STEP 1 of 2

SELECT RECEPTORS

Select receptors in the table (below) or browse the classification tree (right). You can select entire families or individual receptors.

Once you have selected all your receptors, click the green button.

For more information on this tool, see the docs.

Species

  Receptor classification Ligands Structures G protein coupling


Class
 
Ligand type
 
Family
 
Receptor
(UniProt)
Receptor
(GtP)
Count Count PDB(s)
 
Gs
 
Gi/o
 
Gq/11
 
G12/13
 
A Aminergic 5-Hydroxytryptamine 5HT1A 5-HT1A 9643 5 7E2X,7E2Y,... - Primary - -
A Aminergic 5-Hydroxytryptamine 5HT1B 5-HT1B 1714 5 4IAQ,4IAR,... - Primary - -
A Aminergic 5-Hydroxytryptamine 5HT1D 5-HT1D 1527 1 7E32 - Primary - -
A Aminergic 5-Hydroxytryptamine 5HT1E 5-HT1E 200 1 7E33 - Primary - -
A Aminergic 5-Hydroxytryptamine 5HT1F 5-HT1F 185 1 7EXD - Primary - -
A Aminergic 5-Hydroxytryptamine 5HT2A 5-HT2A 5769 14 6A93,6A94,... - Secondary Primary -
A Aminergic 5-Hydroxytryptamine 5HT2B 5-HT2B 2404 11 4IB4,4NC3,... - - Primary -
A Aminergic 5-Hydroxytryptamine 5HT2C 5-HT2C 4418 6 6BQG,6BQH,... - Secondary Primary -
A Aminergic 5-Hydroxytryptamine 5HT4R 5-HT4 1041 3 7XT8,7XT9,... Primary - - Secondary
A Aminergic 5-Hydroxytryptamine 5HT5A 5-HT5A 484 5 7UM4,7UM5,... - Primary Secondary -
A Aminergic 5-Hydroxytryptamine 5HT6R 5-HT6 4249 3 7XTB,7YS6,... Primary - Secondary -
A Aminergic 5-Hydroxytryptamine 5HT7R 5-HT7 3190 1 7XTC Primary - - -
A Aminergic Acetylcholine (muscarinic) ACM1 M1 4439 6 5CXV,6OIJ,... - - Primary -
A Aminergic Acetylcholine (muscarinic) ACM2 M2 3001 14 3UON,4MQS,... Secondary Primary Secondary -
A Aminergic Dopamine DRD2 D2 12263 6 6CM4,6LUQ,... - Primary - -
A Aminergic Acetylcholine (muscarinic) ACM3 M3 2636 9 4DAJ,4U14,... - - Primary -
A Aminergic Acetylcholine (muscarinic) ACM4 M4 1632 11 5DSG,6KP6,... - Primary - -
A Aminergic Acetylcholine (muscarinic) ACM5 M5 1173 1 6OL9 - - Primary -
A Aminergic Adrenoceptors ADA1A α1A-adrenoceptor 2930 6 7YM8,7YMH,... - - Primary Secondary
A Aminergic Adrenoceptors ADA1B α1B-adrenoceptor 1813 1 7B6W - - Primary -
A Aminergic Adrenoceptors ADA1D α1D-adrenoceptor 1901 0 - - - Primary -
A Aminergic Adrenoceptors ADA2A α2A-adrenoceptor 1458 8 6KUX,6KUY,... Secondary Primary - -
A Aminergic Adrenoceptors ADA2B α2B-adrenoceptor 858 2 6K41,6K42 Secondary Primary - -
A Aminergic Adrenoceptors ADA2C α2C-adrenoceptor 1011 1 6KUW Secondary Primary - -
A Aminergic Adrenoceptors ADRB1 β1-adrenoceptor 2115 34 2VT4,2Y00,... Primary Secondary - -
A Aminergic Adrenoceptors ADRB2 β2-adrenoceptor 2661 42 2R4R,2R4S,... Primary Secondary - -
A Aminergic Adrenoceptors ADRB3 β3-adrenoceptor 1614 3 7DH5,7XJH,... Primary Secondary - -
A Aminergic Dopamine DRD1 D1 2962 20 7CKW,7CKX,... Primary - - -
A Aminergic Dopamine DRD3 D3 6218 4 3PBL,7CMU,... - Primary - -
A Aminergic Dopamine DRD4 D4 3108 4 5WIU,5WIV,... - Primary - -
A Aminergic Dopamine DRD5 D5 491 1 8IRV Primary - - -
A Aminergic Histamine HRH1 H1 2564 2 3RZE,7DFL - - Primary -
A Aminergic Histamine HRH2 H2 811 1 7UL3 Secondary - Primary -
A Aminergic Histamine HRH3 H3 5627 1 7F61 - Primary - -
A Aminergic Histamine HRH4 H4 1479 4 7YFC,7YFD,... - Primary - -
A Aminergic Trace amine TAAR1 TA1 2038 22 8JLJ,8JLK,... Primary - Secondary -
A Peptide Angiotensin AGTR1 AT1 2935 7 4YAY,4ZUD,... - Primary Primary -
A Peptide Angiotensin AGTR2 AT2 942 7 5UNF,5UNG,... - Primary - -
