Mutant Browser

Download
Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
pth1r_rat 2.60x60 233 TM2 R => H N/A N/A Gardella TJ et al (1996)
pth1r_rat 2.60x60 233 TM2 R => Q N/A N/A Gardella TJ et al (1996)
pth1r_rat 2.60x60 233 TM2 R => N N/A N/A Gardella TJ et al (1996)
pth1r_rat 2.60x60 233 TM2 R => K N/A N/A Gardella TJ et al (1996)
pth1r_rat 7.49x49 451 TM7 Q => K N/A N/A Gardella TJ et al (1996)
pth1r_rat 5.61x61 385 TM5 L => M N/A N/A Qian F et al (1998)
pth1r_rat 8.64x64 480 H8 A => M N/A N/A Qian F et al (1998)
pth1r_rat 537 C-term A => M N/A N/A Qian F et al (1998)
pth1r_rat 577 C-term A => M N/A N/A Qian F et al (1998)
pth1r_rat 63 N-term M => I N/A N/A Mannstadt M et al (1998)
pth1r_rat 31 N-term V => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 32 N-term F => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 33 N-term T => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 34 N-term K => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 35 N-term E => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 36 N-term E => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 37 N-term Q => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 38 N-term I => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 39 N-term F => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 4.38x39 317 TM4 E => A N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.38x39 317 TM4 E => D N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.38x39 317 TM4 E => K N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.39x40 318 TM4 K => A N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.39x40 318 TM4 K => E N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.39x40 318 TM4 K => S N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.40x41 319 TM4 K => A N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.40x41 319 TM4 K => E N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.41x42 320 TM4 Y => F N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.41x42 320 TM4 Y => A N/A N/A Iida-Klein A et al (1997)
pth1r_rat 4.41x42 320 TM4 Y => L N/A N/A Iida-Klein A et al (1997)
pth1r_rat 33 N-term T => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 37 N-term Q => A N/A N/A Mannstadt M et al (1998)
pth1r_rat 40 N-term L => M N/A N/A Mannstadt M et al (1998)
pth1r_rat 41 N-term L => M N/A N/A Mannstadt M et al (1998)
pth1r_rat 63 N-term M => I N/A N/A Mannstadt M et al (1998)
pth1r_rat 2.60x60 233 TM2 R => H N/A N/A Gardella TJ et al (1996)
pth1r_rat 2.60x60 233 TM2 R => K N/A N/A Gardella TJ et al (1996)
pth1r_rat 2.60x60 233 TM2 R => N N/A N/A Gardella TJ et al (1996)
pth1r_rat 2.60x60 233 TM2 R => Q N/A N/A Gardella TJ et al (1996)
pth1r_rat 4.40x41 319 TM4 K => R N/A N/A Iida-Klein A et al (1997)
pth1r_rat 5.61x61 385 TM5 L => M N/A N/A Qian F et al (1998)
pth1r_rat 7.49x49 451 TM7 Q => K N/A N/A Gardella TJ et al (1996)
pth1r_rat 8.64x64 480 H8 A => M N/A N/A Qian F et al (1998)
pth1r_rat 537 C-term A => M N/A N/A Qian F et al (1998)
pth1r_rat 577 C-term A => M N/A N/A Qian F et al (1998)
pth1r_rat 6.42x42 410 TM6 T => P N/A N/A Schipani E et al (1997)
pth1r_rat 2.50x50 223 TM2 H => R N/A N/A Schipani E et al (1997)
pth1r_rat 2.50x50 223 TM2 H => R 4.667↓ Single-point (Functional - cAMP accumulation) teriparatide Schipani E et al (1997) Salam W et al (2025)
pth1r_rat 6.42x42 410 TM6 T => P 4.667↓ Single-point (Functional - cAMP accumulation) teriparatide Schipani E et al (1997) Salam W et al (2025)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L H I I A Q V P P P P A A A A V ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G A A R I A P S L A L L L C C P V L S S A Y A L V D A D D V F T K E E Q I F L L H R A Q A Q C D K L L K E V L H T A A N I M E S D K G W T P A S T S G K P R K E K A S G K F Y P E S K E N K D V P T G S R R R G R P C L P E W D N I V C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E V V P G H N R T W A N Y S E C L K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R A G L S L P L S P R L P P A T T N G H S Q L P G H A K P G A P A T E T E T L P V T M A V P K D D G F L N G S C S G L D E E A S G S A R P P P L L Q E E W E T V M C-term F M T N E T R E R E V F D R L G M I Y T V G Y S M S L A S L T V A V L I L A Y F C T R N Y I H M H M F L S F M L R A A S I F V K D A V L Y S G F T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T I F G W G L P A V F V A V W V G V R A T L A G H K K W I I Q V P I L A S V V L N F I L F I N I I R V L A T K L D T R Q Q Y R K L L R S T L V L V P L F G V H Y T V F M A L G T L W Q I Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I R K W T L K R K V Q A E S W S R A L D F A R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
T L S A L S M S Y G V T Y I M G L R D F 1 M H M F L S F M L R A A S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T I G F W G L P A V F V A V W V 4 F L I F N L V V S A L I P V Q I I W K K H 5 L V L V P L F G V H Y T V F M A L 6 I A V F F G Q F S N F L M E Y H M Q I 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM2
2x43 2.50x50 H223
2x53 2.60x60 R233
TM4
4x39 4.38x39 E317
4x40 4.39x40 K318
4x41 4.40x41 K319
4x42 4.41x42 Y320
TM5
5x65 5.61x61 L385
TM6
6x37 6.42x42 T410
TM7
7x45 7.49x49 Q451
H8
8x64 8.64x64 A480