Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
aa2ar_human 45.51x51 167 ECL2 L => E 1.37↑ K(i) (Binding - Radioligand competition/displacement) DPCPX Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↑ pK(d) (Biing - Surface plasmon resonance) Triazine3e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 70.0↓ EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) KW6002 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 20.0↑ RT (Binding - Radioligand kinetics (association/dissociation)) HMA Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 2.57x56 59 TM2 A => V 2.11↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Y 20.957↓ K(i) (Binding - Radioligand competition/displacement) Theophylline Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 154 ECL2 N => Q No effect K(i) (Binding - Radioligand competition/displacement) XAC Fraser NJ et al (2006) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.45x45 280 TM7 N => A 9.284↓ K(d) (Binding - Radioligand saturation) NECA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => T 1.545↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 63.096↓ pK(d) (Biing - Surface plasmon resonance) ZM241385 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 3.03↑ K(i) (Binding - Radioligand saturation) DPCPX Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 8.547↑ K(i) (Binding - Radioligand competition/displacement) ADAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => Q 22.193↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => A Abolished effect k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => L 5.93↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => A N/A N/A Kim J et al (1995)
aa2ar_human 7.46x46 281 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 6.52x52 250 TM6 H => N 3.218↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => W 1.018↑ EC50 (Functional - cAMP accumulation) CGS21680 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 7.35x34 270 TM7 M => T 6.68↓ K(i) (Binding - Radioligand competition/displacement) SCH442416 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 157 ECL2 Q => A 1.063↑ k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 25.0↑ pK(d) (Biing - Surface plasmon resonance) Triazine3f Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Lebon G et al (2011)
aa2ar_human 5.43x44 182 TM5 F => W 1.02↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.35x34 270 TM7 M => T 5.556↑ K(i) (Binding - Radioligand competition/displacement) DPCPX Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R 139.267↓ K(i) (Binding - Radioligand competition/displacement) NECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => E 1.41↑ K(i) (Binding - Radioligand competition/displacement) 522607-99-4 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 1.087↑ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.35x34 270 TM7 M => T 1.47↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 151 ECL2 E => Q Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) Chromone1a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 76.923↑ IC50 (Binding - Radioligand competition/displacement) 12k Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.38x38 90 TM3 S => A 3.922↑ K(i) (Binding - Radioligand competition/displacement) R-PIA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 3.509↑ K(i) (Binding - Radioligand competition/displacement) BTH4 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => E 1.429↑ K(i) (Binding - Radioligand competition/displacement) SCH442416 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018687 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => L 3.487↓ K(i) (Binding - Radioligand competition/displacement) DPCPX Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.51x51 249 TM6 L => A Abolished effect K(d) (Binding - Radioligand saturation) ZM241385 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Jiang Q et al (1996)
aa2ar_human 264 ECL3 H => A 1.38↓ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 7.3↓ K(i) (Binding - Radioligand competition/displacement) SCH442416 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.259↑ pK(d) (Biing - Surface plasmon resonance) Triazine3d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => A Abolished effect K(d) (Binding - Other) ZM241385 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 5.42x43 181 TM5 N => D 111.111↑ EC50 (Functional - cAMP accumulation) Cid76018686 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) Triazine15 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A N/A N/A Kim J et al (1995)
aa2ar_human 45.51x51 167 ECL2 L => A 1.0 pK(d) (Biing - Surface plasmon resonance) ZM241385 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 7.943↓ pK(d) (Biing - Surface plasmon resonance) SCH420814 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.56x56 254 TM6 C => A 1.093↑ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 2.512↓ pK(d) (Biing - Surface plasmon resonance) NOTDISCLOSED Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.0 pK(d) (Biing - Surface plasmon resonance) Triazine3c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 7.42x41 277 TM7 S => C 3.077↑ K(i) (Binding - Radioligand competition/displacement) BTH4 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 63.096↓ pK(d) (Biing - Surface plasmon resonance) Theophylline Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => E 2.32↓ K(i) (Binding - Radioligand competition/displacement) XAC Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.52x52 54 TM2 A => L 187.5↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 1.243↓ K(i) (Binding - Radioligand competition/displacement) SCH58261 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 5.42x43 181 TM5 N => A 5.012↓ pK(d) (Biing - Surface plasmon resonance) Triazine3c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => A N/A N/A Kim J et al (1995)
aa2ar_human 6.41x41 239 TM6 V => A 1.767↑ K(i) (Binding - Radioligand competition/displacement) Theophylline Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 9.449↓ K(i) (Binding - Radioligand competition/displacement) XAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => A Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R N/A N/A Jiang Q et al (1996)
aa2ar_human 5.43x44 182 TM5 F => Y N/A N/A Kim J et al (1995)
aa2ar_human 6.52x52 250 TM6 H => Y 1.202↑ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => E 1.15↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 39.811↓ pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 2.512↓ pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 1.232↑ IC50 (Binding - Radioligand competition/displacement) Amiloride Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 6.31↓ pK(d) (Biing - Surface plasmon resonance) Triazine3h Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => T 3.012↑ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => L 1.333↑ K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 5.43x44 182 TM5 F => Y 12.434↓ K(i) (Binding - Radioligand competition/displacement) CADO Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 7.937↑ pK(d) (Biing - Surface plasmon resonance) Triazine3d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => F 25.0↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => A N/A N/A Xu F et al (2011)
aa2ar_human 161 ECL2 E => A 1.686↓ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 151 ECL2 E => A N/A N/A Kim J et al (1996)
aa2ar_human 7.42x41 277 TM7 S => N N/A N/A Kim J et al (1995)