A Peptide Apelin APJ apelin 573 8 5VBL,6KNM,... - Primary - -
A Peptide Bombesin NMBR BB1 191 1 8H0P - - Primary -
A Peptide Bombesin GRPR BB2 309 4 7W3Z,7W40,... - - Primary -
A Peptide Bombesin BRS3 BB3 325 0 - - - Primary -
A Peptide Bradykinin BKRB1 B1 875 1 7EIB - Primary Primary -
A Peptide Bradykinin BKRB2 B2 695 3 7F2O,7F6H,... Primary Primary Primary -
A Peptide Cholecystokinin CCKAR CCK1 2204 10 7EZH,7EZK,... Secondary - Primary -
A Peptide Cholecystokinin GASR CCK2 2304 5 7F8V,7F8W,... - - Primary -
A Peptide Complement peptide C3AR C3a 218 9 8HK2,8HK3,... - - - -
A Peptide Complement peptide C5AR1 C5a1 474 12 5O9H,6C1Q,... - Primary Secondary -
A Peptide Complement peptide C5AR2 C5a2 11 0 - - - - -
A Peptide Endothelin EDNRA ETA 2527 1 8HCQ - - Primary -
A Peptide Endothelin EDNRB ETB 1700 12 5GLH,5GLI,... Primary Primary Primary -
A Peptide Formylpeptide FPR1 FPR1 482 4 7EUO,7T6T,... - Primary - -
A Peptide Formylpeptide FPR2 FPR2/ALX 819 9 6LW5,6OMM,... - Primary Secondary -
A Peptide Formylpeptide FPR3 FPR3 7 0 - - Primary - -
A Peptide Galanin GALR1 GAL1 169 2 7WQ3,7XJJ - Primary - -
A Peptide Galanin GALR2 GAL2 169 4 7WQ4,7XBD,... - Secondary Primary Secondary
A Peptide Galanin GALR3 GAL3 232 0 - - Primary - -
A Peptide Ghrelin GHSR ghrelin 2021 7 6KO5,7F83,... - Secondary Primary Secondary
A Peptide Gonadotrophin-releasing hormone GNRHR GnRH1 2017 1 7BR3 - Secondary Primary -
A Peptide Kisspeptin KISSR kisspeptin 310 0 - - - Primary -
A Peptide Melanin-concentrating hormone MCHR1 MCH1 3639 0 - Primary Primary Primary -
A Peptide Melanin-concentrating hormone MCHR2 MCH2 53 0 - - - Primary -
A Peptide Melanocortin MSHR MC1 1615 4 7F4D,7F4F,... Primary - - -
A Peptide Melanocortin ACTHR MC2 8 1 8GY7 Primary - - -
A Peptide Melanocortin MC3R MC3 1468 1 8IOC Primary - - -
A Peptide Melanocortin MC4R MC4 3566 8 6W25,7AUE,... Primary - - -
A Peptide Melanocortin MC5R MC5 1266 2 8INR,8IOD Primary - - -
A Peptide Motilin MTLR motilin 468 2 8IBU,8IBV - - Primary Primary
A Peptide Neuromedin U NMUR1 NMU1 125 2 7W53,7W56 - - Primary -
A Peptide Neuromedin U NMUR2 NMU2 139 3 7W55,7W57,... - - Primary -
A Peptide Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 148 0 - - Primary - -
A Peptide Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 186 0 - - Primary - -
A Peptide Neuropeptide S NPSR1 NPS 15105 0 - Secondary - Primary -
A Peptide Neuropeptide W/neuropeptide B NPBW1 NPBW1 341 0 - - Primary - -
A Peptide Neuropeptide W/neuropeptide B NPBW2 NPBW2 4 0 - - Primary - -
A Peptide Neuropeptide Y NPY1R Y1 1018 4 5ZBH,5ZBQ,... - Primary - -
A Olfactory Olfactory OR1A1 Olfactory 1A1 0 0 - - - - -
A Peptide Neuropeptide Y NPY2R Y2 830 4 7DDZ,7X9B,... - Primary Secondary -
A Peptide Neuropeptide Y NPY4R Y4 222 1 7X9C - Primary Secondary -
A Peptide Neuropeptide Y NPY5R Y5 1396 0 - - Primary - -
A Peptide Neuropeptide Y NPY6R y6 0 0 - - - - -
A Peptide Neurotensin NTR1 NTS1 625 31 3ZEV,4BUO,... Secondary Secondary Primary -
A Peptide Neurotensin NTR2 NTS2 184 0 - - - Primary -
A Peptide Opioid OPRD δ 5839 7 4EJ4,4N6H,... - Primary - -
A Peptide Opioid OPRK κ 8050 11 4DJH,6B73,... - Primary - Secondary
A Peptide Opioid OPRM μ 9554 21 4DKL,5C1M,... - Primary Secondary -
A Peptide Opioid OPRX NOP 1765 4 4EA3,5DHG,... - Primary - -
A Peptide Orexin OX1R OX1 3561 14 4ZJ8,4ZJC,... Primary Primary Primary -
