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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ntr1_rat 422 C-term T => G N/A N/A Chabry J et al (1995)
ntr1_rat 424 C-term Y => G N/A N/A Chabry J et al (1995)
ntr1_rat 1.33x33 65 TM1 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.39x39 156 TM3 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 4.60x61 204 TM4 M => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 4.64x65 208 TM4 M => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.36x37 235 TM5 K => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 1.34x34 66 TM1 L => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.36x37 235 TM5 K => Q N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.36x37 235 TM5 K => R N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.40x41 239 TM5 Q => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.43x44 242 TM5 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.52x52 325 TM6 H => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.54x54 327 TM6 R => M N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.54x54 327 TM6 R => E N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.55x55 328 TM6 R => M N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.32x31 348 TM7 H => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.38x37 354 TM7 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 1.35x35 67 TM1 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.28x28 145 TM3 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.29x29 146 TM3 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.30x30 147 TM3 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.37x37 154 TM3 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 4.62x63 206 TM4 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.37x38 236 TM5 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.38x39 237 TM5 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.39x40 238 TM5 I => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.44x45 243 TM5 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.51x51 324 TM6 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.58x58 331 TM6 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.60x60 333 TM6 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.30x29 346 TM7 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.31x30 347 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.33x32 349 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.34x33 350 TM7 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.35x34 351 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.42x41 358 TM7 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.43x42 359 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 1.36x36 68 TM1 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.26x26 143 TM3 R => K N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.26x26 143 TM3 R => Q N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.26x26 143 TM3 R => M N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 2.50x50 113 TM2 D => A N/A N/A Martin S et al (1999)
ntr1_rat 4.64x65 208 TM4 M => A N/A N/A Barroso S et al (2000)
ntr1_rat 6.58x58 331 TM6 F => A N/A N/A Barroso S et al (2000)
ntr1_rat 339 ECL3 W => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.28x27 344 TM7 F => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.31x30 347 TM7 Y => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.31x30 347 TM7 Y => M N/A N/A Barroso S et al (2000)
ntr1_rat 7.31x30 347 TM7 Y => F N/A N/A Barroso S et al (2000)
ntr1_rat 6.54x54 327 TM6 R => M N/A N/A Barroso S et al (2000)
ntr1_rat 3.22x22 139 TM3 D => A N/A N/A Barroso S et al (2000)
ntr1_rat 1.33x33 65 TM1 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 1.35x35 67 TM1 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 1.36x36 68 TM1 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 2.50x50 113 TM2 D => A N/A N/A Martin S et al (1999)
ntr1_rat 3.22x22 139 TM3 D => A N/A N/A Barroso S et al (2000)
ntr1_rat 3.22x22 139 TM3 D => G N/A N/A Barroso S et al (2000)
ntr1_rat 3.26x26 143 TM3 R => K N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.26x26 143 TM3 R => M N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.26x26 143 TM3 R => Q N/A N/A Barroso S et al (2000)
ntr1_rat 3.26x26 143 TM3 R => Q N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.28x28 145 TM3 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.29x29 146 TM3 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.30x30 147 TM3 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.37x37 154 TM3 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.39x39 156 TM3 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 4.60x61 204 TM4 M => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 4.62x63 206 TM4 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 4.64x65 208 TM4 M => A N/A N/A Barroso S et al (2000)
ntr1_rat 4.64x65 208 TM4 M => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.36x37 235 TM5 K => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.36x37 235 TM5 K => Q N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.36x37 235 TM5 K => R N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.37x38 236 TM5 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.38x39 237 TM5 V => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.39x40 238 TM5 I => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.40x41 239 TM5 Q => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.43x44 242 TM5 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 5.44x45 243 TM5 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.51x51 324 TM6 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.52x52 325 TM6 H => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.54x54 327 TM6 R => E N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.54x54 327 TM6 R => M N/A N/A Barroso S et al (2000)