aa2ar_human 45.51x51 167 ECL2 L => E 1.02↑ K(i) (Binding - Radioligand competition/displacement) SLV320 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 6.31↓ pK(d) (Biing - Surface plasmon resonance) Triazine3d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) ZM241385 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => L 1.46↑ K(i) (Binding - Radioligand competition/displacement) BTH4 Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 794.328↓ pK(d) (Biing - Surface plasmon resonance) Chromone1b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.59x59 257 TM6 F => A Abolished effect EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.50x50 52 TM2 D => A 14.0↓ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => Y 1.901↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 170 ECL2 D => K N/A N/A Kim J et al (1996)
aa2ar_human 4.43x43 122 TM4 K => A Abolished effect K(i) (Binding - Radioligand competition/displacement) NECA Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.63x63 202 TM5 L => A N/A N/A Dore AS et al (2011)
aa2ar_human 7.42x41 277 TM7 S => A 42.677↓ K(i) (Binding - Radioligand saturation) R-PIA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A N/A N/A Gao ZG et al (2002)
aa2ar_human 6.52x52 250 TM6 H => Y 1.456↑ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => E 1.313↓ K(i) (Binding - Radioligand competition/displacement) CID 85129620 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 161 ECL2 E => A 1.671↓ K(i) (Binding - Radioligand competition/displacement) (r)-N6-Phenylisopropyladenosine Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.52x52 54 TM2 A => L Abolished effect K(i) (Binding - Radioligand competition/displacement) NECA Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => A 630.957↓ pEC50 (Functional - cAMP accumulation) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 5.012↓ pK(d) (Biing - Surface plasmon resonance) Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A 3.981↓ pK(d) (Biing - Surface plasmon resonance) ZM241385 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.36x36 88 TM3 T => D 2.172↓ EC50 (Functional - cAMP accumulation) Cid76018686 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A Decreased effect pK(d) (Biing - Surface plasmon resonance) Chromone1d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.32x31 267 TM7 L => A 24.39↑ pEC50 (Functional - cAMP accumulation) CGS21680 Lebon G et al (2015) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => F 1.048↑ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D Gain of effect (wt had no effect) K(i) (Binding - Radioligand competition/displacement) Cid76018686 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => L 2.016↑ K(i) (Binding - Radioligand competition/displacement) DPMA Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 1.585↓ pK(d) (Biing - Surface plasmon resonance) Triazine15 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 87.176↓ K(i) (Binding - Radioligand competition/displacement) DPMA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Y 2.667↑ K(i) (Binding - Radioligand competition/displacement) SCH58261 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 16.949↑ K(i) (Binding - Radioligand competition/displacement) R-PIA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.112↑ EC50 (Functional - cAMP accumulation) CGS21680 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R N/A N/A Jiang Q et al (1996)
aa2ar_human 3.36x36 88 TM3 T => D Abolished effect K(i) (Binding - Radioligand competition/displacement) ST092443 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => T 1.25↓ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => N 11.628↑ K(i) (Binding - Radioligand competition/displacement) IB-MECA Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => A N/A N/A Kim J et al (1995)
aa2ar_human 7.43x42 278 TM7 H => N Abolished effect K(d) (Binding - Radioligand saturation) NECA Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 1.902↓ K(i) (Binding - Radioligand competition/displacement) ADAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 45.51x51 167 ECL2 L => A 2.512↓ pK(d) (Biing - Surface plasmon resonance) Triazine15 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.56x56 254 TM6 C => A N/A N/A Kim J et al (1995)
aa2ar_human 169 ECL2 E => Q 1.648↓ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => A 6.31↓ pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 1.0 K(i) (Binding - Radioligand competition/displacement) XAC Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.27x27 79 TM3 F => A N/A N/A Lebon G et al (2011)
aa2ar_human 7.43x42 278 TM7 H => Y 2.031↓ K(i) (Binding - Radioligand competition/displacement) XAC Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.50x50 166 ECL2 C => S 1.224↓ K(i) (radioligand binding) NECA De Filippo E et al (2016)
aa2ar_human 159 ECL2 C => A 1.898↑ K(d) (Binding - Radioligand saturation) CGS21680 Naranjo AN et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => A N/A N/A Kim SK et al (2003)
aa2ar_human 3.37x37 89 TM3 Q => A 6.452↑ K(i) (Binding - Radioligand competition/displacement) BTH4 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 151 ECL2 E => D Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 7.43x42 278 TM7 H => A 306.667↓ EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => K Abolished effect K(d) (Binding - Radioligand saturation) NECA Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 1.19↑ K(i) (Binding - Radioligand competition/displacement) PSB36 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 264 ECL3 H => A 2.513↑ pEC50 (Functional - cAMP accumulation) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => N N/A N/A Kim J et al (1995)
aa2ar_human 151 ECL2 E => D Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A N/A N/A Kim SK et al (2003)
aa2ar_human 3.36x36 88 TM3 T => A 7.528↓ K(i) (Binding - Radioligand competition/displacement) Adenosine Bertheleme N et al (2013) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 39.811↓ pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q 1.667↓ K(d) (Binding - Radioligand saturation) ZM241385 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S N/A N/A Jiang Q et al (1996)
aa2ar_human 5.43x44 182 TM5 F => W 3.041↓ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 3.162↓ pK(d) (Biing - Surface plasmon resonance) Chromone1d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 187.5↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 7.943↓ pK(d) (Biing - Surface plasmon resonance) ZM241385 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => W 7.236↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => A Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => S N/A N/A Jiang Q et al (1996)
aa2ar_human 6.56x56 254 TM6 C => A 2.451↑ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 13.514↑ K(i) (Binding - Radioligand competition/displacement) CADO Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 7.943↓ pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 161 ECL2 E => A 1.535↓ K(i) (Binding - Radioligand competition/displacement) CADO Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A Decreased effect pK(d) (Biing - Surface plasmon resonance) NOTDISCLOSED Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) Chromone1b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => Y 7.049↓ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => S N/A N/A Kim J et al (1995)
aa2ar_human 151 ECL2 E => Q N/A N/A Kim J et al (1996)
aa2ar_human 7.45x45 280 TM7 N => A 3.155↑ IC50 (Binding - Radioligand competition/displacement) Amiloride Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.35x34 270 TM7 M => T 1.38↓ K(i) (Binding - Radioligand competition/displacement) XAC Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q 5.5↓ K(i) (Binding - Radioligand competition/displacement) NECA Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => L N/A N/A Jiang Q et al (1997)
