Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
gipr_human 6.37x37 338 TM6 R => A 1.633↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 6.42x42 343 TM6 T => A 6.135↑ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 3.50x50 237 TM3 E => A Abolished effect IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 7.49x49 384 TM7 Q => A 2.653↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 3.33x33 220 TM3 Q => A 4.694↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 5.60x60 320 TM5 I => A 1.458↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 3.58x58 245 TM3 L => S 2.51↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 3.43x43 230 TM3 N => A 6.48↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 7.46x45 381 TM7 S => A 1.634↑ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 6.56x56 357 TM6 F => A 15.714↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 3.50x50 237 TM3 E => A 10.163↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 2.67x67 190 TM2 R => A 71.071↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 7.57x57 392 TM7 Y => A 2.98↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 2.50x50 173 TM2 H => A Abolished effect EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 3.36x36 223 TM3 T => A 3.418↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 6.53x53 354 TM6 E => A 4.902↑ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 7.57x57 392 TM7 Y => A 5.0↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 2.46x46 169 TM2 R => A 1.198↓ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 5.40x40 300 TM5 R => A 41.99↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 3.58x58 245 TM3 L => S 7.092↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 6.53x53 354 TM6 E => A 2.695↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 7.49x49 384 TM7 Q => A 1.633↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 6.38x38 339 TM6 L => S 4.202↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 3.44x44 231 TM3 Y => A 2.143↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 7.46x45 381 TM7 S => A 1.805↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 6.52x52 353 TM6 H => A 1.276↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 2.46x46 169 TM2 R => A 6.796↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 6.42x42 343 TM6 T => S 2.227↑ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 2.50x50 173 TM2 H => N 1.065↓ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 3.37x37 224 TM3 Q => A 5.612↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 5.60x60 320 TM5 I => A 1.939↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 3.44x44 231 TM3 Y => F 4.031↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 6.42x42 343 TM6 T => A 6.667↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 5.50x50 310 TM5 N => A 6.673↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 2.60x60 183 TM2 R => A 76.378↓ EC50 (Binding - Radioligand competition/displacement) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 6.38x38 339 TM6 L => S 5.286↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 2.50x50 173 TM2 H => A Abolished effect IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 6.37x37 338 TM6 R => A 2.479↓ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 5.57x57 317 TM5 I => S 6.633↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 2.50x50 173 TM2 H => N 4.102↓ EC50 (Functional - cAMP accumulation) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 198 ECL1 G => C N/A N/A Miyawaki K et al (1999)
gipr_human 7.57x57 392 TM7 Y => A 4.847↓ EC50 (Functional - cAMP accumulation) GIP Yaqub T et al (2010) Hollenstein K et al (2014)
gipr_human 5.50x50 310 TM5 N => A 1.276↓ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 5.57x57 317 TM5 I => S 2.004↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790
gipr_human 6.42x42 343 TM6 T => S 4.739↑ IC50 (Binding - Radioligand competition/displacement) GIP Cordomi A et al (2015) 10.5281/zenodo.60790


Residue

Diagrams

ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N Q A L ECL1ICL2 V G G S E E ICL2ECL2 N T Q C W E R N E V K A I ECL2ICL3 R Q M R C R ICL3ECL3 E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N E A N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L G H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T D Y R L R L A R S T L T L V P L L G V H E V V F A P V T E G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W 5 L T L V P L L G V H E V V F A P V T E 6 V S V L F G Q F S S L F I E F G L K A 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
GIP receptor
TM2
2x39 2.46x46 R169
2x43 2.50x50 H173
2x53 2.60x60 R183
2x60 2.67x67 R190
TM3
3x29 3.33x33 Q220
3x32 3.36x36 T223
3x33 3.37x37 Q224
3x39 3.43x43 N230
3x40 3.44x44 Y231
3x46 3.50x50 E237
3x54 3.58x58 L245
TM5
5x44 5.40x40 R300
5x54 5.50x50 N310
5x61 5.57x57 I317
5x64 5.60x60 I320
TM6
6x32 6.37x37 R338
6x33 6.38x38 L339
6x37 6.42x42 T343
6x47 6.52x52 H353
6x48 6.53x53 E354
6x51 6.56x56 F357
TM7
7x41 7.46x45 S381
7x45 7.49x49 Q384
7x53 7.57x57 Y392