Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
glp1r_rat 8.57x57 416 H8 S => A N/A N/A Widmann C et al (1996)
glp1r_rat 1.64x64 169 TM1 F => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.51x51 321 TM5 F => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.52x52 322 TM5 L => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.54x54 324 TM5 F => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.57x57 327 TM5 V => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.58x58 328 TM5 I => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.59x59 329 TM5 C => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.60x60 330 TM5 I => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.61x61 331 TM5 V => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.62x62 332 TM5 I => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.63x63 333 TM5 A => L N/A N/A Mathi SK et al (1997)
glp1r_rat 5.64x64 334 TM5 K => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.65x65 335 TM5 L => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.66x66 336 TM5 K => L N/A N/A Mathi SK et al (1997)
glp1r_rat 12.48x48 170 ICL1 R => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.49x49 171 ICL1 H => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.50x50 172 ICL1 L => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.51x51 173 ICL1 H => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.44x44 174 TM2 C => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.45x45 175 TM2 T => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.46x46 176 TM2 R => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.47x47 177 TM2 N => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.38x39 262 TM4 E => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.39x40 263 TM4 Q => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.40x41 264 TM4 R => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.41x42 265 TM4 I => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.42x43 266 TM4 F => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.43x44 267 TM4 K => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.44x45 268 TM4 L => A N/A N/A Mathi SK et al (1997)
glp1r_rat 39 N-term W => A N/A N/A Wilmen A et al (1997)
glp1r_rat 72 N-term W => A N/A N/A Wilmen A et al (1997)
glp1r_rat 87 N-term W => A N/A N/A Wilmen A et al (1997)
glp1r_rat 91 N-term W => A N/A N/A Wilmen A et al (1997)
glp1r_rat 110 N-term W => A N/A N/A Wilmen A et al (1997)
glp1r_rat 120 N-term W => A N/A N/A Wilmen A et al (1997)
glp1r_rat 1.64x64 169 TM1 F => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.48x48 170 ICL1 R => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.49x49 171 ICL1 H => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.50x50 172 ICL1 L => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.51x51 173 ICL1 H => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.44x44 174 TM2 C => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.45x45 175 TM2 T => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.46x46 176 TM2 R => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.47x47 177 TM2 N => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.50x50 180 TM2 H => R N/A N/A Mathi SK et al (1997)
glp1r_rat 4.41x42 265 TM4 I => A N/A N/A Mathi SK et al (1997)
glp1r_rat 4.42x43 266 TM4 F => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.57x57 327 TM5 V => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.58x58 328 TM5 I => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.61x61 331 TM5 V => A N/A N/A Mathi SK et al (1997)
glp1r_rat 6.37x37 348 TM6 R => A N/A N/A Mathi SK et al (1997)
glp1r_rat 6.37x37 348 TM6 R => G N/A N/A Mathi SK et al (1997)
glp1r_rat 6.39x39 350 TM6 A => E N/A N/A Mathi SK et al (1997)
glp1r_rat 6.39x39 350 TM6 A => K N/A N/A Mathi SK et al (1997)
glp1r_rat 8.57x57 416 H8 S => A N/A N/A Widmann C et al (1996)
glp1r_rat 8.72x72 431 H8 S => A N/A N/A Widmann C et al (1996)
glp1r_rat 432 C-term S => A N/A N/A Widmann C et al (1996)
glp1r_rat 441 C-term S => A N/A N/A Widmann C et al (1996)
glp1r_rat 444 C-term S => A N/A N/A Widmann C et al (1996)
glp1r_rat 451 C-term S => A N/A N/A Widmann C et al (1996)
glp1r_rat 5.61x61 331 TM5 V => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.58x58 328 TM5 I => A N/A N/A Mathi SK et al (1997)
glp1r_rat 5.57x57 327 TM5 V => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.47x47 177 TM2 N => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.46x46 176 TM2 R => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.45x45 175 TM2 T => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.44x44 174 TM2 C => A N/A N/A Mathi SK et al (1997)
