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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
crfr1_human 5.43x43 276 TM5 M => I 35.481↓ pK(i) (Binding - Radioligand competition/displacement) NBI 27914 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.30x30 189 TM3 R => H 1.375↓ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.479↑ pK(i) (Binding - Radioligand competition/displacement) astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.30x30 189 TM3 R => H 1.667↓ EC50 (Functional - cAMP accumulation) sauvagine Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 48.978↓ pK(i) (Binding - Radioligand competition/displacement) aryltriazole-(S)-71 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => I <5.012↓ pK(i) (Binding - Radioligand competition/displacement) antalarmin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.82↓ pK(i) (Binding - Radioligand competition/displacement) NBI 30775 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 1.047↑ pK(d) (Binding - Radioligand competition/displacement) [125I]sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.47x47 206 TM3 M => A 9.709↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 266 ECL2 V => E 1.5↓ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 6.49x49 323 TM6 L => A 3.774↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => W 1.047↑ pK(d) (Binding - Radioligand competition/displacement) sauvagine-[Tyr0,Gln1, Leu17] Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 257 ECL2 K => Q N/A N/A Liaw CW et al (1997)
crfr1_human 5.43x43 276 TM5 M => I 1.818↑ pK(d) (Binding - Radioligand competition/displacement) [125I]astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.46x46 279 TM5 V => A 4.049↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => W 4.677↓ pEC50 (Functional - cAMP accumulation) astressin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.698↓ pK(i) (Binding - Radioligand competition/displacement) arylamidrazone-51 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 52.481↓ pK(i) (Binding - Radioligand competition/displacement) NBI 35965 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 75.858↓ pK(i) (Binding - Radioligand competition/displacement) NBI 35965 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 257 ECL2 K => R 1.138↑ K(i) (Binding - Radioligand competition/displacement) sauvagine Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 20.417↓ pK(i) (Binding - Radioligand competition/displacement) antalarmin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.047↓ pK(i) (Binding - Radioligand competition/displacement) astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.30x30 189 TM3 R => H 1.115↑ EC50 (Functional - cAMP accumulation) urocortin Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 17.783↓ pK(i) (Binding - Radioligand competition/displacement) DMP696 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 194.984↓ pK(i) (Binding - Radioligand competition/displacement) desmethyl-NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.445↓ pK(i) (Binding - Radioligand competition/displacement) DMP696 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 1.024↑ pK(i) (Binding - Radioligand competition/displacement) arylamidrazone-51 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.122↑ pK(d) (Binding - Radioligand competition/displacement) [125I]sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 4.44x45 230 TM4 M => L 3.663↑ EC50 (Functional - cAMP accumulation) sauvagine-[Tyr0,Gln1, Leu17] Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.0 pK(i) (Binding - Radioligand competition/displacement) antalarmin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 10.965↓ pK(i) (Binding - Radioligand competition/displacement) antalarmin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => A <416.869↓ pK(i) (Binding - Radioligand competition/displacement) antalarmin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => W 1.905↓ pK(i) (Binding - Radioligand competition/displacement) astressin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => A 2.399↓ pEC50 (Functional - cAMP accumulation) antalarmin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.50x50 283 TM5 N => A 83.333↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 6.45x45 319 TM6 L => A 9.709↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 244.824↓ K(i) (Binding - Radioligand competition/displacement) NBI 27914 Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 3.31x31 190 TM3 L => C 1.143↑ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 6.50x50 324 TM6 G => A 3.774↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 3.31x31 190 TM3 L => C N/A N/A Liaw CW et al (1997)
