Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
drd3_human 9 N-term S => G 2.445↑ K(i) (Binding - Radioligand competition/displacement) Aripiprazole Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W >1111.111↓ K(i) (Binding - Radioligand competition/displacement) Dopamine Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 1.385↑ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 3.162↓ pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P N/A N/A Lundstrom K et al (1998)
drd3_human 5.42x43 192 TM5 S => A N/A N/A Sartania N et al (1999)
drd3_human 7.31x30 361 TM7 S => P 3.981↓ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 76.913↓ K(i) (Binding - Radioligand competition/displacement) Apomorphine Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 3.824↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.32x32 110 TM3 D => A N/A N/A Kufareva I et al (2011)
drd3_human 7.35x34 365 TM7 Y => L 1.862↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.38x37 368 TM7 T => F 1.0 pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 2.513↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => L 8.708↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 7.937↑ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => A 7.059↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.65x64 90 TM2 E => Q 5.615↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.35x34 365 TM7 Y => L 1.4↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => S 34.0↓ K(i) (Binding - Radioligand competition/displacement) Chlorpromazine Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.236↑ K(i) (Binding - Radioligand competition/displacement) Dopamine Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => Q 1.765↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.31x30 361 TM7 S => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 1.585↑ pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => L 19.231↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => S 272.5↓ K(i) (Binding - Radioligand competition/displacement) UH-232 Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => L 1.2↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.42x43 192 TM5 S => A 1.163↓ K(i) (Binding - Radioligand competition/displacement) Quinpirole Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 2.513↑ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.083↓ K(d) (Binding - Radioligand saturation) [3H]7-OH-DPAT Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 7.667↓ K(i) (Binding - Radioligand competition/displacement) Butaclamol Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 5.43x44 193 TM5 S => A 2.77↑ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 3.165↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => F 1.361↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.35x34 365 TM7 Y => L 1.4↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 1.39x39 36 TM1 Y => L 22.0↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 1.39x39 36 TM1 Y => L 12.0↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.35x34 365 TM7 Y => L 3.853↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.35x34 365 TM7 Y => L 2.0↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.61x60 86 TM2 V => F 8.636↓ K(i) (Binding - Radioligand competition/displacement) paper-1b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 66.0↓ K(i) (Binding - Radioligand competition/displacement) paper-3b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => I 1.508↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 1.39x39 36 TM1 Y => F 1.667↑ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.39x40 189 TM5 V => I 1.6↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 6.55x55 349 TM6 H => A 12.658↑ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => A 1.44↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 1.39x39 36 TM1 Y => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.25↑ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 6.55x55 349 TM6 H => L 1.996↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 3.704↓ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => I 2.52↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.31x30 361 TM7 S => P 1.585↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 6.282↓ K(i) (Binding - Radioligand competition/displacement) D315 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L N/A N/A Lundstrom K et al (1998)
drd3_human 2.64x63 89 TM2 L => F 1.969↓ K(i) (Binding - Radioligand competition/displacement) paper-2a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 1.019↓ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 29.6↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.61x60 86 TM2 V => F 67.568↓ K(i) (Binding - Radioligand competition/displacement) paper-3a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 3.538↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.24x24 102 TM3 C => H 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G N/A N/A Leszczynska-Rodziewicz A et al (2005)
drd3_human 5.46x461 196 TM5 S => A 1.748↑ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 7.35x34 365 TM7 Y => L 3.676↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.64x63 89 TM2 L => F 1.0 K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 2.513↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 45.51x51 182 ECL2 S => I 3.125↑ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.38x37 368 TM7 T => V 1.259↓ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 28.378↓ K(i) (Binding - Radioligand competition/displacement) Raclopride Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => I 2.185↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 45.51x51 182 ECL2 S => I 3.354↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 6.34x34 328 TM6 T => S N/A N/A McAllister G et al (1993)
drd3_human 1.39x39 36 TM1 Y => F 1.8↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => S N/A N/A Alberts GL et al (1998)