ntr1_rat 6.54x54 327 TM6 R => M N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.55x55 328 TM6 R => M N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.58x58 331 TM6 F => A N/A N/A Barroso S et al (2000)
ntr1_rat 6.58x58 331 TM6 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.58x58 331 TM6 F => Y N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 6.60x60 333 TM6 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 339 ECL3 W => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.28x27 344 TM7 F => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.30x29 346 TM7 F => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.30x29 346 TM7 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.31x30 347 TM7 Y => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.31x30 347 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.31x30 347 TM7 Y => F N/A N/A Barroso S et al (2000)
ntr1_rat 7.31x30 347 TM7 Y => M N/A N/A Barroso S et al (2000)
ntr1_rat 7.32x31 348 TM7 H => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.33x32 349 TM7 Y => A N/A N/A Barroso S et al (2000)
ntr1_rat 7.33x32 349 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.34x33 350 TM7 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.35x34 351 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.38x37 354 TM7 T => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.42x41 358 TM7 F => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 7.43x42 359 TM7 Y => A N/A N/A Labbe-Jullie C et al (1998)
ntr1_rat 3.32x32 149 TM3 R => M 1.143↑ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 3.33x33 150 TM3 D => A 4.902↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 224 ECL2 V => A 166.667↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 6.48x48 321 TM6 W => A 3.467↑ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 6.51x51 324 TM6 Y => F 2.167↑ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 6.55x55 328 TM6 R => M 18.868↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 339 ECL3 W => A 41.667↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.28x27 344 TM7 F => A 142.857↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.31x30 347 TM7 Y => F 250.0↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.32x31 348 TM7 H => A 76.923↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.33x32 349 TM7 Y => A 250.0↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.35x34 351 TM7 Y => A 500.0↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.35x34 351 TM7 Y => F 1.529↑ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.39x38 355 TM7 N => A 3.636↓ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 7.42x41 358 TM7 F => A 6.5↑ EC50 (Functional - IP accumulation) JMV431 Deluigi M et al (2021)
ntr1_rat 3.32x32 149 TM3 R => M 19.074↑ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 3.33x33 150 TM3 D => A 1.264↑ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 224 ECL2 V => A 9.346↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 6.48x48 321 TM6 W => A 14.928↑ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 6.51x51 324 TM6 Y => F 1.549↑ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 6.55x55 328 TM6 R => M 1.499↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 339 ECL3 W => A 7.299↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.28x27 344 TM7 F => A 6.41↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.31x30 347 TM7 Y => F 10.989↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.32x31 348 TM7 H => A 5.848↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.33x32 349 TM7 Y => A 21.277↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.35x34 351 TM7 Y => A 76.923↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.35x34 351 TM7 Y => F 1.103↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.39x38 355 TM7 N => A 1.664↓ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.42x41 358 TM7 F => A 43.83↑ K(i) (Binding - Other) JMV431 Deluigi M et al (2021)
ntr1_rat 7.31x30 347 TM7 Y => F 2.94↑ K(i) (Binding - Other) meclinertant Deluigi M et al (2021)
ntr1_rat 7.31x30 347 TM7 Y => F 2.922↑ K(i) (Binding - Other) SR142948A Deluigi M et al (2021)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM1
1x33 1.33x33 V65
1x34 1.34x34 L66
1x35 1.35x35 V67
1x36 1.36x36 T68
TM2
2x50 2.50x50 D113
TM3
3x22 3.22x22 D139
3x26 3.26x26 R143
3x28 3.28x28 Y145
3x29 3.29x29 Y146
3x30 3.30x30 F147
3x32 3.32x32 R149
3x33 3.33x33 D150
3x37 3.37x37 Y154
3x39 3.39x39 T156
TM4
4x61 4.60x61 M204
4x63 4.62x63 F206
4x65 4.64x65 M208
TM5
5x37 5.36x37 K235
5x38 5.37x38 V236
5x39 5.38x39 V237
5x40 5.39x40 I238
5x41 5.40x41 Q239
5x44 5.43x44 T242
5x45 5.44x45 F243
TM6
6x48 6.48x48 W321
6x51 6.51x51 Y324
6x52 6.52x52 H325
6x54 6.54x54 R327
6x55 6.55x55 R328
6x58 6.58x58 F331
6x60 6.60x60 Y333
TM7
7x27 7.28x27 F344
7x29 7.30x29 F346
7x30 7.31x30 Y347
7x31 7.32x31 H348
7x32 7.33x32 Y349
7x33 7.34x33 F350
7x34 7.35x34 Y351
7x37 7.38x37 T354
7x38 7.39x38 N355
7x41 7.42x41 F358
7x42 7.43x42 Y359