Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
mc4r_rat 5.71x71 225 TM5 R => A N/A N/A Kim CS et al (2002)
mc4r_rat 281 ECL3 M => T N/A N/A Oosterom J et al (1999)
mc4r_rat 6.29x29 239 TM6 A => S N/A N/A Kim CS et al (2002)
mc4r_rat 273 ECL3 Q => T N/A N/A Oosterom J et al (1999)
mc4r_rat 6.57x57 267 TM6 F => L N/A N/A Oosterom J et al (1999)
mc4r_rat 5.70x70 224 TM5 K => A N/A N/A Kim CS et al (2002)
mc4r_rat 6.58x58 268 TM6 Y => I N/A N/A Oosterom J et al (1999)
mc4r_rat 236 ICL3 R => A N/A N/A Kim CS et al (2002)
mc4r_rat 6.60x60 270 TM6 S => T N/A N/A Oosterom J et al (1999)
mc4r_rat 236 ICL3 R => Q N/A N/A Kim CS et al (2002)
mc4r_rat 5.66x66 220 TM5 R => A N/A N/A Kim CS et al (2002)
mc4r_rat 6.30x30 240 TM6 N => C N/A N/A Kim CS et al (2002)
mc4r_rat 232 ICL3 T => V N/A N/A Kim CS et al (2002)
mc4r_rat 232 ICL3 T => A N/A N/A Kim CS et al (2002)
mc4r_rat 235 ICL3 I => P N/A N/A Kim CS et al (2002)
mc4r_rat 6.28x28 238 TM6 G => H N/A N/A Kim CS et al (2002)


Residue

Diagrams

ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 V L P G T G T I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M N S T H H H G M Y T S L H L W N R S S H G L H G N A S E S L G K G H S D G G C Y E Q L F V N-termC-term P L G G I C E L P G R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V R R V G I I I S C I W A A C T V S G V L F I I Y S S S A V I I C L I T M F F T M L V L M A S L Y V H M F L M A R L H I K R I A Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L L F Y I S C H F N L Y L I L I M C N A V I D P L I Y A L R S Q E F K E Y L R K T I I C F
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G V L F I 4 Y L S A M L V L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L L F 6 L P D I V A N C M I L I L Y L N F H 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM5
5x66 5.66x66 R220
5x70 5.70x70 K224
5x71 5.71x71 R225
TM6
6x28 6.28x28 G238
6x29 6.29x29 A239
6x30 6.30x30 N240
6x57 6.57x57 F267
6x58 6.58x58 Y268
6x60 6.60x60 S270