Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
hrh1_human 3.32x32 107 TM3 D => A N/A N/A Ohta K et al (1994)
hrh1_human 3.32x32 107 TM3 D => N N/A N/A Ohta K et al (1994)
hrh1_human 3.32x32 107 TM3 D => E N/A N/A Ohta K et al (1994)
hrh1_human 5.42x43 194 TM5 T => A N/A N/A Ohta K et al (1994)
hrh1_human 5.46x461 198 TM5 N => A N/A N/A Ohta K et al (1994)
hrh1_human 4.53x53 155 TM4 S => A N/A N/A Moguilevsky N et al (1995)
hrh1_human 3.32x32 107 TM3 D => A N/A N/A Nonaka H et al (1998)
hrh1_human 5.42x43 194 TM5 T => A N/A N/A Nonaka H et al (1998)
hrh1_human 5.46x461 198 TM5 N => A N/A N/A Nonaka H et al (1998)
hrh1_human 396 ICL3 S => A N/A N/A Fujimoto K et al (1999)
hrh1_human 398 ICL3 S => A N/A N/A Fujimoto K et al (1999)
hrh1_human 3.32x32 107 TM3 D => A N/A N/A Nonaka H et al (1998)
hrh1_human 4.53x53 155 TM4 S => A N/A N/A Moguilevsky N et al (1995)
hrh1_human 5.42x43 194 TM5 T => A N/A N/A Moguilevsky N et al (1995)
hrh1_human 5.42x43 194 TM5 T => A N/A N/A Nonaka H et al (1998)
hrh1_human 5.46x461 198 TM5 N => A N/A N/A Moguilevsky N et al (1995)
hrh1_human 5.46x461 198 TM5 N => A N/A N/A Nonaka H et al (1998)
hrh1_human 396 ICL3 S => A N/A N/A Fujimoto K et al (1999)
hrh1_human 398 ICL3 S => A N/A N/A Fujimoto K et al (1999)
hrh1_human 395 ICL3 R => E N/A N/A Mathiesen JM et al (2006)
hrh1_human 393 ICL3 R => E N/A N/A Mathiesen JM et al (2006)
hrh1_human 3.50x50 125 TM3 R => Y N/A N/A Shimamura T et al (2011)
hrh1_human 1.42x42 37 TM1 I => V 1.585↓ pK(i) (Binding - Radioligand competition/displacement) cetirizine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.43x43 38 TM1 C => S 1.0 pK(i) (Binding - Radioligand competition/displacement) cetirizine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 2.513↓ pK(i) (Binding - Radioligand competition/displacement) cetirizine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A N/A pK(i) (Binding - Radioligand competition/displacement) cetirizine Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => A 1.0 pK(i) (Binding - Radioligand competition/displacement) cetirizine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => C 1.585↑ pK(i) (Binding - Radioligand competition/displacement) cetirizine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => T 1.585↑ pK(i) (Binding - Radioligand competition/displacement) cetirizine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 4.53x53 155 TM4 S => A 2.513↓ pK(i) (Binding - Radioligand competition/displacement) cetirizine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.995↑ pK(i) (Binding - Radioligand competition/displacement) cetirizine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.0 pK(i) (Binding - Radioligand competition/displacement) cetirizine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 1.259↑ pK(i) (Binding - Radioligand competition/displacement) cetirizine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.34x33 449 TM7 L => V 1.0 pK(i) (Binding - Radioligand competition/displacement) cetirizine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.44x43 459 TM7 I => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) cetirizine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => C 1.585↓ pK(i) (Binding - Radioligand competition/displacement) cetirizine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => Q 1.259↓ pK(i) (Binding - Radioligand competition/displacement) cetirizine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => S 1.259↓ pK(i) (Binding - Radioligand competition/displacement) cetirizine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A N/A pK(i) (Binding - Radioligand competition/displacement) epinastine Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A 19.608↓ K(d) (Binding - Radioligand saturation) OLOPATADINE Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.479↓ K(d) (Binding - Radioligand saturation) OLOPATADINE Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.681↓ K(d) (Binding - Radioligand saturation) OLOPATADINE Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A 1.58489319246111e+23↑ pK(i) (Binding - Radioligand competition/displacement) OLOPATADINE Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 4.53x53 155 TM4 S => A 1.996↓ pK(i) (Binding - Radioligand competition/displacement) (R)-cetirizine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 3.984↓ pK(i) (Binding - Radioligand competition/displacement) (R)-cetirizine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.0 pK(i) (Binding - Radioligand competition/displacement) (R)-cetirizine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) (R)-cetirizine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.411↑ K(i) (Binding - Radioligand competition/displacement) (+)-chlorpheniramine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 6.944↓ K(i) (Binding - Radioligand competition/displacement) (+)-chlorpheniramine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.68↑ K(i) (Binding - Radioligand competition/displacement) 2-METHYLHISTAMINE Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A >23.81↓ K(i) (Binding - Radioligand