glp1r_rat 12.51x51 173 ICL1 H => A N/A N/A Mathi SK et al (1997)
glp1r_rat 2.50x50 180 TM2 H => R N/A N/A Schipani E et al (1997)
glp1r_rat 2.50x50 180 TM2 H => R 20.0↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Vilardaga JP et al (1996) Graaf Cd et al (2016)
glp1r_rat 2.50x50 180 TM2 H => R 21.277↓ IC50 (Binding - Radioligand competition/displacement) CHEMBL410972 Vilardaga JP et al (1996) Graaf Cd et al (2016)
glp1r_rat 6.37x37 348 TM6 R => G 5.0↓ K(d) (Binding - Radioligand competition/displacement) CHEMBL410972 Vilardaga JP et al (1996) Graaf Cd et al (2016)
glp1r_rat 6.37x37 348 TM6 R => G 11.905↓ IC50 (Binding - Radioligand competition/displacement) CHEMBL410972 Vilardaga JP et al (1996) Graaf Cd et al (2016)
glp1r_rat 6.37x37 348 TM6 R => A No effect K(d) (Binding - Radioligand saturation) CHEMBL410972 Takhar S et al (1996) Graaf Cd et al (2016)
glp1r_rat 6.38x38 349 TM6 L => A No effect K(d) (Binding - Radioligand saturation) CHEMBL410972 Takhar S et al (1996) Graaf Cd et al (2016)
glp1r_rat 6.39x39 350 TM6 A => K No effect K(d) (Binding - Radioligand saturation) CHEMBL410972 Takhar S et al (1996) Graaf Cd et al (2016)
glp1r_rat 6.39x39 350 TM6 A => E Abolished effect K(d) (Binding - Radioligand saturation) CHEMBL410972 Takhar S et al (1996) Graaf Cd et al (2016)
glp1r_rat 6.40x40 351 TM6 K => A N/A K(d) (Binding - Radioligand saturation) CHEMBL410972 Takhar S et al (1996) Graaf Cd et al (2016)
glp1r_rat 8.72x72 431 H8 S => A No effect EC50 (Functional - cAMP accumulation) glucagon Widmann C et al (1996) Salam W et al (2025)
glp1r_rat 441 C-term S => A No effect EC50 (Functional - cAMP accumulation) glucagon Widmann C et al (1996) Salam W et al (2025)
glp1r_rat 444 C-term S => A No effect EC50 (Functional - cAMP accumulation) glucagon Widmann C et al (1996) Salam W et al (2025)
glp1r_rat 451 C-term S => A No effect EC50 (Functional - cAMP accumulation) glucagon Widmann C et al (1996) Salam W et al (2025)
glp1r_rat 1.64x64 169 TM1 F => A 1.147↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 12.48x48 170 ICL1 R => A 1.444↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 12.49x49 171 ICL1 H => A 1.513↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 12.50x50 172 ICL1 L => A 1.147↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 12.51x51 173 ICL1 H => A 1.696↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 2.44x44 174 TM2 C => A 1.696↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 2.45x45 175 TM2 T => A 1.696↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 2.46x46 176 TM2 R => A 1.41↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 2.47x47 177 TM2 N => A Abolished effect K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 4.38x39 262 TM4 E => A Abolished effect K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 4.39x40 263 TM4 Q => A Abolished effect K(d) (Binding - Radioligand competition/displacement) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 4.40x41 264 TM4 R => A Abolished effect K(d) (Binding - Radioligand competition/displacement) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 4.41x42 265 TM4 I => A Abolished effect K(d) (Binding - Radioligand competition/displacement) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 4.42x43 266 TM4 F => A Abolished effect K(d) (Binding - Radioligand competition/displacement) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 4.43x44 267 TM4 K => A Abolished effect K(d) (Binding - Radioligand competition/displacement) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 4.44x45 268 TM4 L => A Abolished effect K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.51x51 321 TM5 F => A 1.098↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.52x52 322 TM5 L => A 1.025↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.53x53 323 TM5 V => A 1.708↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.54x54 324 TM5 F => A 1.0 K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.57x57 327 TM5 V => A 1.414↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.58x58 328 TM5 I => A 1.342↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.59x59 329 TM5 C => A 1.079↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.60x60 330 TM5 I => A 1.783↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.61x61 331 TM5 V => A 1.171↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.62x62 332 TM5 I => A 1.206↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.63x63 333 TM5 A => L 1.0 K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.64x64 334 TM5 K => A 2.05↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.65x65 335 TM5 L => A 1.139↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 5.66x66 336 TM5 K => A 1.108↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Mathi SK et al (1997) Yang D et al (2016)