A Peptide Orexin OX2R OX2 3468 11 4S0V,5WQC,... Primary Primary Primary -
A Peptide Peptide P518 QRFPR QRFP 114 0 - - Primary Primary -
A Peptide Prolactin-releasing peptide PRLHR PrRP 239 0 - - - - -
A Peptide Proteinase-activated PAR1 PAR1 906 1 3VW7 - - - -
A Peptide Proteinase-activated PAR2 PAR2 166 3 5NDD,5NDZ,... - - - -
A Peptide Proteinase-activated PAR3 PAR3 0 0 - - - - -
A Peptide Proteinase-activated PAR4 PAR4 982 0 - - - - -
A Peptide Relaxin family peptide RXFP1 RXFP1 5112 1 7TMW Primary Primary - -
A Peptide Relaxin family peptide RXFP2 RXFP2 24 0 - Primary Primary - -
A Peptide Relaxin family peptide RL3R1 RXFP3 114 0 - - Primary - -
A Peptide Relaxin family peptide RL3R2 RXFP4 69 3 7YJ4,7YK6,... - Primary - -
A Peptide Somatostatin SSR1 SST1 656 0 - - Primary - -
A Peptide Somatostatin SSR2 SST2 1068 17 7T10,7T11,... - Primary - -
A Peptide Somatostatin SSR3 SST3 853 0 - - Primary - -
A Peptide Somatostatin SSR4 SST4 641 2 7XMS,7XMT - Primary - -
A Peptide Somatostatin SSR5 SST5 912 0 - - Primary - -
A Peptide Tachykinin NK1R NK1 2997 12 6E59,6HLL,... Primary - Primary -
A Peptide Tachykinin NK2R NK2 1213 1 7XWO Primary - Primary -
A Peptide Tachykinin NK3R NK3 1030 0 - - - Primary -
A Olfactory Olfactory OR1G1 Olfactory 1G1 0 0 - - - - -
A Peptide Thyrotropin-releasing hormone TRFR TRH1 54 4 7WKD,7X1T,... - - Primary -
A Peptide Urotensin UR2R UT 714 0 - - - Primary -
A Peptide Vasopressin and oxytocin V1AR V1A 1443 0 - - - Primary -
A Peptide Vasopressin and oxytocin V1BR V1B 539 0 - - - Primary -
A Peptide Vasopressin and oxytocin V2R V2 1303 5 7BB6,7BB7,... Primary - - -
A Peptide Vasopressin and oxytocin OXYR OT 1373 3 6TPK,7QVM,... - Secondary Primary -
A Protein Chemerin receptor CML1 chemerin 91 2 7YKD,8SG1 - Primary - -
A Protein Chemerin receptor CML2 chemerin 2 7 0 - - - - -
A Protein Chemokine CCR1 CCR1 808 3 7VL8,7VL9,... - Primary - -
A Protein Chemokine CCR2 CCR2 1845 4 5T1A,6GPS,... - Primary - -
A Protein Chemokine CCR3 CCR3 1157 1 7X9Y - Primary - -
A Protein Chemokine CCR4 CCR4 503 0 - - Primary - -
A Protein Chemokine CCR5 CCR5 2194 11 4MBS,5UIW,... - Primary - -
A Protein Chemokine CCR6 CCR6 257 1 6WWZ - Primary - -
A Protein Chemokine CCR7 CCR7 9 1 6QZH - Primary - -
A Protein Chemokine CCR8 CCR8 191 2 8TLM,8U1U - Primary - -
A Protein Chemokine CCR9 CCR9 170 1 5LWE - Primary - -
A Protein Chemokine CCR10 CCR10 42 0 - - Primary - -
A Protein Chemokine CXCR1 CXCR1 319 1 8IC0 - Primary Secondary -
A Protein Chemokine CXCR2 CXCR2 1023 3 6LFL,6LFM,... - Primary - -
A Protein Chemokine CXCR3 CXCR3 1617 6 8HNK,8HNL,... - Primary - -
A Protein Chemokine CXCR4 CXCR4 976 6 3ODU,3OE0,... - Primary - -
A Protein Chemokine CXCR5 CXCR5 78 0 - - Primary - -
A Protein Chemokine CXCR6 CXCR6 51 0 - - Primary - -
A Protein Chemokine CX3C1 CX3CR1 66 2 7XBW,7XBX - Primary - -
A Protein Chemokine XCR1 XCR1 2 0 - - Primary - -
A Protein Chemokine ACKR1 ACKR1 0 0 - - - - -
A Protein Chemokine ACKR2 ACKR2 0 0 - - - - -
A Protein Chemokine ACKR3 ACKR3 809 7 7SK3,7SK4,... - - - -
A Protein Chemokine ACKR4 ACKR4 3 0 - - - - -
A Protein Chemokine CCRL2 CCRL2 155 0 - - - - -
A Protein Glycoprotein hormone FSHR FSH 96 2 8I2G,8I2H Primary Primary Primary -
A Protein Glycoprotein hormone LSHR LH 113 4 7FIG,7FIH,... Primary - Secondary -
A Protein Glycoprotein hormone TSHR TSH 16293 7 7T9I,7T9M,... Primary - Secondary -
