Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
gnrhr_mouse 4.40x40 154 TM4 K => Q N/A N/A Arora KK et al (1997)
gnrhr_mouse 3.51x51 140 TM3 S => A N/A N/A Arora KK et al (1997)
gnrhr_mouse 7.49x49 318 TM7 D => N N/A N/A Mitchell R et al (1998)
gnrhr_mouse 3.49x49 138 TM3 D => E N/A N/A Arora KK et al (1997)
gnrhr_mouse 3.51x51 140 TM3 S => A N/A N/A Arora KK et al (1995)
gnrhr_mouse 7.49x49 318 TM7 D => N N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 3.50x50 139 TM3 R => S N/A N/A Arora KK et al (1997)
gnrhr_mouse 34.51x51 147 ICL2 L => A N/A N/A Arora KK et al (1995)
gnrhr_mouse 7.53x53 322 TM7 Y => F N/A N/A Arora KK et al (1996)
gnrhr_mouse 7.32x31 301 TM7 E => Q N/A N/A Flanagan CA et al (1998)
gnrhr_mouse 7.49x49 318 TM7 D => L N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 1.50x50 53 TM1 N => D N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 3.50x50 139 TM3 R => A N/A N/A Arora KK et al (1997)
gnrhr_mouse 7.49x49 318 TM7 D => E N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 12.50x50 73 ICL1 L => R N/A N/A Arora KK et al (1998)
gnrhr_mouse 7.49x49 318 TM7 D => N N/A N/A Arora KK et al (1996)
gnrhr_mouse 24 N-term I => T N/A N/A Knollman PE et al (2005)
gnrhr_mouse 34.51x51 147 ICL2 L => A N/A N/A Arora KK et al (1995)
gnrhr_mouse 2.53x53 90 TM2 E => Q N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 3.51x51 140 TM3 S => A N/A N/A Arora KK et al (1997)
gnrhr_mouse 7.53x53 322 TM7 Y => A N/A N/A Arora KK et al (1996)
gnrhr_mouse 7.49x49 318 TM7 D => N N/A N/A Arora KK et al (1996)
gnrhr_mouse 34.51x51 147 ICL2 L => D N/A N/A Arora KK et al (1995)
gnrhr_mouse 3.51x51 140 TM3 S => Y N/A N/A Arora KK et al (1995)
gnrhr_mouse 3.49x49 138 TM3 D => N N/A N/A Arora KK et al (1997)
gnrhr_mouse 3.51x51 140 TM3 S => Y N/A N/A Arora KK et al (1995)
gnrhr_mouse 2.50x50 87 TM2 N => D N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 1.58x58 61 TM1 Q => E N/A N/A Arora KK et al (1998)
gnrhr_mouse 6.61x61 292 TM6 D => N N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 7.49x49 318 TM7 D => N N/A N/A Awara WM et al (1996)
gnrhr_mouse 1.59x59 62 TM1 K => Q N/A N/A Arora KK et al (1998)
gnrhr_mouse 8 N-term E => Q N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 4.42x42 156 TM4 E => Q N/A N/A Arora KK et al (1997)
gnrhr_mouse 2.50x50 87 TM2 N => Q N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 1.55x55 58 TM1 L => A N/A N/A Arora KK et al (1998)
gnrhr_mouse 18 N-term N => Q N/A N/A Davidson JS et al (1995)
gnrhr_mouse 5.44x45 216 TM5 G => S N/A N/A Knollman PE et al (2005)
gnrhr_mouse 3.49x49 138 TM3 D => N N/A N/A Arora KK et al (1997)
gnrhr_mouse 3.32x32 121 TM3 K => Q N/A N/A Blomenrohr M et al (2001)
gnrhr_mouse 7.32x31 301 TM7 E => Q N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 2.61x60 98 TM2 D => N N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 1.56x56 59 TM1 K => Q N/A N/A Arora KK et al (1998)
gnrhr_mouse 294 ECL3 E => Q N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 7.53x53 322 TM7 Y => A N/A N/A Arora KK et al (1996)
gnrhr_mouse 3.50x50 139 TM3 R => S N/A N/A Arora KK et al (1997)
gnrhr_mouse 2.43x43 80 TM2 L => A N/A N/A Arora KK et al (1998)
gnrhr_mouse 3.49x49 138 TM3 D => E N/A N/A Arora KK et al (1997)
gnrhr_mouse 7.49x49 318 TM7 D => N N/A N/A Zhou W et al (1994)
gnrhr_mouse 3.50x50 139 TM3 R => Q N/A N/A Arora KK et al (1997)
gnrhr_mouse 2.50x50 87 TM2 N => D N/A N/A Zhou W et al (1994)
gnrhr_mouse 11 N-term P => Q N/A N/A Knollman PE et al (2005)
gnrhr_mouse 3.50x50 139 TM3 R => A N/A N/A Arora KK et al (1997)
gnrhr_mouse 2.50x50 87 TM2 N => A N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 12.51x51 74 ICL1 S => E N/A N/A Arora KK et al (1998)
gnrhr_mouse 151 ICL2 S => A N/A N/A Arora KK et al (1997)
gnrhr_mouse 7.53x53 322 TM7 Y => F N/A N/A Arora KK et al (1996)
gnrhr_mouse 3.22x22 111 TM3 E => Q N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 6.34x34 265 TM6 L => R N/A N/A Knollman PE et al (2005)
gnrhr_mouse 2.61x60 98 TM2 D => E N/A N/A Janovick JA et al (2011)
gnrhr_mouse 1.50x50 53 TM1 N => L N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 7.49x49 318 TM7 D => A N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 4 N-term N => Q N/A N/A Davidson JS et al (1995)
gnrhr_mouse 2.65x64 102 TM2 N => Q N/A N/A Davidson JS et al (1995)
gnrhr_mouse 1.50x50 53 TM1 N => A N/A N/A Flanagan CA et al (1999)
gnrhr_mouse 4.39x39 153 TM4 S => A N/A N/A Arora KK et al (1997)
gnrhr_mouse 34.51x51 147 ICL2 L => D N/A N/A Arora KK et al (1995)
gnrhr_mouse 7.32x31 301 TM7 E => Q N/A N/A Flanagan CA et al (1994)
gnrhr_mouse 3.50x50 139 TM3 R => Q N/A N/A Arora KK et al (1997)
gnrhr_mouse 185 ECL2 D => N N/A N/A Flanagan CA et al (1994)


