0	Human	Functional	pED50	=	7.6	7.6	7	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372591	54361	None	0	Human	Functional	pED50	=	7.6	7.6	-60	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160858	54361	None	0	Human	Functional	pED50	=	7.6	7.6	-60	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372290	54467	None	0	Human	Functional	pED50	=	6.6	6.6	-5	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160939	54467	None	0	Human	Functional	pED50	=	6.6	6.6	-5	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	794	None	13	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	2551.0	794	None	13	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	794	None	13	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	794	None	13	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	794	None	13	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	794	None	13	Human	Functional	pED50	=	6.6	6.6	-2	13	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	44372254	53982	None	0	Human	Functional	pED50	=	7.6	7.6	-	1	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL160554	53982	None	0	Human	Functional	pED50	=	7.6	7.6	-	1	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10086044	48992	None	0	Human	Functional	pED50	=	8.5	8.5	6	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL156050	48992	None	0	Human	Functional	pED50	=	8.5	8.5	6	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9903828	119557	None	0	Human	Functional	pED50	=	8.4	8.4	28	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345415	119557	None	0	Human	Functional	pED50	=	8.4	8.4	28	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372506	119533	None	0	Human	Functional	pED50	=	8.4	8.4	19	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345205	119533	None	0	Human	Functional	pED50	=	8.4	8.4	19	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372278	49424	None	0	Human	Functional	pED50	=	8.4	8.4	11	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156445	49424	None	0	Human	Functional	pED50	=	8.4	8.4	11	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	44372277	168466	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL434469	168466	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10242016	168402	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL434072	168402	None	0	Human	Functional	pED50	=	7.4	7.4	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372289	119540	None	0	Human	Functional	pED50	=	6.3	6.3	-2	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345250	119540	None	0	Human	Functional	pED50	=	6.3	6.3	-2	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44213237	101976	None	0	Human	Functional	pED50	=	6.2	6.2	-	0	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL300998	101976	None	0	Human	Functional	pED50	=	6.2	6.2	-	0	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44372647	120084	None	0	Human	Functional	pED50	=	8.1	8.1	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL350223	120084	None	0	Human	Functional	pED50	=	8.1	8.1	-1	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44371814	51414	None	0	Human	Functional	pED50	=	8.0	8.0	3	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL158180	51414	None	0	Human	Functional	pED50	=	8.0	8.0	3	2	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372452	119687	None	0	Human	Functional	pED50	=	6.0	6.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL346580	119687	None	0	Human	Functional	pED50	=	6.0	6.0	-	0	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9913341	82189	None	4	Human	Functional	pIC50	=	9.3	9.3	28	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL216927	82189	None	4	Human	Functional	pIC50	=	9.3	9.3	28	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL553058	82189	None	4	Human	Functional	pIC50	=	9.3	9.3	28	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44590172	170421	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444688	170421	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL527216	170421	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590171	178853	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL468609	178853	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554632	178853	None	0	Human	Functional	pIC50	=	8	8.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590176	189174	None	0	Human	Functional	pIC50	=	8	8.0	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509614	189174	None	0	Human	Functional	pIC50	=	8	8.0	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555707	189174	None	0	Human	Functional	pIC50	=	8	8.0	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	155566290	176685	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	176685	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	176685	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	11690968	106557	None	0	Human	Functional	pIC50	=	8.0	8.0	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085072	106557	None	0	Human	Functional	pIC50	=	8.0	8.0	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140185	106557	None	0	Human	Functional	pIC50	=	8.0	8.0	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44590179	172820	None	0	Human	Functional	pIC50	=	7	7.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450538	172820	None	0	Human	Functional	pIC50	=	7	7.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553446	172820	None	0	Human	Functional	pIC50	=	7	7.0	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590167	179130	None	0	Human	Functional	pIC50	=	7	7.0	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL471214	179130	None	0	Human	Functional	pIC50	=	7	7.0	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589495	186086	None	0	Human	Functional	pIC50	=	7	7.0	-10	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486982	186086	None	0	Human	Functional	pIC50	=	7	7.0	-10	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590122	192669	None	0	Human	Functional	pIC50	=	7	7.0	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL521244	192669	None	0	Human	Functional	pIC50	=	7	7.0	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16125400	84697	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222449	84697	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76313456	106565	None	0	Human	Functional	pIC50	=	6	6.0	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085066	106565	None	0	Human	Functional	pIC50	=	6	6.0	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140216	106565	None	0	Human	Functional	pIC50	=	6	6.0	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	162675053	183364	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4796491	183364	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	71455968	83960	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206599	83960	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	10397133	107118	None	1	Human	Functional	pIC50	=	6.0	6.0	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL315676	107118	None	1	Human	Functional	pIC50	=	6.0	6.0	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71716773	86600	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86600	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	162353372	181493	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4763422	181493	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	71463135	83968	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206607	83968	None	0	Human	Functional	pIC50	=	7.0	7.0	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71716773	86600	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	86600	None	0	Rat	Functional	pIC50	=	6.0	6.0	2	2	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	109018479	181924	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	CHEMBL4778178	181924	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	76327901	103550	None	0	Human	Functional	pIC50	=	5.9	5.9	1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085084	103550	None	0	Human	Functional	pIC50	=	5.9	5.9	1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	44233675	103433	None	0	Human	Functional	pIC50	=	5.9	5.9	-11	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084639	103433	None	0	Human	Functional	pIC50	=	5.9	5.9	-11	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11518068	106562	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085059	106562	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140213	106562	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	44590180	172749	None	0	Human	Functional	pIC50	=	7.9	7.9	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL449640	172749	None	0	Human	Functional	pIC50	=	7.9	7.9	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540398	172749	None	0	Human	Functional	pIC50	=	7.9	7.9	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590175	188739	None	0	Human	Functional	pIC50	=	7.9	7.9	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL503025	188739	None	0	Human	Functional	pIC50	=	7.9	7.9	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553433	188739	None	0	Human	Functional	pIC50	=	7.9	7.9	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	52176747	159123	None	0	Human	Functional	pIC50	=	5.9	5.9	-2	8	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159123	None	0	Human	Functional	pIC50	=	5.9	5.9	-2	8	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	162353379	181068	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4758449	181068	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	25034111	193527	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL526009	193527	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44590123	183966	None	0	Human	Functional	pIC50	=	6.9	6.9	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480877	183966	None	0	Human	Functional	pIC50	=	6.9	6.9	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034111	193527	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL526009	193527	None	0	Human	Functional	pIC50	=	6.9	6.9	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589497	175397	None	0	Human	Functional	pIC50	=	5.9	5.9	-5	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL457302	175397	None	0	Human	Functional	pIC50	=	5.9	5.9	-5	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44233417	86080	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2307674	86080	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10092649	193182	None	43	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193182	None	43	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	10092649	193182	None	43	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193182	None	43	Rat	Functional	pIC50	=	5.9	5.9	-16	11	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	290	2473	None	4	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	4022	2473	None	4	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	5926	2473	None	4	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL40554	2473	None	4	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL74300	2473	None	4	Human	Functional	pIC50	=	4.9	4.9	-21	5	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	71450616	83967	None	0	Human	Functional	pIC50	=	7.9	7.9	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206606	83967	None	0	Human	Functional	pIC50	=	7.9	7.9	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	11503336	106570	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085071	106570	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140242	106570	None	0	Human	Functional	pIC50	=	7.9	7.9	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	76309756	103549	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085083	103549	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76313457	103546	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085080	103546	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	13940563	208488	None	1	Rat	Functional	pIC50	=	5.9	5.9	5	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL8510	208488	None	1	Rat	Functional	pIC50	=	5.9	5.9	5	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353393	179545	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	CHEMBL4740422	179545	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	16664965	84936	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223668	84936	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76320693	103548	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085082	103548	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	109035013	180581	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	CHEMBL4752973	180581	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	76309755	103544	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085079	103544	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76320692	106564	None	0	Human	Functional	pIC50	=	5.8	5.8	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085065	106564	None	0	Human	Functional	pIC50	=	5.8	5.8	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140215	106564	None	0	Human	Functional	pIC50	=	5.8	5.8	-5	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71459691	83966	None	0	Human	Functional	pIC50	=	7.8	7.8	5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206605	83966	None	0	Human	Functional	pIC50	=	7.8	7.8	5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	44590170	188478	None	0	Human	Functional	pIC50	=	7.8	7.8	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501348	188478	None	0	Human	Functional	pIC50	=	7.8	7.8	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553431	188478	None	0	Human	Functional	pIC50	=	7.8	7.8	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	109032820	182981	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4791819	182981	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	162353369	180901	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756442	180901	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	44232953	103446	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084663	103446	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	15681301	120384	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL352832	120384	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	15945874	188873	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505452	188873	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	15945874	188873	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505452	188873	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589984	190667	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL518001	190667	None	0	Human	Functional	pIC50	=	6.8	6.8	-7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590035	191863	None	0	Human	Functional	pIC50	=	6.8	6.8	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL519760	191863	None	0	Human	Functional	pIC50	=	6.8	6.8	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034180	188519	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL502000	188519	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589571	172690	None	0	Human	Functional	pIC50	=	5.8	5.8	-10	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448904	172690	None	0	Human	Functional	pIC50	=	5.8	5.8	-10	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589570	172860	None	0	Human	Functional	pIC50	=	5.8	5.8	-15	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL451040	172860	None	0	Human	Functional	pIC50	=	5.8	5.8	-15	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10465524	59013	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL169011	59013	None	0	Human	Functional	pIC50	=	4.8	4.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161134	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161134	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161134	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161134	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137408729	190851	None	0	Human	Functional	pIC50	=	5.8	5.8	-870	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5182783	190851	None	0	Human	Functional	pIC50	=	5.8	5.8	-870	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	15681299	120543	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	CHEMBL354259	120543	None	0	Human	Functional	pIC50	=	5.8	5.8	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	156015978	178428	None	0	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178428	None	0	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178428	None	0	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10397356	120780	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL354738	120780	None	0	Human	Functional	pIC50	=	5.8	5.8	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	161134	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161134	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161134	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161134	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	162353388	181085	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4758633	181085	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	71459689	83950	None	0	Human	Functional	pIC50	=	6.8	6.8	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206585	83950	None	0	Human	Functional	pIC50	=	6.8	6.8	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	168276820	190215	None	0	Human	Functional	pIC50	=	5.8	5.8	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190215	None	0	Human	Functional	pIC50	=	5.8	5.8	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190215	None	0	Human	Functional	pIC50	=	5.8	5.8	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	71454215	83959	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206595	83959	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	109013312	180240	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4748774	180240	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	162658112	181177	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4759774	181177	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	11602980	103557	None	0	Human	Functional	pIC50	=	7.7	7.7	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085091	103557	None	0	Human	Functional	pIC50	=	7.7	7.7	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	76324336	103552	None	0	Human	Functional	pIC50	=	6.7	6.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085086	103552	None	0	Human	Functional	pIC50	=	6.7	6.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	162353384	181196	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4760037	181196	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	71452455	83953	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206588	83953	None	0	Human	Functional	pIC50	=	6.7	6.7	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	44590125	183967	None	0	Human	Functional	pIC50	=	6.7	6.7	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480878	183967	None	0	Human	Functional	pIC50	=	6.7	6.7	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590036	188484	None	0	Human	Functional	pIC50	=	6.7	6.7	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501419	188484	None	0	Human	Functional	pIC50	=	6.7	6.7	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	152278786	182858	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182858	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162646559	179746	None	0	Human	Functional	pIC50	=	5.7	5.7	-154	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4742997	179746	None	0	Human	Functional	pIC50	=	5.7	5.7	-154	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	25034112	188500	None	0	Human	Functional	pIC50	=	4.7	4.7	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL501727	188500	None	0	Human	Functional	pIC50	=	4.7	4.7	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	367	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	5487427	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	5487427.0	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	8592	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	CHEMBL1900528	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	CHEMBL3305968	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	CHEMBL4650755	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	DB01409	3824	None	10	Human	Functional	pIC50	=	8.7	8.7	-3	8	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.6019/CHEMBL5442687