crfr1_human 5.57x57 290 TM5 I => A 10.753↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 3.40x40 199 TM3 H => V 1.6↓ K(i) (Binding - Radioligand competition/displacement) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 3.32x32 191 TM3 V => I 1.143↑ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 4.44x45 230 TM4 M => L 3.663↑ EC50 (Functional - cAMP accumulation) CRF Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 6.46x46 320 TM6 L => A 1.193↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 5.47x47 280 TM5 L => A 47.619↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => I 1.288↓ pEC50 (Functional - cAMP accumulation) sauvagine Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 3.40x40 199 TM3 H => V 44.118↓ K(i) (Binding - Radioligand competition/displacement) NBI 27914 Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => W <83.333↑ pK(i) (Binding - Radioligand competition/displacement) antalarmin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 4.074↓ pK(i) (Binding - Radioligand competition/displacement) NBI 27914 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 262 ECL2 K => R 1.466↑ EC50 (Functional - cAMP accumulation) sauvagine-[Tyr0,Gln1, Leu17] Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => A 50.0↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.513↑ pK(d) (Binding - Radioligand competition/displacement) [125I]astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => W 11.22↓ pEC50 (Functional - cAMP accumulation) antalarmin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.862↑ pK(i) (Binding - Radioligand competition/displacement) GTPγS Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.54x54 287 TM5 L => A 23.81↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 3.30x30 189 TM3 R => H N/A N/A Liaw CW et al (1997)
crfr1_human 3.44x44 203 TM3 F => I 1.514↓ pK(i) (Binding - Radioligand competition/displacement) astressin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => A 26.915↓ pK(d) (Binding - Radioligand competition/displacement) sauvagine-[Tyr0,Gln1, Leu17] Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 3.32x32 191 TM3 V => I N/A N/A Liaw CW et al (1997)
crfr1_human 5.43x43 276 TM5 M => L 1.023↓ pK(i) (Binding - Radioligand competition/displacement) NBI 30775 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 1.288↓ pK(i) (Binding - Radioligand competition/displacement) astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.096↓ pK(i) (Binding - Radioligand competition/displacement) antalarmin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.514↓ pK(i) (Binding - Radioligand competition/displacement) aryltriazole-(S)-71 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 266 ECL2 V => D N/A N/A Liaw CW et al (1997)
crfr1_human 5.43x43 276 TM5 M => V 61.66↓ pK(i) (Binding - Radioligand competition/displacement) NBI 27914 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 3.548↓ pK(i) (Binding - Radioligand competition/displacement) desmethyl-NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => I 43.652↓ pEC50 (Functional - cAMP accumulation) antalarmin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.51x51 284 TM5 F => A 2.222↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.905↑ pK(i) (Binding - Radioligand competition/displacement) sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => K 1.35↑ pK(d) (Binding - Radioligand competition/displacement) sauvagine-[Tyr0,Gln1, Leu17] Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => I 1.047↑ pK(d) (Binding - Radioligand competition/displacement) sauvagine-[Tyr0,Gln1, Leu17] Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 1.202↓ pK(i) (Binding - Radioligand competition/displacement) GTPγS Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 7.413↓ pK(i) (Binding - Radioligand competition/displacement) DMP696 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 3.467↓ pK(i) (Binding - Radioligand competition/displacement) NBI 27914 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 6.53x53 327 TM6 Y => A 10.753↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => A 20.893↓ pEC50 (Functional - cAMP accumulation) astressin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 7.244↓ pK(i) (Binding - Radioligand competition/displacement) NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 263 ECL2 R => D 1.143↑ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 7.49x49 355 TM7 Q => A 83.333↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 4.68x68 254 TM4 D => E 1.453↑ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => A 23.988↓ pEC50 (Functional - cAMP accumulation) sauvagine Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.288↓ pK(i) (Binding - Radioligand competition/displacement) GTPγS Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 1.23↑ pK(d) (Binding - Radioligand competition/displacement) [125I]sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 27.542↓ pK(i) (Binding - Radioligand competition/displacement) aryltriazole-(S)-71 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 199.526↓ pK(i) (Binding - Radioligand competition/displacement) desmethyl-NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.513↑ pK(i) (Binding - Radioligand competition/displacement) sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.30x30 189 TM3 R => H 1.667↓ EC50 (Functional - cAMP accumulation) sauvagine Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 4.68x68 254 TM4 D => E N/A N/A Liaw CW et al (1997)