aa2ar_human 3.37x37 89 TM3 Q => L N/A N/A Jiang Q et al (1996)
aa2ar_human 5.34x36 173 TM5 P => R N/A N/A Kim J et al (1996)
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 7.46x46 281 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 4.43x43 122 TM4 K => A 187.5↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.49x49 284 TM7 N => A Abolished effect pEC50 (Functional - cAMP accumulation) CGS21680 Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 6.52x52 250 TM6 H => Y 2.201↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q 1.227↓ IC50 (Binding - Radioligand competition/displacement) CGS15943 Ijzerman AP et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 7.46x46 281 TM7 S => T 10.417↑ K(i) (Binding - Radioligand competition/displacement) R-PIA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.57x56 59 TM2 A => V 2.89↓ K(i) (Binding - Radioligand competition/displacement) ZM241385 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 2.076↓ K(i) (Binding - Radioligand competition/displacement) ZM241385 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 5.012↓ pK(d) (Biing - Surface plasmon resonance) Chromone1c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 161 ECL2 E => A 1.03↓ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.36x36 88 TM3 T => R N/A N/A Jiang Q et al (1996)
aa2ar_human 3.39x39 91 TM3 S => A 1.522↓ K(d) (Binding - Radioligand saturation) ZM241385 Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018684 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 23.51x51 71 ECL1 C => A 1.536↑ K(d) (Binding - Radioligand saturation) CGS21680 Naranjo AN et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => N 1.062↑ K(i) (Binding - Radioligand competition/displacement) DPMA Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A 1.0 pK(d) (Biing - Surface plasmon resonance) KW6002 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 39.811↓ pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D 1.834↓ K(i) (Binding - Radioligand competition/displacement) CAS35788-28-4 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D Gain of effect (wt had no effect) K(i) (Binding - Radioligand competition/displacement) Cid76018687 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.0 pK(d) (Biing - Surface plasmon resonance) Theophylline Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Lebon G et al (2011)
aa2ar_human 154 ECL2 N => Q Increased effect K(i) (Binding - Radioligand competition/displacement) NECA Fraser NJ et al (2006) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) Cid22948626 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => Y 54.276↓ K(i) (Binding - Radioligand competition/displacement) CADO Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => D Abolished effect K(d) (Binding - Radioligand saturation) XAC Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.60x59 62 TM2 F => A N/A N/A Lebon G et al (2011)
aa2ar_human 7.43x42 278 TM7 H => Y 70.0↓ K(i) (Binding - Radioligand competition/displacement) CGS21680 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => Y 2.215↓ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Q Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D Gain of effect (wt had no effect) K(i) (Binding - Radioligand competition/displacement) Cid76018681 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 153 ECL2 K => A 1.202↓ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Yang X et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.49x49 284 TM7 N => A 3.937↑ IC50 (Binding - Radioligand competition/displacement) Amiloride Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 5.236↑ K(i) (Binding - Radioligand competition/displacement) CADO Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.38x38 90 TM3 S => A 1.233↑ K(i) (Binding - Radioligand competition/displacement) SCH58261 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 2.078↓ K(i) (Binding - Radioligand competition/displacement) XAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => N N/A N/A Kim J et al (1995)
aa2ar_human 3.36x36 88 TM3 T => S 1.53↓ K(i) (Binding - Radioligand competition/displacement) ZM241385 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => A 1.35↑ pEC50 (Functional - cAMP accumulation) CGS21680 Lebon G et al (2015) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 32.258↑ IC50 (Binding - Radioligand competition/displacement) 12i Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 1.51↓ K(i) (Binding - Radioligand competition/displacement) DPCPX Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 1.0 pK(d) (Biing - Surface plasmon resonance) Theophylline Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.52x52 54 TM2 A => L N/A N/A Lebon G et al (2011)
aa2ar_human 3.39x39 91 TM3 S => A 1.0 K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018685 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A N/A N/A Dore AS et al (2011)
aa2ar_human 5.42x43 181 TM5 N => S 2.057↓ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 1.543↓ % (Binding - Radioligand competition/displacement) CID57403156 Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 170 ECL2 D => K No effect (Binding - Radioligand saturation) XAC Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A Decreased effect pK(d) (Biing - Surface plasmon resonance) Theophylline Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => D N/A N/A Kim SK et al (2003)
aa2ar_human 3.37x37 89 TM3 Q => H 1.51↓ K(d) (Binding - Radioligand competition/displacement) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => T 3.03↑ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Y 3.0↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 66.207↓ K(i) (Binding - Radioligand saturation) IB-MECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => D No effect K(d) (Binding - Radioligand saturation) QNB Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.34x36 173 TM5 P => R N/A N/A Kim J et al (1996)
aa2ar_human 7.39x38 274 TM7 I => A N/A N/A Kim SK et al (2003)
aa2ar_human 3.36x36 88 TM3 T => D Decreased effect K(i) (Binding - Radioligand competition/displacement) NECA Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 1.996↑ pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 15.849↓ pK(d) (Biing - Surface plasmon resonance) Triazine3h Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.41x41 239 TM6 V => A Abolished effect K(i) (Binding - Radioligand competition/displacement) NECA Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => E N/A N/A Kim SK et al (2003)
aa2ar_human 3.36x36 88 TM3 T => A 1.259↑ pEC50 (Functional - cAMP accumulation) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 3.984↑ pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 5.043↓ K(d) (Binding - Radioligand saturation) ZM241385 Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 52.632↑ RT (Binding - Radioligand kinetics (association/dissociation)) 12i Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.38x38 12 TM1 V => A N/A N/A Lebon G et al (2011)
aa2ar_human 264 ECL3 H => A 1.276↑ % (Binding - Radioligand saturation) CID44394716 Segala E et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 4.333↓ K(d) (Binding - Other) ZM241385 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => A N/A N/A Kim J et al (1995)
aa2ar_human 7.35x34 270 TM7 M => T 1.51↓ K(i) (Binding - Radioligand competition/displacement) Istradefylline Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => F 2.106↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 3.162↓ pK(d) (Biing - Surface plasmon resonance) Chromone1d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) ZM241385 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 151 ECL2 E => Q N/A N/A Kim J et al (1996)