	44589585	189000	None	0	Human	Functional	pIC50	=	8.6	8.6	-1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507375	189000	None	0	Human	Functional	pIC50	=	8.6	8.6	-1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555474	189000	None	0	Human	Functional	pIC50	=	8.6	8.6	-1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590177	189030	None	0	Human	Functional	pIC50	=	8.6	8.6	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507874	189030	None	0	Human	Functional	pIC50	=	8.6	8.6	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554918	189030	None	0	Human	Functional	pIC50	=	8.6	8.6	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	163938	106974	None	7	Human	Functional	pIC50	=	7.7	7.7	316	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	CHEMBL314737	106974	None	7	Human	Functional	pIC50	=	7.7	7.7	316	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	152278786	182858	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	182858	None	1	Human	Functional	pIC50	=	6.7	6.7	-117	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162353375	180001	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4745885	180001	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	10262405	57613	None	0	Human	Functional	pIC50	=	4.7	4.7	-2	2	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166782	57613	None	0	Human	Functional	pIC50	=	4.7	4.7	-2	2	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44234194	103451	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084670	103451	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10262466	98397	None	0	Rat	Functional	pIC50	=	6.7	6.7	-10	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL275104	98397	None	0	Rat	Functional	pIC50	=	6.7	6.7	-10	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	76324335	103547	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085081	103547	None	0	Human	Functional	pIC50	=	5.7	5.7	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10399393	208244	None	0	Human	Functional	pIC50	=	5.7	5.7	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL83074	208244	None	0	Human	Functional	pIC50	=	5.7	5.7	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	162658421	181207	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4760150	181207	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	156015807	178404	None	0	Human	Functional	pIC50	=	6.7	6.7	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178404	None	0	Human	Functional	pIC50	=	6.7	6.7	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178404	None	0	Human	Functional	pIC50	=	6.7	6.7	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	76324334	106533	None	0	Human	Functional	pIC50	=	6.6	6.6	-15	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085070	106533	None	0	Human	Functional	pIC50	=	6.6	6.6	-15	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140112	106533	None	0	Human	Functional	pIC50	=	6.6	6.6	-15	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	156015978	178428	None	0	Human	Functional	pIC50	=	7.6	7.6	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	178428	None	0	Human	Functional	pIC50	=	7.6	7.6	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	178428	None	0	Human	Functional	pIC50	=	7.6	7.6	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	138578683	184909	None	0	Human	Functional	pIC50	=	5.6	5.6	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	CHEMBL4851711	184909	None	0	Human	Functional	pIC50	=	5.6	5.6	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	44265375	208605	None	0	Rat	Functional	pIC50	=	6.6	6.6	-3	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL8610	208605	None	0	Rat	Functional	pIC50	=	6.6	6.6	-3	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	162353386	181086	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758635	181086	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	44233189	103456	None	0	Human	Functional	pIC50	=	6.6	6.6	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084678	103456	None	0	Human	Functional	pIC50	=	6.6	6.6	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	162667844	182639	None	0	Human	Functional	pIC50	=	4.6	4.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4787283	182639	None	0	Human	Functional	pIC50	=	4.6	4.6	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	44418764	82190	None	0	Human	Functional	pIC50	=	6.6	6.6	-1	4	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	CHEMBL216928	82190	None	0	Human	Functional	pIC50	=	6.6	6.6	-1	4	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	44590033	183784	None	0	Human	Functional	pIC50	=	6.6	6.6	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480299	183784	None	0	Human	Functional	pIC50	=	6.6	6.6	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590166	189525	None	0	Human	Functional	pIC50	=	5.6	5.6	-3	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL513228	189525	None	0	Human	Functional	pIC50	=	5.6	5.6	-3	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	76316970	103541	None	0	Human	Functional	pIC50	=	6.6	6.6	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085076	103541	None	0	Human	Functional	pIC50	=	6.6	6.6	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10220392	208463	None	0	Human	Functional	pIC50	=	4.6	4.6	-6	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL84893	208463	None	0	Human	Functional	pIC50	=	4.6	4.6	-6	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11508710	103555	None	0	Human	Functional	pIC50	=	7.6	7.6	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085089	103555	None	0	Human	Functional	pIC50	=	7.6	7.6	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	156493644	185168	None	0	Human	Functional	pIC50	=	5.6	5.6	-1737	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4855467	185168	None	0	Human	Functional	pIC50	=	5.6	5.6	-1737	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	156493614	185506	None	0	Human	Functional	pIC50	=	5.6	5.6	-338	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4860985	185506	None	0	Human	Functional	pIC50	=	5.6	5.6	-338	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	168272462	190273	None	0	Human	Functional	pIC50	=	5.6	5.6	-51	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5173887	190273	None	0	Human	Functional	pIC50	=	5.6	5.6	-51	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	137630050	161134	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	161134	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	161134	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	161134	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	46830362	7896	None	0	Human	Functional	pIC50	=	5.6	5.6	-5	5	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1090097	7896	None	0	Human	Functional	pIC50	=	5.6	5.6	-5	5	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	76331543	103558	None	0	Human	Functional	pIC50	=	6.6	6.6	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085092	103558	None	0	Human	Functional	pIC50	=	6.6	6.6	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186334	None	0	Human	Functional	pIC50	=	6.6	6.6	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186334	None	0	Human	Functional	pIC50	=	6.6	6.6	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186334	None	0	Human	Functional	pIC50	=	6.6	6.6	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	9990434	106395	None	0	Human	Functional	pIC50	=	5.6	5.6	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL313918	106395	None	0	Human	Functional	pIC50	=	5.6	5.6	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44455159	97818	None	0	Rat	Functional	pIC50	=	4.5	4.5	-25	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL271704	97818	None	0	Rat	Functional	pIC50	=	4.5	4.5	-25	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	46682613	181262	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760823	181262	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	162353378	183017	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4792360	183017	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	44590174	170160	None	0	Human	Functional	pIC50	=	8.4	8.4	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444300	170160	None	0	Human	Functional	pIC50	=	8.4	8.4	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL466271	170160	None	0	Human	Functional	pIC50	=	8.4	8.4	3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590178	172841	None	0	Human	Functional	pIC50	=	8.4	8.4	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450781	172841	None	0	Human	Functional	pIC50	=	8.4	8.4	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540400	172841	None	0	Human	Functional	pIC50	=	8.4	8.4	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	11583262	106553	None	0	Human	Functional	pIC50	=	7.5	7.5	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085060	106553	None	0	Human	Functional	pIC50	=	7.5	7.5	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140181	106553	None	0	Human	Functional	pIC50	=	7.5	7.5	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156493565	185092	None	0	Human	Functional	pIC50	=	5.5	5.5	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4854289	185092	None	0	Human	Functional	pIC50	=	5.5	5.5	-1318	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	168276820	190215	None	0	Human	Functional	pIC50	=	5.5	5.5	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	190215	None	0	Human	Functional	pIC50	=	5.5	5.5	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	190215	None	0	Human	Functional	pIC50	=	5.5	5.5	-63	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	10058347	105987	None	0	Human	Functional	pIC50	=	4.5	4.5	-2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL312823	105987	None	0	Human	Functional	pIC50	=	4.5	4.5	-2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71450615	83965	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206604	83965	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	11819427	57569	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166423	57569	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	47358375	180868	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756164	180868	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	11584660	93321	None	8	Human	Functional	pIC50	=	6.5	6.5	-1	5	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	93321	None	8	Human	Functional	pIC50	=	6.5	6.5	-1	5	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	44590182	183257	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL479526	183257	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590034	190086	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL517087	190086	None	0	Human	Functional	pIC50	=	6.5	6.5	-12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094791	83289	None	0	Human	Functional	pIC50	=	5.5	5.5	-3	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL218755	83289	None	0	Human	Functional	pIC50	=	5.5	5.5	-3	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353374	180149	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4747590	180149	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	138578970	185773	None	0	Human	Functional	pIC50	=	5.5	5.5	-1862	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4864914	185773	None	0	Human	Functional	pIC50	=	5.5	5.5	-1862	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	44634573	2748	None	1	Human	Functional	pIC50	=	5.5	5.5	-380	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	465	6	0	2	5.0	Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2	10.6019/CHEMBL5442687
	9168	2748	None	1	Human	Functional	pIC50	=	5.5	5.5	-380	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	465	6	0	2	5.0	Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2	10.6019/CHEMBL5442687
	CHEMBL1474387	2748	None	1	Human	Functional	pIC50	=	5.5	5.5	-380	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	465	6	0	2	5.0	Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2	10.6019/CHEMBL5442687
	CHEMBL1622930	2748	None	1	Human	Functional	pIC50	=	5.5	5.5	-380	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	465	6	0	2	5.0	Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2	10.6019/CHEMBL5442687
	71452456	83970	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206609	83970	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	122203596	155896	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155896	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155896	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	137637944	155905	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4059829	155905	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	71450617	83971	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206610	83971	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	162353382	181840	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	CHEMBL4777127	181840	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	11626847	106532	None	0	Human	Functional	pIC50	=	7.5	7.5	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085068	106532	None	0	Human	Functional	pIC50	=	7.5	7.5	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140111	106532	None	0	Human	Functional	pIC50	=	7.5	7.5	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	130	3500	None	32	Human	Functional	pIC50	=	5.5	5.5	-1698	10	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	3378093	3500	None	32	Human	Functional	pIC50	=	5.5	5.5	-1698	10	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	CHEMBL281350	3500	None	32	Human	Functional	pIC50	=	5.5	5.5	-1698	10	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	2551	794	None	13	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	2551.0	794	None	13	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	298	794	None	13	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	488	794	None	13	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	CHEMBL965	794	None	13	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	DB00411	794	None	13	Human	Functional	pIC50	=	5.5	5.5	-2	13	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	10092649	193182	None	43	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193182	None	43	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	44233419	103454	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084674	103454	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	10092649	193182	None	43	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	193182	None	43	Human	Functional	pIC50	=	5.5	5.5	-43	11	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	164606754	184808	None	11	Human	Functional	pIC50	=	5.5	5.5	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184808	None	11	Human	Functional	pIC50	=	5.5	5.5	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184808	None	11	Human	Functional	pIC50	=	5.5	5.5	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	138578253	186561	None	0	Human	Functional	pIC50	=	5.5	5.5	-1230	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4876599	186561	None	0	Human	Functional	pIC50	=	5.5	5.5	-1230	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	24882532	95170	None	0	Rat	Functional	pIC50	=	5.5	5.5	-7	4	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255523	95170	None	0	Rat	Functional	pIC50	=	5.5	5.5	-7	4	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	137638270	156969	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	CHEMBL4071900	156969	None	0	Human	Functional	pIC50	=	6.5	6.5	-3	5	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	137647734	157938	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4083681	157938	None	0	Human	Functional	pIC50	=	6.5	6.5	-2	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	156016041	178352	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178352	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178352	None	0	Human	Functional	pIC50	=	6.5	6.5	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	155896	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155896	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155896	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	6603703	208	None	8	Human	Functional	pIC50	=	5.5	5.5	-1174	18	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.6019/CHEMBL5442687
	9637	208	None	8	Human	Functional	pIC50	=	5.5	5.5	-1174	18	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.6019/CHEMBL5442687
	CHEMBL291143	208	None	8	Human	Functional	pIC50	=	5.5	5.5	-1174	18	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.6019/CHEMBL5442687
	174174	523	None	33	Human	Functional	pIC50	=	6.5	6.5	-15	7	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.6019/CHEMBL5442687
	174174.0	523	None	33	Human	Functional	pIC50	=	6.5	6.5	-15	7	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.6019/CHEMBL5442687
	260	523	None	33	Human	Functional	pIC50	=	6.5	6.5	-15	7	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.6019/CHEMBL5442687
	320	523	None	33	Human	Functional	pIC50	=	6.5	6.5	-15	7	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.6019/CHEMBL5442687
	CHEMBL517712	523	None	33	Human	Functional	pIC50	=	6.5	6.5	-15	7	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.6019/CHEMBL5442687
	DB00572	523	None	33	Human	Functional	pIC50	=	6.5	6.5	-15	7	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.6019/CHEMBL5442687
	76327903	103559	None	0	Human	Functional	pIC50	=	6.4	6.4	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085093	103559	None	0	Human	Functional	pIC50	=	6.4	6.4	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	69444105	103542	None	0	Human	Functional	pIC50	=	7.4	7.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085077	103542	None	0	Human	Functional	pIC50	=	7.4	7.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015807	178404	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	178404	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	178404	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	137655063	159065	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096143	159065	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	5	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	11552174	103556	None	0	Human	Functional	pIC50	=	7.4	7.4	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085090	103556	None	0	Human	Functional	pIC50	=	7.4	7.4	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44589583	172584	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448294	172584	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555471	172584	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590168	172832	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450652	172832	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540399	172832	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589584	188887	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505651	188887	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540144	188887	None	0	Human	Functional	pIC50	=	7.4	7.4	-6	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094788	142002	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL386983	142002	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353381	180135	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4747438	180135	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	44589498	172861	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL451043	172861	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	10419574	58112	None	0	Human	Functional	pIC50	=	5.4	5.4	2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL167438	58112	None	0	Human	Functional	pIC50	=	5.4	5.4	2	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	1692	2154	None	25	Human	Functional	pIC50	=	5.4	5.4	-131	18	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	411	6	2	4	5.5	CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C	10.6019/CHEMBL5442687