crfr1_human 5.43x43 276 TM5 M => A 2.951↓ pK(i) (Binding - Radioligand competition/displacement) NBI 35965 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 1.175↑ pK(i) (Binding - Radioligand competition/displacement) astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 1.38↓ pK(i) (Binding - Radioligand competition/displacement) arylamidrazone-51 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 18.197↓ pK(i) (Binding - Radioligand competition/displacement) NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 1.143↓ K(i) (Binding - Radioligand competition/displacement) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 263 ECL2 R => E N/A N/A Liaw CW et al (1997)
crfr1_human 5.43x43 276 TM5 M => V 4.169↓ pK(i) (Binding - Radioligand competition/displacement) NBI 30775 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.778↓ pK(i) (Binding - Radioligand competition/displacement) aryltriazole-(S)-71 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.072↑ pK(i) (Binding - Radioligand competition/displacement) NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 1.122↑ pK(i) (Binding - Radioligand competition/displacement) DMP696 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 1.445↑ pK(i) (Binding - Radioligand competition/displacement) sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 262 ECL2 K => R 1.207↓ K(i) (Binding - Radioligand competition/displacement) sauvagine Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
crfr1_human 257 ECL2 K => Q 1.066↑ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 1.122↑ pK(d) (Binding - Radioligand competition/displacement) [125I]astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 1.0 pK(i) (Binding - Radioligand competition/displacement) sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => A 1.024↑ pK(i) (Binding - Radioligand competition/displacement) astressin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => I 5.495↓ pEC50 (Functional - cAMP accumulation) astressin Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.479↓ pK(i) (Binding - Radioligand competition/displacement) arylamidrazone-51 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 4.44x45 230 TM4 M => L 1.741↓ K(i) (Binding - Radioligand competition/displacement) sauvagine Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
crfr1_human 3.44x44 203 TM3 F => W 1.995↓ pEC50 (Functional - cAMP accumulation) sauvagine Spyridaki K et al (2014) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.349↓ pK(i) (Binding - Radioligand competition/displacement) NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 6.42x42 316 TM6 T => A 2.32↑ Single-point (Binding - Radioligand competition/displacement) [ 3H]CP-376395 Hollenstein K et al (2013) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.513↑ pK(d) (Binding - Radioligand competition/displacement) [125I]astressin Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => L 2.239↓ pK(i) (Binding - Radioligand competition/displacement) NBI 35965 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 257 ECL2 K => R 11.409↓ EC50 (Functional - cAMP accumulation) sauvagine-[Tyr0,Gln1, Leu17] Assil-Kishawi I et al (2002) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => V 1.23↓ pK(i) (Binding - Radioligand competition/displacement) GTPγS Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 1.202↑ pK(d) (Binding - Radioligand competition/displacement) [125I]sauvagine Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 4.68x68 254 TM4 D => E 1.453↑ EC50 (Functional - cAMP accumulation) CRF Liaw CW et al (1997) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => A 5.495↓ pK(i) (Binding - Radioligand competition/displacement) desmethyl-NBI 34041 Hoare SR et al (2006) Hollenstein K et al (2014)
crfr1_human 5.43x43 276 TM5 M => I 5.012↓ pK(i) (Binding - Radioligand competition/displacement) NBI 30775 Hoare SR et al (2006) Hollenstein K et al (2014)


Residue

Diagrams

ICL1 R S I R ICL1ECL1 M S P E V H Q S N ECL1ICL2 T Y S T D R ICL2ECL2 N E K C W F G K R P G V Y ECL2ICL3 R A S T T ICL3ECL3 N P G E D ECL3N-term M G G H P Q L R L V K A L L L L G L N P V S A S L Q D Q H C E S L S L A S N I S G L Q C N A S V D L I G T C W P R S P A G Q L V V R P C P A F F Y G V R Y N T T N N G Y R E C L A N G S W A A R V N Y S E C N-termC-term R A M S I P T S P T R V S F H S I K Q S T A V C-term Q E I L N E E K K S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L C L R N I I H W N L I S A F I L R N A T W F V V Q L T V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E I R K W Q D R A R V R S A R W H R K H S I V A
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L L A V L S I C H G L Y N I I V A V H Y 1 W N L I S A F I L R N A T W F V V Q L T 2 G F M W F F N T V H F Y N Y A A T V L R 3 R K W M F I C G I W G V P F P I I V A W A 4 L F I F N I L L V L I M P G Q Y I Y D T 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S E L F S N F Y I F V 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF1 receptor
TM3
3x26 3.30x30 R189
3x27 3.31x31 L190
3x28 3.32x32 V191
3x36 3.40x40 H199
3x40 3.44x44 F203
3x43 3.47x47 M206
TM4
4x45 4.44x45 M230
4x68 4.68x68 D254
TM5
5x47 5.43x43 M276
5x50 5.46x46 V279
5x51 5.47x47 L280
5x54 5.50x50 N283
5x55 5.51x51 F284
5x58 5.54x54 L287
5x61 5.57x57 I290
TM6
6x37 6.42x42 T316
6x40 6.45x45 L319
6x41 6.46x46 L320
6x44 6.49x49 L323
6x45 6.50x50 G324
6x48 6.53x53 Y327
TM7
7x45 7.49x49 Q355