A Protein Prokineticin PKR1 PKR1 167 0 - Secondary - Primary -
A Protein Prokineticin PKR2 PKR2 9 0 - Secondary Secondary Primary -
A Lipid Free fatty acid FFAR1 FFA1 1726 7 4PHU,5KW2,... Secondary Secondary Primary -
A Lipid Free fatty acid FFAR2 FFA2 196 0 - - Secondary Primary -
A Lipid Free fatty acid FFAR3 FFA3 73 0 - - Primary - -
A Lipid Free fatty acid FFAR4 FFA4 453 10 8G59,8H4I,... - - Primary -
A Lipid Free fatty acid GPR42 GPR42 0 0 - - - - -
A Lipid Leukotriene LT4R1 BLT1 364 3 5X33,7K15,... - Primary Primary -
A Lipid Leukotriene LT4R2 BLT2 84 0 - - Primary Secondary -
A Lipid Leukotriene CLTR1 CysLT1 669 2 6RZ4,6RZ5 - Secondary Primary -
A Lipid Leukotriene CLTR2 CysLT2 98 4 6RZ6,6RZ7,... - Secondary Primary -
A Lipid Leukotriene OXER1 OXE 80 0 - - Primary - -
A Lipid Lysophospholipid (LPA) LPAR1 LPA1 304 12 4Z34,4Z35,... - Primary Primary Primary
A Lipid Lysophospholipid (LPA) LPAR2 LPA2 127 0 - - Primary Primary Primary
A Lipid Lysophospholipid (LPA) LPAR3 LPA3 157 0 - - Primary Primary -
A Lipid Lysophospholipid (LPA) LPAR4 LPA4 20 0 - Primary Primary Primary Primary
A Lipid Lysophospholipid (LPA) LPAR5 LPA5 115 0 - - - Primary Primary
A Lipid Lysophospholipid (LPA) LPAR6 LPA6 12 1 5XSZ Primary Primary - Primary
A Lipid Lysophospholipid (S1P) S1PR1 S1P1 2631 16 3V2W,3V2Y,... - Primary - -
A Lipid Lysophospholipid (S1P) S1PR2 S1P2 408 1 7T6B Primary - Primary Primary
A Lipid Lysophospholipid (S1P) S1PR3 S1P3 1111 4 7C4S,7EW2,... - Primary Primary Primary
A Lipid Lysophospholipid (S1P) S1PR4 S1P4 499 0 - - Primary - Primary
A Lipid Lysophospholipid (S1P) S1PR5 S1P5 425 2 7EW1,7YXA - Primary - Primary
A Lipid Cannabinoid CNR1 CB1 6940 11 5TGZ,5U09,... Secondary Primary - -
A Lipid Cannabinoid CNR2 CB2 7098 8 5ZTY,6KPC,... Secondary Primary - -
A Lipid GPR18, GPR55 and GPR119 GPR18 GPR18 50 0 - - Primary Primary -
A Lipid GPR18, GPR55 and GPR119 GPR55 GPR55 650 0 - - - Primary Primary
A Lipid GPR18, GPR55 and GPR119 GP119 GPR119 1619 4 7WCM,7WCN,... Primary - - -
A Lipid Platelet-activating factor PTAFR PAF 1401 2 5ZKP,5ZKQ - Primary Primary -
A Lipid Prostanoid PD2R DP1 714 0 - Primary - - -
A Lipid Prostanoid PD2R2 DP2 2852 3 6D26,6D27,... - Primary - -
A Lipid Prostanoid PE2R1 EP1 1050 0 - - Secondary Primary -
A Lipid Prostanoid PE2R2 EP2 774 3 7CX2,7CX3,... Primary - - -
A Lipid Prostanoid PE2R3 EP3 1136 4 6AK3,6M9T,... - Primary Secondary -
A Lipid Prostanoid PE2R4 EP4 1050 8 5YHL,5YWY,... Primary Secondary - -
A Lipid Prostanoid PF2R FP 231 3 8IUK,8IUL,... Secondary - Primary -
A Lipid Prostanoid PI2R IP 427 0 - Primary Secondary Secondary -
A Lipid Prostanoid TA2R TP 1333 2 6IIU,6IIV - - Primary -
A Melatonin Melatonin MTR1A MT1 1058 8 6ME2,6ME3,... - Primary Secondary -
A Melatonin Melatonin MTR1B MT2 956 5 6ME6,6ME7,... - Primary - -
A Nucleotide Adenosine AA1R A1 8020 5 5N2S,5UEN,... Secondary Primary Secondary -
A Nucleotide Adenosine AA2AR A2A 6788 76 2YDO,2YDV,... Primary - Secondary -
A Nucleotide Adenosine AA2BR A2B 2547 4 7XY6,7XY7,... Primary - Secondary -
A Nucleotide Adenosine AA3R A3 5010 0 - - Primary - -
A Nucleotide P2Y P2RY1 P2Y1 728 3 4XNV,4XNW,... - Secondary Primary -
A Nucleotide P2Y P2RY2 P2Y2 323 0 - - Secondary Primary Secondary
A Nucleotide P2Y P2RY4 P2Y4 180 0 - - - Primary -
A Nucleotide P2Y P2RY6 P2Y6 262 0 - - - Primary Secondary