	5311340	2154	None	25	Human	Functional	pIC50	=	5.4	5.4	-131	18	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	411	6	2	4	5.5	CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C	10.6019/CHEMBL5442687
	CHEMBL140979	2154	None	25	Human	Functional	pIC50	=	5.4	5.4	-131	18	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	411	6	2	4	5.5	CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C	10.6019/CHEMBL5442687
	76327900	106539	None	0	Human	Functional	pIC50	=	6.4	6.4	-12	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085061	106539	None	0	Human	Functional	pIC50	=	6.4	6.4	-12	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140142	106539	None	0	Human	Functional	pIC50	=	6.4	6.4	-12	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71457771	83963	None	0	Human	Functional	pIC50	=	6.4	6.4	-5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206602	83963	None	0	Human	Functional	pIC50	=	6.4	6.4	-5	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	76320694	103551	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085085	103551	None	0	Human	Functional	pIC50	=	6.4	6.4	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	71454213	83956	None	0	Human	Functional	pIC50	=	7.4	7.4	11	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206591	83956	None	0	Human	Functional	pIC50	=	7.4	7.4	11	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	71450662	84040	None	0	Human	Functional	pIC50	=	6.4	6.4	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207176	84040	None	0	Human	Functional	pIC50	=	6.4	6.4	1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	42611190	3156	None	14	Human	Functional	pIC50	=	5.4	5.4	-1071	21	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	475	4	2	2	7.4	OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F	10.6019/CHEMBL5442687
	5802	3156	None	14	Human	Functional	pIC50	=	5.4	5.4	-1071	21	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	475	4	2	2	7.4	OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F	10.6019/CHEMBL5442687
	CHEMBL1800685	3156	None	14	Human	Functional	pIC50	=	5.4	5.4	-1071	21	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	475	4	2	2	7.4	OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F	10.6019/CHEMBL5442687
	3929516	107426	None	4	Human	Functional	pIC50	=	5.4	5.4	-1	2	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.6019/CHEMBL5442687
	CHEMBL317757	107426	None	4	Human	Functional	pIC50	=	5.4	5.4	-1	2	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.6019/CHEMBL5442687
	CHEMBL543113	107426	None	4	Human	Functional	pIC50	=	5.4	5.4	-1	2	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.6019/CHEMBL5442687
	162649767	180208	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4748337	180208	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	10150497	4074	None	40	Human	Functional	pIC50	=	5.4	5.4	-660	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.6019/CHEMBL5442687
	3240	4074	None	40	Human	Functional	pIC50	=	5.4	5.4	-660	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.6019/CHEMBL5442687
	CHEMBL392760	4074	None	40	Human	Functional	pIC50	=	5.4	5.4	-660	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.6019/CHEMBL5442687
	71452454	83952	None	0	Human	Functional	pIC50	=	6.4	6.4	-41	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206587	83952	None	0	Human	Functional	pIC50	=	6.4	6.4	-41	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	2705	3842	None	44	Human	Functional	pIC50	=	6.4	6.4	-3	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.6019/CHEMBL5442687
	360	3842	None	44	Human	Functional	pIC50	=	6.4	6.4	-3	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.6019/CHEMBL5442687
	443879	3842	None	44	Human	Functional	pIC50	=	6.4	6.4	-3	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.6019/CHEMBL5442687
	443879.0	3842	None	44	Human	Functional	pIC50	=	6.4	6.4	-3	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.6019/CHEMBL5442687
	CHEMBL1382	3842	None	44	Human	Functional	pIC50	=	6.4	6.4	-3	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.6019/CHEMBL5442687
	DB01036	3842	None	44	Human	Functional	pIC50	=	6.4	6.4	-3	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.6019/CHEMBL5442687
	54816802	181378	None	1	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4762056	181378	None	1	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	487	3634	None	20	Human	Functional	pIC50	=	5.4	5.4	-1	9	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.6019/CHEMBL5442687
	60602	3634	None	20	Human	Functional	pIC50	=	5.4	5.4	-1	9	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.6019/CHEMBL5442687
	CHEMBL405355	3634	None	20	Human	Functional	pIC50	=	5.4	5.4	-1	9	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.6019/CHEMBL5442687
	DB09239	3634	None	20	Human	Functional	pIC50	=	5.4	5.4	-1	9	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	609	10	1	8	6.0	COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C	10.6019/CHEMBL5442687
	10081053	57587	None	0	Human	Functional	pIC50	=	5.4	5.4	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166593	57587	None	0	Human	Functional	pIC50	=	5.4	5.4	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44233187	86059	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2306159	86059	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10129	3322	None	44	Human	Functional	pIC50	=	7.3	7.3	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	10.6019/CHEMBL5442687
	11753673	3322	None	44	Human	Functional	pIC50	=	7.3	7.3	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	10.6019/CHEMBL5442687
	11753673.0	3322	None	44	Human	Functional	pIC50	=	7.3	7.3	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	10.6019/CHEMBL5442687
	5303	3322	None	44	Human	Functional	pIC50	=	7.3	7.3	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	10.6019/CHEMBL5442687
	CHEMBL3833319	3322	None	44	Human	Functional	pIC50	=	7.3	7.3	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	10.6019/CHEMBL5442687
	DB11855	3322	None	44	Human	Functional	pIC50	=	7.3	7.3	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	10.6019/CHEMBL5442687
	52936725	61270	None	22	Human	Functional	pIC50	=	5.3	5.3	-954	10	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	432	6	2	4	6.3	Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1	10.6019/CHEMBL5442687
	CHEMBL1766103	61270	None	22	Human	Functional	pIC50	=	5.3	5.3	-954	10	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	432	6	2	4	6.3	Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1	10.6019/CHEMBL5442687
	76327902	103554	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085088	103554	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	164606754	184808	None	11	Human	Functional	pIC50	=	5.3	5.3	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	184808	None	11	Human	Functional	pIC50	=	5.3	5.3	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	184808	None	11	Human	Functional	pIC50	=	5.3	5.3	-954	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	109035056	181429	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	CHEMBL4762755	181429	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	11619198	106547	None	0	Human	Functional	pIC50	=	7.3	7.3	-10	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085058	106547	None	0	Human	Functional	pIC50	=	7.3	7.3	-10	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140170	106547	None	0	Human	Functional	pIC50	=	7.3	7.3	-10	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015153	178412	None	0	Human	Functional	pIC50	=	7.3	7.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178412	None	0	Human	Functional	pIC50	=	7.3	7.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178412	None	0	Human	Functional	pIC50	=	7.3	7.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	28	3496	None	35	Human	Functional	pIC50	=	5.3	5.3	-1	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	3292447	3496	None	35	Human	Functional	pIC50	=	5.3	5.3	-1	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	CHEMBL20963	3496	None	35	Human	Functional	pIC50	=	5.3	5.3	-1	15	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	10.6019/CHEMBL5442687
	162353371	181756	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4775999	181756	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	16040727	169546	None	0	Human	Functional	pIC50	=	8.3	8.3	2	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL442672	169546	None	0	Human	Functional	pIC50	=	8.3	8.3	2	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL495102	169546	None	0	Human	Functional	pIC50	=	8.3	8.3	2	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590169	188350	None	0	Human	Functional	pIC50	=	8.3	8.3	7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL499565	188350	None	0	Human	Functional	pIC50	=	8.3	8.3	7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL539885	188350	None	0	Human	Functional	pIC50	=	8.3	8.3	7	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590181	173668	None	0	Human	Functional	pIC50	=	7.3	7.3	12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL453248	173668	None	0	Human	Functional	pIC50	=	7.3	7.3	12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL551113	173668	None	0	Human	Functional	pIC50	=	7.3	7.3	12	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034110	188874	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505453	188874	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	10376012	58750	None	0	Human	Functional	pIC50	=	5.3	5.3	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168561	58750	None	0	Human	Functional	pIC50	=	5.3	5.3	1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76320690	106516	None	0	Human	Functional	pIC50	=	6.3	6.3	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085063	106516	None	0	Human	Functional	pIC50	=	6.3	6.3	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140092	106516	None	0	Human	Functional	pIC50	=	6.3	6.3	-2	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	137654353	159108	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	6	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096589	159108	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	6	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	2986945	95108	None	4	Rat	Functional	pIC50	=	4.3	4.3	-47	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255169	95108	None	4	Rat	Functional	pIC50	=	4.3	4.3	-47	5	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	2904292	183686	None	11	Human	Functional	pIC50	=	4.3	4.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4800495	183686	None	11	Human	Functional	pIC50	=	4.3	4.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	15681300	57580	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166537	57580	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11510358	106540	None	0	Human	Functional	pIC50	=	7.3	7.3	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085069	106540	None	0	Human	Functional	pIC50	=	7.3	7.3	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140143	106540	None	0	Human	Functional	pIC50	=	7.3	7.3	-4	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	58975257	103432	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084638	103432	None	0	Human	Functional	pIC50	=	5.3	5.3	-1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	36014865	182776	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	CHEMBL4789054	182776	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	44233928	86108	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2308786	86108	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	71455969	83964	None	0	Human	Functional	pIC50	=	6.3	6.3	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206603	83964	None	0	Human	Functional	pIC50	=	6.3	6.3	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11547053	106521	None	0	Human	Functional	pIC50	=	7.3	7.3	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085074	106521	None	0	Human	Functional	pIC50	=	7.3	7.3	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140097	106521	None	0	Human	Functional	pIC50	=	7.3	7.3	-9	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	662	3680	None	7	Human	Functional	pIC50	=	5.3	5.3	-2	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	756	14	2	8	6.3	COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C	10.6019/CHEMBL5442687
	9853583	3680	None	7	Human	Functional	pIC50	=	5.3	5.3	-2	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	756	14	2	8	6.3	COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C	10.6019/CHEMBL5442687
	CHEMBL2021721	3680	None	7	Human	Functional	pIC50	=	5.3	5.3	-2	12	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	756	14	2	8	6.3	COc1ccc2c(c1)ccc(c2)S(=O)(=O)N[C@@H](c1ccc2c(c1)OCO2)CC(=O)N[C@@H](C(=O)N(C(C)C)C)Cc1ccc(cc1)CN1[C@H](C)CCC[C@@H]1C	10.6019/CHEMBL5442687
	71454217	83962	None	0	Human	Functional	pIC50	=	6.3	6.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206601	83962	None	0	Human	Functional	pIC50	=	6.3	6.3	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	109014373	179908	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4744856	179908	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	156016041	178352	None	0	Human	Functional	pIC50	=	7.2	7.2	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	178352	None	0	Human	Functional	pIC50	=	7.2	7.2	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	178352	None	0	Human	Functional	pIC50	=	7.2	7.2	-1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	71455966	83955	None	0	Human	Functional	pIC50	=	7.2	7.2	2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206590	83955	None	0	Human	Functional	pIC50	=	7.2	7.2	2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	52176747	159123	None	0	Rat	Functional	pIC50	=	5.2	5.2	-13	8	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	159123	None	0	Rat	Functional	pIC50	=	5.2	5.2	-13	8	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	15681303	59007	None	0	Human	Functional	pIC50	=	4.2	4.2	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168991	59007	None	0	Human	Functional	pIC50	=	4.2	4.2	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44590173	189200	None	0	Human	Functional	pIC50	=	8.2	8.2	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL510029	189200	None	0	Human	Functional	pIC50	=	8.2	8.2	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555019	189200	None	0	Human	Functional	pIC50	=	8.2	8.2	1	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	156015153	178412	None	0	Human	Functional	pIC50	=	7.2	7.2	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	178412	None	0	Human	Functional	pIC50	=	7.2	7.2	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	178412	None	0	Human	Functional	pIC50	=	7.2	7.2	1	2	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11712408	106578	None	0	Human	Functional	pIC50	=	7.2	7.2	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085067	106578	None	0	Human	Functional	pIC50	=	7.2	7.2	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140261	106578	None	0	Human	Functional	pIC50	=	7.2	7.2	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	25150014	3885	None	44	Human	Functional	pIC50	=	6.2	6.2	-15	9	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.6019/CHEMBL5442687
	3952	3885	None	44	Human	Functional	pIC50	=	6.2	6.2	-15	9	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.6019/CHEMBL5442687
	CHEMBL449588	3885	None	44	Human	Functional	pIC50	=	6.2	6.2	-15	9	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.6019/CHEMBL5442687
	108993425	181864	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4777543	181864	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	168289751	191919	None	0	Human	Functional	pIC50	=	5.2	5.2	-47	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	CHEMBL5198423	191919	None	0	Human	Functional	pIC50	=	5.2	5.2	-47	2	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	104850	3330	None	58	Human	Functional	pIC50	=	5.2	5.2	-562	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.6019/CHEMBL5442687
	4150	3330	None	58	Human	Functional	pIC50	=	5.2	5.2	-562	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.6019/CHEMBL5442687
	743	3330	None	58	Human	Functional	pIC50	=	5.2	5.2	-562	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.6019/CHEMBL5442687
	CHEMBL111	3330	None	58	Human	Functional	pIC50	=	5.2	5.2	-562	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.6019/CHEMBL5442687
	DB06155	3330	None	58	Human	Functional	pIC50	=	5.2	5.2	-562	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.6019/CHEMBL5442687
	2551	794	None	13	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	2551.0	794	None	13	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	298	794	None	13	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	488	794	None	13	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	CHEMBL965	794	None	13	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	DB00411	794	None	13	Human	Functional	pIC50	=	7.2	7.2	-2	13	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	1201549	597	None	17	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	1201549.0	597	None	17	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	333	597	None	17	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	7601	597	None	17	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL1201203	597	None	17	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL438151	597	None	17	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	DB00245	597	None	17	Human	Functional	pIC50	=	7.2	7.2	-26	26	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	44590124	169897	None	0	Human	Functional	pIC50	=	6.2	6.2	-39	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL443925	169897	None	0	Human	Functional	pIC50	=	6.2	6.2	-39	2	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	162657046	180949	None	0	Human	Functional	pIC50	=	6.2	6.2	-99	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4757103	180949	None	0	Human	Functional	pIC50	=	6.2	6.2	-99	4	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	76316969	106579	None	0	Human	Functional	pIC50	=	6.2	6.2	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085075	106579	None	0	Human	Functional	pIC50	=	6.2	6.2	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140262	106579	None	0	Human	Functional	pIC50	=	6.2	6.2	-11	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	1890	2759	None	31	Human	Functional	pIC50	=	5.2	5.2	-51	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.6019/CHEMBL5442687
	4449	2759	None	31	Human	Functional	pIC50	=	5.2	5.2	-51	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.6019/CHEMBL5442687
	7247	2759	None	31	Human	Functional	pIC50	=	5.2	5.2	-51	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.6019/CHEMBL5442687
	CHEMBL623	2759	None	31	Human	Functional	pIC50	=	5.2	5.2	-51	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.6019/CHEMBL5442687
	DB01149	2759	None	31	Human	Functional	pIC50	=	5.2	5.2	-51	28	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.6019/CHEMBL5442687