competition/displacement) 2-METHYLHISTAMINE Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect K(d) (Binding - Radioligand saturation) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 3.33x33 108 TM3 Y => A Abolished effect K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 4.56x57 158 TM4 W => A Abolished effect K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 5.47x47 199 TM5 F => A Abolished effect K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.48x48 428 TM6 W => A Abolished effect K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.51x51 431 TM6 Y => A Abolished effect K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A Abolished effect K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 7.246↓ K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 7.43x42 458 TM7 Y => A 6.944↓ K(d) (Binding - Radioligand competition/displacement) (+)-trans-H2-PAT Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 4.53x53 155 TM4 S => A 1.996↓ pK(i) (Binding - Radioligand competition/displacement) (S)-cetirizine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 6.329↓ pK(i) (Binding - Radioligand competition/displacement) (S)-cetirizine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 10.0↑ pK(i) (Binding - Radioligand competition/displacement) (S)-cetirizine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 12.589↑ pK(i) (Binding - Radioligand competition/displacement) (S)-cetirizine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 3.28x28 103 TM3 W => A 20.0↓ pK(i) (Binding - Radioligand competition/displacement) 8R-Terguride Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.0 pK(i) (Binding - Radioligand competition/displacement) 8R-Terguride Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 6.329↓ pK(i) (Binding - Radioligand competition/displacement) 8R-Terguride Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 7.943↑ pK(i) (Binding - Radioligand competition/displacement) (S)-hydroxyzine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 3.28x28 103 TM3 W => A 31.25↓ pK(i) (Binding - Radioligand competition/displacement) 8R-Lisuride Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) 8R-Lisuride Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 20.0↓ pK(i) (Binding - Radioligand competition/displacement) 8R-Lisuride Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.917↑ K(i) (Binding - Radioligand competition/displacement) (+)-chlorpheniramine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 4.651↓ K(i) (Binding - Radioligand competition/displacement) (+)-chlorpheniramine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) terfenadine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.167↓ K(i) (Binding - Radioligand competition/displacement) 2-(2-thiazolyl)ethanamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 6.135↓ K(i) (Binding - Radioligand competition/displacement) 2-(2-thiazolyl)ethanamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.523↑ K(i) (Binding - Radioligand competition/displacement) 2-(3-bromophenyl)histamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 6.41↓ K(i) (Binding - Radioligand competition/displacement) 2-(3-bromophenyl)histamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 1.42x42 37 TM1 I => V 1.585↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.43x43 38 TM1 C => S 1.0 pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 5.012↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 3.981↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 2.513↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 1.259↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 1.996↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 7.34x33 449 TM7 L => V 1.259↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.43x42 458 TM7 Y => A 5.012↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.44x43 459 TM7 I => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL264491 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) methylhistaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) methylhistaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 3.984↓ pK(i) (Binding - Radioligand competition/displacement) methylhistaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) methylhistaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 3.165↓ pK(i) (Binding - Radioligand competition/displacement) methylhistaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 1.0 pK(i) (Binding - Radioligand competition/displacement) histaprodifen Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) histaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 1.995↑ pK(i) (Binding - Radioligand competition/displacement) histaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.996↓ pK(i) (Binding - Radioligand competition/displacement) histaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) histaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 1.996↓ pK(i) (Binding - Radioligand competition/displacement) histaprodifen Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.157↓ K(i) (Binding - Radioligand competition/displacement) 2-pyridylethylamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 3.39↓ K(i) (Binding - Radioligand competition/displacement) 2-pyridylethylamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 4.53x53 155 TM4 S => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) (+)-chlorpheniramine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 2.512↑ pK(i) (Binding - Radioligand competition/displacement) (+)-chlorpheniramine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.996↓ pK(i) (Binding - Radioligand competition/displacement) (+)-chlorpheniramine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 1.42x42 37 TM1 I => V 1.416↓ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.43x43 38 TM1 C => S 1.167↓ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 1.091↑ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.66x65 89 TM2 L => H Abolished effect K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.28x28 103 TM3 W => A 7.937↓ pK(d) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 3.28x28 103 TM3 W => A 7.937↓ pK(i) (Binding - Radioligand competition/displacement) mepyramine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect K(d) (Binding - Radioligand saturation) mepyramine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => E 50.0↓ K(d) (Binding - Radioligand saturation) mepyramine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => N 125.0↓ K(d) (Binding - Radioligand saturation) mepyramine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect pK(d) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect K(d) (Binding - Radioligand saturation) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 3.33x33 108 TM3 Y => A Abolished effect K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => A 3.155↓ K(d) (Binding - Radioligand saturation) mepyramine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => C 3.25↑ K(d) (Binding - Radioligand saturation) mepyramine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => T 2.079↓ K(d) (Binding - Radioligand saturation) mepyramine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 4.51x51 153 TM4 F => L 8.403↓ K(d) (Binding - Radioligand saturation) mepyramine Seifert R et al (2003) Kooistra AJ et al (2013)
hrh1_human 4.53x53 155 TM4 S => A 1.423↑ K(d) (Binding - Radioligand saturation) mepyramine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 4.56x57 158 TM4 W => A Abolished effect K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 3.231↑ K(d) (Binding - Radioligand saturation) mepyramine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 2.167↑ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 3.152↑ K(d) (Binding - Radioligand saturation) mepyramine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 2.636↑ K(d) (Binding - Radioligand saturation) mepyramine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 4.111↑ K(d) (Binding - Radioligand saturation) mepyramine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 4.667↑ K(d) (Binding - Radioligand saturation) mepyramine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.995↑ pK(d) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.135↓ K(d) (Binding - Radioligand saturation) mepyramine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.362↓ K(d) (Binding - Radioligand saturation) mepyramine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.271↓ K(d) (Binding - Radioligand saturation) mepyramine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 2.513↓ pK(d) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.538↓ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.47x47 199 TM5 F => A Abolished effect K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => A 1.585↑ pK(b) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => E 1.259↓ pK(b) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => F 1.259↑ pK(b) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => G 2.513↓ pK(b) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => K 1.585↑ pK(b) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => R 1.996↓ pK(b) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => S 3.165↓ pK(b) (Binding - Radioligand saturation) mepyramine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.48x48 428 TM6 W => A Abolished effect K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.51x51 431 TM6 Y => A Abolished effect K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A >23.256↓ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A Abolished effect K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 11.905↓ K(d) (Binding - Radioligand saturation) mepyramine Seifert R et al (2003) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 1.714↑ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 4.386↓ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 9.901↓ K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 7.34x33 449 TM7 L => V 1.167↓ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.43x42 458 TM7 Y => A 2.5↓ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.43x42 