Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
oxyr_human 23.52x52 107 ECL1 G => A N/A N/A Yarwood NJ et al (1995)
oxyr_human 6.53x53 293 TM6 F => I N/A N/A Yarwood NJ et al (1995)
oxyr_human 2.50x50 85 TM2 D => N N/A N/A Yarwood NJ et al (1995)
oxyr_human 3.50x50 137 TM3 R => A N/A N/A Fanelli F et al (1999)
oxyr_human 2.50x50 85 TM2 D => A N/A N/A Fanelli F et al (1999)
oxyr_human 8 N-term N => D N/A N/A Gimpl G et al (2001)
oxyr_human 8 N-term N => D N/A N/A Kimura T et al (1997)
oxyr_human 15 N-term N => D N/A N/A Gimpl G et al (2001)
oxyr_human 26 N-term N => D N/A N/A Kimura T et al (1997)
oxyr_human 32 N-term P => A N/A N/A Wesley VJ et al (2002)
oxyr_human 33 N-term R => A N/A N/A Wesley VJ et al (2002)
oxyr_human 34 N-term R => A N/A N/A Wesley VJ et al (2002)
oxyr_human 1.28x28 35 TM1 N => A N/A N/A Wesley VJ et al (2002)
oxyr_human 1.29x29 36 TM1 E => A N/A N/A Wesley VJ et al (2002)
oxyr_human 1.50x50 57 TM1 N => A N/A N/A Fanelli F et al (1999)
oxyr_human 1.50x50 57 TM1 N => A N/A N/A Gimpl G et al (2001)
oxyr_human 2.43x43 78 TM2 M => A N/A N/A Breton C et al (2001)
oxyr_human 2.50x50 85 TM2 D => A N/A N/A Fanelli F et al (1999)
oxyr_human 2.50x50 85 TM2 D => A N/A N/A Gimpl G et al (2001)
oxyr_human 2.50x50 85 TM2 D => E N/A N/A Gimpl G et al (2001)
oxyr_human 2.50x50 85 TM2 D => N N/A N/A Gimpl G et al (2001)
oxyr_human 23.52x52 107 ECL1 G => A N/A N/A Gimpl G et al (2001)
oxyr_human 3.36x36 123 TM3 M => A N/A N/A Breton C et al (2001)
oxyr_human 3.49x49 136 TM3 D => A N/A N/A Fanelli F et al (1999)
oxyr_human 3.49x49 136 TM3 D => A N/A N/A Gimpl G et al (2001)
oxyr_human 3.49x49 136 TM3 D => N N/A N/A Favre N et al (2005)
oxyr_human 3.49x49 136 TM3 D => Q N/A N/A Fanelli F et al (1999)
oxyr_human 3.49x49 136 TM3 D => Q N/A N/A Gimpl G et al (2001)
oxyr_human 3.50x50 137 TM3 R => A N/A N/A Fanelli F et al (1999)
oxyr_human 3.50x50 137 TM3 R => A N/A N/A Gimpl G et al (2001)
oxyr_human 3.50x50 137 TM3 R => K N/A N/A Fanelli F et al (1999)
oxyr_human 5.35x36 197 TM5 P => R N/A N/A Politowska E et al (2001)
oxyr_human 5.38x39 200 TM5 Y => W N/A N/A Politowska E et al (2001)
oxyr_human 5.41x42 203 TM5 W => L N/A N/A Politowska E et al (2001)
oxyr_human 5.47x47 209 TM5 Y => A N/A N/A Gimpl G et al (2001)
oxyr_human 5.47x47 209 TM5 Y => F N/A N/A Gimpl G et al (2001)
oxyr_human 6.28x28 268 TM6 K => A N/A N/A Yang M et al (2002)
oxyr_human 6.30x30 270 TM6 K => V N/A N/A Yang M et al (2002)
oxyr_human 6.44x44 284 TM6 F => A N/A N/A Gimpl G et al (2001)
oxyr_human 6.44x44 284 TM6 F => Y N/A N/A Gimpl G et al (2001)
oxyr_human 6.53x53 293 TM6 F => I N/A N/A Gimpl G et al (2001)
oxyr_human 6.56x56 296 TM6 M => A N/A N/A Breton C et al (2001)
oxyr_human 6.56x56 296 TM6 M => T N/A N/A Politowska E et al (2001)
oxyr_human 7.39x38 315 TM7 M => A N/A N/A Breton C et al (2001)
oxyr_human 7.54x54 330 TM7 M => A N/A N/A Breton C et al (2001)
oxyr_human 8.62x62 348 H8 S => A N/A N/A Oakley RH et al (2001)
oxyr_human 360 C-term T => A N/A N/A Oakley RH et al (2001)
oxyr_human 363 C-term S => A N/A N/A Oakley RH et al (2001)
oxyr_human 370 C-term S => A N/A N/A Oakley RH et al (2001)
oxyr_human 379 C-term S => A N/A N/A Oakley RH et al (2001)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R Q K H ICL1ECL1 R F Y G ECL1ICL2 P L R S L ICL2ECL2 S L R E V A D G V F D C W A V F I Q P ECL2ICL3 A A A E A P E G A A A G D G G R V A L A R V S S V ICL3ECL3 D A N A P ECL3N-term M E G A L A A N W S A E A A N A S A A P P G A E G N R T A G P P R R N-termC-term S Y L K G R R L G E T S A S K K S N S S S F V L S H R S S S Q R S C S Q P S T A C-term N E A L A R V E V A V L C L I L L L A L S G N A C V L L A L R T T S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I T F P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q R R R T D R L A V L A T W L G C L V A S A P Q V H I F W G P K A Y I T W I T L A V Y I V P V I V L A A C Y G L I S F K I W Q N L R L K T A A A K L I S K A K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W K E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L V Q C S A L F H E R F L C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N G S L A L L L I L C L V A V E V R A 1 K H L S I A D L V V A F V Q V L P Q L L W 2 L L L L Y T S A F M G V V Q L Y K V L R 3 D R L A V L A T W L G C L V A S A P Q 4 Y C A A L V I V P V I Y V A L T I W T I Y 5 F I I V L A F I V C W T P F F F V Q M W 6 W P N C C S N L S A L L M V I I F A S 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
OT receptor
TM1
1x28 1.28x28 N35
1x29 1.29x29 E36
1x50 1.50x50 N57
TM2
2x43 2.43x43 M78
2x50 2.50x50 D85
TM3
3x36 3.36x36 M123
3x49 3.49x49 D136
3x50 3.50x50 R137
TM5
5x36 5.35x36 P197
5x39 5.38x39 Y200
5x42 5.41x42 W203
5x47 5.47x47 Y209
TM6
6x28 6.28x28 K268
6x30 6.30x30 K270
6x44 6.44x44 F284
6x53 6.53x53 F293
6x56 6.56x56 M296
TM7
7x38 7.39x38 M315
7x54 7.54x54 M330
H8
8x62 8.62x62 S348