	162353391	180927	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	CHEMBL4756873	180927	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	76313454	106563	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085064	106563	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140214	106563	None	0	Human	Functional	pIC50	=	6.2	6.2	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	186334	None	0	Human	Functional	pIC50	=	6.2	6.2	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	186334	None	0	Human	Functional	pIC50	=	6.2	6.2	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	186334	None	0	Human	Functional	pIC50	=	6.2	6.2	-870	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	76309754	106577	None	0	Human	Functional	pIC50	=	6.2	6.2	-8	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085062	106577	None	0	Human	Functional	pIC50	=	6.2	6.2	-8	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140260	106577	None	0	Human	Functional	pIC50	=	6.2	6.2	-8	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	1421986	8267	None	2	Human	Functional	pIC50	=	5.2	5.2	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1092461	8267	None	2	Human	Functional	pIC50	=	5.2	5.2	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	11442478	106534	None	0	Human	Functional	pIC50	=	8.1	8.1	-7	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085073	106534	None	0	Human	Functional	pIC50	=	8.1	8.1	-7	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140113	106534	None	0	Human	Functional	pIC50	=	8.1	8.1	-7	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	10109893	82196	None	0	Human	Functional	pIC50	=	8.1	8.1	89	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL216983	82196	None	0	Human	Functional	pIC50	=	8.1	8.1	89	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL544840	82196	None	0	Human	Functional	pIC50	=	8.1	8.1	89	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	162353376	180533	None	0	Human	Functional	pIC50	=	4.2	4.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4752380	180533	None	0	Human	Functional	pIC50	=	4.2	4.2	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	11820032	98277	None	0	Rat	Functional	pIC50	=	7.1	7.1	1	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL274329	98277	None	0	Rat	Functional	pIC50	=	7.1	7.1	1	2	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353377	181271	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760904	181271	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353390	181055	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4758316	181055	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	162670602	183043	None	0	Human	Functional	pIC50	=	4.1	4.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4792675	183043	None	0	Human	Functional	pIC50	=	4.1	4.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	133640439	181479	None	1	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4763304	181479	None	1	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	10240891	208556	None	0	Human	Functional	pIC50	=	5.1	5.1	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL85678	208556	None	0	Human	Functional	pIC50	=	5.1	5.1	1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	16094783	136654	None	0	Human	Functional	pIC50	=	7.1	7.1	12	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL373888	136654	None	0	Human	Functional	pIC50	=	7.1	7.1	12	3	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44589496	186087	None	0	Human	Functional	pIC50	=	7.1	7.1	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486983	186087	None	0	Human	Functional	pIC50	=	7.1	7.1	-15	3	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	174174	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	174174.0	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	174174	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	174174.0	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	260	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	320	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	CHEMBL517712	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	DB00572	523	None	33	Human	Functional	pIC50	=	8.1	8.1	-15	7	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	76309757	103553	None	0	Human	Functional	pIC50	=	7.1	7.1	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085087	103553	None	0	Human	Functional	pIC50	=	7.1	7.1	-1	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71463136	83969	None	0	Human	Functional	pIC50	=	7.1	7.1	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206608	83969	None	0	Human	Functional	pIC50	=	7.1	7.1	-2	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71459724	84041	None	0	Human	Functional	pIC50	=	6.1	6.1	-63	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207177	84041	None	0	Human	Functional	pIC50	=	6.1	6.1	-63	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	302	2977	None	15	Rat	Functional	pIC50	=	7.1	7.1	-7	8	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	4630	2977	None	15	Rat	Functional	pIC50	=	7.1	7.1	-7	8	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL7634	2977	None	15	Rat	Functional	pIC50	=	7.1	7.1	-7	8	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	122203596	155896	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	155896	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	155896	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	71454214	83957	None	0	Human	Functional	pIC50	=	6.1	6.1	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206592	83957	None	0	Human	Functional	pIC50	=	6.1	6.1	1	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10375322	58747	None	0	Human	Functional	pIC50	=	5.1	5.1	-1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168545	58747	None	0	Human	Functional	pIC50	=	5.1	5.1	-1	3	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71454212	83951	None	0	Human	Functional	pIC50	=	7.1	7.1	5	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206586	83951	None	0	Human	Functional	pIC50	=	7.1	7.1	5	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	16125704	84698	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222450	84698	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL4755618	216526	None	39	Human	Functional	pIC50	=	5.1	5.1	1	2	Agonist activity at muscarinic M2 receptor (unknown origin)Agonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL		None	None	None		Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12	10.1021/acs.jmedchem.1c02148
	11617374	103543	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085078	103543	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	155522355	176514	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	176514	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	176514	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	49665121	170566	None	10	Human	Functional	pIC50	=	6.0	6.0	3	3	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	CHEMBL4448840	170566	None	10	Human	Functional	pIC50	=	6.0	6.0	3	3	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	129989	451	None	33	Human	Functional	pIC50	=	6.0	6.0	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.6019/CHEMBL5442687
	8584	451	None	33	Human	Functional	pIC50	=	6.0	6.0	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.6019/CHEMBL5442687
	CHEMBL43383	451	None	33	Human	Functional	pIC50	=	6.0	6.0	-	1	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.6019/CHEMBL5442687
	162353387	181337	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4761549	181337	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	71457770	83961	None	0	Human	Functional	pIC50	=	7.0	7.0	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206600	83961	None	0	Human	Functional	pIC50	=	7.0	7.0	-1	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10376182	58773	None	0	Human	Functional	pIC50	=	5.0	5.0	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168639	58773	None	0	Human	Functional	pIC50	=	5.0	5.0	-1	2	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71455965	83954	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206589	83954	None	0	Human	Functional	pIC50	=	7.0	7.0	-3	3	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	162353383	182683	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	CHEMBL4787944	182683	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	162657652	181091	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758742	181091	None	0	Human	Functional	pIC50	=	5.0	5.0	-	1	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	10372836	102452	None	36	Human	Functional	pIC50	=	6.0	6.0	-616	3	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	739	13	6	9	6.4	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.6019/CHEMBL5442687
	CHEMBL3039518	102452	None	36	Human	Functional	pIC50	=	6.0	6.0	-616	3	GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2GPCR PRESTO-Tango dose-response in antagonist mode with target: CHRM2	ChEMBL	739	13	6	9	6.4	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.6019/CHEMBL5442687
	71463134	83958	None	0	Human	Functional	pIC50	=	6	6.0	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206594	83958	None	0	Human	Functional	pIC50	=	6	6.0	-2	2	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11519069	3939	None	2	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070	3939	None	2	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070.0	3939	None	2	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	4816	3939	None	2	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	7354	3939	None	2	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	CHEMBL1187833	3939	None	2	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	DB09076	3939	None	2	Human	Functional	pKd	=	10.5	10.5	1	3	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	25195533	78417	None	2	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2103803	78417	None	2	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2110584	78417	None	2	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589580	173251	None	0	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL452142	173251	None	0	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL553448	173251	None	0	Human	Functional	pKd	=	10.3	10.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	132947	3864	None	7	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	361	3864	None	7	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	CHEMBL265256	3864	None	7	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	132947	3864	None	7	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	361	3864	None	7	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	CHEMBL265256	3864	None	7	Human	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	25034186	203895	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL540396	203895	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL604842	203895	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589579	189162	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL509515	189162	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL540148	189162	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	11766733	155844	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202003	155844	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL405739	155844	None	0	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	132947	3864	None	7	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	361	3864	None	7	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	CHEMBL265256	3864	None	7	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	10770914	25069	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL134692	25069	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44232952	103438	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084650	103438	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10580398	21618	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL131748	21618	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	23724781	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	23724781.0	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	316	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	317	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	71183	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL1354199	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL3140030	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL376897	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	DB00462	2835	None	13	Guinea pig	Functional	pKd	=	9.3	9.3	-	8	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	23724781	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	23724781.0	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	316	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	317	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	71183	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL1354199	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL3140030	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL376897	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	DB00462	2835	None	13	Human	Functional	pKd	=	9.3	9.3	-60	8	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	10109130	133083	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370232	133083	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10291366	140786	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381623	140786	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	69058946	106531	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084658	106531	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140110	106531	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10629559	23759	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL133561	23759	None	0	Human	Functional	pKd	=	9.3	9.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	10628017	21723	None	0	Human	Functional	pKd	=	9.2	9.2	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL131865	21723	None	0	Human	Functional	pKd	=	9.2	9.2	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939891	169467	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL442014	169467	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939891	169467	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	CHEMBL442014	169467	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	9946298	72852	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200171	72852	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406481	72900	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200319	72900	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406573	72999	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200693	72999	None	0	Human	Functional	pKd	=	9.1	9.1	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10532418	24613	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL134294	24613	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	25034182	172687	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL448870	172687	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL540359	172687	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	25034182	172687	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448870	172687	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540359	172687	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16116085	11850	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182201	11850	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219786	11850	None	0	Human	Functional	pKd	=	9	9.0	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	12872437	12062	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL1183585	12062	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL306182	12062	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	11691950	12766	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL1187853	12766	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL524097	12766	None	0	Human	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	174174	523	None	33	Human	Functional	pKd	=	8.9	8.9	-15	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	174174.0	523	None	33	Human	Functional	pKd	=	8.9	8.9	-15	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	260	523	None	33	Human	Functional	pKd	=	8.9	8.9	-15	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	320	523	None	33	Human	Functional	pKd	=	8.9	8.9	-15	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	CHEMBL517712	523	None	33	Human	Functional	pKd	=	8.9	8.9	-15	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	DB00572	523	None	33	Human	Functional	pKd	=	8.9	8.9	-15	7	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	10771937	21700	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202004	21700	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL131846	21700	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	25034184	188504	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL501803	188504	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL539887	188504	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589581	188896	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL505751	188896	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL540145	188896	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	14939896	82118	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201996	82118	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216566	82118	None	0	Human	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406686	140998	None	0	Human	Functional	pKd	=	8.7	8.7	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL382213	140998	None	0	Human	Functional	pKd	=	8.7	8.7	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	174174	523	None	33	Human	Functional	pKd	=	8.7	8.7	-15	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	174174.0	523	None	33	Human	Functional	pKd	=	8.7	8.7	-15	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	260	523	None	33	Human	Functional	pKd	=	8.7	8.7	-15	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	320	523	None	33	Human	Functional	pKd	=	8.7	8.7	-15	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	CHEMBL517712	523	None	33	Human	Functional	pKd	=	8.7	8.7	-15	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	DB00572	523	None	33	Human	Functional	pKd	=	8.7	8.7	-15	7	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	44341782	9995	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL114885	9995	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44318928	208221	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	CHEMBL82859	208221	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	44319043	208517	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85391	208517	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11753447	187457	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493265	187457	None	0	Human	Functional	pKd	=	7	7.0	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	2166	3123	None	33	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	305	3123	None	33	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	5910	3123	None	33	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	5910.0	3123	None	33	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL550	3123	None	33	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	DB01085	3123	None	33	Rat	Functional	pKd	=	5	5.0	-131	10	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	128222	102143	None	5	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL302179	102143	None	5	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44341878	110396	None	0	Human	Functional	pKd	=	6.0	6.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL324026	110396	None	0	Human	Functional	pKd	=	6.0	6.