aa2ar_human 7.42x41 277 TM7 S => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Triazine3c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 154 ECL2 N => Q No effect K(d) (Binding - Radioligand saturation) ZM241385 Fraser NJ et al (2006) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => R N/A N/A Jiang Q et al (1996)
aa2ar_human 6.51x51 249 TM6 L => A 1.172↑ EC50 (Functional - cAMP accumulation) CGS21680 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R Decreased effect EC50 (Functional - cAMP accumulation) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 630.957↓ pK(d) (Biing - Surface plasmon resonance) Chromone1e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S 5.233↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => F 1.506↑ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 3.162↓ pK(d) (Biing - Surface plasmon resonance) Chromone1e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 3.162↓ pK(d) (Biing - Surface plasmon resonance) NOTDISCLOSED Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => D N/A N/A Kim SK et al (2003)
aa2ar_human 6.56x56 254 TM6 C => A 1.921↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D 6.303↓ K(i) (Binding - Radioligand competition/displacement) CAS35788-28-4 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 159 ECL2 C => S 4.016↑ K(i) (radioligand binding) NECA De Filippo E et al (2016)
aa2ar_human 2.64x63 66 TM2 I => A 1.259↑ pK(d) (Biing - Surface plasmon resonance) Triazine15 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 1.812↓ % (Binding - Radioligand competition/displacement) CID57403241 Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 4.43x43 122 TM4 K => A 1.0 K(i) (Binding - Radioligand competition/displacement) XAC Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => N N/A N/A Jiang Q et al (1997)
aa2ar_human 1.39x39 13 TM1 E => Q N/A N/A Gao ZG et al (2000)
aa2ar_human 7.42x41 277 TM7 S => N N/A N/A Kim J et al (1995)
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.37x37 89 TM3 Q => H N/A N/A Jiang Q et al (1996)
aa2ar_human 6.56x56 254 TM6 C => A N/A N/A Kim J et al (1995)
aa2ar_human 2.64x63 66 TM2 I => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) Triazine3d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => E 1.236↓ K(i) (Binding - Radioligand competition/displacement) Cid13307390 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↑ pK(d) (Biing - Surface plasmon resonance) Triazine3c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 4.43x43 122 TM4 K => A N/A N/A Dore AS et al (2011)
aa2ar_human 7.46x46 281 TM7 S => T 1.269↑ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.39x39 91 TM3 S => A 1.086↑ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => C 3.84↓ K(i) (Binding - Radioligand competition/displacement) CADO Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 3.162↓ pK(d) (Biing - Surface plasmon resonance) Triazine3b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.585↓ pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Triazine15 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) Chromone1b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.59x59 257 TM6 F => A Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => A 15.136↓ pEC50 (Functional - cAMP accumulation) NECA Lebon G et al (2015) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.39x38 274 TM7 I => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Q Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => A Abolished effect EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => W 1.5↓ K(d) (Binding - Other) ZM241385 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R 62.443↓ K(i) (Binding - Radioligand competition/displacement) DPMA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.38x38 90 TM3 S => A 1.927↑ K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 4.578↓ K(i) (Binding - Radioligand competition/displacement) ZM241385 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 5.917↑ IC50 (Binding - Radioligand competition/displacement) Amiloride Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => S 8.816↓ K(i) (Binding - Radioligand competition/displacement) CADO Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => Q N/A N/A Kim J et al (1995)
aa2ar_human 169 ECL2 E => A 3.165↑ pEC50 (Functional - cAMP accumulation) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => Y 8.805↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => D N/A N/A Jiang Q et al (1997)
aa2ar_human 3.37x37 89 TM3 Q => L 1.148↓ K(d) (Binding - Radioligand competition/displacement) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => E Abolished effect K(i) (Binding - Radioligand competition/displacement) NECA Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 153 ECL2 K => A 1.266↑ k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => A 29.512↓ pIC50 (Functional - Ca2+ accumulation) ZM241385 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.45x45 280 TM7 N => A 1.042↑ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Jiang Q et al (1996)
aa2ar_human 7.36x35 271 TM7 Y => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) Triazine15 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.59x59 257 TM6 F => R N/A N/A Kim J et al (1995)
aa2ar_human 7.42x41 277 TM7 S => A 401.379↓ K(i) (Binding - Radioligand saturation) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 5.012↓ pK(d) (Biing - Surface plasmon resonance) Triazine3h Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => Y 1.091↑ EC50 (Functional - cAMP accumulation) CGS21680 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 100.0↓ pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 3.185↓ K(d) (Binding - Radioligand saturation) NECA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.50x50 166 ECL2 C => S 1.661↓ K(i) (radioligand binding) PSB-15826 De Filippo E et al (2016)
aa2ar_human 7.42x41 277 TM7 S => A 5.0↑ pK(d) (Biing - Surface plasmon resonance) Triazine3g Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => Q Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => C 2.692↓ K(i) (Binding - Radioligand competition/displacement) ADAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.56x56 254 TM6 C => A Abolished effect EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 4.243↓ K(i) (Binding - Radioligand competition/displacement) SCH58261 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 5.42x43 181 TM5 N => A 19.953↓ pK(d) (Biing - Surface plasmon resonance) Triazine3a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => D 1.339↑ K(i) (Binding - Radioligand competition/displacement) 522607-99-4 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 170 ECL2 D => K N/A N/A Kim J et al (1996)
aa2ar_human 6.59x59 257 TM6 F => A N/A N/A Kim J et al (1995)
aa2ar_human 7.42x41 277 TM7 S => A 1.996↑ pK(d) (Biing - Surface plasmon resonance) Chromone1b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.52x52 54 TM2 A => L 1.0 K(i) (Binding - Radioligand competition/displacement) XAC Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => N 1.267↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.0 pK(d) (Biing - Surface plasmon resonance) Chromone1c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 151 ECL2 E => D N/A N/A Kim J et al (1996)
aa2ar_human 7.42x41 277 TM7 S => N N/A N/A Kim J et al (1995)
aa2ar_human 3.33x33 85 TM3 L => A 12.589↓ pK(d) (Biing - Surface plasmon resonance) Triazine3g Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => D 10.417↑ K(i) (Binding - Radioligand competition/displacement) CID 85129620 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A Abolished effect N/A NECA Bertheleme N et al (2013) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R N/A N/A Jiang Q et al (1996)