glp1r_rat 39 N-term W => A Abolished effect K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 72 N-term W => A Abolished effect K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 87 N-term W => A 1.277↓ K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 87 N-term W => A 1.059↑ K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 87 N-term W => A 1.499↓ K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 91 N-term W => A Abolished effect K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 110 N-term W => A Abolished effect K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 120 N-term W => A Abolished effect K(d) (Binding - Radioligand saturation) glucagon-like peptide 1-(7-37) Wilmen A et al (1997) Yang D et al (2016)
glp1r_rat 2.50x50 180 TM2 H => R 35.5↓ Single-point (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Schipani E et al (1997)
glp1r_rat 2.52x52 182 TM2 N => A 2.304↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 2.60x60 190 TM2 R => A >18.868↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 2.67x67 197 TM2 K => A 5.076↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A 9.901↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 2.72x72 202 TM2 K => A 3.831↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 212 ECL1 H => A 2.12↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 215 ECL1 D => A 4.292↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 222 ECL1 D => A 1.227↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 3.30x30 227 TM3 R => A 1.227↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 3.43x43 240 TM3 N => A >18.868↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 3.50x50 247 TM3 E => A >18.868↓ K(d) (Binding - Radioligand saturation) CHEMBL410972 Xiao Q et al (2000) Yang D et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A 7.752↓ IC50 (Binding - Radioligand saturation) Exendin-4 Lopez de Maturana R et al (2002) Graaf Cd et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A 10.417↓ EC50 (Functional - cAMP accumulation) Exendin-4 Lopez de Maturana R et al (2002) Graaf Cd et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A 3.597↓ IC50 (Binding - Radioligand saturation) exendin(15-39) Lopez de Maturana R et al (2002) Graaf Cd et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A 4.608↓ IC50 (Binding - Radioligand saturation) exendin-(9-39) Lopez de Maturana R et al (2002) Graaf Cd et al (2016)
glp1r_rat 2.68x68 198 TM2 D => N 4.167↓ IC50 (Binding - Radioligand saturation) exendin-(9-39) Lopez de Maturana R et al (2002) Graaf Cd et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A 43.478↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Lopez de Maturana R et al (2002) Graaf Cd et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Lopez de Maturana R et al (2002) Yang D et al (2016)
glp1r_rat 2.68x68 198 TM2 D => N 1.375↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Lopez de Maturana R et al (2002) Yang D et al (2016)
glp1r_rat 2.68x68 198 TM2 D => A 62.5↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Lopez de Maturana R et al (2002) Yang D et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) Exendin-4 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) Exendin-4 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => L Abolished effect pIC50 (Binding - Radioligand saturation) Exendin-4 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) exendin-4(1-30) Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) exendin-4(9-30) Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) exendin-4(9-39) Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) exendin-(9-39) Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => L Abolished effect pIC50 (Binding - Radioligand saturation) exendin-(9-39) Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) glucagon-like peptide 1-(1-30) Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => L Abolished effect pIC50 (Binding - Radioligand saturation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => L Abolished effect pIC50 (Binding - Radioligand saturation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => R 3.165↓ pIC50 (Binding - Radioligand saturation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A 1.343↑ EC50 (Functional - cAMP accumulation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => L 1.253↑ EC50 (Functional - cAMP accumulation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => R 1.022↑ EC50 (Functional - cAMP accumulation) CHEMBL410972 Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 4.64x64 288 TM4 K => A Abolished effect pIC50 (Binding - Radioligand saturation) glucagon-like peptide 1-(9-30) Al-Sabah S et al (2003) Graaf Cd et al (2016)