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939893	9536	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL112244	9536	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	154734599	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	327	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	4108	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL27673	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	154734599	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	327	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	4108	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	CHEMBL27673	2503	None	8	Human	Functional	pKd	=	7.9	7.9	47	5	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	44319071	208477	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL84993	208477	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11556983	187471	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493331	187471	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL538864	187471	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL555476	187471	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	44341782	9995	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL114885	9995	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	44341782	9995	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL114885	9995	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	10789183	104422	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310132	104422	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44318782	208591	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85996	208591	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44380974	57582	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	CHEMBL166544	57582	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	101720828	97173	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	16147087	97173	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202002	97173	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL267643	97173	None	0	Human	Functional	pKd	=	7.9	7.9	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	44381057	58129	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL167587	58129	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44380592	59328	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	CHEMBL170554	59328	None	0	Human	Functional	pKd	=	6.9	6.9	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	154734599	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	327	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	4108	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL27673	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	154734599	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	327	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	4108	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL27673	2503	None	8	Human	Functional	pKd	=	7.8	7.8	47	5	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	101676031	97381	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16175987	97381	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201998	97381	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL269272	97381	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	319	1324	None	32	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	321	1324	None	32	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031	1324	None	32	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031.0	1324	None	32	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	784	1324	None	32	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	CHEMBL1346	1324	None	32	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	DB00496	1324	None	32	Human	Functional	pKd	=	7.8	7.8	-436	18	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	2705	3842	None	44	Human	Functional	pKd	=	7.8	7.8	-3	12	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	360	3842	None	44	Human	Functional	pKd	=	7.8	7.8	-3	12	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879	3842	None	44	Human	Functional	pKd	=	7.8	7.8	-3	12	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879.0	3842	None	44	Human	Functional	pKd	=	7.8	7.8	-3	12	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	CHEMBL1382	3842	None	44	Human	Functional	pKd	=	7.8	7.8	-3	12	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	DB01036	3842	None	44	Human	Functional	pKd	=	7.8	7.8	-3	12	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	44380973	120795	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	CHEMBL354855	120795	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	44319342	208176	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82512	208176	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319339	208365	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83982	208365	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44341864	109267	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL321687	109267	None	0	Human	Functional	pKd	=	5.8	5.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44380309	58793	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168736	58793	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44298537	101096	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL294613	101096	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	44380837	58457	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	CHEMBL168304	58457	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	44381064	58278	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168235	58278	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	10316726	12032	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12032	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12032	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16144765	96932	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL265592	96932	None	0	Human	Functional	pKd	=	7.8	7.8	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	44380612	59210	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	CHEMBL170113	59210	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	44341975	9530	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	CHEMBL112208	9530	None	0	Human	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	44380613	58512	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	CHEMBL168322	58512	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	154734599	2503	None	8	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	327	2503	None	8	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	4108	2503	None	8	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL27673	2503	None	8	Human	Functional	pKd	=	7.7	7.7	47	5	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	10049361	208579	None	0	Human	Functional	pKd	=	7.7	7.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85892	208579	None	0	Human	Functional	pKd	=	7.7	7.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	9913892	208295	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83459	208295	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	14537191	148077	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL39342	148077	None	0	Human	Functional	pKd	=	5.7	5.7	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	10486393	141789	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202000	141789	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL385625	141789	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10794142	22944	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL132926	22944	None	0	Human	Functional	pKd	=	8.6	8.6	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	1734	116	None	5	Human	Functional	pKd	=	8.6	8.6	-97	6	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	307	116	None	5	Human	Functional	pKd	=	8.6	8.6	-97	6	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	CHEMBL168067	116	None	5	Human	Functional	pKd	=	8.6	8.6	-97	6	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	16086059	80806	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215180	80806	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	10722780	22306	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL132377	22306	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355098	24711	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134382	24711	None	0	Human	Functional	pKd	=	6.7	6.7	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355099	165346	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL422977	165346	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	11365314	187458	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493266	187458	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	44341764	9956	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL114681	9956	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10402105	110554	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL324855	110554	None	0	Human	Functional	pKd	=	5.6	5.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	14211056	107219	None	0	Rat	Functional	pKd	=	5.6	5.6	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316309	107219	None	0	Rat	Functional	pKd	=	5.6	5.6	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380611	58841	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	CHEMBL168841	58841	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	44380972	120314	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL352334	120314	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	14939888	10164	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	CHEMBL115878	10164	None	0	Human	Functional	pKd	=	6.6	6.6	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	44381066	59041	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	CHEMBL169290	59041	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	14939894	10298	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL116172	10298	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406598	73050	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200957	73050	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	129989	451	None	33	Human	Functional	pKd	=	8.5	8.5	-	1	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	8584	451	None	33	Human	Functional	pKd	=	8.5	8.5	-	1	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	CHEMBL43383	451	None	33	Human	Functional	pKd	=	8.5	8.5	-	1	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	71128	96863	None	21	Human	Functional	pKd	=	8.5	8.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	CHEMBL26505	96863	None	21	Human	Functional	pKd	=	8.5	8.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	66875589	103445	None	0	Human	Functional	pKd	=	8.4	8.4	-	1	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084662	103445	None	0	Human	Functional	pKd	=	8.4	8.4	-	1	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589576	189164	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509520	189164	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555706	189164	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44406480	72869	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200210	72869	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44319009	106992	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL314831	106992	None	0	Human	Functional	pKd	=	7.5	7.5	-	0	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11249888	187483	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493465	187483	None	0	Human	Functional	pKd	=	6.5	6.5	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537192	100278	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL288482	100278	None	0	Human	Functional	pKd	=	5.5	5.5	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	189509	106056	None	10	Rat	Functional	pKd	=	5.5	5.5	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL313227	106056	None	10	Rat	Functional	pKd	=	5.5	5.5	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44365882	58141	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL167690	58141	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	2028	2979	None	52	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	359	2979	None	52	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634	2979	None	52	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634.0	2979	None	52	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	CHEMBL1231	2979	None	52	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	DB01062	2979	None	52	Human	Functional	pKd	=	7.4	7.4	-7	14	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	44406520	135327	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL372566	135327	None	0	Human	Functional	pKd	=	7.4	7.4	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	15114860	107212	None	0	Rat	Functional	pKd	=	6.4	6.4	-	0	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316282	107212	None	0	Rat	Functional	pKd	=	6.4	6.4	-	0	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	14211057	111488	None	0	Rat	Functional	pKd	=	5.4	5.4	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL327363	111488	None	0	Rat	Functional	pKd	=	5.4	5.4	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	10316726	12032	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	12032	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	12032	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16115945	12301	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1184886	12301	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376057	12301	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	10606253	157365	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL407678	157365	None	0	Human	Functional	pKd	=	8.4	8.4	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939895	82150	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201997	82150	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216629	82150	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10055202	11537	None	1	Human	Functional	pKd	=	6.4	6.4	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	CHEMBL11805	11537	None	1	Human	Functional	pKd	=	6.4	6.4	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	14939897	96602	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201994	96602	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL262913	96602	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44233192	106538	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084643	106538	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140141	106538	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11504490	192711	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL521523	192711	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	11504490	192711	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	CHEMBL521523	192711	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	44589582	171744	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL446587	171744	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL550885	171744	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16042745	185407	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL485932	185407	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL538360	185407	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10557581	21781	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202001	21781	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL131913	21781	None	0	Human	Functional	pKd	=	8.3	8.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10418181	9588	None	1	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112500	9588	None	1	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201995	9588	None	1	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	9843814	127316	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	CHEMBL36583	127316	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	14449843	24830	None	0	Human	Functional	pKd	=	6.3	6.3	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134488	24830	None	0	Human	Functional	pKd	=	6.3	6.3	-	0	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	14211049	107044	None	0	Rat	Functional	pKd	=	5.3	5.3	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL315191	107044	None	0	Rat	Functional	pKd	=	5.3	5.3	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	2200	3131	None	31	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	328	3131	None	31	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848	3131	None	31	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848.0	3131	None	31	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	CHEMBL9967	3131	None	31	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	DB00670	3131	None	31	Human	Functional	pKd	=	4.3	4.3	-114	10	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	44381142	59080	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	CHEMBL169523	59080	None	0	Human	Functional	pKd	=	7.3	7.3	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	10653319	24251	None	0	Human	Functional	pKd	=	5.3	5.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL133993	24251	None	0	Human	Functional	pKd	=	5.3	5.3	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44380591	58768	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL168616	58768	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44406521	73932	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL201933	73932	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44233190	103457	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084679	103457	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589578	173273	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL452193	173273	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL540401	173273	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	44589577	189076	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL508343	189076	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL540146	189076	None	0	Human	Functional	pKd	=	8.2	8.2	-	0	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	25132856	187322	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL492437	187322	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537188	136633	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL37372	136633	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	14211052	208994	None	0	Rat	Functional	pKd	=	6.2	6.2	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL88578	208994	None	0	Rat	Functional	pKd	=	6.2	6.2	-	1	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380614	57484	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	CHEMBL165700	57484	None	0	Human	Functional	pKd	=	7.2	7.2	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	59993948	73167	None	0	Human	Functional	pKd	=	6.2	6.2	-	0	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	CHEMBL2011501	73167	None	0	Human	Functional	pKd	=	6.2	6.2	-	0	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	14537189	162738	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL416974	162738	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	14939893	9536	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112244	9536	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10369736	59382	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	CHEMBL170793	59382	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	44381205	57544	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	CHEMBL166232	57544	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	10508599	115293	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL334690	115293	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44381378	57543	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	CHEMBL166229	57543	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	129989	451	None	33	Human	Functional	pKd	=	8.0	8.0	-	1	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	8584	451	None	33	Human	Functional	pKd	=	8.0	8.0	-	1	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	CHEMBL43383	451	None	33	Human	Functional	pKd	=	8.0	8.0	-	1	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	10651844	115553	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL335115	115553	None	0	Human	Functional	pKd	=	8.0	8.0	-	0	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	14914761	9966	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	CHEMBL114738	9966	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	44380975	57624	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	CHEMBL166803	57624	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	44365718	58803	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168786	58803	None	0	Human	Functional	pKd	=	7.0	7.0	-	0	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	9916852	207377	None	0	Human	Functional	pKi	=	11	11.