Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
ghsr_human 5.43x43 217 TM5 S => A N/A N/A Feighner SD et al (1998)
ghsr_human 6.56x56 284 TM6 Y => F N/A N/A Feighner SD et al (1998)
ghsr_human 6.51x51 279 TM6 F => L N/A N/A Feighner SD et al (1998)
ghsr_human 3.33x33 124 TM3 E => Q N/A N/A Palyha OC et al (2000)
ghsr_human 3.33x33 124 TM3 E => D N/A N/A Feighner SD et al (1998)
ghsr_human 3.51x51 142 TM3 Y => A N/A N/A Feighner SD et al (1998)
ghsr_human 2.60x60 99 TM2 D => N N/A N/A Feighner SD et al (1998)
ghsr_human 3.25x25 116 TM3 C => A N/A N/A Feighner SD et al (1998)
ghsr_human 5.39x39 213 TM5 M => K N/A N/A Feighner SD et al (1998)
ghsr_human 3.32x32 123 TM3 S => A N/A N/A Feighner SD et al (1998)
ghsr_human 3.25x25 116 TM3 C => A N/A N/A Feighner SD et al (1998)
ghsr_human 5.39x39 213 TM5 M => K N/A N/A Feighner SD et al (1998)
ghsr_human 3.33x33 124 TM3 E => Q N/A N/A Feighner SD et al (1998)
ghsr_human 6.52x52 280 TM6 H => Q N/A N/A Feighner SD et al (1998)
ghsr_human 5.39x39 213 TM5 M => K N/A N/A Feighner SD et al (1998)
ghsr_human 6.52x52 280 TM6 H => F N/A N/A Feighner SD et al (1998)
ghsr_human 2.60x60 99 TM2 D => N N/A N/A Feighner SD et al (1998)
ghsr_human 3.29x29 120 TM3 Q => H N/A N/A Feighner SD et al (1998)
ghsr_human 5.44x44 218 TM5 S => A N/A N/A Feighner SD et al (1998)
ghsr_human 3.33x33 124 TM3 E => D N/A N/A Palyha OC et al (2000)
ghsr_human 3.33x33 124 TM3 E => D N/A N/A Feighner SD et al (1998)
ghsr_human 3.33x33 124 TM3 E => D N/A N/A Feighner SD et al (1998)
ghsr_human 5.43x43 217 TM5 S => A N/A N/A Feighner SD et al (1998)
ghsr_human 6.51x51 279 TM6 F => L N/A N/A Feighner SD et al (1998)
ghsr_human 3.33x33 124 TM3 E => Q N/A N/A Feighner SD et al (1998)
ghsr_human 6.51x51 279 TM6 F => H N/A N/A Feighner SD et al (1998)
ghsr_human 3.33x33 124 TM3 E => Q N/A N/A Feighner SD et al (1998)


Residue

Diagrams

ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 F E P G S L E I ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x60 2.60x60 D99
TM3
3x25 3.25x25 C116
3x29 3.29x29 Q120
3x32 3.32x32 S123
3x33 3.33x33 E124
3x51 3.51x51 Y142
TM5
5x39 5.39x39 M213
5x43 5.43x43 S217
5x44 5.44x44 S218
TM6
6x51 6.51x51 F279
6x52 6.52x52 H280
6x56 6.56x56 Y284