458 TM7 Y => A 10.87↓ K(d) (Binding - Radioligand competition/displacement) mepyramine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 7.44x43 459 TM7 I => L 1.2↑ K(d) (Binding - Radioligand saturation) mepyramine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => C 2.079↓ K(d) (Binding - Radioligand saturation) mepyramine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => L Abolished effect K(d) (Binding - Radioligand saturation) mepyramine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => Q 2.387↓ K(d) (Binding - Radioligand saturation) mepyramine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => S 2.155↓ K(d) (Binding - Radioligand saturation) mepyramine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A N/A pK(i) (Binding - Radioligand competition/displacement) mepyramine Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A N/A pK(i) (Binding - Radioligand competition/displacement) ketotifen Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A 2.04173794466954e+189↑ pK(i) (Binding - Radioligand competition/displacement) doxepin Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 1.42x42 37 TM1 I => V 2.513↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.43x43 38 TM1 C => S 2.513↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 1.259↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.28x28 103 TM3 W => A <100.0↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect K(i) (Binding - Radioligand competition/displacement) histamine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => E Abolished effect K(i) (Binding - Radioligand competition/displacement) histamine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => N Abolished effect K(i) (Binding - Radioligand competition/displacement) histamine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A N/A pK(i) (Binding - Radioligand competition/displacement) histamine Nonaka H et al (1998) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => A 12.658↓ pK(i) (Binding - Radioligand competition/displacement) histamine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => C 1.995↑ pK(i) (Binding - Radioligand competition/displacement) histamine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.36x36 111 TM3 S => T 1.0 pK(i) (Binding - Radioligand competition/displacement) histamine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 4.53x53 155 TM4 S => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) histamine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 15.873↓ pK(i) (Binding - Radioligand competition/displacement) histamine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 2.513↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 3.546↓ K(i) (Binding - Radioligand competition/displacement) histamine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 2.294↓ K(i) (Binding - Radioligand competition/displacement) histamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 5.0↓ pK(i) (Binding - Radioligand competition/displacement) histamine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 5.0↓ pK(i) (Binding - Radioligand competition/displacement) histamine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 3.165↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1000.0↓ K(i) (Binding - Radioligand competition/displacement) histamine Ohta K et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A >83.333↓ K(i) (Binding - Radioligand competition/displacement) histamine Leurs R et al (1994) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 200.0↓ pK(i) (Binding - Radioligand competition/displacement) histamine Moguilevsky N et al (1995) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 15.873↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 50.0↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => A 7.943↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => E 5.012↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => F 1.259↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => G 15.849↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => K 25.119↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => R 25.119↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.40x40 420 TM6 I => S 1.0 pK(i) (Binding - Radioligand competition/displacement) histamine Bakker RA et al (2008) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 1.585↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 40.0↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A >3.333↓ K(i) (Binding - Radioligand competition/displacement) histamine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 7.34x33 449 TM7 L => V 1.996↓ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.43x42 458 TM7 Y => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.43x42 458 TM7 Y => A 16.949↓ K(i) (Binding - Radioligand competition/displacement) histamine Cordova-Sintjago TC et al (2012) Kooistra AJ et al (2013)