aa2ar_human 45.52x52 168 ECL2 F => D Abolished effect pEC50 (Functional - cAMP accumulation) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => F 2.545↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 1.926↓ K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => D N/A N/A Kim SK et al (2003)
aa2ar_human 1.39x39 13 TM1 E => A 3.984↑ pEC50 (Functional - cAMP accumulation) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 151 ECL2 E => Q Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.585↓ pK(d) (Biing - Surface plasmon resonance) Chromone1e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) Chromone1e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => Q 8.547↑ K(i) (Binding - Radioligand competition/displacement) IB-MECA Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => Y 30.126↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => A N/A N/A Gao ZG et al (2002)
aa2ar_human 7.43x42 278 TM7 H => E 1.562↓ K(i) (Binding - Radioligand competition/displacement) Cid13307390 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 1584.893↓ pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => N 1.152↓ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 8.13↑ K(i) (Binding - Radioligand competition/displacement) IB-MECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S N/A N/A Jiang Q et al (1996)
aa2ar_human 7.43x42 278 TM7 H => Y 9.677↓ K(i) (Binding - Radioligand competition/displacement) DPMA Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.35x34 270 TM7 M => T 5.0↑ K(i) (Binding - Radioligand competition/displacement) PSB36 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018683 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S 40.733↓ K(i) (Binding - Radioligand competition/displacement) NECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R N/A N/A Jiang Q et al (1996)
aa2ar_human 169 ECL2 E => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Q N/A N/A Kim J et al (1995)
aa2ar_human 7.39x38 274 TM7 I => A 33.333↓ EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => S 4.02↓ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S 1.534↑ K(d) (Binding - Radioligand saturation) XAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A 7.943↓ pK(d) (Biing - Surface plasmon resonance) SCH420814 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A 6.31↓ pK(d) (Biing - Surface plasmon resonance) Triazine3a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => D 14.286↑ K(i) (Binding - Radioligand competition/displacement) NECA Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 25.0↑ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) Triazine3b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => D 10.309↑ K(i) (Binding - Radioligand competition/displacement) 5'-Deoxy-5'-aminoadenosine Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D No effect K(i) (Binding - Radioligand competition/displacement) Cid44280242 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.41x42 180 TM5 F => A Abolished effect EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018688 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => E 1.253↑ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 1.05↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => A Abolished effect EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 6.55x55 253 TM6 N => A N/A N/A Kim J et al (1995)
aa2ar_human 3.37x37 89 TM3 Q => A 32.258↑ K(i) (Binding - Radioligand competition/displacement) ADAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 6.31↓ pK(d) (Biing - Surface plasmon resonance) Triazine3g Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => W 2.41↑ K(i) (Binding - Radioligand competition/displacement) NECA Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.38x38 90 TM3 S => A 1.692↑ K(i) (Binding - Radioligand competition/displacement) BTH4 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => F 6.762↓ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.35x34 270 TM7 M => T 7.943↓ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Glukhova A et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D 9.346↑ K(i) (Binding - Radioligand competition/displacement) CID 75022550 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A N/A % (Binding - Radioligand competition/displacement) 12h Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.41x42 180 TM5 F => A 2.347↑ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => Q 61.588↓ k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D Gain of effect (wt had no effect) K(i) (Binding - Radioligand competition/displacement) Cid76018683 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Dore AS et al (2011)
aa2ar_human 159 ECL2 C => S 8.264↑ EC50 (cAMP accumulation) NECA De Filippo E et al (2016)
aa2ar_human 5.41x42 180 TM5 F => A 2.312↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 4.78↓ K(i) (Binding - Radioligand competition/displacement) SLV320 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 3.38x38 90 TM3 S => A 4.673↑ K(i) (Binding - Radioligand competition/displacement) NECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => Q 1.322↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D 90.909↑ K(i) (Binding - Radioligand competition/displacement) Cid13307390 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Chromone1c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D 1.083↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 156 ECL2 S => A 1.412↑ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D Gain of effect (wt had no effect) K(i) (Binding - Radioligand competition/displacement) Cid76018685 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 4.63↑ K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 3.663↓ % (Binding - Radioligand competition/displacement) CID57399649 Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.38x38 236 TM6 A => L N/A N/A Lebon G et al (2011)
aa2ar_human 6.48x48 246 TM6 W => Y 3.165↑ pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => N 1.984↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q N/A N/A Gao ZG et al (2000)
aa2ar_human 7.43x42 278 TM7 H => D 2.625↓ K(i) (Binding - Radioligand competition/displacement) Cid13307390 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 1.02↑ % (Binding - Radioligand competition/displacement) CID57392707 Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 151 ECL2 E => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Theophylline Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 264 ECL3 H => A 7.413↓ pEC50 (Functional - cAMP accumulation) NECA Lebon G et al (2015) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 262 ECL3 C => G N/A N/A Kim J et al (1996)
aa2ar_human 2.64x63 66 TM2 I => A 10.0↓ pK(d) (Biing - Surface plasmon resonance) SCH420814 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 2.512↓ pK(d) (Biing - Surface plasmon resonance) Chromone1e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 125.893↓ pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 22.222↑ RT (Binding - Radioligand kinetics (association/dissociation)) 12h Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S N/A N/A Jiang Q et al (1996)
aa2ar_human 6.52x52 250 TM6 H => A Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q N/A N/A IJzerman AP et al (1997)
aa2ar_human 7.36x35 271 TM7 Y => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) Triazine3d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => C 1.2↓ K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D Abolished effect K(i) (Binding - Radioligand competition/displacement) Oprea1_724488 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 1.67↓ K(i) (Binding - Radioligand competition/displacement) SCH58261 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A N/A N/A LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 154 ECL2 N => A N/A N/A Lebon G et al (2011)