Residue

Diagrams

ICL1 K T Q K R K K G K L S ICL1ECL1 I T V Q W Y A ECL1ICL2 P L A V Q S ICL2ECL2 R M I Y L A D G S G P T V F S Q C V T H C S F P ECL2ICL3 K L Q L N ICL3ECL3 P E M L N R V ECL3N-term M A N N A S L E Q D P N H C S A I N N S I P L I Q G K L P T L N-termC-term L C-term T V S G K I R V T V T F F L F L L S T A F N A S F L L K L Q K W R M K V L L K H L T L A N L L E T L I V M P L D G M W N G E F L C K V L S Y L K L F S M Y A P A F M M V V I S L D R S L A I T Q N S K L E Q S M I S L A W I L S I V F A G P Q L Y I F Q W W H Q A F Y N F F T F G C L F I I P L L I M L I C N A K I I F A L T R V L H Q D P R Q S K N N I P R A R L R T L K M T V A F A T S F V V C W T P Y Y V L G I W Y W F D S E P V N H F F F L F A F L N P C F D P L I Y G Y F S
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N F A T S L L F L F F T V T V R I K G 1 K H L T L A N L L E T I L V M P L D G M W 2 V V M M F A P A Y M S F L K L Y S L V K 3 E Q S M I S L A W I L S I V F A G P Q 4 N C I L M I L L P I I F L C G F T F F N Y 5 V A F A T S F V V C W T P Y Y V L G I W 6 L P D F C P N L F A F L F F F H N V P 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
GnRH1 receptor
TM1
1x50 1.50x50 N53
1x55 1.55x55 L58
1x56 1.56x56 K59
1x58 1.58x58 Q61
1x59 1.59x59 K62
TM2
2x43 2.43x43 L80
2x50 2.50x50 N87
2x53 2.53x53 E90
2x60 2.61x60 D98
2x64 2.65x64 N102
TM3
3x22 3.22x22 E111
3x32 3.32x32 K121
3x49 3.49x49 D138
3x50 3.50x50 R139
3x51 3.51x51 S140
TM4
4x39 4.39x39 S153
4x40 4.40x40 K154
4x42 4.42x42 E156
TM5
5x45 5.44x45 G216
TM6
6x34 6.34x34 L265
6x61 6.61x61 D292
TM7
7x31 7.32x31 E301
7x49 7.49x49 D318
7x53 7.53x53 Y322