A Nucleotide P2Y P2Y11 P2Y11 44 0 - Secondary - Primary -
A Nucleotide P2Y P2Y12 P2Y12 1196 5 4NTJ,4PXZ,... - - - -
A Nucleotide P2Y P2Y13 P2Y13 17 0 - - Primary - -
A Nucleotide P2Y P2Y14 P2Y14 349 0 - - Primary - -
A Steroid Bile acid GPBAR GPBA 754 4 7BW0,7CFM,... Primary - - -
A Steroid Estrogen (G protein-coupled) GPER1 GPER 13 0 - Secondary Primary - -
A Alicarboxylic acid Hydroxycarboxylic acid HCAR1 HCA1 188 0 - - Primary - -
A Alicarboxylic acid Hydroxycarboxylic acid HCAR2 HCA2 620 23 7XK2,7ZL9,... - Primary - -
A Alicarboxylic acid Hydroxycarboxylic acid HCAR3 HCA3 121 2 8IHJ,8IHK - Primary - -
A Alicarboxylic acid Oxoglutarate OXGR1 oxoglutarate 44 0 - - - Primary -
A Alicarboxylic acid Succinate SUCR1 succinate 73 3 6IBB,6RNK,... - Primary Secondary -
A Sensory Opsins OPSD Rhodopsin 1 70 1F88,1GZM,... - - - -
A Sensory Opsins OPN3 OPN3 0 0 - - - - -
A Sensory Opsins OPN4 OPN4 0 0 - - Primary Primary -
A Sensory Opsins OPN5 OPN5 0 0 - - Primary - -
A Sensory Opsins OPSB OPN1SW 0 0 - - - - -
A Sensory Opsins OPSG OPN1MW 0 0 - - - - -
A Sensory Opsins OPSR OPN1LW 0 0 - - - - -
A Olfactory Olfactory O2T11 Olfactory 2T11 0 0 - - - - -
A Olfactory Olfactory O51A2 Olfactory 51A2 0 0 - - - - -
A Olfactory Olfactory O51A4 Olfactory 51A4 0 0 - - - - -
A Olfactory Olfactory O51A7 Olfactory 51A7 0 0 - - - - -
A Olfactory Olfactory O51B2 Olfactory 51B2 0 0 - - - - -
A Olfactory Olfactory O51B4 Olfactory 51B4 0 0 - - - - -
A Olfactory Olfactory O51B5 Olfactory 51B5 0 0 - - - - -
A Olfactory Olfactory O51B6 Olfactory 51B6 0 0 - - - - -
A Olfactory Olfactory O51D1 Olfactory 51D1 0 0 - - - - -
A Olfactory Olfactory O51E1 Olfactory 51E1 0 0 - - - - -
A Olfactory Olfactory O51E2 Olfactory 51E2 24 1 8F76 - - - -
A Olfactory Olfactory O51F1 Olfactory 51F1 0 0 - - - - -
A Olfactory Olfactory O51F2 Olfactory 51F2 0 0 - - - - -
A Olfactory Olfactory O51G1 Olfactory 51G1 0 0 - - - - -
A Olfactory Olfactory O51G2 Olfactory 51G2 0 0 - - - - -
A Olfactory Olfactory O51I1 Olfactory 51I1 0 0 - - - - -
A Olfactory Olfactory O51I2 Olfactory 51I2 0 0 - - - - -
A Olfactory Olfactory O51J1 Olfactory 51J1 0 0 - - - - -
A Olfactory Olfactory O51L1 Olfactory 51L1 0 0 - - - - -
A Olfactory Olfactory O51M1 Olfactory 51M1 0 0 - - - - -
A Olfactory Olfactory O51Q1 Olfactory 51Q1 0 0 - - - - -
A Olfactory Olfactory O51S1 Olfactory 51S1 0 0 - - - - -
A Olfactory Olfactory O51T1 Olfactory 51T1 0 0 - - - - -
A Olfactory Olfactory O51V1 Olfactory 51V1 0 0 - - - - -
A Olfactory Olfactory O52E4 Olfactory 52E4 0 3 8HTI,8J46,... - - - -
A Orphan A orphans GPR3 GPR3 2 0 - Primary - - -
A Orphan A orphans GPR4 GPR4 72 0 - Primary Primary Primary Primary
A Orphan A orphans GPR6 GPR6 776 0 - Primary Primary - -
A Orphan A orphans GPR12 GPR12 2 1 7Y3G Primary Primary - -
A Orphan A orphans GPR15 GPR15 3 0 - - - - -
A Orphan A orphans GPR17 GPR17 82 1 7Y89 - Primary Secondary -
A Orphan A orphans GPR19 GPR19 1 0 - - - - -
A Orphan A orphans GPR20 GPR20 0 3 8HS2,8HS3,... - Primary - -
A Orphan A orphans GPR21 GPR21 0 5 8HIX,8HJ0,... - - - -
A Orphan A orphans GPR22 GPR22 0 0 - - Primary - -
A Orphan A orphans GPR25 GPR25 0 0 - - - - -
A Orphan A orphans GPR26 GPR26 0 0 - Primary - - -
A Orphan A orphans GPR27 GPR27 21 0 - - - Primary -
A Orphan A orphans GPR31 GPR31 1 0 - - Primary - -
A Orphan A orphans GPR32 GPR32 3 0 - - - - -
A Orphan A orphans GPR33 GPR33 0 0 - - Primary - -