drd3_human 2.65x64 90 TM2 E => Q 1.2↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.39x38 369 TM7 T => V 1.623↑ K(i) (Binding - Radioligand competition/displacement) D315 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 2.165↑ K(i) (Binding - Radioligand competition/displacement) paper-2b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 7.35x34 365 TM7 Y => L 3.92↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.38x37 368 TM7 T => F 1.0 pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 6.34x34 328 TM6 T => S N/A N/A McAllister G et al (1993)
drd3_human 7.39x38 369 TM7 T => V 1.573↓ K(i) (Binding - Radioligand competition/displacement) D264 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 5.43x44 193 TM5 S => A 1.099↑ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => L 9.24↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.32x32 110 TM3 D => E 1.446↓ K(i) (Binding - Radioligand competition/displacement) paper-1a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.0 pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G N/A N/A Lundstrom K et al (1996)
drd3_human 45.51x51 182 ECL2 S => I 1.059↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.38x37 368 TM7 T => F 1.259↓ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => I 2.412↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 3.165↑ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 2.333↓ K(d) (Binding - Radioligand saturation) [3H]spiperone Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 61.884↓ K(i) (Binding - Radioligand competition/displacement) Dopamine Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.996↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 3.24x24 102 TM3 C => H 1.259↓ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 4.982↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.585↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => I 4.28↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 1.326↑ K(i) (Binding - Radioligand competition/displacement) GR103691 Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F N/A N/A Lundstrom K et al (1998)
drd3_human 2.64x63 89 TM2 L => F 16.538↓ K(i) (Binding - Radioligand competition/displacement) paper-2b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 5.181↑ K(i) (Binding - Radioligand competition/displacement) paper-1a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 56.702↓ K(i) (Binding - Radioligand competition/displacement) (-)-3-PPP Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 45.52x52 183 ECL2 I => F 15.385↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.61x60 86 TM2 V => F 2.987↓ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.585↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 1.852↓ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 166.667↑ K(i) (Binding - Radioligand competition/displacement) paper-1a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.13↓ K(i) (Binding - Radioligand competition/displacement) SDZ 208-912 Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 16.458↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 3.165↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 3.165↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 45.51x51 182 ECL2 S => I 5.246↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.46x461 196 TM5 S => A 1.637↑ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 54.72↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.65x64 90 TM2 E => L 2.6↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => S 6.0↓ K(i) (Binding - Radioligand competition/displacement) Spiperone Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.259↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 116.0↓ K(i) (Binding - Radioligand competition/displacement) paper-3b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 39.36↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.39x40 189 TM5 V => A 1.6↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.43x44 193 TM5 S => A N/A N/A Sartania N et al (1999)
drd3_human 5.39x40 189 TM5 V => I 1.912↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 1.39x39 36 TM1 Y => L 2.5↑ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 1.39x39 36 TM1 Y => F 2.5↑ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.31x30 361 TM7 S => A N/A N/A Lundstrom K et al (1998)
drd3_human 2.64x63 89 TM2 L => F 39.189↓ K(i) (Binding - Radioligand competition/displacement) paper-3a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 45.51x51 182 ECL2 S => I 1.0 K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.42x43 192 TM5 S => A 10.959↓ K(i) (Binding - Radioligand competition/displacement) D237 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 45.51x51 182 ECL2 S => I 2.5↑ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 1.062↑ K(i) (Binding - Radioligand competition/displacement) Terguride Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 1.4↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 1.011↓ K(i) (Binding - Radioligand competition/displacement) Olanzapine Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 3.071↓ K(i) (Binding - Radioligand competition/displacement) Cabergoline Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => I 2.4↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 6.55x55 349 TM6 H => A 5.714↑ K(i) (Binding - Radioligand competition/displacement) paper-2a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => A 1.246↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 45.52x52 183 ECL2 I => F 2.64↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.46x461 196 TM5 S => A 1.227↑ K(i) (Binding - Radioligand competition/displacement) Quinpirole Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 25.0↓ K(i) (Binding - Radioligand competition/displacement) paper-2b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 1115.385↓ K(i) (Binding - Radioligand competition/displacement) paper-4c Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 5.012↓ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V N/A N/A Lundstrom K et al (1998)