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL76164	207377	None	0	Human	Functional	pKi	=	11	11.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	44314347	102918	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL305693	102918	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10230930	80665	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	CHEMBL2151158	80665	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	44314697	104235	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL309720	104235	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314564	207266	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL75108	207266	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188574	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188574	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188574	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314328	103766	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308787	103766	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10417432	104930	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311099	104930	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10009554	207169	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL74141	207169	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314698	207610	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL78131	207610	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	188574	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	188574	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	188574	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314329	207014	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL72932	207014	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314699	103234	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308166	103234	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314713	104926	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311054	104926	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164615651	188618	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188618	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188618	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164614830	188607	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4858774	188607	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028275	188607	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314554	105739	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL312571	105739	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	3009356	105679	None	0	Human	Functional	pKi	=	5.5	5.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL312344	105679	None	0	Human	Functional	pKi	=	5.5	5.5	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	483747	105465	None	1	Human	Functional	pKi	=	6.3	6.3	-	1	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL311795	105465	None	1	Human	Functional	pKi	=	6.3	6.3	-	1	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	3009352	96692	None	0	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL263555	96692	None	0	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	3009353	168128	None	0	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL432170	168128	None	0	Human	Functional	pKi	=	5.3	5.3	-	0	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	1935	3734	None	62	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	3734	None	62	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	3734	None	62	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	3734	None	62	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	3734	None	62	Human	Functional	pKi	=	5.2	5.2	-57	12	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	164615651	188618	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	188618	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	188618	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	313	2691	None	0	Human	Functional	pA2	<	6.3	6.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9862767
	2520	206466	None	47	Pig	Functional	pEC50	=	8.4	8.4	-3	20	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL1280	206466	None	47	Pig	Functional	pEC50	=	8.4	8.4	-3	20	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL6966	206466	None	47	Pig	Functional	pEC50	=	8.4	8.4	-3	20	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	1935	3734	None	62	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	3734	None	62	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	3734	None	62	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	3734	None	62	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	3734	None	62	Pig	Functional	pEC50	=	8.3	8.3	-1	12	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	1979	77355	None	47	Human	Functional	pEC50	=	8.2	8.2	-43	7	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	77355	None	47	Human	Functional	pEC50	=	8.2	8.2	-43	7	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	123603	883	None	21	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2684	883	None	21	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2684.0	883	None	21	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	584	883	None	21	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	9658	883	None	21	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	CHEMBL168815	883	None	21	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	DB00185	883	None	21	Human	Functional	pEC50	=	8.2	8.2	-22	5	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2370	623	None	23	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	2370.0	623	None	23	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	297	623	None	23	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	358	623	None	23	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	CHEMBL1482	623	None	23	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	DB01019	623	None	23	Guinea pig	Functional	pEC50	=	8.2	8.2	19	3	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	1273	1754	None	13	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	1754	None	13	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	1754	None	13	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	1754	None	13	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	1754	None	13	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	1754	None	13	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	1754	None	13	Pig	Functional	pEC50	=	8.2	8.2	38	4	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	2166	3123	None	33	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	3123	None	33	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	3123	None	33	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910.0	3123	None	33	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	3123	None	33	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	3123	None	33	Human	Functional	pEC50	=	8.2	8.2	-28	10	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5831	218453	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	5	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	5831.0	218453	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	5	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	CHEMBL965	218453	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	5	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	DB00411	218453	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	5	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	21158560	112856	None	8	Pig	Functional	pEC50	=	8.1	8.1	3090	2	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	CHEMBL3305985	112856	None	8	Pig	Functional	pEC50	=	8.1	8.1	3090	2	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	13637	579	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Determined in a functional M2-GIRK assay, measuring potentiation of acetylcholine (EC<sub>20</sub>) mediated M<sub>2</sub>R activation; Positive cooperativity >1Determined in a functional M2-GIRK assay, measuring potentiation of acetylcholine (EC<sub>20</sub>) mediated M<sub>2</sub>R activation; Positive cooperativity >1	Guide to Pharmacology	584	5	3	7	2.8	C[C@H](NC(=O)C1=CN(C2=NC(N3C[C@@H](O)[C@H](O)C3)=C(F)C=C2C1=O)C4=C(F)C=C(F)C=C4F)C(F)(F)C(F)(F)F	39463278
	10101670	1509	None	0	Human	Functional	pEC50	=	7.1	7.1	52	2	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	7635	1509	None	0	Human	Functional	pEC50	=	7.1	7.1	52	2	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	CHEMBL32985	1509	None	0	Human	Functional	pEC50	=	7.1	7.1	52	2	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	10104167	2059	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	10104167	2059	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	6937	2059	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	6937	2059	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	CHEMBL3121473	2059	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	CHEMBL3121473	2059	None	2	Human	Functional	pEC50	=	9.8	9.8	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	288	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	288	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	6979053	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	6979053	252	None	0	Human	Functional	pEC50	None	5.7	5.7	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	286	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	286	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	6954180	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	6954180	251	None	0	Human	Functional	pEC50	None	6.3	6.3	3	5	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	18381	220193	None	0	Human	Functional	pIC50	=	8.3	8.3	-1	4	NoneNone	Drug Central	469	4	2	6	3.2	CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C(=NO1)C1=C(Cl)C=CC=C1Cl	None
	11434515	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11434515	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	11434515.0	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11434515.0	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	11519741	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11519741	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	4484	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	4484	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	7449	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	7449	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	CHEMBL1194325	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	CHEMBL1194325	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	DB08897	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	DB08897	261	None	6	Human	Functional	pIC50	=	10.1	10.1	1	11	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	1935	3734	None	62	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	2551	3734	None	62	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	6687	3734	None	62	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	CHEMBL95	3734	None	62	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	DB00382	3734	None	62	Mouse	Functional	pIC50	=	5.7	5.7	-19	12	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	154059	3637	None	37	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	154059.0	3637	None	37	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	2457	3637	None	37	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	7483	3637	None	37	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	CHEMBL1734	3637	None	37	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	DB01591	3637	None	37	Human	Functional	pIC50	=	6.2	6.2	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	11693	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	11693	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	3494	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	3494	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	3494.0	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	3494.0	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	4302	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	4302	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	7459	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	7459	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	9933193	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	9933193	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	9933193.0	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	9933193.0	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	CHEMBL1201335	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	CHEMBL1201335	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	DB00986	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	DB00986	1827	None	12	Human	Functional	pIC50	=	9.1	9.1	-3	7	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	3562	None	29	Human	Binding	pAC50	=	9.2	9.2	-8	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3000322.0	3562	None	29	Human	Binding	pAC50	=	9.2	9.2	-8	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	3562	None	29	Human	Binding	pAC50	=	9.2	9.2	-8	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	3562	None	29	Human	Binding	pAC50	=	9.2	9.2	-8	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	3562	None	29	Human	Binding	pAC50	=	9.2	9.2	-8	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11434515	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	11434515.0	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	11519741	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	4484	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	7449	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL1194325	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	DB08897	261	None	6	Human	Binding	pAC50	=	9.1	9.1	-6	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	367	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427.0	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	3824	None	10	Human	Binding	pAC50	=	9.1	9.1	-2	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	11693	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494.0	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193.0	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1827	None	12	Human	Binding	pAC50	=	9.1	9.1	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	25897919	55668	None	12	Human	Binding	pAC50	=	9.1	9.1	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657308	55668	None	12	Human	Binding	pAC50	=	9.1	9.1	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55668	None	12	Human	Binding	pAC50	=	9.1	9.1	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55668	None	12	Human	Binding	pAC50	=	9.1	9.1	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00332	55668	None	12	Human	Binding	pAC50	=	9.1	9.1	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	25897919	55668	None	12	Human	Binding	pAC50	=	8.9	8.9	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657308	55668	None	12	Human	Binding	pAC50	=	8.9	8.9	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55668	None	12	Human	Binding	pAC50	=	8.9	8.9	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55668	None	12	Human	Binding	pAC50	=	8.9	8.9	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00332	55668	None	12	Human	Binding	pAC50	=	8.9	8.9	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	11693	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494.0	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	9933193.0	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1827	None	12	Human	Binding	pAC50	=	8.9	8.9	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	2705	3842	None	44	Human	Binding	pAC50	=	8.0	8.0	-1	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3842	None	44	Human	Binding	pAC50	=	8.0	8.0	-1	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3842	None	44	Human	Binding	pAC50	=	8.0	8.0	-1	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879.0	3842	None	44	Human	Binding	pAC50	=	8.0	8.0	-1	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3842	None	44	Human	Binding	pAC50	=	8.0	8.0	-1	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3842	None	44	Human	Binding	pAC50	=	8.0	8.0	-1	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	3157	1470	None	44	Human	Binding	pAC50	=	5.0	5.0	-	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	3157.0	1470	None	44	Human	Binding	pAC50	=	5.0	5.0	-	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	None	44	Human	Binding	pAC50	=	5.0	5.0	-	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	None	44	Human	Binding	pAC50	=	5.0	5.0	-	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	None	44	Human	Binding	pAC50	=	5.0	5.0	-	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	None	44	Human	Binding	pAC50	=	5.0	5.0	-	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Binding	pAC50	=	5.0	5.0	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Binding	pAC50	=	5.0	5.0	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Binding	pAC50	=	5.0	5.0	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Binding	pAC50	=	5.0	5.0	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Binding	pAC50	=	5.0	5.0	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Binding	pAC50	=	5.0	5.0	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	133	2496	None	39	Human	Binding	pAC50	=	5.0	5.0	-	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	1723	2496	None	39	Human	Binding	pAC50	=	5.0	5.0	-	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	28693	2496	None	39	Human	Binding	pAC50	=	5.0	5.0	-	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL19215	2496	None	39	Human	Binding	pAC50	=	5.0	5.0	-	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	DB13520	2496	None	39	Human	Binding	pAC50	=	5.0	5.0	-	42	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	16119814	56359	None	20	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	CHEMBL1630575	56359	None	20	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	441383	20340	None	41	Human	Binding	pAC50	=	5.0	5.0	-28	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1306	20340	None	41	Human	Binding	pAC50	=	5.0	5.0	-28	17	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Binding	pAC50	=	6.0	6.0	-2	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	4919	208692	None	16	Human	Binding	pAC50	=	7.0	7.0	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	4919.0	208692	None	16	Human	Binding	pAC50	=	7.0	7.0	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	208692	None	16	Human	Binding	pAC50	=	7.0	7.0	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00387	208692	None	16	Human	Binding	pAC50	=	7.0	7.0	-3	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3652	4097	None	50	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4097	None	50	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4097	None	50	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809.0	4097	None	50	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4097	None	50	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4097	None	50	Human	Binding	pAC50	=	7.0	7.0	-18	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	3152	188518	None	61	Human	Binding	pAC50	=	6.0	6.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188518	None	61	Human	Binding	pAC50	=	6.0	6.0	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	2200	3131	None	31	Human	Binding	pAC50	=	6.0	6.0	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3131	None	31	Human	Binding	pAC50	=	6.0	6.0	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3131	None	31	Human	Binding	pAC50	=	6.0	6.0	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848.0	3131	None	31	Human	Binding	pAC50	=	6.0	6.0	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3131	None	31	Human	Binding	pAC50	=	6.0	6.0	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3131	None	31	Human	Binding	pAC50	=	6.0	6.0	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	1613	2348	None	42	Human	Binding	pAC50	=	6.0	6.0	-35	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	None	42	Human	Binding	pAC50	=	6.0	6.0	-35	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	None	42	Human	Binding	pAC50	=	6.0	6.0	-35	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964.0	2348	None	42	Human	Binding	pAC50	=	6.0	6.0	-35	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	None	42	Human	Binding	pAC50	=	6.0	6.0	-35	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	None	42	Human	Binding	pAC50	=	6.0	6.0	-35	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	43815	187026	None	38	Human	Binding	pAC50	=	5.9	5.9	-15	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	187026	None	38	Human	Binding	pAC50	=	5.9	5.9	-15	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	187026	None	38	Human	Binding	pAC50	=	5.9	5.9	-15	24	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	1209	1658	None	52	Human	Binding	pAC50	=	4.9	4.9	-22	31	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	None	52	Human	Binding	pAC50	=	4.9	4.9	-22	31	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	None	52	Human	Binding	pAC50	=	4.9	4.9	-22	31	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	None	52	Human	Binding	pAC50	=	4.9	4.9	-22	31	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	None	52	Human	Binding	pAC50	=	4.9	4.9	-22	31	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	5994	4643	None	51	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4643	None	51	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	2200	3131	None	31	Human	Binding	pAC50	=	5.9	5.9	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	3131	None	31	Human	Binding	pAC50	=	5.9	5.9	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	3131	None	31	Human	Binding	pAC50	=	5.9	5.9	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848.0	3131	None	31	Human	Binding	pAC50	=	5.9	5.9	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	3131	None	31	Human	Binding	pAC50	=	5.9	5.9	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	3131	None	31	Human	Binding	pAC50	=	5.9	5.9	-35	12	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	5050	78229	None	41	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL2105300	78229	None	41	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
