Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht6r_rat 5.46x461 196 TM5 T => A N/A N/A Boess FG et al (1997)
5ht6r_rat 4.53x53 154 TM4 A => S N/A N/A Boess FG et al (1997)
5ht6r_rat 3.32x32 106 TM3 D => N N/A N/A Boess FG et al (1998)
5ht6r_rat 3.28x28 102 TM3 W => F N/A N/A Boess FG et al (1998)
5ht6r_rat 6.55x55 288 TM6 N => S N/A N/A Kohen R et al (2001)
5ht6r_rat 5.46x461 196 TM5 T => A 3.673↑ K(i) (Binding - Radioligand competition/displacement) methysergide Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 5.952↓ K(i) (Binding - Radioligand competition/displacement) methysergide Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.041↑ K(i) (Binding - Radioligand competition/displacement) methysergide Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 7.068↑ K(i) (Binding - Radioligand competition/displacement) methysergide Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 4.0↓ K(i) (Binding - Radioligand competition/displacement) METHIOTHEPINE Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.409↑ K(i) (Binding - Radioligand competition/displacement) METHIOTHEPINE Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 1.072↓ pK(i) (Binding - Radioligand competition/displacement) METHIOTHEPINE Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 1.065↓ K(i) (Binding - Radioligand competition/displacement) METHIOTHEPINE Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 2.0↓ K(i) (Binding - Radioligand competition/displacement) 5-benzyloxytryptamine Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 2.463↓ K(i) (Binding - Radioligand competition/displacement) dipropyl-5-CT Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 1.988↓ K(i) (Binding - Radioligand competition/displacement) lisuride Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.266↓ K(i) (Binding - Radioligand competition/displacement) lisuride Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 34.483↓ K(i) (Binding - Radioligand competition/displacement) lisuride Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 3.425↓ K(i) (Binding - Radioligand competition/displacement) 5-CT Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 2.181↑ K(i) (Binding - Radioligand competition/displacement) metergoline Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.007↑ K(i) (Binding - Radioligand competition/displacement) metergoline Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 1.065↓ K(i) (Binding - Radioligand competition/displacement) metergoline Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 2.34↑ K(i) (Binding - Radioligand competition/displacement) ritanserin Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.477↓ K(i) (Binding - Radioligand competition/displacement) ritanserin Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 2.008↓ K(i) (Binding - Radioligand competition/displacement) ritanserin Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 3.086↓ K(i) (Binding - Radioligand competition/displacement) α-methyl-5-HT Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 2.882↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL29846 Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 52.632↓ pK(i) (Binding - Radioligand competition/displacement) SB357134 Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 2.203↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.374↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 2.188↑ pK(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 5.917↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 7.299↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 1.524↓ K(i) (Binding - Radioligand competition/displacement) clozapine Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.012↑ K(i) (Binding - Radioligand competition/displacement) clozapine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 2.66↓ K(i) (Binding - Radioligand competition/displacement) clozapine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 3.802↓ pK(i) (Binding - Radioligand competition/displacement) SB 271046 Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y N/A pK(i) (Binding - Radioligand competition/displacement) Ro 04-6790 Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 3.175↓ K(i) (Binding - Radioligand competition/displacement) ergotamine Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.458↓ K(i) (Binding - Radioligand competition/displacement) ergotamine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 16.129↓ K(i) (Binding - Radioligand competition/displacement) ergotamine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.417↑ K(i) (Binding - Radioligand competition/displacement) Mesulergine Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 2.725↓ K(d) (Binding - Radioligand saturation) LSD Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 3.32x32 106 TM3 D => N Abolished effect K(d) (Binding - Radioligand saturation) LSD Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.105↓ K(d) (Binding - Radioligand saturation) LSD Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 1.096↑ pK(i) (Binding - Radioligand competition/displacement) LSD Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 17.857↓ K(d) (Binding - Radioligand saturation) LSD Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 4.464↓ pK(i) (Binding - Radioligand competition/displacement) SB258585 Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 1.832↓ K(i) (Binding - Radioligand competition/displacement) amitriptyline Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.175↓ K(i) (Binding - Radioligand competition/displacement) amitriptyline Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 1.268↑ K(i) (Binding - Radioligand competition/displacement) amitriptyline Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 4.53x53 154 TM4 A => S 1.144↓ K(i) (Binding - Radioligand competition/displacement) mianserin Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 5.38x39 188 TM5 F => Y 1.024↓ pK(i) (Binding - Radioligand competition/displacement) mianserin Hirst WD et al (2003) Vass M et al (2019)
5ht6r_rat 5.46x461 196 TM5 T => A 3.057↑ K(i) (Binding - Radioligand competition/displacement) mianserin Boess FG et al (1997) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 3.968↓ K(i) (Binding - Radioligand competition/displacement) 5-MeO-DMT Boess FG et al (1998) Vass M et al (2019)
5ht6r_rat 3.28x28 102 TM3 W => F 2.778↓ K(i) (Binding - Radioligand competition/displacement) 5-MeOT Boess FG et al (1998) Vass M et al (2019)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 P A L R ICL1ECL1 R W V L ECL1ICL2 P L R Y K L R M ICL2ECL2 W H E L G K A R T P A P G Q C R L L A ECL2ICL3 T G T A G Q A L E T L Q V P R T P R P G M E S A D S R R L A ICL3ECL3 D C I ECL3N-term M V P E P G P V N S S T P A W G P G P P P A P G G N-termC-term V H C P P E H R P A L P P P P C G P L T A V P D Q A S A C S R C C L C L C R Q T Q I Q T P L Q G A P R A C S S Q P S F C C L E R P P G T P R H P P G P P L W S T S L S Q T L W S L R Y G R I H S V P P C-term S G W V A A A L C V V I V L T A A A N S L L I V L I C T Q N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S T A P R A L A L I L G A W S L A A L A S F L P L L L G S L P F V L V A S G V T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L T T K H S R K A L K A S L T L G I L L G M F F V T W L P F F V A N I A Q A V C S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D L G R F K R A F L P C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N A A A T L V I V V C L A A A V W G S 1 V S L F T S D L M V G V L V M P P A M L N 2 L C L N L I S A S C C M V D F A T W L L 3 A L A L I L G A W S L A A L A S F L P L 4 Y T F C I A G S P L F F T V G S A V L V F 5 G I L L G M F F V T W L P F F V A N I A 6 I P N M T S N C Y G L W T L V D F L G 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT6 receptor
TM3
3x28 3.28x28 W102
3x32 3.32x32 D106
TM4
4x53 4.53x53 A154
TM5
5x39 5.38x39 F188
5x461 5.46x461 T196
TM6
6x55 6.55x55 N288