aa2ar_human 2.50x50 52 TM2 D => A 16.905↓ IC50 (Binding - Radioligand competition/displacement) Amiloride Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q 2.106↓ K(i) (Binding - Radioligand competition/displacement) Theophylline Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => E N/A N/A Kim SK et al (2003)
aa2ar_human 3.32x32 84 TM3 V => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.32x31 267 TM7 L => A 2.331↑ k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => N 1.054↑ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => S 2.347↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 23.975↓ K(d) (Binding - Radioligand saturation) NECA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 262 ECL3 C => G No effect (Binding - Radioligand saturation) CGS21680 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.35x34 270 TM7 M => T 1.1↓ K(i) (Binding - Radioligand competition/displacement) SLV320 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 5.42x43 181 TM5 N => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018688 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => W 3.098↓ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 5.42x43 181 TM5 N => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018684 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 6.135↑ K(i) (Binding - Radioligand competition/displacement) NECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 14.493↑ K(i) (Binding - Radioligand competition/displacement) NECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 15.385↑ EC50 (Functional - cAMP accumulation) NECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Triazine3e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 3.37x37 89 TM3 Q => D 12.821↑ K(i) (Binding - Radioligand competition/displacement) Cid13307390 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => E 1.131↓ K(i) (Binding - Radioligand competition/displacement) 5'-Deoxy-5'-aminoadenosine Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.49x49 284 TM7 N => A 2.5↑ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => T 1.322↓ K(i) (Binding - Radioligand competition/displacement) CADO Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Chromone1e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.38x38 90 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 7.42x41 277 TM7 S => N 1.454↓ K(i) (Binding - Radioligand competition/displacement) CADO Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => F N/A N/A Kim J et al (1995)
aa2ar_human 6.58x58 256 TM6 T => A 2.512↓ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 1.0 pK(d) (Biing - Surface plasmon resonance) Triazine3b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 146 ECL2 C => S Abolished EC50 (cAMP accumulation) PSB-15826 De Filippo E et al (2016)
aa2ar_human 7.42x41 277 TM7 S => N 1.275↓ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.51x51 249 TM6 L => A N/A N/A Xu F et al (2011)
aa2ar_human 6.52x52 250 TM6 H => F 14.013↓ K(i) (Binding - Radioligand competition/displacement) CADO Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => E 1.125↑ K(i) (Binding - Radioligand competition/displacement) Cid13307390 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.32x32 84 TM3 V => D Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 161 ECL2 E => A N/A N/A Kim J et al (1996)
aa2ar_human 45.51x51 167 ECL2 L => A 10.0↓ pK(d) (Biing - Surface plasmon resonance) SCH420814 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => D Abolished effect pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 161 ECL2 E => A 1.87↓ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 1.403↑ K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 83.246↓ K(i) (Binding - Radioligand competition/displacement) NECA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => C 2.571↓ K(i) (Binding - Radioligand competition/displacement) ZM241385 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => N 3.663↑ K(i) (Binding - Radioligand competition/displacement) Amiloride Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => T 3.65↑ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 154 ECL2 N => Q No effect K(i) (Binding - Radioligand competition/displacement) ZM241385 Fraser NJ et al (2006) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 7.46x46 281 TM7 S => N 2.519↑ K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 2.79↓ K(i) (Binding - Radioligand competition/displacement) Istradefylline Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R N/A N/A Jiang Q et al (1996)
aa2ar_human 45.52x52 168 ECL2 F => A 630.957↓ pEC50 (Functional - cAMP accumulation) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Triazine3g Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q 1.032↑ K(i) (Binding - Radioligand competition/displacement) XAC Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 146 ECL2 C => S 25.641↑ EC50 (cAMP accumulation) CGS21680 De Filippo E et al (2016)
aa2ar_human 6.52x52 250 TM6 H => A N/A N/A Gao ZG et al (2002)
aa2ar_human 5.41x42 180 TM5 F => A N/A N/A Kim J et al (1995)
aa2ar_human 6.41x41 239 TM6 V => A 187.5↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.25x25 77 TM3 C => A 1.35↑ K(d) (Binding - Radioligand saturation) CGS21680 Naranjo AN et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.50x50 166 ECL2 C => S 30.059↓ EC50 (cAMP accumulation) Adenosine De Filippo E et al (2016)
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Triazine3a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 146 ECL2 C => S 7.353↑ EC50 (cAMP accumulation) NECA De Filippo E et al (2016)
aa2ar_human 7.42x41 277 TM7 S => A 1.996↑ pK(d) (Biing - Surface plasmon resonance) Chromone1a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) Triazine3b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 45.52x52 168 ECL2 F => W 1.496↓ K(i) (Binding - Radioligand competition/displacement) CGS21680 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.51x51 249 TM6 L => A Abolished effect K(d) (Binding - Other) ZM241385 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 5.012↓ pK(d) (Biing - Surface plasmon resonance) NOTDISCLOSED Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Gao ZG et al (2002)
aa2ar_human 7.36x35 271 TM7 Y => A Abolished effect k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Y Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 6.41x41 239 TM6 V => A 1.0 K(i) (Binding - Radioligand competition/displacement) XAC Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 264 ECL3 H => Q 1.082↓ % (Binding - Radioligand saturation) ZM241385 Segala E et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A 1.0 pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 7.943↓ pK(d) (Biing - Surface plasmon resonance) Triazine3f Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A 3.981↓ pK(d) (Biing - Surface plasmon resonance) Triazine3a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 159 ECL2 C => S 21.588↓ EC50 (cAMP accumulation) Adenosine De Filippo E et al (2016)
aa2ar_human 3.37x37 89 TM3 Q => S 3.01↓ K(d) (Binding - Radioligand competition/displacement) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) SCH420814 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 1.585↑ pK(d) (Biing - Surface plasmon resonance) Chromone1c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => C 2.541↓ K(i) (Binding - Radioligand competition/displacement) SCH58261 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.996↑ pK(d) (Biing - Surface plasmon resonance) Triazine3f Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 5.0↑ pK(i) (Binding - Radioligand competition/displacement) CGS21680 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A 1.302↓ IC50 (Binding - Radioligand competition/displacement) Amiloride Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A N/A N/A Kim SK et al (2003)
