Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
mtr1b_human 3.35x35 123 TM3 S => A N/A N/A Gerdin MJ et al (2003)
mtr1b_human 4.60x61 175 TM4 N => A N/A N/A Gerdin MJ et al (2003)
mtr1b_human 5.47x47 209 TM5 F => A N/A N/A Mazna P et al (2004)
mtr1b_human 5.46x461 208 TM5 H => A N/A N/A Gerdin MJ et al (2003)
mtr1b_human 6.41x41 257 TM6 F => A N/A N/A Gerdin MJ et al (2003)
mtr1b_human 5.43x44 205 TM5 V => A N/A N/A Mazna P et al (2004)
mtr1b_human 6.41x41 257 TM6 F => W N/A N/A Gerdin MJ et al (2003)
mtr1b_human 6.48x48 264 TM6 W => S N/A N/A Gerdin MJ et al (2003)
mtr1b_human 4.60x61 175 TM4 N => H N/A N/A Gerdin MJ et al (2003)
mtr1b_human 3.39x39 127 TM3 S => N N/A N/A Gerdin MJ et al (2003)
mtr1b_human 6.55x55 271 TM6 G => T N/A N/A Mazna P et al (2004)
mtr1b_human 6.48x48 264 TM6 W => A N/A N/A Gerdin MJ et al (2003)
mtr1b_human 7.38x37 293 TM7 S => A N/A N/A Gerdin MJ et al (2003)
mtr1b_human 5.46x461 208 TM5 H => F N/A N/A Gerdin MJ et al (2003)
mtr1b_human 7.43x42 298 TM7 Y => A N/A N/A Mazna P et al (2004)
mtr1b_human 6.56x56 272 TM6 L => A N/A N/A Mazna P et al (2004)
mtr1b_human 3.39x39 127 TM3 S => A N/A N/A Gerdin MJ et al (2003)


Residue

Diagrams

ICL1 R K L R ICL1ECL1 G W A L ECL1ICL2 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A P Q I ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P N-termC-term P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R L W N F R R E I L L A
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N G V V D V A T T V I L V A S L A P A 1 V S L A L A D L V V A Y F P Y P L I L V A 2 A T I N F V S G I V S L G M V F A S A K 3 T P L H I C L I W L L T V V A L L P N 4 Y C F S V V A I P L L F H I V V V A A T Y 5 F V V F V I F A I C W A P L N C I G L A 6 I A N L C S N F Y A L L Y S T V F L G 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT2 receptor
TM3
3x35 3.35x35 S123
3x39 3.39x39 S127
TM4
4x61 4.60x61 N175
TM5
5x44 5.43x44 V205
5x461 5.46x461 H208
5x47 5.47x47 F209
TM6
6x41 6.41x41 F257
6x48 6.48x48 W264
6x55 6.55x55 G271
6x56 6.56x56 L272
TM7
7x37 7.38x37 S293
7x42 7.43x42 Y298