Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => Q 1000.0↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Citrullinel] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F 12.658↑ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Val] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 2.60x60 172 TM2 R => Q 27.143↓ EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 184 ECL1 Y => F 5.129↓ pK(i) (Binding - Radioligand competition/displacement) VIP Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 2.60x60 172 TM2 R => Q 50.0↓ IC50 (Binding - Radioligand competition/displacement) VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q 30.0↓ IC50 (Binding - Radioligand competition/displacement) Ro 25-1553 Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => I 1111.111↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q >1000.0↓ EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 87 N-term G => P N/A N/A Couvineau A et al (1995)
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q 13.0↓ IC50 (Binding - Radioligand competition/displacement) C6-VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => L 2.571↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q 100.0↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Asn] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => L Abolished effect EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Val] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 2.60x60 172 TM2 R => Q 18.889↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => L 55.556↓ EC50 (Functional - cAMP accumulation) C6-VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q 18.0↓ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Glu] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => L 25.0↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q 100.0↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Gln] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 2.60x60 172 TM2 R => Q 1000.0↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => L 21.429↓ EC50 (Functional - cAMP accumulation) VIP Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => Q Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => L 166.667↑ EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q 66.667↑ IC50 (Binding - Radioligand competition/displacement) VIP-[Asp3Gln] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) Ro 25-1553 Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 2.60x60 172 TM2 R => Q 10.0↓ EC50 (Functional - cAMP accumulation) VIP-[Asp3Glu] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 184 ECL1 Y => F Abolished effect pEC50 (Functional - cAMP accumulation) VIP-[Thr11Arg] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 184 ECL1 Y => F 8.13↑ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Arg] Nachtergael I et al (2003) Hollenstein K et al (2014)
vipr2_human 2.67x67 179 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) VIP-[Asp3Asn] Vertongen P et al (2001) 10.5281/zenodo.60790
vipr2_human 184 ECL1 Y => F 14.706↑ pK(i) (Binding - Radioligand competition/displacement) VIP-[Thr11Citrullinel] Nachtergael I et al (2003) Hollenstein K et al (2014)


Residue

Diagrams

ICL1 R K L H ICL1ECL1 Y S S S G T L H C P D Q P S S ECL1ICL2 M L ICL2ECL2 D T G C W D T N D ECL2ICL3 T S P D V G G ICL3ECL3 P I S I S ECL3N-term M R T L L P P A L L T C W L L A P V N S I H P E C R F H L E I Q E E E T K C A E L L R S Q T E K H K A C S G V W D N I T C W R P A N V G E T V T V P C P K V F S N F Y S K A G N I S K N C T S D G W S E T F P D F V D A C G Y S N-termC-term V C G S S F S R N G S E G A L Q F H R G S R A Q S F L Q T E T S V I C-term D P E D E S K I T F Y I L V K A I Y T L G Y S V S L M S L A T G S I I L C L F C T R N Y I H L N L F L S F I L R A I S V L V K D D V L W V G C K L S L V F L Q Y C I M A N F F W L L V E G L Y L H T L L V A P P R R C F L A Y L L I G W G L P T V C I G A W T A A R L Y L E H S V P W W V I R I P I L I S I I V N F V L F I S I I R I L L Q K L N D Q S Q Y K R L A K S T L L L I P L F G V H Y M V F A V F S K Y Q I L F E L C L G S F Q G L V V A V L Y C F L N S E L K R R C P S R D V Q C E K W R S T P S A Y R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A L S M L S V S Y G L T Y I A K V L I Y 1 L N L F L S F I L R A I S V L V K D D V 2 V L L W F F N A M I C Y Q L F V L S L K 3 C F L A Y L L G I W G L P T V C I G A W T 4 F L V F N V I I S I L I P I R I V W W P V 5 L L L I P L F G V H Y M V F A V F 6 V A V V L G Q F S G L C L E F L I Q Y 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
VPAC2 receptor
TM2
2x53 2.60x60 R172
2x60 2.67x67 K179