aa2ar_human 3.32x32 84 TM3 V => A Abolished effect K(d) (Binding - Radioligand saturation) XAC Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => Q N/A N/A Kim J et al (1996)
aa2ar_human 7.49x49 284 TM7 N => A 2.695↑ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.36x35 271 TM7 Y => A N/A N/A Kim J et al (1995)
aa2ar_human 7.43x42 278 TM7 H => Y 1.667↓ k1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.46x46 48 TM2 L => A N/A N/A Lebon G et al (2011)
aa2ar_human 7.46x46 281 TM7 S => N N/A N/A Jiang Q et al (1996)
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 154 ECL2 N => Q No effect K(i) (Binding - Radioligand competition/displacement) Theophylline Fraser NJ et al (2006) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => A 3.981↓ pK(d) (Biing - Surface plasmon resonance) Triazine3h Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 7.943↓ pK(d) (Biing - Surface plasmon resonance) SCH420814 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => Y N/A N/A Kim J et al (1995)
aa2ar_human 5.41x42 180 TM5 F => A 1.356↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 3.165↑ pEC50 (Functional - cAMP accumulation) LUF-5834 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 6.329↑ pK(d) (Biing - Surface plasmon resonance) Triazine3h Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 153 ECL2 K => A 1.202↑ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 15.873↑ pK(d) (Biing - Surface plasmon resonance) Triazine3e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => N 4.785↑ K(d) (Binding - Radioligand saturation) CGS21680 Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.50x50 52 TM2 D => A Abolished effect pEC50 (Functional - cAMP accumulation) CGS21680 Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↑ pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => N N/A N/A Jiang Q et al (1997)
aa2ar_human 3.31x31 83 TM3 F => A N/A N/A Lebon G et al (2011)
aa2ar_human 45.51x51 167 ECL2 L => E 1.33↓ K(i) (Binding - Radioligand competition/displacement) Istradefylline Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => Y N/A N/A Kim J et al (1995)
aa2ar_human 7.46x46 281 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 5.38x40 177 TM5 M => A 1.259↑ pK(d) (Biing - Surface plasmon resonance) Chromone1a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => D 1.12↑ K(i) (Binding - Radioligand competition/displacement) NECA Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 23.81↓ % (Binding - Radioligand competition/displacement) 12b Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect EC50 (Functional - cAMP accumulation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => N 2.615↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.50x50 52 TM2 D => A 1.314↑ K(d) (Binding - Radioligand saturation) ZM241385 Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Y N/A N/A Gao ZG et al (2000)
aa2ar_human 7.46x46 281 TM7 S => N 3.676↓ K(i) (Binding - Radioligand competition/displacement) ZM241385 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 390.865↓ K(i) (Binding - Radioligand saturation) CADO Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 3.9↓ K(i) (Binding - Radioligand competition/displacement) XAC Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 1.995↓ pK(d) (Biing - Surface plasmon resonance) Chromone1d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.50x50 166 ECL2 C => S 2.99↓ EC50 (cAMP accumulation) NECA De Filippo E et al (2016)
aa2ar_human 6.48x48 246 TM6 W => A 1.192↓ % (Binding - Radioligand competition/displacement) CID57399651 Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => N 3.184↓ K(d) (Binding - Radioligand competition/displacement) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.41x42 180 TM5 F => A N/A N/A Kim J et al (1995)
aa2ar_human 3.36x36 88 TM3 T => A 185.149↓ K(i) (Binding - Radioligand competition/displacement) NECA Bertheleme N et al (2013) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 3.162↓ pK(d) (Biing - Surface plasmon resonance) Triazine3b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.56x56 254 TM6 C => A 1.092↓ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S 15.805↓ K(i) (Binding - Radioligand competition/displacement) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.46x46 281 TM7 S => A N/A N/A Kim J et al (1995)
aa2ar_human 7.49x49 284 TM7 N => A 1.522↓ K(d) (Binding - Radioligand saturation) ZM241385 Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => N Abolished effect K(d) (Binding - Radioligand saturation) XAC Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 1.767↑ K(i) (Binding - Radioligand competition/displacement) Theophylline Magnani F et al (2008) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => F Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.585↓ pK(d) (Biing - Surface plasmon resonance) KW6002 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => A 15.738↓ EC50 (Functional - cAMP accumulation) CGS21680 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 10.0↑ pK(d) (Biing - Surface plasmon resonance) Triazine3a Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) NCGC00015640-02 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.35x34 270 TM7 M => T 5.0↑ K(i) (Binding - Radioligand competition/displacement) KW3902 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A N/A N/A Kim J et al (1995)
aa2ar_human 3.36x36 88 TM3 T => S 6.576↓ K(i) (Binding - Radioligand competition/displacement) CADO Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 159 ECL2 C => S 25.641↑ EC50 (cAMP accumulation) PSB-15826 De Filippo E et al (2016)
aa2ar_human 1.39x39 13 TM1 E => Q 8.929↓ K(i) (Binding - Radioligand competition/displacement) CGS21680 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 3.953↑ EC50 (Functional - cAMP accumulation) DPMA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 1.675↑ k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.65x64 67 TM2 S => N 1.58↓ K(i) (Binding - Radioligand competition/displacement) ZM241385 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) KW6002 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => N 1.288↓ K(i) (Binding - Radioligand competition/displacement) DPCPX Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 4.329↑ K(i) (Binding - Radioligand competition/displacement) XAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => A N/A N/A Kim J et al (1995)
aa2ar_human 3.36x36 88 TM3 T => A 6.65↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.50x50 52 TM2 D => A 18.427↓ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 1.585↓ pK(d) (Biing - Surface plasmon resonance) KW6002 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => A N/A N/A Kim J et al (1996)
aa2ar_human 6.55x55 253 TM6 N => Q N/A N/A Kim J et al (1995)
aa2ar_human 6.52x52 250 TM6 H => N 1.099↑ K(i) (Binding - Radioligand competition/displacement) Nifedipine Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.45x45 47 TM2 S => A N/A N/A Lebon G et al (2011)