glp1r_rat 2.74x74 204 TM2 M => A 2.469↓ EC50 (Functional - cAMP accumulation) CHEMBL410972 Lopez de Maturana R et al (2004) Graaf Cd et al (2016)
glp1r_rat 2.74x74 204 TM2 M => A 2.331↓ IC50 (Binding - Radioligand competition/displacement) CHEMBL410972 Lopez de Maturana R et al (2004) Yang D et al (2016)
glp1r_rat 2.75x75 205 TM2 Y => A 4.587↓ EC50 (Functional - cAMP accumulation) CHEMBL410972 Lopez de Maturana R et al (2004) Graaf Cd et al (2016)
glp1r_rat 2.75x75 205 TM2 Y => A 4.525↓ IC50 (Binding - Radioligand competition/displacement) CHEMBL410972 Lopez de Maturana R et al (2004) Yang D et al (2016)
glp1r_rat 438 C-term C => A 1.613↑ K(d) (Binding - Radioligand saturation) CHEMBL410972 Vazquez P et al (2005) Yang D et al (2016)
glp1r_rat 438 C-term C => A 1.8↑ EC50 (Functional - cAMP accumulation) CHEMBL410972 Vazquez P et al (2005) Yang D et al (2016)
glp1r_rat 3.29x29 226 TM3 C => A 1.445↓ pEC50 (Functional - cAMP accumulation) Exendin-4 Mann RJ et al (2010) Graaf Cd et al (2016)
glp1r_rat 3.29x29 226 TM3 C => A 1.289↓ pIC50 (Binding - Radioligand competition/displacement) exendin-(9-39) Mann RJ et al (2010) Yang D et al (2016)
glp1r_rat 3.29x29 226 TM3 C => A 24.39↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL410972 Mann RJ et al (2010) Yang D et al (2016)
glp1r_rat 3.29x29 226 TM3 C => A 38.462↓ pEC50 (Functional - cAMP accumulation) CHEMBL410972 Mann RJ et al (2010) Graaf Cd et al (2016)
glp1r_rat 45.50x50 296 ECL2 C => A 1.289↓ pEC50 (Functional - cAMP accumulation) Exendin-4 Mann RJ et al (2010) Graaf Cd et al (2016)
glp1r_rat 45.50x50 296 ECL2 C => A 1.318↓ pIC50 (Binding - Radioligand competition/displacement) exendin-(9-39) Mann RJ et al (2010) Yang D et al (2016)
glp1r_rat 45.50x50 296 ECL2 C => A 17.857↓ pIC50 (Binding - Radioligand competition/displacement) CHEMBL410972 Mann RJ et al (2010) Yang D et al (2016)
glp1r_rat 45.50x50 296 ECL2 C => A 3.086↓ pEC50 (Functional - cAMP accumulation) CHEMBL410972 Mann RJ et al (2010) Graaf Cd et al (2016)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V F ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A V T P S L L R L A L L L L G A V G R A G P R P Q G A T V S L S E T V Q K W R E Y R H Q C Q R F L T E A P L L A T G L F C N R T F D D Y A C W P D G P P G S F V N V S C P W Y L P W A S S V L Q G H V Y R F C T A E G I W L H K D N S S L P W R D L S E C E E S K Q G E R N S P N-termC-term S M K P L K C P T S S V S S G A T V G S S V Y A A T C Q N S C S C-term E E Q L L S L Y I I Y T V G Y A L S F S A L V I A S A I L V S F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L G C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q R I F K L Y L S I G W G V P L L F V I P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L V F I R V I C I V I A K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F V K L F T E L S F T S F Q G F M V A V L Y C F V N N E F R K W R L I Q R V Q M E S W E R E R L N D S
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V L A S F S L A Y G V T Y I I Y L S L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F K L Y L S G I W G V P L L F V I P W G 4 F V L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 V A V M F G Q F S T F S L E T F L K V 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x60 1.64x64 F169
TM2
2x37 2.44x44 C174
2x38 2.45x45 T175
2x39 2.46x46 R176
2x40 2.47x47 N177
2x43 2.50x50 H180
2x45 2.52x52 N182
2x53 2.60x60 R190
2x60 2.67x67 K197
2x61 2.68x68 D198
2x65 2.72x72 K202
2x67 2.74x74 M204
2x68 2.75x75 Y205
TM3
3x25 3.29x29 C226
3x26 3.30x30 R227
3x39 3.43x43 N240
3x46 3.50x50 E247
TM4
4x39 4.38x39 E262
4x40 4.39x40 Q263
4x41 4.40x41 R264
4x42 4.41x42 I265
4x43 4.42x43 F266
4x44 4.43x44 K267
4x45 4.44x45 L268
4x64 4.64x64 K288
TM5
5x55 5.51x51 F321
5x56 5.52x52 L322
5x57 5.53x53 V323
5x58 5.54x54 F324
5x61 5.57x57 V327
5x62 5.58x58 I328
5x63 5.59x59 C329
5x64 5.60x60 I330
5x65 5.61x61 V331
5x66 5.62x62 I332
5x67 5.63x63 A333
5x68 5.64x64 K334
5x69 5.65x65 L335
5x70 5.66x66 K336
TM6
6x32 6.37x37 R348
6x33 6.38x38 L349
6x34 6.39x39 A350
6x35 6.40x40 K351
H8
8x57 8.57x57 S416
8x72 8.72x72 S431