hrh1_human 7.44x43 459 TM7 I => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) histamine Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => C 3.981↑ pK(i) (Binding - Radioligand competition/displacement) histamine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => Q 2.512↑ pK(i) (Binding - Radioligand competition/displacement) histamine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.45x45 460 TM7 N => S 6.31↑ pK(i) (Binding - Radioligand competition/displacement) histamine Jongejan A et al (2005) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 3.984↓ pK(i) (Binding - Radioligand competition/displacement) fexofenadine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 1.0 pK(i) (Binding - Radioligand competition/displacement) loratadine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 3.165↓ pK(i) (Binding - Radioligand competition/displacement) loratadine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 1.42x42 37 TM1 I => V 1.259↑ pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.43x43 38 TM1 C => S 1.0 pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 3.162↑ pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 3.32x32 107 TM3 D => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 5.46x461 198 TM5 N => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.52x52 432 TM6 F => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 1.995↑ pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 6.55x55 435 TM6 F => A 2.513↓ pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 7.34x33 449 TM7 L => V 1.585↑ pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.44x43 459 TM7 I => L 1.585↑ pK(i) (Binding - Radioligand competition/displacement) HP-HP Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.42x42 37 TM1 I => V 1.259↓ pK(i) (Binding - Radioligand competition/displacement) VUF8401 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.43x43 38 TM1 C => S 1.0 pK(i) (Binding - Radioligand competition/displacement) VUF8401 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 2.512↑ pK(i) (Binding - Radioligand competition/displacement) VUF8401 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 1.259↑ pK(i) (Binding - Radioligand competition/displacement) VUF8401 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.34x33 449 TM7 L => V 1.0 pK(i) (Binding - Radioligand competition/displacement) VUF8401 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.44x43 459 TM7 I => L 1.0 pK(i) (Binding - Radioligand competition/displacement) VUF8401 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 7.943↑ pK(i) (Binding - Radioligand competition/displacement) (S)-ucb 29992 Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 1.0 pK(i) (Binding - Radioligand competition/displacement) (R)-ucb 29992 Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 3.981↑ pK(i) (Binding - Radioligand competition/displacement) (R)-ucb 29992 Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 2.512↑ pK(i) (Binding - Radioligand competition/displacement) (R)-ucb 29992 Bruysters M et al (2004) Kooistra AJ et al (2013)
hrh1_human 1.42x42 37 TM1 I => V 1.995↑ pK(i) (Binding - Radioligand competition/displacement) VUF4669 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 1.43x43 38 TM1 C => S 1.995↑ pK(i) (Binding - Radioligand competition/displacement) VUF4669 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 2.61x60 84 TM2 N => S 15.849↑ pK(i) (Binding - Radioligand competition/displacement) VUF4669 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 6.53x53 433 TM6 I => V 1.995↑ pK(i) (Binding - Radioligand competition/displacement) VUF4669 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.34x33 449 TM7 L => V 2.512↑ pK(i) (Binding - Radioligand competition/displacement) VUF4669 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 7.44x43 459 TM7 I => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) VUF4669 Bruysters M et al (2005) Kooistra AJ et al (2013)
hrh1_human 5.39x40 191 TM5 K => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) R-hydroxyzine Gillard M et al (2002) Kooistra AJ et al (2013)
hrh1_human 5.42x43 194 TM5 T => A 1.995↑ pK(i) (Binding - Radioligand competition/displacement) R-hydroxyzine Gillard M et al (2002) Kooistra AJ et al (2013)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R K L H ICL1ECL1 S K W S L ECL1ICL2 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N L G V T V L C I T S L V V V L P 1 V S L S V A D L I V G V A V M P M N I L Y 2 I F V S F I S A T S A V Y D M S L W F L 3 A S A T I L G A W F L S F L W V I P I 4 Y F W L M L L T P L Y F N I I A T M V K F 5 G F I M A A F I L C W I P Y F I F F M V 6 L P N L T S N I Y G L W I T F M H L H 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
H1 receptor
TM1
1x42 1.42x42 I37
1x43 1.43x43 C38
TM2
2x60 2.61x60 N84
2x65 2.66x65 L89
TM3
3x28 3.28x28 W103
3x32 3.32x32 D107
3x33 3.33x33 Y108
3x36 3.36x36 S111
3x50 3.50x50 R125
TM4
4x51 4.51x51 F153
4x53 4.53x53 S155
4x57 4.56x57 W158
TM5
5x40 5.39x40 K191
5x43 5.42x43 T194
5x461 5.46x461 N198
5x47 5.47x47 F199
TM6
6x40 6.40x40 I420
6x48 6.48x48 W428
6x51 6.51x51 Y431
6x52 6.52x52 F432
6x53 6.53x53 I433
6x55 6.55x55 F435
TM7
7x33 7.34x33 L449
7x42 7.43x42 Y458
7x43 7.44x43 I459
7x45 7.45x45 N460