aa2ar_human 7.42x41 277 TM7 S => A 5.0↑ pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D 3.596↓ EC50 (Functional - cAMP accumulation) NONAME_3 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.48x48 246 TM6 W => A 3.817↓ % (Binding - Radioligand competition/displacement) CID57392705 Massink A et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.57x56 59 TM2 A => V 3.61↓ K(i) (Binding - Radioligand competition/displacement) XAC Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.57x56 59 TM2 A => V 1.35↓ K(i) (Binding - Radioligand competition/displacement) PSB36 Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 7.519↑ K(i) (Binding - Radioligand competition/displacement) SCH58261 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 161 ECL2 E => A 1.053↑ K(i) (Binding - Radioligand competition/displacement) IB-MECA Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.38x38 90 TM3 S => A 1.906↓ K(i) (Binding - Radioligand competition/displacement) XAC Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.64x63 66 TM2 I => A 1.259↓ pK(d) (Biing - Surface plasmon resonance) Theophylline Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 5.41x42 180 TM5 F => A 1.429↓ K(i) (Binding - Radioligand competition/displacement) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => Q 22.222↑ K(i) (Binding - Radioligand competition/displacement) DPMA Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.36x36 88 TM3 T => D 1.259↓ K(i) (Binding - Radioligand competition/displacement) NONAME_3 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 7.42x41 277 TM7 S => A 5.0↑ pK(d) (Biing - Surface plasmon resonance) KW6002 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => R 4.167↓ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.22x22 74 TM3 C => A 1.558↑ K(d) (Binding - Radioligand saturation) CGS21680 Naranjo AN et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => N 1.977↓ K(i) (Binding - Radioligand competition/displacement) XAC Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => K Abolished effect K(d) (Binding - Radioligand saturation) XAC Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.38x40 177 TM5 M => A Decreased effect pK(d) (Biing - Surface plasmon resonance) Caffeine Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A N/A N/A Jiang Q et al (1996)
aa2ar_human 169 ECL2 E => Q 2.556↓ K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 169 ECL2 E => Q 2.344↓ pK(i) (Binding - Radioligand competition/displacement) ZM241385 Guo D et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 6.31↓ pK(d) (Biing - Surface plasmon resonance) Chromone1c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.43x42 278 TM7 H => Y 1.759↓ k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.50x50 166 ECL2 C => S 1.14↑ K(i) (radioligand binding) CGS21680 De Filippo E et al (2016)
aa2ar_human 3.37x37 89 TM3 Q => D 2.398↑ K(i) (Binding - Radioligand competition/displacement) CGS15943 Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => A Abolished effect K(d) (Binding - Radioligand saturation) NECA Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Chromone1b Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 1.172↑ K(d) (Binding - Radioligand saturation) ZM241385 Lane JR et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.32x32 84 TM3 V => D Abolished effect K(d) (Binding - Radioligand saturation) NECA Jiang Q et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.42x43 181 TM5 N => D No effect K(i) (Binding - Radioligand competition/displacement) Cid22948626 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.34x36 173 TM5 P => R No effect (Binding - Radioligand saturation) XAC Kim J et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q 3.032↓ K(i) (Binding - Radioligand competition/displacement) DPMA Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => A N/A N/A Kim J et al (1995)
aa2ar_human 5.43x44 182 TM5 F => W N/A N/A Kim J et al (1995)
aa2ar_human 7.42x41 277 TM7 S => T 1.679↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 1.39x39 13 TM1 E => Q 2.069↓ k-1 (Binding - Radioligand kinetics (association/dissociation)) ZM241385 Gao Z et al (2002) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => A 1.307↑ EC50 (Functional - cAMP accumulation) CGS21680 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018681 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => C 1.274↑ K(i) (Binding - Radioligand competition/displacement) CGS15943 Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 262 ECL3 C => G N/A N/A Scholl DJ et al (2000)
aa2ar_human 264 ECL3 H => A 5.623↓ pEC50 (Functional - cAMP accumulation) CGS21680 Lebon G et al (2015) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => T N/A N/A Kim J et al (1995)
aa2ar_human 7.42x41 277 TM7 S => E 1.364↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim S et al (2007) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 107.239↓ K(i) (Binding - Radioligand saturation) DPMA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect pK(d) (Biing - Surface plasmon resonance) Triazine3h Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 159 ECL2 C => S 4.049↑ K(i) (radioligand binding) PSB-15826 De Filippo E et al (2016)
aa2ar_human 159 ECL2 C => S 2.597↑ K(i) (radioligand binding) CGS21680 De Filippo E et al (2016)
aa2ar_human 2.57x56 59 TM2 A => V 1.48↓ K(i) (Binding - Radioligand competition/displacement) DPCPX Cheng RK et al (2017) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => D 1.289↑ K(i) (Binding - Radioligand competition/displacement) Cid76018682 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.45x45 280 TM7 N => A 3.559↑ IC50 (Binding - Radioligand competition/displacement) HMA Massink A et al (2014) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 264 ECL3 H => Q 1.342↑ % (Binding - Radioligand saturation) CID44394716 Segala E et al (2016) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.52x52 250 TM6 H => F N/A N/A Kim J et al (1995)
aa2ar_human 7.36x35 271 TM7 Y => A 3.162↓ pK(d) (Biing - Surface plasmon resonance) XAC Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.36x36 88 TM3 T => D No effect K(i) (Binding - Radioligand competition/displacement) Cid76018686 Jacobson KA et al (2005) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.37x37 89 TM3 Q => A 10.417↑ K(i) (Binding - Radioligand competition/displacement) R-PIA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 7.42x41 277 TM7 S => A 1.0 pK(d) (Biing - Surface plasmon resonance) Chromone1e Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S 10.0↓ K(i) (Binding - Radioligand competition/displacement) DPMA Jiang Q et al (1996) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.33x33 85 TM3 L => A 7.943↓ pK(d) (Biing - Surface plasmon resonance) Triazine15 Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.52x52 168 ECL2 F => Y 2.292↓ K(d) (Binding - Other) ZM241385 Jaakola V et al (2010) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.36x36 88 TM3 T => S N/A N/A Jiang Q et al (1996)
aa2ar_human 7.43x42 278 TM7 H => Y Abolished effect K(d) (Binding - Radioligand saturation) XAC Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 2.48x48 50 TM2 A => L N/A N/A Lebon G et al (2011)
aa2ar_human 3.36x36 88 TM3 T => S N/A N/A Jiang Q et al (1996)
aa2ar_human 6.55x55 253 TM6 N => A Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 45.51x51 167 ECL2 L => A 1.259↑ pK(d) (Biing - Surface plasmon resonance) Chromone1c Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 5.43x44 182 TM5 F => Y 8.543↓ K(i) (Binding - Radioligand competition/displacement) NECA Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 3.39x39 91 TM3 S => A N/A N/A Jiang Q et al (1996)
aa2ar_human 3.33x33 85 TM3 L => A 6.31↓ pK(d) (Biing - Surface plasmon resonance) Chromone1d Zhukov A et al (2011) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 6.55x55 253 TM6 N => S Abolished effect K(d) (Binding - Radioligand saturation) CGS21680 Kim J et al (1995) https://doi.org/10.1016/j.tips.2017.11.001
aa2ar_human 148 ECL2 Q => A 1.244↓ k-1 (Binding - Radioligand kinetics (association/dissociation))