drd3_human 6.55x55 349 TM6 H => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 5.0↓ K(i) (Binding - Radioligand competition/displacement) YM-9151-02 Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => A 1.4↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.24x24 102 TM3 C => H N/A N/A Lundstrom K et al (1998)
drd3_human 5.43x44 193 TM5 S => A 2.075↓ K(i) (Binding - Radioligand competition/displacement) Dopamine Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.22↑ K(i) (Binding - Radioligand competition/displacement) (-)-3-PPP Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 2.347↑ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 4.353↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.31x30 361 TM7 S => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 3.219↓ K(i) (Binding - Radioligand competition/displacement) paper-2a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => F 1.063↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 1.437↑ K(i) (Binding - Radioligand competition/displacement) OPC-4392 Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 6.329↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => Q 1.588↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.31x30 361 TM7 S => P 1.0 pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.0 K(d) (Binding - Radioligand saturation) [3H]7-OH-DPAT Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 4.647↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.32x32 110 TM3 D => E 1.133↑ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 2.8↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.42x43 192 TM5 S => A 1.009↓ K(d) (Binding - Radioligand saturation) Spiperone Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => F 1.626↑ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 45.52x52 183 ECL2 I => F 1.2↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => L 1.562↑ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.38x37 368 TM7 T => V 1.995↓ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 3.205↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 15.849↓ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.112↑ K(i) (Binding - Radioligand competition/displacement) D237 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => L 1.088↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.39x38 369 TM7 T => V N/A N/A Lundstrom K et al (1998)
drd3_human 1.39x39 36 TM1 Y => L 6.471↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 1.39x39 36 TM1 Y => L 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.041↑ K(i) (Binding - Radioligand competition/displacement) Risperidone Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G N/A N/A Lundstrom K et al (1996)
drd3_human 7.39x38 369 TM7 T => V 1.621↑ K(d) (Binding - Radioligand saturation) Spiperone Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 30.0↓ K(i) (Binding - Radioligand competition/displacement) FAUC73 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.072↓ K(i) (Binding - Radioligand competition/displacement) ACR16 Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 2.668↓ K(i) (Binding - Radioligand competition/displacement) D264 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 600.0↓ K(i) (Binding - Radioligand competition/displacement) paper-5c Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 28.462↓ K(i) (Binding - Radioligand competition/displacement) paper-2b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => A 1.308↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.65x64 90 TM2 E => Q 10.0↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.38x37 368 TM7 T => F 1.585↑ pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L N/A N/A Lundstrom K et al (1998)
drd3_human 3.36x36 114 TM3 C => L 1.8↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.24x24 102 TM3 C => H 3.984↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 10.0↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 45.52x52 183 ECL2 I => F 12.647↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 1.121↑ K(i) (Binding - Radioligand competition/displacement) BP897 Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 1.26↓ K(i) (Binding - Radioligand competition/displacement) paper-3b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 172 ECL2 F => A N/A N/A Lundstrom K et al (1998)
drd3_human 1.39x39 36 TM1 Y => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) Chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 75.0↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 7.35x34 365 TM7 Y => L 1.677↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 45.51x51 182 ECL2 S => I 1.316↑ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.24x24 102 TM3 C => H 3.165↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 45.52x52 183 ECL2 I => F 2.769↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.32x32 110 TM3 D => E 460.0↓ K(i) (Binding - Radioligand competition/displacement) paper-3b Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 1.219↓ K(i) (Binding - Radioligand competition/displacement) paper-2a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 25.641↓ K(i) (Binding - Radioligand competition/displacement) paper-4c Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G N/A N/A Kaiser R et al (2003)
drd3_human 3.24x24 102 TM3 C => H 1.585↑ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => L 2.778↑ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => L 2.618↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 1.55↑ K(i) (Binding - Radioligand competition/displacement) Bifeprunox Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 37.786↓ K(i) (Binding - Radioligand competition/displacement) Quinpirole Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 5.39x40 189 TM5 V => A 1.0 K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.65x64 90 TM2 E => L 1.441↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => S 13.704↓ K(i) (Binding - Radioligand competition/displacement) Pramipexole Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L N/A N/A Lundstrom K et al (1998)