A Orphan A orphans GPR34 GPR34 86 5 8K4N,8SAI,... - Primary - -
A Orphan A orphans GPR35 GPR35 369 1 8H8J - - - -
A Orphan A orphans GPR37 GPR37 2 0 - - Primary - -
A Orphan A orphans G37L1 GPR37L1 1 0 - - Primary - -
A Orphan A orphans GPR39 GPR39 83 0 - Secondary - Primary Secondary
A Orphan A orphans GPR45 GPR45 0 0 - - - - -
A Orphan A orphans MTR1L GPR50 0 0 - - - - -
A Orphan A orphans GPR52 GPR52 333 5 6LI0,6LI1,... - - - -
A Orphan A orphans GPR61 GPR61 1 3 8KGK,8TB0,... - - - -
A Orphan A orphans GPR62 GPR62 0 0 - - - - -
A Orphan A orphans GPR63 GPR63 3 0 - - - - -
A Orphan A orphans PSYR GPR65 0 0 - Primary - - -
A Orphan A orphans OGR1 GPR68 6 0 - - Primary Primary -
A Orphan A orphans GPR75 GPR75 1 0 - - - Primary -
A Orphan A orphans GPR78 GPR78 0 0 - Primary - - -
A Orphan A orphans GPR82 GPR82 0 0 - - - - -
A Orphan A orphans GPR83 GPR83 3 0 - - - - -
A Orphan A orphans GPR84 GPR84 594 4 8G05,8J18,... - Primary - -
A Orphan A orphans GPR85 GPR85 0 0 - - - - -
A Orphan A orphans GPR87 GPR87 3 0 - - - - -
A Orphan A orphans GPR88 GPR88 315 2 7EJX,7WZ4 - - - -
A Orphan A orphans GP101 GPR101 0 3 8W8Q,8W8R,... Primary - - -
A Orphan A orphans GP132 GPR132 4 4 8HQE,8HQM,... - - - -
A Orphan A orphans GP135 GPR135 0 0 - - - - -
A Orphan A orphans GP139 GPR139 282 4 7VUG,7VUH,... - - Primary -
A Orphan A orphans GP141 GPR141 0 0 - - - - -
A Orphan A orphans GP142 GPR142 193 0 - - - - -
A Orphan A orphans GP146 GPR146 0 0 - - - - -
A Orphan A orphans GP148 GPR148 0 0 - - - - -
A Orphan A orphans GP149 GPR149 0 0 - - - - -
A Orphan A orphans GP150 GPR150 0 0 - - - - -
A Orphan A orphans GP151 GPR151 0 0 - - - - -
A Orphan A orphans GP152 GPR152 0 0 - - - - -
A Orphan A orphans GP153 GPR153 0 0 - - - - -
A Orphan A orphans GP160 GPR160 0 0 - - - - -
A Orphan A orphans GP161 GPR161 1 1 8KH4 - - - -
A Orphan A orphans GP162 GPR162 0 0 - - - - -
A Orphan A orphans GP171 GPR171 0 0 - - - - -
A Orphan A orphans GP173 GPR173 0 0 - - - - -
A Orphan A orphans GP174 GPR174 106 3 7XV3,8IZB,... - - - -
A Orphan A orphans GP176 GPR176 0 0 - - - - -
A Orphan A orphans GP182 GPR182 1 0 - - - - -
A Orphan A orphans GP183 GPR183 105 2 7TUY,7TUZ - Primary - -
A Orphan A orphans LGR4 LGR4 4 0 - - - - -
A Orphan A orphans LGR5 LGR5 4 0 - - - - -
A Orphan A orphans LGR6 LGR6 8 0 - - - - -
A Orphan A orphans MAS MAS1 13 0 - - Primary Primary -
A Orphan A orphans MAS1L MAS1L 0 0 - - - - -
A Orphan A orphans MRGRD MRGPRD 1 4 7Y12,7Y13,... - Primary Primary -
A Orphan A orphans MRGRE MRGPRE 0 0 - - - - -
A Orphan A orphans MRGRF MRGPRF 0 0 - - - - -
A Orphan A orphans MRGRG MRGPRG 0 0 - - - - -
A Orphan A orphans MRGX1 MRGPRX1 158 4 8DWC,8DWG,... - - Primary -
A Orphan A orphans MRGX2 MRGPRX2 21 14 7S8L,7S8M,... - Primary Primary -
A Orphan A orphans MRGX3 MRGPRX3 0 0 - - - Primary -
A Orphan A orphans MRGX4 MRGPRX4 203 1 7S8P - - Primary -
A Orphan A orphans P2RY8 P2RY8 0 0 - - - - -
A Orphan A orphans P2Y10 P2RY10 79 0 - - - - -
A Orphan A orphans TAAR2 TAAR2 0 0 - - - - -
A Orphan A orphans TAAR3 TAAR3 1 0 - - - - -
A Orphan A orphans TAAR5 TAAR5 5 0 - - - - -
A Orphan A orphans TAAR6 TAAR6 0 0 - - - - -
A Orphan A orphans TAA7F TAAR7F 0 1 8PM2 - - - -
A Orphan A orphans TAAR8 TAAR8 0 0 - - - - -
A Orphan A orphans TAAR9 TAAR9 0 7 8ITF,8IW1,... - - - -
B1 Peptide Calcitonin CALCR CT 167 16 5UZ7,6NIY,... Primary - Secondary -
