Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht7r_human 42 N-term G => V N/A N/A Bastiani CA et al (2003)
5ht7r_human 7.33x32 364 TM7 W => V 1.148↑ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => A 5.882↓ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => D 2.188↓ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => R Abolished effect pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => T Abolished effect pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.36x35 367 TM7 R => V Abolished effect pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.43x42 374 TM7 Y => A 21.739↓ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.43x42 374 TM7 Y => F 9.091↓ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.43x42 374 TM7 Y => T 9.091↓ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 8.48x48 389 H8 R => D 1.996↓ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 8.49x49 390 H8 D => K 2.188↓ pK(d) (Binding - Radioligand saturation) 5-CT Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 8.60x60 401 H8 C => S 1.385↓ K(d) (Binding - Radioligand saturation) [3H]5-CT Manfra O et al (2015) Vass M et al (2019)
5ht7r_human 7.33x32 364 TM7 W => V 1.621↓ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => A 1.259↓ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => D 1.024↓ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => R Abolished effect pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.35x34 366 TM7 E => T Abolished effect pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.36x35 367 TM7 R => V Abolished effect pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.43x42 374 TM7 Y => A 1.82↑ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.43x42 374 TM7 Y => F 3.39↓ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 7.43x42 374 TM7 Y => T 8.929↓ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 8.48x48 389 H8 R => D 1.288↑ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 8.49x49 390 H8 D => K 2.632↓ pK(d) (Binding - Radioligand saturation) SB269970 Impellizzeri AA et al (2015) Vass M et al (2019)
5ht7r_human 8.60x60 401 H8 C => S 1.312↑ K(d) (Binding - Radioligand competition/displacement) clozapine Manfra O et al (2015) Vass M et al (2019)
5ht7r_human 8.60x60 401 H8 C => S 3.889↑ K(d) (Binding - Radioligand competition/displacement) olanzapine Manfra O et al (2015) Vass M et al (2019)
5ht7r_human 3.32x32 162 TM3 D => A Abolished pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 3.36x36 166 TM3 C => A 111.111↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 3.37x37 167 TM3 T => A 1000.0↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 45.52x52 233 ECL2 I => A 71.429↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 5.39x40 240 TM5 T => A 250.0↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 5.42x43 243 TM5 S => A 30.303↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 6.48x48 340 TM6 W => A 38.462↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 6.51x51 343 TM6 F => A 41.667↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 6.52x52 344 TM6 F => A 4.785↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 6.52x52 344 TM6 F => V 250.0↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 6.55x55 347 TM6 S => A 3.236↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
5ht7r_human 7.43x42 374 TM7 Y => A 6.329↓ pEC50 (Functional - cAMP accumulation) 5-CT Huang S et al (2022)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K K L R ICL1ECL1 K W I F ECL1ICL2 P L T Y P V R Q ICL2ECL2 W A Q N V N D D K V C L I S Q ECL2ICL3 F P R V E P D S V I A L N G I V K L Q K E V E E C A N L S R L L K H E R K N ICL3ECL3 C G T S C S C I ECL3N-term M M D V N S S G R P D L Y G H L R S F L L P E V G R G L P D L S P D G G A D P V A G S W A P H L L S E V T A S P A P T W D A P P D N A S G C G E Q I N Y N-termC-term R N I N R K L S A A G M H E A L K L A E R P E R P E F V L R A C T R R V L L R P E K R P P V S V W V L Q S P D H H N W L A D K M L T T V E K K V M I H D C-term G R V E K V V I G S I L T L I T L L T I A G N C L V V I S V C F V Q P S N Y L I V S L A L A D L S V A V A V M P F V S V T D L I G G G H F F C N V F I A M D V M C C T A S I M T L C V I S I D R Y L G I T R N G K C M A K M I L S V W L L S A S I T L P P L F G D F G Y T I Y S T A V A F Y I P M S V M L F M Y Y Q I Y K A A R K S A A K H K F P G I S I F K R E Q K A A T T L G I I V G A F T V C W L P F F L L S T A R P F I P L W V E R T F L W L G Y A N S L I N P F I Y A F F N R D Y R S Q Y L R T T L L Q C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
C N G A I T L L T I L T L I S G I V V K 1 V S L A L A D L S V A A V V M P F V S V T 2 V C L T M I S A T C C M V D M A I F V N 3 M A K M I L S V W L L S A S I T L P P L 4 Y M F L M V S M P I Y F A V A T S Y I T Y 5 G I I V G A F T V C W L P F F L L S T A 6 F P N I L S N A Y G L W L F T R E V W 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT7 receptor
TM3
3x32 3.32x32 D162
3x36 3.36x36 C166
3x37 3.37x37 T167
TM5
5x40 5.39x40 T240
5x43 5.42x43 S243
TM6
6x48 6.48x48 W340
6x51 6.51x51 F343
6x52 6.52x52 F344
6x55 6.55x55 S347
TM7
7x32 7.33x32 W364
7x34 7.35x34 E366
7x35 7.36x35 R367
7x42 7.43x42 Y374
H8
8x48 8.48x48 R389
8x49 8.49x49 D390
8x60 8.60x60 C401