	31315	93461	None	51	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL245807	93461	None	51	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	5353853	17993	None	30	Human	Binding	pAC50	=	4.9	4.9	-	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9556529	17993	None	30	Human	Binding	pAC50	=	4.9	4.9	-	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1262	17993	None	30	Human	Binding	pAC50	=	4.9	4.9	-	15	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2018	3007	None	26	Human	Binding	pAC50	=	4.9	4.9	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	9941444	3007	None	26	Human	Binding	pAC50	=	4.9	4.9	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	CHEMBL3349607	3007	None	26	Human	Binding	pAC50	=	4.9	4.9	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	DB06663	3007	None	26	Human	Binding	pAC50	=	4.9	4.9	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	3775	14481	None	19	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	3775.0	14481	None	19	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	14481	None	19	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB01625	14481	None	19	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	4097	14488	None	8	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	4097.0	14488	None	8	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1201264	14488	None	8	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	DB00940	14488	None	8	Human	Binding	pAC50	=	7.9	7.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	2774	3868	None	59	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	3868	None	59	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593.0	3868	None	59	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	3868	None	59	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	3868	None	59	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	3868	None	59	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	3868	None	59	Human	Binding	pAC50	=	5.9	5.9	-1	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	2402	3370	None	38	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	None	38	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095.0	3370	None	38	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	None	38	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	None	38	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	None	38	Human	Binding	pAC50	=	4.9	4.9	-	25	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	15387	45836	None	41	Human	Binding	pAC50	=	4.9	4.9	-16	23	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1531134	45836	None	41	Human	Binding	pAC50	=	4.9	4.9	-16	23	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	1273	1754	None	13	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	3450	1754	None	13	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	356	1754	None	13	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	6172	1754	None	13	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	67425	1754	None	13	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL360055	1754	None	13	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	DB00483	1754	None	13	Human	Binding	pAC50	=	5.9	5.9	-1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
	4904	155611	None	29	Human	Binding	pAC50	=	6.9	6.9	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL404215	155611	None	29	Human	Binding	pAC50	=	6.9	6.9	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4209	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893.0	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	176870	197941	None	62	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
	CHEMBL553	197941	None	62	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
	4209	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893.0	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	None	48	Human	Binding	pAC50	=	4.9	4.9	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	3678	94845	None	37	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	3678.0	94845	None	37	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL253371	94845	None	37	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	DB01616	94845	None	37	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	460612	208502	None	43	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	6918992	208502	None	43	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL852	208502	None	43	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
	5282592	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	5282592.0	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6646	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6646.0	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1200851	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1201235	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1615437	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00725	14482	None	2	Human	Binding	pAC50	=	6.9	6.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
	16222096	80514	None	50	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	CHEMBL2146883	80514	None	50	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	6918456	14521	None	67	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	6918456.0	14521	None	67	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	CHEMBL1201772	14521	None	67	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	DB06209	14521	None	67	Human	Binding	pAC50	=	4.9	4.9	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
	103	4153	None	44	Human	Binding	pAC50	=	5.9	5.9	-177	53	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	None	44	Human	Binding	pAC50	=	5.9	5.9	-177	53	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	None	44	Human	Binding	pAC50	=	5.9	5.9	-177	53	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	None	44	Human	Binding	pAC50	=	5.9	5.9	-177	53	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	None	44	Human	Binding	pAC50	=	5.9	5.9	-177	53	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2444	14484	None	20	Human	Binding	pAC50	=	5.9	5.9	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	2444.0	14484	None	20	Human	Binding	pAC50	=	5.9	5.9	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201245	14484	None	20	Human	Binding	pAC50	=	5.9	5.9	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	DB01237	14484	None	20	Human	Binding	pAC50	=	5.9	5.9	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
	1201549	597	None	17	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1201549.0	597	None	17	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	None	17	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	None	17	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	None	17	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	None	17	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	None	17	Human	Binding	pAC50	=	6.8	6.8	-5	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24958200	8576	None	54	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
	CHEMBL1094636	8576	None	54	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
	5523	3851	None	17	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	5523.0	3851	None	17	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	8286	3851	None	17	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1237044	3851	None	17	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	DB00193	3851	None	17	Human	Binding	pAC50	=	5.8	5.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
	5426	178790	None	69	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
	CHEMBL468	178790	None	69	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
	135398745	2914	None	65	Human	Binding	pAC50	=	6.8	6.8	-38	65	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135398745.0	2914	None	65	Human	Binding	pAC50	=	6.8	6.8	-38	65	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	None	65	Human	Binding	pAC50	=	6.8	6.8	-38	65	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	None	65	Human	Binding	pAC50	=	6.8	6.8	-38	65	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	None	65	Human	Binding	pAC50	=	6.8	6.8	-38	65	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	3627	44143	None	12	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1515447	44143	None	12	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	3447	208834	None	19	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
	CHEMBL87563	208834	None	19	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Binding	pAC50	=	4.8	4.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Binding	pAC50	=	4.8	4.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Binding	pAC50	=	4.8	4.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Binding	pAC50	=	4.8	4.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Binding	pAC50	=	4.8	4.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	20299	14511	None	12	Human	Binding	pAC50	=	7.8	7.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	20299.0	14511	None	12	Human	Binding	pAC50	=	7.8	7.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201354	14511	None	12	Human	Binding	pAC50	=	7.8	7.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00505	14511	None	12	Human	Binding	pAC50	=	7.8	7.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	1712	2492	None	34	Human	Binding	pAC50	=	6.8	6.8	-5	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078	2492	None	34	Human	Binding	pAC50	=	6.8	6.8	-5	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078.0	2492	None	34	Human	Binding	pAC50	=	6.8	6.8	-5	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	7227	2492	None	34	Human	Binding	pAC50	=	6.8	6.8	-5	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	CHEMBL1088	2492	None	34	Human	Binding	pAC50	=	6.8	6.8	-5	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	DB00933	2492	None	34	Human	Binding	pAC50	=	6.8	6.8	-5	21	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4594	42886	None	68	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
	CHEMBL1503	42886	None	68	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
	5584	205669	None	29	Human	Binding	pAC50	=	6.8	6.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	5584.0	205669	None	29	Human	Binding	pAC50	=	6.8	6.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL644	205669	None	29	Human	Binding	pAC50	=	6.8	6.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB00726	205669	None	29	Human	Binding	pAC50	=	6.8	6.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4735	197545	None	57	Human	Binding	pAC50	=	5.8	5.8	-9	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL361506	197545	None	57	Human	Binding	pAC50	=	5.8	5.8	-9	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL55	197545	None	57	Human	Binding	pAC50	=	5.8	5.8	-9	10	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	2166	3123	None	33	Human	Binding	pAC50	=	4.8	4.8	-10	7	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	3123	None	33	Human	Binding	pAC50	=	4.8	4.8	-10	7	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	3123	None	33	Human	Binding	pAC50	=	4.8	4.8	-10	7	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910.0	3123	None	33	Human	Binding	pAC50	=	4.8	4.8	-10	7	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	3123	None	33	Human	Binding	pAC50	=	4.8	4.8	-10	7	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	3123	None	33	Human	Binding	pAC50	=	4.8	4.8	-10	7	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2745	3861	None	30	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	5572	3861	None	30	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	5572.0	3861	None	30	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	66007	3861	None	30	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7315	3861	None	30	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1490	3861	None	30	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00376	3861	None	30	Human	Binding	pAC50	=	7.8	7.8	-46	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	154417	23189	None	39	Human	Binding	pAC50	=	7.8	7.8	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23189	None	39	Human	Binding	pAC50	=	7.8	7.8	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	5311064	1366	None	35	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	534	1366	None	35	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	806	1366	None	35	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL493682	1366	None	35	Human	Binding	pAC50	=	4.8	4.8	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
	2286	3183	None	36	Human	Binding	pAC50	=	6.8	6.8	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	None	36	Human	Binding	pAC50	=	6.8	6.8	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927.0	3183	None	36	Human	Binding	pAC50	=	6.8	6.8	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	None	36	Human	Binding	pAC50	=	6.8	6.8	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	None	36	Human	Binding	pAC50	=	6.8	6.8	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	None	36	Human	Binding	pAC50	=	6.8	6.8	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Binding	pAC50	=	5.8	5.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Binding	pAC50	=	5.8	5.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Binding	pAC50	=	5.8	5.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Binding	pAC50	=	5.8	5.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Binding	pAC50	=	5.8	5.8	-32	41	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2480	19447	None	37	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	CHEMBL129529	19447	None	37	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	49803313	112649	None	55	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL3301622	112649	None	55	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
	3344	200774	None	37	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	CHEMBL576127	200774	None	37	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
	54758501	139154	None	52	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	CHEMBL3786343	139154	None	52	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	6127	14505	None	4	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	6127.0	14505	None	4	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14505	None	4	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13720	14505	None	4	Human	Binding	pAC50	=	6.8	6.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72287	61081	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	72287.0	61081	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1764	61081	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB01403	61081	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL4743867	216518	None	10	Human	Binding	pAC50	=	5.8	5.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	71109	78235	None	5	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	CHEMBL2105453	78235	None	5	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
	24821094	67115	None	58	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67115	None	58	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	62867	3129	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	7557	3129	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL398880	3129	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01621	3129	None	27	Human	Binding	pAC50	=	5.8	5.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	3103	41672	None	36	Human	Binding	pAC50	=	6.8	6.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	3103.0	41672	None	36	Human	Binding	pAC50	=	6.8	6.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1492	41672	None	36	Human	Binding	pAC50	=	6.8	6.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB01146	41672	None	36	Human	Binding	pAC50	=	6.8	6.8	-	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	9571107	167617	None	23	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	CHEMBL430	167617	None	23	Human	Binding	pAC50	=	4.8	4.8	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
	2337	3256	None	51	Human	Binding	pAC50	=	5.8	5.8	-31	62	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	None	51	Human	Binding	pAC50	=	5.8	5.8	-31	62	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	None	51	Human	Binding	pAC50	=	5.8	5.8	-31	62	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002.0	3256	None	51	Human	Binding	pAC50	=	5.8	5.8	-31	62	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	None	51	Human	Binding	pAC50	=	5.8	5.8	-31	62	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	None	51	Human	Binding	pAC50	=	5.8	5.8	-31	62	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5591	157623	None	57	Human	Binding	pAC50	=	4.8	4.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157623	None	57	Human	Binding	pAC50	=	4.8	4.8	-	2	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	1224	1432	None	51	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	None	51	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100.0	1432	None	51	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	None	51	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	None	51	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	None	51	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	None	51	Human	Binding	pAC50	=	5.8	5.8	-6	13	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	40973	46049	None	50	Human	Binding	pAC50	=	5.7	5.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1533	46049	None	50	Human	Binding	pAC50	=	5.7	5.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