B1 Peptide Calcitonin CALRL calcitonin -like 742 6 6E3Y,6UUN,... - - - -
B1 Peptide Corticotropin-releasing factor CRFR1 CRF1 2487 7 4K5Y,4Z9G,... Primary - Secondary -
B1 Peptide Corticotropin-releasing factor CRFR2 CRF2 170 3 6PB1,7TRY,... Primary - Secondary -
B1 Peptide Glucagon GHRHR GHRH 78 3 7CZ5,7V9L,... Primary - - -
B1 Peptide Glucagon GIPR GIP 178 8 7DTY,7FIN,... Primary - - -
B1 Peptide Glucagon GLP1R GLP-1 982 41 5NX2,5VAI,... Primary - - -
B1 Peptide Glucagon GLP2R GLP-2 114 1 7D68 Primary - - -
B1 Peptide Glucagon GLR glucagon 1315 16 4L6R,5EE7,... Primary - - -
B1 Peptide Glucagon SCTR secretin 8 3 6WI9,6WZG,... Primary - - -
B1 Peptide Parathyroid hormone PTH1R PTH1 185 22 6FJ3,6NBF,... Primary - Secondary -
B1 Peptide Parathyroid hormone PTH2R PTH2 25 1 7F16 - - - -
B1 Peptide VIP and PACAP PACR PAC1 120 5 6LPB,6M1H,... Primary - Primary -
B1 Peptide VIP and PACAP VIPR1 VPAC1 96 3 6VN7,8E3Y,... Primary Secondary Secondary -
B1 Peptide VIP and PACAP VIPR2 VPAC2 98 2 7VQX,7WBJ Primary - - -
B2 Adhesion ADGRL AGRL1 ADGRL1 3 0 - - - Primary -
B2 Adhesion ADGRL AGRL2 ADGRL2 1 0 - - - - -
B2 Adhesion ADGRL AGRL3 ADGRL3 1 6 7SF7,7WY5,... - - - -
B2 Adhesion ADGRL AGRL4 ADGRL4 0 0 - - - - -
B2 Adhesion ADGRE AGRE1 ADGRE1 0 0 - - - - -
B2 Adhesion ADGRE AGRE2 ADGRE2 0 0 - - - Primary -
B2 Adhesion ADGRE AGRE3 ADGRE3 0 0 - - - - -
B2 Adhesion ADGRE AGRE4 ADGRE4P 0 0 - - - - -
B2 Adhesion ADGRE AGRE5 ADGRE5 0 4 7YDH,7YDJ,... - - - Primary
B2 Adhesion ADGRA AGRA1 ADGRA1 0 0 - - - - -
C Amino acid Metabotropic glutamate GRM7 mGlu7 234 1 7EPC - Primary - -
B2 Adhesion ADGRA AGRA2 ADGRA2 0 0 - - - - -
B2 Adhesion ADGRA AGRA3 ADGRA3 0 0 - - - - -
B2 Adhesion ADGRC CELR1 CELSR1 0 0 - - - - -
B2 Adhesion ADGRC CELR2 CELSR2 0 0 - - - - -
B2 Adhesion ADGRC CELR3 CELSR3 0 0 - - - - -
B2 Adhesion ADGRD AGRD1 ADGRD1 0 2 7EPT,7WU2 Primary - - -
B2 Adhesion ADGRD AGRD2 ADGRD2 0 0 - - - - -
B2 Adhesion ADGRF AGRF1 ADGRF1 0 9 7WU3,7WU4,... - - - -
B2 Adhesion ADGRF AGRF2 ADGRF2 0 0 - - - - -
C Amino acid GABAB GABR1 GABAB1 70 1 6W2Y - - - -
B2 Adhesion ADGRF AGRF3 ADGRF3 0 0 - - - - -
B2 Adhesion ADGRF AGRF4 ADGRF4 0 0 - - - - -
B2 Adhesion ADGRF AGRF5 ADGRF5 0 0 - - - - -
B2 Adhesion ADGRB AGRB1 ADGRB1 1 0 - - - - -
B2 Adhesion ADGRB AGRB2 ADGRB2 0 0 - - - - -
C Ion Calcium-sensing CASR CaS 596 18 7DD5,7DD6,... - Primary Primary Primary
B2 Adhesion ADGRB AGRB3 ADGRB3 0 0 - - - - -
B2 Adhesion ADGRG AGRG1 ADGRG1 0 1 7SF8 - - Primary Primary
B2 Adhesion ADGRG AGRG2 ADGRG2 0 6 7WUI,7WUQ,... - - Secondary -
B2 Adhesion ADGRG AGRG3 ADGRG3 1 2 7D76,7D77 - Primary - -
B2 Adhesion ADGRG AGRG4 ADGRG4 0 1 7WUJ - - - -
B2 Adhesion ADGRG AGRG5 ADGRG5 0 1 7EQ1 - - - -
B2 Adhesion ADGRG AGRG6 ADGRG6 0 0 - - - - -
B2 Adhesion ADGRG AGRG7 ADGRG7 0 0 - - - - -
B2 Adhesion ADGRV AGRV1 ADGRV1 0 0 - - - - -
F Protein Frizzled FZD10 FZD10 0 0 - - - - Secondary
C Amino acid GABAB GABR2 GABAB2 2 12 6UO8,6UO9,... - - - -
C Amino acid Metabotropic glutamate GRM1 mGlu1 1066 3 4OR2,7DGD,... Secondary Secondary Primary -
C Amino acid Metabotropic glutamate GRM2 mGlu2 1982 21 7E9G,7EPA,... - Primary - -
C Amino acid Metabotropic glutamate GRM3 mGlu3 395 3 7WI6,7WI8,... - Primary - -
C Amino acid Metabotropic glutamate GRM4 mGlu4 908 2 7E9H,8JD6 - Primary - -
C Amino acid Metabotropic glutamate GRM5 mGlu5 3883 14 4OO9,5CGC,... Secondary Secondary Primary -