drd3_human 6.55x55 349 TM6 H => A 3.704↑ K(i) (Binding - Radioligand competition/displacement) paper-3a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 3.165↑ pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 45.51x51 182 ECL2 S => I 1.618↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.65x64 90 TM2 E => Q 1.0 K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.24x24 102 TM3 C => H 1.995↓ pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => L 2.5↑ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.24x24 102 TM3 C => H 3.984↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => L 1.667↑ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.43x44 193 TM5 S => A 1.054↓ K(i) (Binding - Radioligand competition/displacement) Quinpirole Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 1.259↑ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => L 7.0↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 7.31x30 361 TM7 S => A 3.165↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => F Abolished effect K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.332↑ K(i) (Binding - Radioligand competition/displacement) Ziprasidone Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 3.385↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.61x60 86 TM2 V => F 1.108↓ K(i) (Binding - Radioligand competition/displacement) paper-1a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 1.033↓ K(i) (Binding - Radioligand competition/displacement) Quetiapine Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => F 5.2↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.42x43 192 TM5 S => A 18.519↓ K(i) (Binding - Radioligand competition/displacement) 5-OH-DPAT (D323) Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.585↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 12.568↓ K(i) (Binding - Radioligand competition/displacement) paper-3a Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 5.46x461 196 TM5 S => A 1.172↑ K(i) (Binding - Radioligand competition/displacement) Dopamine Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 2.65x64 90 TM2 E => Q 12.36↓ K(i) (Binding - Radioligand competition/displacement) GSK598809 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 6.55x55 349 TM6 H => L 5.012↓ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 15.278↓ K(i) (Binding - Radioligand competition/displacement) Dopamine Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S N/A N/A Alberts GL et al (1998)
drd3_human 2.65x64 90 TM2 E => Q 6.708↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 6.55x55 349 TM6 H => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 45.52x52 183 ECL2 I => F 1.8↓ K(i) (Binding - Radioligand competition/displacement) Eticlopride Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.32x32 110 TM3 D => E >52.632↓ K(i) (Binding - Radioligand competition/displacement) FAUC73 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.0 pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 1.572↑ K(i) (Binding - Radioligand competition/displacement) Lisuride Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 5.0↑ pK(i) (Binding - Radioligand competition/displacement) Dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 3.162↓ pK(i) (Binding - Radioligand competition/displacement) Haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.0 pK(i) (Binding - Radioligand competition/displacement) GR103691 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V N/A N/A Lundstrom K et al (1998)
drd3_human 5.39x40 189 TM5 V => A 8.824↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 6.51x51 345 TM6 F => W 2.262↑ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 3.165↑ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.122↑ K(i) (Binding - Radioligand competition/displacement) 5-OH-DPAT (D323) Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 45.52x52 183 ECL2 I => F 16.176↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 3.36x36 114 TM3 C => L 26.569↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 5.46x461 196 TM5 S => A N/A N/A Sartania N et al (1999)
drd3_human 9 N-term S => G 1.065↓ K(i) (Binding - Radioligand competition/displacement) Clozapine Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 101.415↓ K(i) (Binding - Radioligand competition/displacement) AJ-76 Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 9 N-term S => G 5.0↑ pK(i) (Binding - Radioligand competition/displacement) GR218231 Lundstrom K et al (1996) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 10.0↓ pK(i) (Binding - Radioligand competition/displacement) Raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 1.585↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 3.558↓ K(d) (Binding - Radioligand competition/displacement) [3H]spiperone Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 388.889↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 13.2↓ K(i) (Binding - Radioligand competition/displacement) paper-5c Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 4.108↓ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)
drd3_human 2.64x63 89 TM2 L => F 1.07↑ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => L 2.123↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2018)
drd3_human 9 N-term S => G 1.131↑ K(i) (Binding - Radioligand competition/displacement) Haloperidol Tadori Y et al (2008) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => F 1.805↑ K(i) (Binding - Radioligand competition/displacement) Haloperidol Ferruz N et al (2018) Vass M et al (2018)


Residue

Diagrams

ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S S H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
D3 receptor
TM1
1x39 1.39x39 Y36
TM2
2x60 2.61x60 V86
2x63 2.64x63 L89
2x64 2.65x64 E90
TM3
3x24 3.24x24 C102
3x32 3.32x32 D110
3x36 3.36x36 C114
TM5
5x40 5.39x40 V189
5x43 5.42x43 S192
5x44 5.43x44 S193
5x461 5.46x461 S196
TM6
6x34 6.34x34 T328
6x51 6.51x51 F345
6x55 6.55x55 H349
TM7
7x30 7.31x30 S361
7x34 7.35x34 Y365
7x37 7.38x37 T368
7x38 7.39x38 T369
7x42 7.43x42 Y373