	3606	205946	None	40	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL6615	205946	None	40	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Binding	pAC50	=	6.7	6.7	-27	39	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Binding	pAC50	=	6.7	6.7	-27	39	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Binding	pAC50	=	6.7	6.7	-27	39	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Binding	pAC50	=	6.7	6.7	-27	39	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Binding	pAC50	=	6.7	6.7	-27	39	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Binding	pAC50	=	6.7	6.7	-27	39	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1599	2341	None	28	Human	Binding	pAC50	=	4.7	4.7	-	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955	2341	None	28	Human	Binding	pAC50	=	4.7	4.7	-	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955.0	2341	None	28	Human	Binding	pAC50	=	4.7	4.7	-	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7215	2341	None	28	Human	Binding	pAC50	=	4.7	4.7	-	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL841	2341	None	28	Human	Binding	pAC50	=	4.7	4.7	-	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00836	2341	None	28	Human	Binding	pAC50	=	4.7	4.7	-	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135400189	44589	None	42	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	CHEMBL1520	44589	None	42	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Binding	pAC50	=	6.7	6.7	-22	91	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	4417	55578	None	40	Human	Binding	pAC50	=	6.7	6.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1439099	55578	None	40	Human	Binding	pAC50	=	6.7	6.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1620794	55578	None	40	Human	Binding	pAC50	=	6.7	6.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	656603	194645	None	3	Human	Binding	pAC50	=	6.7	6.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL5292015	194645	None	3	Human	Binding	pAC50	=	6.7	6.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6077	150786	None	16	Human	Binding	pAC50	=	6.7	6.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150786	None	16	Human	Binding	pAC50	=	6.7	6.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	40466968	209494	None	46	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	60947	209494	None	46	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL916	209494	None	46	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	27857	194644	None	25	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL5291995	194644	None	25	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
	41049	106816	None	25	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	41049.0	106816	None	25	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	CHEMBL314437	106816	None	25	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	DB13478	106816	None	25	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
	18609376	206817	None	38	Human	Binding	pAC50	=	4.7	4.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	6279	206817	None	38	Human	Binding	pAC50	=	4.7	4.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL717	206817	None	38	Human	Binding	pAC50	=	4.7	4.7	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	3294	2006	None	61	Human	Binding	pAC50	=	5.7	5.7	-194	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	None	61	Human	Binding	pAC50	=	5.7	5.7	-194	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360.0	2006	None	61	Human	Binding	pAC50	=	5.7	5.7	-194	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	None	61	Human	Binding	pAC50	=	5.7	5.7	-194	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	None	61	Human	Binding	pAC50	=	5.7	5.7	-194	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	None	61	Human	Binding	pAC50	=	5.7	5.7	-194	44	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	1726	2497	None	8	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	1993	2497	None	8	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	1993.0	2497	None	8	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	7438	2497	None	8	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	CHEMBL978	2497	None	8	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	DB06709	2497	None	8	Human	Binding	pAC50	=	5.7	5.7	-2	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
	5440	28732	None	28	Human	Binding	pAC50	=	5.7	5.7	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5440.0	28732	None	28	Human	Binding	pAC50	=	5.7	5.7	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28732	None	28	Human	Binding	pAC50	=	5.7	5.7	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB00372	28732	None	28	Human	Binding	pAC50	=	5.7	5.7	-	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	193962	103848	None	63	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	CHEMBL308954	103848	None	63	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
	9853053	120583	None	54	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL354541	120583	None	54	Human	Binding	pAC50	=	4.7	4.7	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	24821094	67115	None	58	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67115	None	58	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	2895	206050	None	27	Human	Binding	pAC50	=	6.6	6.6	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2895.0	206050	None	27	Human	Binding	pAC50	=	6.6	6.6	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	206050	None	27	Human	Binding	pAC50	=	6.6	6.6	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	206050	None	27	Human	Binding	pAC50	=	6.6	6.6	-1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	121515	201555	None	41	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL588934	201555	None	41	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	443869	78170	None	28	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2103761	78170	None	28	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	432824	78293	None	10	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	CHEMBL2106996	78293	None	10	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	10180	98923	None	36	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL279014	98923	None	36	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	208898	66220	None	50	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	208898.0	66220	None	50	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	CHEMBL184412	66220	None	50	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	DB04855	66220	None	50	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	4761	13446	None	28	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	4761.0	13446	None	28	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1193	13446	None	28	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1580221	13446	None	28	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1653	13446	None	28	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	DB01620	13446	None	28	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
	1547484	940	None	51	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1547484.0	940	None	51	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	654	940	None	51	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	9072	940	None	51	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL43064	940	None	51	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00568	940	None	51	Human	Binding	pAC50	=	5.6	5.6	-	20	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	151537	162759	None	30	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	41867	162759	None	30	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL417	162759	None	30	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	9324	9240	None	40	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL110691	9240	None	40	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	5039	63203	None	12	Human	Binding	pAC50	=	5.6	5.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	5039.0	63203	None	12	Human	Binding	pAC50	=	5.6	5.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	CHEMBL1790041	63203	None	12	Human	Binding	pAC50	=	5.6	5.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	DB00863	63203	None	12	Human	Binding	pAC50	=	5.6	5.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	5284632	67423	None	10	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	5284632.0	67423	None	10	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	67423	None	10	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	67423	None	10	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00209	67423	None	10	Human	Binding	pAC50	=	7.6	7.6	-1	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4642	42000	None	22	Human	Binding	pAC50	=	7.6	7.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	4642.0	42000	None	22	Human	Binding	pAC50	=	7.6	7.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	42000	None	22	Human	Binding	pAC50	=	7.6	7.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	DB00383	42000	None	22	Human	Binding	pAC50	=	7.6	7.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	4034	55838	None	37	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	4034.0	55838	None	37	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55838	None	37	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	DB00737	55838	None	37	Human	Binding	pAC50	=	4.6	4.6	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	7099	197978	None	47	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	CHEMBL55400	197978	None	47	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
	9419	35931	None	28	Human	Binding	pAC50	=	5.6	5.6	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	9419.0	35931	None	28	Human	Binding	pAC50	=	5.6	5.6	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1442422	35931	None	28	Human	Binding	pAC50	=	5.6	5.6	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	DB13225	35931	None	28	Human	Binding	pAC50	=	5.6	5.6	-	6	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	4940	14476	None	26	Human	Binding	pAC50	=	6.6	6.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14476	None	26	Human	Binding	pAC50	=	6.6	6.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	4021	100534	None	72	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	CHEMBL290916	100534	None	72	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	9429	204590	None	44	Human	Binding	pAC50	=	5.6	5.6	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	9429.0	204590	None	44	Human	Binding	pAC50	=	5.6	5.6	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	204590	None	44	Human	Binding	pAC50	=	5.6	5.6	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	DB01622	204590	None	44	Human	Binding	pAC50	=	5.6	5.6	-	5	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3152	188518	None	61	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188518	None	61	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	22530	56146	None	40	Human	Binding	pAC50	=	6.6	6.6	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1600878	56146	None	40	Human	Binding	pAC50	=	6.6	6.6	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1625607	56146	None	40	Human	Binding	pAC50	=	6.6	6.6	-	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	5351322	94844	None	30	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL25336	94844	None	30	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	708857	56200	None	27	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1626223	56200	None	27	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
	9400	14497	None	27	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
	CHEMBL1201302	14497	None	27	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
	2726	919	None	48	Human	Binding	pAC50	=	5.6	5.6	-79	72	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2726.0	919	None	48	Human	Binding	pAC50	=	5.6	5.6	-79	72	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	None	48	Human	Binding	pAC50	=	5.6	5.6	-79	72	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	None	48	Human	Binding	pAC50	=	5.6	5.6	-79	72	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	None	48	Human	Binding	pAC50	=	5.6	5.6	-79	72	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	None	48	Human	Binding	pAC50	=	5.6	5.6	-79	72	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	3180	14479	None	25	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201217	14479	None	25	Human	Binding	pAC50	=	5.6	5.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	1712095	197848	None	22	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
	CHEMBL551978	197848	None	22	Human	Binding	pAC50	=	4.6	4.6	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
	25295	13625	None	28	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1194287	13625	None	28	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Binding	pAC50	=	4.5	4.5	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Binding	pAC50	=	4.5	4.5	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Binding	pAC50	=	4.5	4.5	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Binding	pAC50	=	4.5	4.5	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Binding	pAC50	=	4.5	4.5	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Binding	pAC50	=	4.5	4.5	-	35	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	22323	15305	None	29	Human	Binding	pAC50	=	4.5	4.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15305	None	29	Human	Binding	pAC50	=	4.5	4.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15305	None	29	Human	Binding	pAC50	=	4.5	4.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	4098	32513	None	25	Human	Binding	pAC50	=	5.5	5.5	-15	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1255739	32513	None	25	Human	Binding	pAC50	=	5.5	5.5	-15	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1411979	32513	None	25	Human	Binding	pAC50	=	5.5	5.5	-15	11	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
	23724781	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	23724781.0	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	316	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	317	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	71183	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1354199	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3140030	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL376897	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB00462	2835	None	13	Human	Binding	pAC50	=	8.5	8.5	-5	9	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	2039	2982	None	13	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	5749	2982	None	13	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	5749.0	2982	None	13	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	7257	2982	None	13	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	CHEMBL1201286	2982	None	13	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	DB00219	2982	None	13	Human	Binding	pAC50	=	8.5	8.5	-	1	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
	2293	3186	None	19	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	329	3186	None	19	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	4934	3186	None	19	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	4934.0	3186	None	19	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	CHEMBL1180725	3186	None	19	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	DB00782	3186	None	19	Human	Binding	pAC50	=	8.5	8.5	-2	4	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
	25897919	55668	None	12	Human	Binding	pAC50	=	8.5	8.5	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657308	55668	None	12	Human	Binding	pAC50	=	8.5	8.5	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	657309	55668	None	12	Human	Binding	pAC50	=	8.5	8.5	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1621597	55668	None	12	Human	Binding	pAC50	=	8.5	8.5	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	DB00332	55668	None	12	Human	Binding	pAC50	=	8.5	8.5	1	8	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	6917866	167534	None	5	Human	Binding	pAC50	=	8.5	8.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL4297364	167534	None	5	Human	Binding	pAC50	=	8.5	8.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
	2784	952	None	9	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	2784.0	952	None	9	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	351	952	None	9	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	366	952	None	9	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	676	952	None	9	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL620	952	None	9	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	DB00771	952	None	9	Human	Binding	pAC50	=	8.5	8.5	1	3	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
	174174	523	None	33	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	174174.0	523	None	33	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	260	523	None	33	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	320	523	None	33	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	CHEMBL517712	523	None	33	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	DB00572	523	None	33	Human	Binding	pAC50	=	8.4	8.4	-7	14	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
	2286	3183	None	36	Human	Binding	pAC50	=	7.5	7.5	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	None	36	Human	Binding	pAC50	=	7.5	7.5	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927.0	3183	None	36	Human	Binding	pAC50	=	7.5	7.5	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	None	36	Human	Binding	pAC50	=	7.5	7.5	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	None	36	Human	Binding	pAC50	=	7.5	7.5	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	None	36	Human	Binding	pAC50	=	7.5	7.5	-4	29	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	68778	115269	None	46	Human	Binding	pAC50	=	6.5	6.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL334491	115269	None	46	Human	Binding	pAC50	=	6.5	6.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	1548955	88615	None	14	Human	Binding	pAC50	=	5.5	5.5	-1	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2800	88615	None	14	Human	Binding	pAC50	=	5.5	5.5	-1	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2355051	88615	None	14	Human	Binding	pAC50	=	5.5	5.5	-1	18	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Binding	pAC50	=	6.5	6.5	-19	55	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Binding	pAC50	=	5.5	5.5	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Binding	pAC50	=	5.5	5.5	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Binding	pAC50	=	5.5	5.5	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Binding	pAC50	=	5.5	5.5	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Binding	pAC50	=	5.5	5.5	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Binding	pAC50	=	5.5	5.5	-295	51	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	3607	36392	None	50	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
	CHEMBL144673	36392	None	50	Human	Binding	pAC50	=	5.5	5.5	-	0	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting

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Ligand source activities (1 row/activity)