C Amino acid Metabotropic glutamate GRM6 mGlu6 144 0 - - Primary - -
T Sensory Taste 2 T2R40 TAS2R40 5 0 - - - - -
C Amino acid Metabotropic glutamate GRM8 mGlu8 185 0 - - Primary - -
C Sensory Taste 1 TS1R1 TAS1R1 0 0 - - - - -
C Sensory Taste 1 TS1R2 TAS1R2 0 0 - - - - -
C Sensory Taste 1 TS1R3 TAS1R3 0 0 - - - - -
C Orphan C Orphans GP156 GPR156 0 0 - - - - -
C Orphan C Orphans GP158 GPR158 0 5 7EWL,7EWP,... - - - -
C Orphan C Orphans GP179 GPR179 0 0 - - - - -
C Orphan C Orphans RAI3 GPRC5A 0 0 - - - - -
C Orphan C Orphans GPC5B GPRC5B 0 0 - - - - -
C Orphan C Orphans GPC5C GPRC5C 0 0 - - - - -
C Orphan C Orphans GPC5D GPRC5D 1 0 - - - - -
C Orphan C Orphans GPC6A GPRC6 19 0 - - - Primary -
D1 Ste2-like STE2 STE2 STE2 0 1 7AD3 - - - -
F Protein Frizzled FZD1 FZD1 8 0 - - Secondary Secondary -
F Protein Frizzled FZD2 FZD2 5 0 - - Primary - -
F Protein Frizzled FZD3 FZD3 0 0 - Primary - - -
F Protein Frizzled FZD4 FZD4 3 1 6BD4 - - - Primary
F Protein Frizzled FZD5 FZD5 1 1 6WW2 - - - -
F Protein Frizzled FZD6 FZD6 4 0 - - Primary Primary -
F Protein Frizzled FZD7 FZD7 39 1 7EVW Primary Primary - -
F Protein Frizzled FZD8 FZD8 2 0 - - - - -
F Protein Frizzled FZD9 FZD9 0 0 - - Primary - -
F Protein Frizzled SMO SMO 970 19 4JKV,4N4W,... - Primary - Primary
T Sensory Taste 2 TA2R1 TAS2R1 5 0 - - - - -
T Sensory Taste 2 TA2R3 TAS2R3 2 0 - - - - -
T Sensory Taste 2 TA2R4 TAS2R4 6 0 - - - - -
T Sensory Taste 2 TA2R5 TAS2R5 4 0 - - - - -
T Sensory Taste 2 TA2R7 TAS2R7 4 0 - - - - -
T Sensory Taste 2 TA2R8 TAS2R8 325 0 - - - - -
T Sensory Taste 2 TA2R9 TAS2R9 4 0 - - - - -
T Sensory Taste 2 T2R10 TAS2R10 9 0 - - - - -
T Sensory Taste 2 T2R13 TAS2R13 3 0 - - - - -
T Sensory Taste 2 T2R14 TAS2R14 174 0 - - - - -
T Sensory Taste 2 T2R16 TAS2R16 8 0 - - - - -
T Sensory Taste 2 T2R19 TAS2R19 1 0 - - - - -
T Sensory Taste 2 T2R20 TAS2R20 7 0 - - - - -
T Sensory Taste 2 T2R30 TAS2R30 4 0 - - - - -
T Sensory Taste 2 T2R31 TAS2R31 14 0 - - - - -
T Sensory Taste 2 T2R38 TAS2R38 13 0 - - - - -
T Sensory Taste 2 T2R39 TAS2R39 16 0 - - - - -
T Sensory Taste 2 T2R41 TAS2R41 2 0 - - - - -
T Sensory Taste 2 T2R42 TAS2R42 1 0 - - - - -
T Sensory Taste 2 T2R43 TAS2R43 14 0 - - - - -
T Sensory Taste 2 T2R45 TAS2R45 1 0 - - - - -
T Sensory Taste 2 T2R46 TAS2R46 26 3 7XP4,7XP5,... - - - -
T Sensory Taste 2 T2R50 TAS2R50 3 0 - - - - -
T Sensory Taste 2 T2R60 TAS2R60 1 0 - - - - -
Other Orphan Other GPCR orphans GP107 GPR107 0 0 - - - - -
Other Orphan Other GPCR orphans G137A GPR137 0 0 - - - - -
Other Orphan Other GPCR orphans TPRA1 TPRA1 0 0 - - - - -
Other Orphan Other GPCR orphans GP143 GPR143 1 0 - - - - -
Other Orphan Other GPCR orphans GP157 GPR157 0 0 - - - - -
Other Orphan Other GPCR orphans TM116 GPR214 0 0 - - - - -
A Aminergic 5-Hydroxytryptamine 5HT5B 5-HT5B 1 0 - - - - -
A Orphan A orphans TAAR4 TAAR4P 3 0 - - - - -
A Other Unclassified US28 US28 25 7 4XT1,4XT3,... - - - -
A Sensory Opsins A0A0K0YBE3 Other 0 0 - - - - -
A Sensory Opsins R9R6C6 TMTOPS2 0 0 - - - - -
A Sensory Opsins A0A1E1G6Y8 Parapinopsin 0 0 - - - - -
A Sensory Opsins Q95P33 CI-OPSIN1 0 0 - - - - -
A Sensory Opsins E7FEE5 OPN7B 0 0 - - - - -
A Sensory Opsins R9R6D2 TMT 0 0 - - - - -
A Other Unclassified Q3KSP2 BILF1 0 1 7JHJ - - - -
A Sensory Opsins Q868G4 AMPHIOP1 0 0 - - - - -
A Sensory Opsins F1NU85 OPN5-like 0 0 - - - - -
A Sensory Opsins W5J8F8 AND_008710 0 0 - - - - -